Saya, Hideyuki

J-GLOBAL         Last updated: Jun 6, 2019 at 04:05
 
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Name
Saya, Hideyuki
Affiliation
Keio University
Section
School of Medicine Institute for Advanced Medical Research (Division of Gene Regulation)
Job title
Professor
Other affiliation
School of Medicine
Research funding number
80264282

Profile

Hideyuki Saya MD, PhD graduated from Kobe University School of Medicine in 1981 and was Resident in the Neurosurgery until 1983. After which he joined the Graduate School of Medical Sciences granting his PhD in 1987. He studied as a Postdoctoral Fellow in UCSF until 1988 then was appointed Assistant Professor at the Neuro-Oncology, M.D. Anderson Cancer Center. Houston, TX. From 1994 to 2006 he was Professor, Kumamoto University School of Medicine before taking his current position in Keio University School of Medicine in 2007. He is currently a vice president of Keio University Hospital and Director of Clinical and Translational Research Center.

Published Papers

 
Suzuki K., Miura Y., Mochida Y., Miyazaki T., Toh K., Anraku Y., Melo V., Liu X., Ishii T., Nagano O., Saya H., Cabral H., Kataoka K.
Journal of Controlled Release   301 28-41   May 2019
© 2019 Elsevier B.V. Nanomedicine modification with ligands directed to receptors on tumor blood vessels has the potential for selectively enhancing nanomedicine accumulation in malignant tissues by overcoming the vascular barrier of tumors. Never...
Tamura R., Miyoshi H., Sampetrean O., Shinozaki M., Morimoto Y., Iwasawa C., Fukaya R., Mine Y., Masuda H., Maruyama T., Narita M., Saya H., Yoshida K., Okano H., Toda M.
Molecular brain   12(1)    May 2019
Glioblastoma exhibits phenotypic and genetic heterogeneity, aggressive invasiveness, therapeutic resistance, and tumor recurrence, which can be explained by the existence of glioma stem cells (GSCs). In this study, we visualized the spatiotemporal...
Motohara T., Masuda K., Morotti M., Zheng Y., El-Sahhar S., Chong K., Wietek N., Alsaadi A., Karaminejadranjbar M., Hu Z., Artibani M., Gonzalez L., Katabuchi H., Saya H., Ahmed A.
Oncogene   38(16) 2885-2898   Apr 2019
© 2018, The Author(s). Metastasis is a complex multistep process that involves critical interactions between cancer cells and a variety of stromal components in the tumor microenvironment, which profoundly influence the different aspects of the me...
Ogihara K., Kikuchi E., Okazaki S., Hagiwara M., Takeda T., Matsumoto K., Kosaka T., Mikami S., Saya H., Oya M.
Cancer Science   110(4) 1431-1441   Apr 2019
© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. The prognostic role of CD44v9, a variant isoform of CD44 and a new cell surface marker of cancer stem cells, remains uncl...
Harigai Ritsuko, Sakai Shigeki, Nobusue Hiroyuki, Hirose Chikako, Sampetrean Oltea, Minami Noriaki, Hata Yukie, Kasama Takashi, Hirose Takanori, Takenouchi Toshiki, Kosaki Kenjiro, Kishi Kazuo, Saya Hideyuki, Arima Yoshimi
Scientific Reports   8(1)    Dec 2018
<p>Neurofibromatosis type 1 (NF1) is caused by germline mutations in the NF1 gene and is characterized by café au lait spots and benign tumours known as neurofibromas. NF1 encodes the tumour suppressor protein neurofibromin, which negatively regul...
Shiota Megumi, Naya Masayuki, Yamamoto Takehiro, Hishiki Takako, Tani Takeharu, Takahashi Hiroyuki, Kubo Akiko, Koike Daisuke, Itoh Mai, Ohmura Mitsuyo, Kabe Yasuaki, Sugiura Yuki, Hiraoka Nobuyoshi, Morikawa Takayuki, Takubo Keiyo, Suina Kentaro, Nagashima Hideaki, Sampetrean Oltea, Nagano Osamu, Saya Hideyuki, Yamazoe Shogo, Watanabe Hiroyuki, Suematsu Makoto
Nature Communications   9(1)    Dec 2018
<p>Gold deposition with diagonal angle towards boehmite-based nanostructure creates random arrays of horse-bean-shaped nanostructures named gold-nanofève (GNF). GNF generates many electromagnetic hotspots as surface-enhanced Raman spectroscopy (SE...
Kobayashi Nana, Okazaki Shogo, Sampetrean Oltea, Irie Junichiro, Itoh Hiroshi, Saya Hideyuki
Scientific Reports   8(1)    Dec 2018
<p>CD44 variant (CD44v) contributes to cancer stemness by stabilizing the xCT subunit of system xc(-) and thereby promoting its glutamate-cystine antiporter activity. CD44 has also been implicated in autoimmune insulitis and inflammation in diabet...
Suina K., Tsuchihashi K., Yamasaki J., Kamenori S., Shintani S., Hirata Y., Okazaki S., Sampetrean O., Baba E., Akashi K., Mitsuishi Y., Takahashi F., Takahashi K., Saya H., Nagano O.
Cancer Science   109(12) 3874-3882   Dec 2018
© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Autocrine and paracrine factors, including glutamate and epidermal growth factor (EGF), are potent inducers of brain tumor...
Tabata Y., Imaizumi Y., Sugawara M., Andoh-Noda T., Banno S., Chai M., Sone T., Yamazaki K., Ito M., Tsukahara K., Saya H., Hattori N., Kohyama J., Okano H.
Stem Cell Reports   11(5) 1171-1184   Nov 2018
© 2018 The Author(s) Parkinson disease (PD) is a progressive neurological disease caused by selective degeneration of dopaminergic (DA) neurons in the substantia nigra. Although most cases of PD are sporadic cases, familial PD provides a versatile...
Miyoshi S., Tsugawa H., Matsuzaki J., Hirata K., Mori H., Saya H., Kanai T., Suzuki H.
