中熊秀喜 (Hideki Nakakuma) - マイポータル

基本情報

所属: 和歌山県立医科大学医学部血液内科学講座教授

学位: 博士(医学)(東京大学)

J-GLOBAL ID: 200901075308742235
researchmap会員ID: 1000193341

研究キーワード

研究分野

ライフサイエンス / 血液、腫瘍内科学 /

経歴

2003年 - 2004年

和歌山県立医科大学
1986年 - 2003年

熊本大学
2003年

- 和歌山県立医科大学
1978年 - 1986年

東京大学
1978年 - 1986年

University of Tokyo

学歴

委員歴

受賞

論文

C9欠損PNH患者における良質の生活の保持

中熊秀喜

119(16) 3866-3868 2012年4月査読有り

MISC

131

Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis

K. Kojima, M. Konopleva, T. Tsao, M. Andreeff, H. Ishida, Y. Shiotsu, L. Jin, Y. Tabe, H. Nakakuma

LEUKEMIA 24(1) 33-43 2010年1月
Establishment of CD5 and CD10 double-positive mature B-cell line, WILL1, showing complex 8q24 translocation involving 14q32 and 6q27

Shima Uneda, Minako Gotoh, Takashi Sonoki, Kazuhiro Nishida, Yasushi Nakamura, Miwa Kurimoto, Nobuyoshi Hanaoka, Hiroshi Matsuoka, Masafumi Taniwaki, Hideki Nakakuma

INTERNATIONAL JOURNAL OF HEMATOLOGY 88(5) 536-542 2008年12月
Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation

Takashi Sonoki, Sonoko Ishihara, Shima Uneda, Nobuyoshi Hanaoka, Miwa Kurimoto, Hiroshi Matsuoka, Hideki Nakakuma

INTERNATIONAL JOURNAL OF HEMATOLOGY 88(3) 299-303 2008年10月
Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

Kensuke Kojima, Marina Konopleva, Twee Tsao, Hideki Nakakuma, Michael Andreeff

BLOOD 112(7) 2886-2895 2008年10月
The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

K. Kojima, M. Shimanuki, M. Shikami, I. J. Samudio, V. Ruvolo, P. Corn, N. Hanaoka, M. Konopleva, M. Andreeff, H. Nakakuma

LEUKEMIA 22(9) 1728-1736 2008年9月
Rapid vanishing of tumors by withdrawal of methotrexate in Epstein-Barr virus-related B cell lymphoproliferative disorder

Shima Uneda, Takashi Sonoki, Yashushi Nakamura, Hiroshi Matsuoka, Hideki Nakakuma

INTERNAL MEDICINE 47(15) 1445-1446 2008年
New insights into molecular pathogenesis of bone marrow failure in paroxysmal nocturnal hemoglobinuria

Tatsuya Kawaguchi, Hideki Nakakuma

INTERNATIONAL JOURNAL OF HEMATOLOGY 86(1) 27-32 2007年7月
Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP.

Hanaoka N, Kawaguchi T, Horikawa K, Nagakura S, Mitsuya H, Nakakuma H

Blood 107(3) 1184-91 2006年
Diagnosis and management of paroxysmal nocturnal hemoglobinuria

C Parker, M Omine, S Richards, J Nishimura, M Bessler, R Ware, P Hillmen, L Luzzatto, N Young, T Kinoshita …

BLOOD 106(12) 3699-3709 2005年12月
Paroxysmal nocturnal hemoglobinuria

Mitsuhiro Omine, Taroh Kinoshita, Hideki Nakakuma, Jaroslaw P. Maciejewski, Charles J. Parker, Gérard Socié

International Journal of Hematology 82(5) 417-421 2005年
Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan

JI Nishimura, Y Kanakura, RE Ware, T Shichishima, H Nakakuma, H Ninomiya, CM Decastro, S Hall, A Kanamaru, KM Sullivan …

MEDICINE 83(3) 193-207 2004年5月
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor

Y Murakami, U Siripanyapinyo, YJ Hong, JY Kang, S Ishihara, H Nakakuma, Y Maeda, T Kinoshita

MOLECULAR BIOLOGY OF THE CELL 14(10) 4285-4295 2003年10月
Pathogenesis of selective expansion of PNH clones

H Nakakuma, T Kawaguchi

INTERNATIONAL JOURNAL OF HEMATOLOGY 77(2) 121-124 2003年2月
PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.

Murakami Y, Siripanyapinyo U, Hong Y, Kang JY, Ishihara S, Nakakuma H, Maeda Y, Kinoshita T

Mol Biol Cell 14(10) 4285-95 2003年
PNH clone acquires both a survival and a growth advantage? In: Paroxysmal nocturnal hemoglobinuria (PNH) and related disorders: Molecular aspects of pathogenesis.

Springer-Verlag Tokyo(jointly worked) 97-104 2003年
PNH clone acquires both a survival and a growth advantage? In: Paroxysmal nocturnal hemoglobinuria (PNH) and related disorders: Molecular aspects of pathogenesis.

Springer-Verlag Tokyo(jointly worked) 97-104 2003年
Pathogenesis of selective expansion of PNH clones

Hideki Nakakuma, Tatsuya Kawaguchi

International Journal of Hematology 77(2) 121-124 2003年
Decreased susceptibility of leukemic cells with PIG-A mutation to natural killer cells in vitro

S Nagakura, S Ishihara, DE Dunn, J Nishimura, T Kawaguchi, K Horikawa, M Hidaka, T Kagimoto, N Eto, H Mitsuya …

BLOOD 100(3) 1031-1037 2002年8月
Two cases showing clonal progression with full evolution from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome to myelodysplastic syndrome and leukemia.

Int J Hematol (jointly worked) 72 206-209 2002年
Frequent detection of T cells with mutations of the hypoxanthine-guanine phosphoribosyl transferase gene in patients with paroxysmal nocturnal hemoglobinuria

K Horikawa, T Kawaguchi, S Ishihara, S Nagakura, M Hidaka, T Kagimoto, H Mitsuya, H Nakakuma

BLOOD 99(1) 24-29 2002年1月

もっとみる

書籍等出版物

Non-immue hemoltic anemia

In Conn's Current Therapy 1999年
The protein kinase C pathway in tumor promotion. (共著)

"Skin carcinogenesis : Mechanism and Human Relevance" Alan R. Liss 1989年
Gene controlled expression of ganglioside . (共著)

"Cellular and Pathological Aspects of Glycoconjugate Metabolism. " Inserm 1984年

所属学協会

共同研究・競争的資金等の研究課題

発作性夜間血色素尿症の病因と病態に関する研究

その他の研究制度 1978年
Study on Etiology and pathogenesis of Paroxysmal Nocturnal Hemoglobinuria

The Other Research Programs 1978年
特発性造血障害の分子病態
癌の免疫エスケープ
Pathogenesis of marrow failure syndromes
Immune escape of tumor cells