論文

査読有り
2023年1月

Protective effects of liposomes encapsulating ferulic acid against CCl4-induced oxidative liver damage in vivo rat model

Journal of Clinical Biochemistry and Nutrition
  • Tabassum Ara
  • ,
  • 小野 智子
  • ,
  • Hasan M
  • ,
  • 大園 瑞音
  • ,
  • 小暮 健太朗

Vol.72
No.1
開始ページ
46
終了ページ
53
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3164/jcbn.22-37

Antioxidants are useful for the treatment of oxidative stress mediated liver damage. A naturally occurring antioxidant γ-oryzanol is rapidly hydrolyzed to its active hydrophobic metabolite, ferulic acid, inside the body. Limitations associated with the hydrophobicity of ferulic acid can be overcome by encapsulating in a liposomal formulation. As intravenously administered nanoparticles (including liposomes) can effectively reach the liver, such systems may be suitable drug delivery carriers to treat liver injury. In this study, we prepared a liposomal formulation of ferulic acid (ferulic-lipo) and examined its effects on liver damage induced by CCl. Ferulic-lipo were ~100 nm in size and drug encapsulation efficiency was about 92%. Ferulic-lipo showed potent scavenging efficacy against hydroxyl radical compared to α-tocopherol liposomes. Ferulic-lipo significantly prevented CCl-mediated cytotoxicity in human hepatocarcinoma cells. Furthermore, intravenous administration of ferulic-lipo significantly reduced alanine aminotransferase and aspartate amino transferase levels in a rat model of liver injury. CCl-mediated reactive oxygen species generation in liver was also reduced by intravenous administration of ferulic-lipo. Hepatoprotective effects of ferulic-lipo were demonstrated by histological observation of CCl-induced liver tissue damage. Therefore, ferulic-lipo exhibit potent antioxidative capacity and were suggested to be an effective formulation for prevention of oxidative damage of liver tissue.

リンク情報
DOI
https://doi.org/10.3164/jcbn.22-37
URL
https://repo.lib.tokushima-u.ac.jp/ja/117266
URL
https://web.db.tokushima-u.ac.jp/cgi-bin/edb_browse?EID=386965
URL
https://www.ncbi.nlm.nih.gov/pubmed/36777075
ID情報
  • DOI : 10.3164/jcbn.22-37
  • ISSN : 0912-0009
  • eISSN : 1880-5086

エクスポート
BibTeX RIS