Anticancer Research   38(11) 6163-6170   Nov 2018
© 2018 International Institute of Anticancer Research.All right reserved. Background/Aim: Cancer stem cells (CSCs) play a critical role in resistance to chemotherapy. CD44 is a cell surface marker of CSCs. CD44 variant 9 (CD44v9) interacts with a ...
Fujimori K., Ishikawa M., Otomo A., Atsuta N., Nakamura R., Akiyama T., Hadano S., Aoki M., Saya H., Sobue G., Okano H.
Nature Medicine   24(10) 1579-1589   Oct 2018
© 2018, The Author(s). Amyotrophic lateral sclerosis (ALS) is a heterogeneous motor neuron disease for which no effective treatment is available, despite decades of research into SOD1-mutant familial ALS (FALS). The majority of ALS patients have n...
Mukai S., Ogawa Y., Saya H., Kawakami Y., Tsubota K.
PLoS ONE   13(10)    Oct 2018
© 2018 Mukai et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr...
Okazaki S., Shintani S., Hirata Y., Suina K., Semba T., Yamasaki J., Umene K., Ishikawa M., Saya H., Nagano O.
Oncotarget   9(73) 33832-33843   Sep 2018
© Okazaki et al. The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition re...
Hosonaga Mari, Arima Yoshimi, Sampetrean Oltea, Komura Daisuke, Koya Ikuko, Sasaki Takashi, Sato Eiichi, Okano Hideyuki, Kudoh Jun, Ishikawa Shumpei, Saya Hideyuki, Ishikawa Takashi
International journal of molecular sciences   19(8)    Aug 2018
<p>Intratumoral human epidermal growth factor receptor 2 (HER2) heterogeneity has been reported in 16–36% of HER2-positive breast cancer and its clinical impact is under discussion. We examined the biological effects of HER2-heterogeneity on mouse...
Saito Yoshiyuki, Onishi Nobuyuki, Takami Hiroshi, Seishima Ryo, Inoue Hiroyoshi, Hirata Yuki, Kameyama Kaori, Tsuchihashi Kenji, Sugihara Eiji, Uchino Shinya, Ito Koichi, Kawakubo Hirofumi, Takeuchi Hiroya, Kitagawa Yuko, Saya Hideyuki, Nagano Osamu
Biochemical and Biophysical Research Communications   497(2) 783-789   Mar 2018
<p>The low turnover rate of thyroid follicular cells and the lack of a long-term thyroid cell culture system have hampered studies of thyroid carcinogenesis. We have now established a thyroid organoid culture system that supports thyroid cell prol...
Otsuki Yuji, Saya Hideyuki, Arima Yoshimi
Developmental Dynamics   247(3) 462-472   Mar 2018
<p>Lung cancer is the most common cancer worldwide. Treatment options for lung cancer include surgery, radiation therapy, chemotherapy, molecularly targeted therapy including epidermal growth factor receptor or anaplastic lymphoma kinase inhibitor...
Shibao Shunsuke, Minami Noriaki, Koike Naoyoshi, Fukui Nobuyuki, Yoshida Kazunari, Saya Hideyuki, Sampetrean Oltea
Neuro-Oncology   20(3) 343-354   Feb 2018
<p>Background. Glioblastomas have been shown to rely on glycolysis as an energy source. However, recent evidence suggests that at least a subset of glioma cells with stem cell-like properties can thrive on oxidative phosphorylation. It remains unc...
Ouchi T., Morikawa S., Shibata S., Takahashi M., Yoshikawa M., Soma T., Miyashita H., Muraoka W., Kameyama K., Kawana H., Arima Y., Saya H., Okano H., Nakagawa T., Asoda S.
Journal of Dental Research   97(7) 779-786   Feb 2018
<p>This study investigated a case of spindle cell carcinoma (SpCC) in tongue pathological lesions. The patient experienced a local recurrence and distant metastasis after surgical intervention. Although standard chemotherapy was administered, a gr...
Hagiwara Masayuki, Kikuchi Eiji, Tanaka Nobuyuki, Kosaka Takeo, Mikami Shuji, Saya Hideyuki, Oya Mototsugu
BMC Cancer   18(1)    Jan 2018
<p>Background: Cisplatin is the most commonly used chemotherapeutic agent in the treatment of patients with metastatic and/or recurrent urothelial cancer. However, the effectiveness of these treatments is severely limited due to the development of...
Semba Takashi, Sugihara Eiji, Kamoshita Nagisa, Ueno Sayaka, Fukuda Keitaro, Yoshino Masafumi, Takao Kazumasa, Yoshikawa Kazunori, Izuhara Kenji, Arima Yoshimi, Suzuki Makoto, Saya Hideyuki
Cancer Science   109(5) 1447-1454   Jan 2018
<p>Metastasis is the leading cause of cancer death. A tumor-supportive microenvironment, or premetastatic niche, at potential secondary tumor sites plays an important role in metastasis, especially in tumor cell colonization. Although a fibrotic m...
Sampetrean Oltea, Saya Hideyuki
Cancer Science   109(1) 6-14   Jan 2018
<p>Malignant gliomas are primary tumors of the central nervous system characterized by diffuse infiltration into the brain and a high recurrence rate. Advances in comprehensive genomic studies have provided unprecedented insight into the genetic a...
Yamauchi Teruo, Fernandez Jose Rodrigo Espinosa, Imamura Chiyo K., Yamauchi Hideko, Jinno Hiromitsu, Takahashi Maiko, Kitagawa Yuko, Nakamura Seigo, Lim Bora, Krishnamurthy Savitri, Reuben James M., Liu Diane, Tripathy Debasish, Chen Helen, Takebe Naoko, Saya Hideyuki, Ueno Naoto T.
Oncotarget   9(6) 6872-6882   Jan 2018
<p>Chemotherapy has been reported to increase the proportion of cancer stem cells (CSCs) and to promote epithelial-mesenchymal transition (EMT) phenotype changes. Anti-HER2 therapy may provide a strategy for eliminating CSC and EMT, which contribu...
Oike Takatsugu, Sato Yuiko, Kobayashi Tami, Miyamoto Kana, Nakamura Satoshi, Kaneko Yosuke, Kobayashi Shu, Harato Kengo, Saya Hideyuki, Matsumoto Morio, Nakamura Masaya, Niki Yasuo, Miyamoto Takeshi
Scientific Reports   7(1)    Dec 2017
<p>Rheumatoid arthritis (RA) is a multi-factorial disease characterized by chronic inflammation and destruction of multiple joints. To date, various biologic treatments for RA such as anti-Tumor necrosis factor alpha antibodies have been developed...
Kitagawa Mayumi, Liao Pei Ju, Lee Kyung Hee, Wong Jasmine, Shang See Cheng, Minami Noriaki, Sampetrean Oltea, Saya Hideyuki, Lingyun Dai, Prabhu Nayana, Diam Go Ka, Sobota Radoslaw, Larsson Andreas, Nordlund Pär, McCormick Frank, Ghosh Sujoy, Epstein David M., Dymock Brian W., Lee Sang Hyun
Nature Communications   8(1)    Dec 2017
<p>Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA sc...
Yu Lei, Moriguchi Takashi, Kaneko Hiroshi, Hayashi Makiko, Hasegawa Atsushi, Nezu Masahiro, Saya Hideyuki, Yamamoto Masayuki, Shimizu Ritsuko
Molecular and Cellular Biology   37(22)    Nov 2017
<p>Acute kidney injury (AKI) is a leading cause of chronic kidney disease. Proximal tubules are considered to be the primary origin of pathogenic inflammatory cytokines in AKI. However, it remains unclear whether other cell types, including collec...
Minami Noriaki, Maeda Yusuke, Shibao Shunsuke, Arima Yoshimi, Ohka Fumiharu, Kondo Yutaka, Maruyama Koji, Kusuhara Masatoshi, Sasayama Takashi, Kohmura Eiji, Saya Hideyuki, Sampetrean Oltea
Cancer Medicine   6(11) 2635-2645   Nov 2017
<p>Therapeutic options for malignant brain tumors are limited, with new drugs being continuously evaluated. Organotypic brain slice culture has been adopted for neuroscience studies as a system that preserves brain architecture, cellular function,...
Kawano Yuko, Iwama Eiji, Tsuchihashi Kenji, Shibahara Daisuke, Harada Taishi, Tanaka Kentaro, Nagano Osamu, Saya Hideyuki, Nakanishi Yoichi, Okamoto Isamu
Lung Cancer   113 72-78   Nov 2017
<p>Objectives The regulation of redox balance in cancer cells is an important factor in tumor development and chemoresistance, with oncogene activation having been shown to induce the generation of reactive oxygen species (ROS). Activating mutatio...
Matsuzaki Yuriko, Sakuma Tetsushi, Yamamoto Takashi, Saya Hideyuki
PLoS One   12(10)    Oct 2017
<p>Phosphatase and tensin homolog (PTEN) is a lipid and protein phosphatase that antagonizes signaling by the phosphatidylinositol 3-kinase (PI3K)–AKT signaling pathway. The PTEN gene is a major tumor suppressor, with mutations of this gene occurr...
Haryu Shinya, Saito Ryuta, Jia Wenting, Shoji Takuhiro, Mano Yui, Sato Aya, Kanamori Masayuki, Sonoda Yukihiko, Sampetrean Oltea, Saya Hideyuki, Tominaga Teiji
Journal of Neuro-Oncology   136(1) 1-9   Sep 2017
<p>Expression of CD44 in glioma cells was previously correlated with tumor grade and is considered a stem cell marker. CD44 stabilizes the cystine–glutamate transporter (xCT) and inhibits apoptosis in cancer stem cells (CSCs). Recently it was foun...
Miyano Kazuki, Cabral Horacio, Miura Yutaka, Matsumoto Yu, Mochida Yuki, Kinoh Hiroaki, Iwata Caname, Nagano Osamu, Saya Hideyuki, Nishiyama Nobuhiro, Kataoka Kazunori, Yamasoba Tatsuya
Journal of Controlled Release   261 275-286   Sep 2017
<p>Recalcitrant head and neck squamous cell carcinoma (HNSCC) usually relapses after therapy due to the enrichment of drug resistant cancer stem-like cells (CSCs). Nanomedicines have shown potential for eradicating both cancer cells and CSCs by ef...
Chonan Yuta, Taki Sotaro, Sampetrean Oltea, Saya Hideyuki, Sudo Ryo
Integrative Biology (United Kingdom)   9(9) 762-773   Sep 2017
<p>Glioblastoma (GBM) is a highly invasive primary brain tumor that displays cellular heterogeneity, which is composed of glioma initiating cells (GICs) and their differentiated progeny. GICs play an important role in driving aggressive invasion. ...
Shimizu Takatsune, Kamel Walied A., Yamaguchi-Iwai Sayaka, Fukuchi Yumi, Muto Akihiro, Saya Hideyuki
Cancer Science   108(9) 1793-1802   Sep 2017
<p>Osteosarcoma is the most common type of primary bone tumor, and novel therapeutic approaches for this disease are urgently required. To identify effective agents, we screened a panel of Food and Drug Administration (FDA)-approved drugs in AXT c...
Furuya Masataka, Masuda Hirotaka, Hara Kanako, Uchida Hiroshi, Sato Kenji, Sato Suguru, Asada Hironori, Maruyama Tetsuo, Yoshimura Yasunori, Katabuchi Hidetaka, Tanaka Mamoru, Saya Hideyuki
Acta Obstetricia et Gynecologica Scandinavica   96(9) 1128-1135   Sep 2017
<p>Introduction: Although endometriosis is a benign disease, it shares some features with cancers, such as invasiveness and the potential to metastasize. This study sought to investigate the epithelial-mesenchymal transition status in human endome...
Ishimoto Takatsugu, Miyake Keisuke, Nandi Tannistha, Yashiro Masakazu, Onishi Nobuyuki, Huang Kie Kyon, Lin Suling Joyce, Kalpana Ramnarayanan, Tay Su Ting, Suzuki Yuka, Cho Byoung Chul, Kuroda Daisuke, Arima Kota, Izumi Daisuke, Iwatsuki Masaaki, Baba Yoshifumi, Oki Eiji, Watanabe Masayuki, Saya Hideyuki, Hirakawa Kosei, Baba Hideo, Tan Patrick
Gastroenterology   153(1) 191-204.e16   Jul 2017
<p>Background & Aims Fibroblasts that interact with cancer cells are called cancer-associated fibroblasts (CAFs), which promote progression of different tumor types. We investigated the characteristics and functions of CAFs in diffuse-type gastric...
Kasai Shin, Furuichi Yoshiyuki, Ando Norie, Kagami Keiko, Abe Masako, Nakane Takaya, Goi Kumiko, Inukai Takeshi, Saitoh Sei, Ohno Shinichi, Okazaki Shogo, Nagano Osamu, Saya Hideyuki, Sugita Kanji
Cell death & disease   8(6) e2857   Jun 2017
<p>Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression. Known that CD44 has the specific binding sites for a natural ligand ...
Nishino Makoto, Ozaki Mari, Hegab Ahmed E., Hamamoto Junko, Kagawa Shizuko, Arai Daisuke, Yasuda Hiroyuki, Naoki Katsuhiko, Soejima Kenzo, Saya Hideyuki, Betsuyaku Tomoko
Journal of Cancer   8(10) 1774-1785   Jun 2017
<p>Background: Preliminary studies have identified cancer stem cells (CSCs) in various cancers and there are several ongoing clinical studies targeting these cells. CD44 (standard or variant isoforms) and/or aldehyde dehydrogenase (ALDH) expressio...
Kikuchi Ryogo, Sampetrean Oltea, Saya Hideyuki, Yoshida Kazunari, Toda Masahiro
Journal of Neuro-Oncology   1-11   May 2017
<p>DEP domain containing 1 (DEPDC1) is a novel oncoantigen expressed in cancer cells, which presents oncogenic activity and high immunogenicity. Although DEPDC1 has been predicted to be a useful antigen for the development of a cancer vaccine, its...
Shitara Kohei, Doi Toshihiko, Nagano Osamu, Fukutani Miki, Hasegawa Hiromi, Nomura Shogo, Sato Akihiro, Kuwata Takeshi, Asai Kai, Einaga Yasuaki, Tsuchihashi Kenji, Suina Kentaro, Maeda Yusuke, Saya Hideyuki, Ohtsu Atsushi
Gastric Cancer   1-6   May 2017
<p>A previous dose-escalation study of sulfasalazine (SSZ), an inhibitor of cystine-glutamate exchange transporter xc (–), in the variant form of CD44 (CD44v)-positive cancer stem cells (CSCs) suggested that administration of SSZ induces the reduc...
Chew Shan Hwu, Okazaki Yasumasa, Akatsuka Shinya, Wang Shenqi, Jiang Li, Ohara Yuuki, Ito Fumiya, Saya Hideyuki, Sekido Yoshitaka, Toyokuni Shinya
Free Radical Biology and Medicine   106 91-99   May 2017
<p>CD44 exists as a standard (CD44s) isoform and different variant isoforms (CD44v) due to alternative splicing. While the complex nature of these different isoforms has not been fully elucidated, CD44v expression has been shown to exert oncogenic...
Ishizawa Jo, Sugihara Eiji, Kuninaka Shinji, Mogushi Kaoru, Kojima Kensuke, Benton Christopher B., Zhao Ran, Chachad Dhruv, Hashimoto Norisato, Jacamo Rodrigo O., Qiu Yihua, Yoo Suk Young, Okamoto Shinichiro, Andreeff Michael, Kornblau Steven M., Saya Hideyuki
Blood   129(14) 1958-1968   Apr 2017
<p>FZR1 (fizzy-related protein homolog; also known as CDH1 [cell division cycle 20 related 1]) functions in the cell cycle as a specific activator of anaphase-promoting complex or cyclosome ubiquitin ligase, regulating late mitosis, G1 ...
Sato Aya, Mizobuchi Yoshifumi, Nakajima Kohei, Shono Kenji, Fujihara Toshitaka, Kageji Teruyoshi, Kitazato Keiko, Matsuzaki Kazuhito, Mure Hideo, Kuwayama Kazuyuki, Sumi Akiko, Saya Hideyuki, Sampetrean Oltea, Nagahirao Shinji
Journal of Neuro-Oncology   132(2) 231-238   Apr 2017
<p>Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against...
Yagishita Atsushi, Ueno Tasuku, Esumi Hiroyasu, Saya Hideyuki, Kaneko Kazuhiro, Tsuchihara Katsuya, Urano Yasuteru
Bioconjugate Chemistry   28(2) 302-306   Feb 2017
<p>Aldehyde dehydrogenase (ALDH) is overexpressed in some subpopulations of stem cells and cancer cells. We have designed and synthesized the first selective fluorescent probe for class 3 ALDH (ALDH3A1). This probe enabled the visualization of ALD...
Kamel Walied A., Sugihara Eiji, Nobusue Hiroyuki, Yamaguchi-Iwai Sayaka, Onishi Nobuyuki, Maki Kenta, Fukuchi Yumi, Matsuo Koichi, Muto Akihiro, Saya Hideyuki, Shimizu Takatsune
Molecular Cancer Therapeutics   16(1) 182-192   Jan 2017
<p>Osteosarcoma is the most common type of primary bone tumor, novel therapeutic agents for which are urgently needed. To identify such agents, we screened a panel of approved drugs with a mouse model of osteosarcoma. The screen identified simvast...
Otsubo Kohei, Nosaki Kaname, Imamura Chiyo K., Ogata Hiroaki, Fujita Akitaka, Sakata Shinya, Hirai Fumihiko, Toyokawa Gouji, Iwama Eiji, Harada Taishi, Seto Takashi, Takenoyama Mitsuhiro, Ozeki Takeshi, Mushiroda Taisei, Inada Mieko, Kishimoto Junji, Tsuchihashi Kenji, Suina Kentaro, Nagano Osamu, Saya Hideyuki, Nakanishi Yoichi, Okamoto Isamu
Cancer Science      2017
<p>Spliced variant isoforms of CD44 (CD44v) are a marker of cancer stem cells in solid tumors. They stabilize the xCT subunit of the transporter system xc(-) and thereby promote synthesis of the antioxidant glutathione. Salazosulfapyridine (SASP) ...
Tayama Shingo, Motohara Takeshi, Narantuya Dashdemberel, Li Chenyan, Fujimoto Koichi, Sakaguchi Isao, Tashiro Hironori, Saya Hideyuki, Nagano Osamu, Katabuchi Hidetaka
Oncotarget   8(27) 44312-44325   2017
<p>Epithelial ovarian cancer is a highly lethal malignancy; moreover, overcoming chemoresistance is the major challenging in treating ovarian cancer patients. The cancer stem cell (CSC) hypothesis considers CSCs to be the main culprits in driving ...
Sato Ryo, Nakano Teppei, Hosonaga Mari, Sampetrean Oltea, Harigai Ritsuko, Sasaki Takashi, Koya Ikuko, Okano Hideyuki, Kudoh Jun, Saya Hideyuki, Arima Yoshimi
BioMed Research International   2017    2017
<p>Metastasis is the main cause of treatment failure and death in cancer patients. Metastasis of tumor cells to the brain occurs frequently in individuals with breast cancer, non-small cell lung cancer, or melanoma. Despite recent advances in our ...
Jeong Sangho, Choi Eunyoung, Petersen Christine P., Roland Joseph T., Federico Alessandro, Ippolito Rossana, D'Armiento Francesco P., Nardone Gerardo, Nagano Osamu, Saya Hideyuki, Romano Marco, Goldenring James R.
United European Gastroenterology Journal   5(1) 37-44   2017
<p>Background: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of ...
Ueda T., Nakata Y., Yamasaki N., Oda H., Sentani K., Kanai A., Onishi N., Ikeda K., Sera Y., Honda Z. I., Tanaka K., Sata M., Ogawa S., Yasui W., Saya H., Takita J., Honda H.
Oncogene   35(34) 4447-4458   Aug 2016
<p>Overexpression of MYCN is a hallmark of neuroblastoma (NB). ALK R1275Q, an activating mutation of ALK (anaplastic lymphoma kinase), has been found in sporadic and familial NB patients. In this report, we demonstrated that ALK R1275Q knock-in, M...
Tominaga K., Shimamura T., Kimura N., Murayama T., Matsubara D., Kanauchi H., Niida A., Shimizu S., Nishioka K., Tsuji E. I., Yano M., Sugano S., Shimono Y., Ishii H., Saya H., Mori M., Akashi K., Tada K. I., Ogawa T., Tojo A., Miyano S., Gotoh N.
Oncogene      Aug 2016
<p>The transcription factor nuclear factor-κB (NF-κB) has important roles for tumorigenesis, but how it regulates cancer stem cells (CSCs) remains largely unclear. We identified insulin-like growth factor 2 (IGF2) is a key target of NF-κB activate...
Teye Kwesi, Numata Sanae, Ishii Norito, Krol Rafal P., Tsuchisaka Atsunari, Hamada Takahiro, Koga Hiroshi, Karashima Tadashi, Ohata Chika, Tsuruta Daisuke, Saya Hideyuki, Haftek Marek, Hashimoto Takashi
PLoS One   11(8)    Aug 2016
<p>CD44, a cell surface proteoglycan, is involved in many biological events. CD44 transcripts undergo complex alternative splicing, resulting in many functionally distinct isoforms. To date, however, the nature of these isoforms in human epidermis...
Sato Ryo, Semba Takashi, Saya Hideyuki, Arima Yoshimi
Stem Cells   34(8) 1997-2007   Aug 2016
<p>Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like properties that are able to self-renew, generate differentiated daughter cells, and give rise to heterogeneous tumor tissue. Tumor heterogeneity is a hallm...
Thanee Malinee, Loilome Watcharin, Techasen Anchalee, Sugihara Eiji, Okazaki Shogo, Abe Shinya, Ueda Shiho, Masuko Takashi, Namwat Nisana, Khuntikeo Narong, Titapun Attapol, Pairojkul Chawalit, Saya Hideyuki, Yongvanit Puangrat
Cancer Science   107(7) 991-1000   Jul 2016
<p>Expression of CD44, especially the variant isoforms (CD44v) of this major cancer stem cell marker, contributes to reactive oxygen species (ROS) defense through stabilizing xCT (a cystine–glutamate transporter) and promoting glutathione synthesi...
Lee Da Hye, Park Jae Oh, Kim Tae Shin, Kim Sang Kyum, Kim Tack Hoon, Kim Min Chul, Park Gun Soo, Kim Jeong Hwan, Kuninaka Shinji, Olson Eric N., Saya Hideyuki, Kim Seon Young, Lee Ho, Lim Dae Sik
Nature Communications   7    Jun 2016
<p>The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells, but its role in cell fate determination and differentiation during liver development remains unclear. Here we report that the Hippo pathway controls l...
Sosulski Amanda, Horn Heiko, Zhang Lihua, Coletti Caroline, Vathipadiekal Vinod, Castro Cesar M., Birrer Michael J., Nagano Osamu, Saya Hideyuki, Lage Kasper, Donahoe Patricia K., Pépin David
PLoS One   11(6)    Jun 2016
<p>CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other cancers. Expression of t...
Wang Ming, Miura Yutaka, Tsuchihashi Kenji, Miyano Kazuki, Nagano Osamu, Yoshikawa Momoko, Tanabe Ami, Makino Jun, Mochida Yuki, Nishiyama Nobuhiro, Saya Hideyuki, Cabral Horacio, Kataoka Kazunori
Journal of Controlled Release   230 26-33   May 2016
<p>Eventual relapse of tumor growth is commonly observed in head and neck cancer patients, following treatment with platinum-based chemotherapies. This occurrence is believed to be related to the failure to eradicate drug resistant, cancer stem ce...
Tsuchihashi Kenji, Okazaki Shogo, Ohmura Mitsuyo, Ishikawa Miyuki, Sampetrean Oltea, Onishi Nobuyuki, Wakimoto Hiroaki, Yoshikawa Momoko, Seishima Ryo, Iwasaki Yoshimi, Morikawa Takayuki, Abe Shinya, Takao Ayumi, Shimizu Misato, Masuko Takashi, Nagane Motoo, Furnari Frank B., Akiyama Tetsu, Suematsu Makoto, Baba Eishi, Akashi Koichi, Saya Hideyuki, Nagano Osamu
Cancer Research   76(10) 2954-2963   May 2016
<p>Extracellular free amino acids contribute to the interaction between a tumor and its microenvironment through effects on cellular metabolism and malignant behavior. System xc(-) is composed of xCT and CD98hc subunits and functions as a plasma m...
Miyawaki Shingo, Kawamura Yoshimi, Oiwa Yuki, Shimizu Atsushi, Hachiya Tsuyoshi, Bono Hidemasa, Koya Ikuko, Okada Yohei, Kimura Tokuhiro, Tsuchiya Yoshihiro, Suzuki Sadafumi, Onishi Nobuyuki, Kuzumaki Naoko, Matsuzaki Yumi, Narita Minoru, Ikeda Eiji, Okanoya Kazuo, Seino Ken Ichiro, Saya Hideyuki, Okano Hideyuki, Miura Kyoko
Nature Communications   7    May 2016
<p>The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming inductio...
Fukaya Raita, Ohta Shigeki, Yaguchi Tomonori, Matsuzaki Yumi, Sugihara Eiji, Okano Hideyuki, Saya Hideyuki, Kawakami Yutaka, Kawase Takeshi, Yoshida Kazunari, Toda Masahiro
Cancer Research   76(9) 2813-2823   May 2016
<p>Tumor-initiating cells thought to drive brain cancer are embedded in a complex heterogeneous histology. In this study, we isolated primary cells from 21 human brain tumor specimens to establish cell lines with high tumorigenic potential and to ...
Takayama Tatsuya, Kubo Taro, Morikawa Ai, Morita Tatsuo, Nagano Osamu, Saya Hideyuki
Medical Oncology   33(5)    May 2016
<p>Cancer stem-like cells (CSCs) with high expression of CD44 splice variant (CD44v) have an enhanced capacity for intracellular reduced glutathione synthesis and defense against reactive oxygen species, resulting in resistance to various therapeu...
Umeyama Kazuhiro, Watanabe Kota, Watanabe Masahito, Horiuchi Keisuke, Nakano Kazuaki, Kitashiro Masateru, Matsunari Hitomi, Kimura Tokuhiro, Arima Yoshimi, Sampetrean Oltea, Nagaya Masaki, Saito Masahiro, Saya Hideyuki, Kosaki Kenjiro, Nagashima Hiroshi, Matsumoto Morio
Scientific Reports   6    Apr 2016
<p>Marfan syndrome (MFS) is an autosomal dominant genetic disease caused by abnormal formation of the extracellular matrix with an incidence of 1 in 3, 000 to 5, 000. Patients with Marfan syndrome experience poor quality of life caused by skeletal...
Shitara Kohei, Doi Toshihiko, Nagano Osamu, Imamura Chiyo K., Ozeki Takeshi, Ishii Yuya, Tsuchihashi Kenji, Takahashi Shunji, Nakajima Takako E., Hironaka Shuichi, Fukutani Miki, Hasegawa Hiromi, Nomura Shogo, Sato Akihiro, Einaga Yasuaki, Kuwata Takeshi, Saya Hideyuki, Ohtsu Atsushi
Gastric Cancer   1-9   Apr 2016
<p>Background: Cancer stem cells (CSCs) have enhanced mechanisms of protection from oxidative stress. A variant form of CD44 (CD44v), a major CSC marker, was shown to interact with xCT, a subunit of cystine–glutamate transporter, which maintains h...
Maeda Yusuke, Echizen Kanae, Oshima Hiroko, Yu Liang, Sakulsak Natthiya, Hirose Osamu, Yamada Yoichi, Taniguchi Tadatsugu, Jenkins Brendan J., Saya Hideyuki, Oshima Masanobu
Cancer Prevention Research   9(3) 253-263   Mar 2016
<p>It has been established that COX-2 and downstream signaling by prostaglandin E2 (PGE2) play a key role in tumorigenesis through generation of inflammatory microenvironment. Tolllike receptor (TLR) signaling through myeloid...
Hayakawa Yoshihiro, Kawada Manabu, Nishikawa Hiroyoshi, Ochiya Takahiro, Saya Hideyuki, Seimiya Hiroyuki, Yao Ryoji, Hayashi Masahiro, Kai Chieko, Matsuda Akira, Naoe Tomoki, Ohtsu Atsushi, Okazaki Taku, Saji Hideo, Sata Masataka, Sugimura Haruhiko, Sugiyama Yuichi, Toi Masakazu, Irimura Tatsuro
Cancer Science   107(2) 189-202   Feb 2016
<p>Non-clinical studies are necessary at each stage of the development of oncology drugs. Many experimental cancer models have been developed to investigate carcinogenesis, cancer progression, metastasis, and other aspects in cancer biology and th...
Okazaki Shogo, Nakatani Fumi, Masuko Kazue, Tsuchihashi Kenji, Ueda Shiho, Masuko Takashi, Saya Hideyuki, Nagano Osamu
Biochemical and Biophysical Research Communications   470(1) 239-244   Jan 2016
<p>The use of monoclonal antibodies (mAbs) for cancer therapy is one of the most important strategies for current cancer treatment. The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, which regulates cancer cell prolif...
Hagiwara Masayuki, Kikuchi Eiji, Kosaka Takeo, Mikami Shuji, Saya Hideyuki, Oya Mototsugu
Urologic Oncology: Seminars and Original Investigations      Jan 2016
<p>Purpose: The variant isoforms of CD44 (CD44v), which has been associated with treatment resistance and tumor recurrence, are contributed to the feature of some of the new cell surface markers for cancer stem cells. The aim of this study is to a...
Yoshida Go J., Saya Hideyuki
Cancer Science   107(1) 5-11   Jan 2016
<p>Cancer stem cells (CSCs) are undifferentiated cancer cells with a high tumorigenic activity, the ability to undergo self-renewal, and a multilineage differentiation potential. Cancer stem cells are responsible for the development of tumor cell ...
Takamoto Yayoi, Arima Yoshimi, Saya Hideyuki
Genes to Cells      2016
<p>Phyllodes tumors (PTs) are rare fibroepithelial tumors of the breast with epithelial and stromal components, and surgical resection is the standard and only available treatment for malignant PTs. To provide a better understanding of these tumor...
Kakehashi Anna, Ishii Naomi, Sugihara Eiji, Gi Min, Saya Hideyuki, Wanibuchi Hideki
Cancer Science      2016
<p>This study investigated whether the expression of CD44 variant 9 (CD44v9) might be a functional marker of tumor-initiating stem-like cells in primary hepatocellular carcinomas (HCCs) of hepatitis C virus (HCV)+ patients and provide a...
Kuwahara Kazuhiko, Yamamoto-Ibusuki Mutsuko, Zhang Zhenhuan, Phimsen Suchada, Gondo Naomi, Yamashita Hiroko, Takeo Toru, Nakagata Naomi, Yamashita Daisuke, Fukushima Yoshimi, Yamamoto Yutaka, Iwata Hiroji, Saya Hideyuki, Kondo Eisaku, Matsuo Keitaro, Takeya Motohiro, Iwase Hirotaka, Sakaguchi Nobuo
Cancer Science      2016
<p>Human chromosome 21 is known to be associated with the high risk of hematological malignancy but with resistance to breast cancer in the study of Down syndrome. In human cancers, we previously observed the significant alterations of the protein...
Kai Kazuharu, Kondo Kimie, Wang Xiaoping, Xie Xuemei, Pitner Mary K., Reyes Monica E., Torres-Adorno Angie M., Masuda Hiroko, Hortobagyi Gabriel N., Bartholomeusz Chandra, Saya Hideyuki, Tripathy Debu, Sen Subrata, Ueno Naoto T.
Molecular Cancer Therapeutics   14(12) 2687-2699   Dec 2015
<p>Currently, no targeted drug is available for triple-negative breast cancer (TNBC), an aggressive breast cancer that does not express estrogen receptor, progesterone receptor, or HER2. TNBC has high mitotic activity, and, because Aurora A and B ...
Adachi Takeya, Kobayashi Tetsuro, Sugihara Eiji, Yamada Taketo, Ikuta Koichi, Pittaluga Stefania, Saya Hideyuki, Amagai Masayuki, Nagao Keisuke
Nature Medicine   21(11) 1272-1279   Nov 2015
<p>The skin harbors a variety of resident leukocyte subsets that must be tightly regulated to maintain immune homeostasis. Hair follicles are unique structures in the skin that contribute to skin dendritic cell homeostasis through chemokine produc...
Nezhad Zhaleh Kashkouli, Nagai Nobuhiro, Yamamoto Kotaro, Kaji Hirokazu, Nishizawa Matsuhiko, Saya Hideyuki, Nakazawa Toru, Abe Toshiaki
Journal of Materials Science: Materials in Medicine   26(9)    Sep 2015
<p>Age-related macular degeneration is the leading cause of legal blindness among older individuals. Therefore, the development of new therapeutic agents and optimum drug delivery systems for its treatment are crucial. In this study, we investigat...
Kozono David, Li Jie, Nitta Masayuki, Sampetrean Oltea, Gonda David, Kushwaha Deepa S., Merzon Dmitry, Ramakrishnan Valya, Zhu Shan, Zhu Kaya, Matsui Hiroko, Harismendy Olivier, Hua Wei, Mao Ying, Kwon Chang Hyuk, Saya Hideyuki, Nakano Ichiro, Pizzo Donald P., Van Den Berg Scott R., Chen Clark C.
Proceedings of the National Academy of Sciences of the United States of America   112(30) E4055-E4064   Jul 2015
<p>The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It remains unclear whether tumorigenicity exists as a static property of a few cells or as...
Kanagawa Hiroya, Masuyama Ritsuko, Morita Mayu, Sato Yuiko, Niki Yasuo, Kobayashi Tami, Katsuyama Eri, Fujie Atsuhiro, Hao Wu, Tando Toshimi, Watanabe Ryuichi, Miyamoto Kana, Morioka Hideo, Matsumoto Morio, Toyama Yoshiaki, Saya Hideyuki, Miyamoto Takeshi
Journal of Bone and Mineral Metabolism      Jul 2015
<p>The increasing number of osteoporosis patients is a pressing issue worldwide. Osteoporosis frequently causes fragility fractures, limiting activities of daily life and increasing mortality. Many osteoporosis patients take numerous medicines due...
Yamaguchi Sayaka I., Ueki Arisa, Sugihara Eiji, Onishi Nobuyuki, Yaguchi Tomonori, Kawakami Yutaka, Horiuchi Keisuke, Morioka Hideo, Matsumoto Morio, Nakamura Masaya, Muto Akihiro, Toyama Yoshiaki, Saya Hideyuki, Shimizu Takatsune
Cancer Science   106(7) 875-882   Jul 2015
<p>Osteosarcoma (OS) is the most frequent primary solid malignant tumor of bone. Its prognosis remains poor in the substantial proportion of patients who do not respond to chemotherapy and novel therapeutic options are therefore needed. We previou...
Fukuda Keitaro, Sugihara Eiji, Ohta Shoichiro, Izuhara Kenji, Funakoshi Takeru, Amagai Masayuki, Saya Hideyuki
PLoS One   10(6)    Jun 2015
<p>Tissue injury promotes metastasis of several human cancers, although factors associated with wound healing that attract circulating tumor cells have remained unknown. Here, we examined the primary and metastatic lesions that appeared 1 month af...
Yoshimura Yayoi, Shiino Akihiko, Muraki Kazue, Fukami Tadateru, Yamada Shigeki, Satow Takeshi, Fukuda Miyuki, Saiki Masaaki, Hojo Masato, Miyamoto Susumu, Onishi Nobuyuki, Saya Hideyuki, Inubushi Toshiro, Nozaki Kazuhiko, Tanigaki Kenji
PLoS One   10(6)    Jun 2015
<p>Glioblastoma multiforme (GBM) is associated with high mortality due to infiltrative growth and recurrence. Median survival of the patients is less than 15 months, increasing requirements for new therapies. We found that both arsenic trioxide an...
Seishima Ryo, Wada Takeyuki, Tsuchihashi Kenji, Okazaki Shogo, Yoshikawa Momoko, Oshima Hiroko, Oshima Masanobu, Sato Toshiro, Hasegawa Hirotoshi, Kitagawa Yuko, Goldenring James R., Saya Hideyuki, Nagano Osamu
Cancer Prevention Research   8(6) 492-501   Jun 2015
<p>Loss of parietal cells initiates the development of spasmolytic polypeptide-expressing metaplasia (SPEM), a precancerous lesion in stomach. CD44 variant (CD44v) that enhances the ability to defend against reactive oxygen species (ROS) in epithe...
Ohmura Mitsuyo, Hishiki Takako, Yamamoto Takehiro, Nakanishi Tsuyoshi, Kubo Akiko, Tsuchihashi Kenji, Tamada Mayumi, Toue Sakino, Kabe Yasuaki, Saya Hideyuki, Suematsu Makoto
Nitric Oxide - Biology and Chemistry   46 102-113   Apr 2015
<p>CD44 expressed in cancer cells was shown to stabilize cystine transporter (xCT) that uptakes cystine and excretes glutamate to supply cysteine as a substrate for reduced glutathione (GSH) for survival. While targeting CD44 serves as a potential...
Mikami Shuji, Mizuno Ryuichi, Kosaka Takeo, Saya Hideyuki, Oya Mototsugu, Okada Yasunori
International Journal of Cancer   136(7) 1504-1514   Apr 2015
<p>Tumor necrosis factor-α (TNF-α) is involved in epithelial-mesenchymal transition (EMT) and expression of CD44, a cancer stem cell marker, in several cancers. This study was performed to clarify the significance of TNF-α and CD44 in clear cell r...
Masuda Kenta, Chiyoda Tatsuyuki, Sugiyama Naoyuki, Segura-Cabrera Aldo, Kabe Yasuaki, Ueki Arisa, Banno Koji, Suematsu Makoto, Aoki Daisuke, Ishihama Yasushi, Saya Hideyuki, Kuninaka Shinji
PLoS One   10(2)    Feb 2015
<p>In budding yeast, the Mitotic Exit Network (MEN) regulates anaphase promoting complex/cyclosome (APC/C) via the Dbf2-Cdc14 signaling cascade. Dbf2 kinase phosphorylates and activates Cdc14 phosphatase, which removes the inhibitory phosphorylati...
Seishima Ryo, Okabayashi Koji, Nagano Osamu, Hasegawa Hirotoshi, Tsuruta Masashi, Shimoda Masayuki, Kameyama Kaori, Saya Hideyuki, Kitagawa Yuko
Clinics and Research in Hepatology and Gastroenterology      2015
<p>Background and objective: Sulfasalazine reduces the risk of ulcerative colitis (UC)-related cancer through its anti-inflammatory effect and induction of oxidative stress in cancer cells by inhibiting the glutamate-cystine transporter, which is ...
Miranda Fabrizio, Mannion David, Liu Shujuan, Zheng Yiyan, Mangala Lingegowda S., Redondo Clara, Herrero-Gonzalez Sandra, Xu Ruoyan, Taylor Charlotte, Chedom Donatien Fotso, Karaminejadranjbar Mohammad, Albukhari Ashwag, Jiang Dahai, Pradeep Sunila, Rodriguez-Aguayo Cristian, Lopez-Berestein Gabriel, Salah Eidarus, Abdul Azeez Kamal R., Elkins Jonathan M., Campo Leticia, Myers Kevin A., Klotz Daniel, Bivona Serena, Dhar Sunanda, Bast Robert C., Saya Hideyuki, Choi Hwan Geun, Gray Nathanael S., Fischer Roman, Kessler Benedikt M., Yau Christopher, Sood Anil K., Motohara Takeshi, Knapp Stefan, Ahmed Ahmed Ashour
Cancer Cell      Dec 2014
<p>The adipocyte-rich microenvironment forms a niche for ovarian cancer metastasis, but the mechanisms driving this process are incompletely understood. Here we show that salt-inducible kinase 2 (SIK2) is overexpressed in adipocyte-rich metastatic...
Saito Katsuya, Iizuka Yukihiko, Ohta Shigeki, Takahashi Satoshi, Nakamura Kenta, Saya Hideyuki, Yoshida Kazunari, Kawakami Yutaka, Toda Masahiro
Neuro-Oncology   16(12) 1618-1629   Dec 2014
<p>BACKGROUND: A cDNA library made from 2 glioma cell lines, U87MG and T98G, was screened by serological identification of antigens by recombinant cDNA expression (SEREX) using serum from a glioblastoma patient. Elongation factor Tu GTP binding do...
Shimizu Takatsune, Sugihara Eiji, Yamaguchi-Iwai Sayaka, Tamaki Sakura, Koyama Yuko, Kamel Walied, Ueki Arisa, Ishikawa Tomoki, Chiyoda Tatsuyuki, Osuka Satoru, Onishi Nobuyuki, Ikeda Hiroko, Kamei Junzo, Matsuo Koichi, Fukuchi Yumi, Nagai Toshihiro, Toguchida Junya, Toyama Yoshiaki, Muto Akihiro, Saya Hideyuki
Cancer Research   74(22) 6531-6541   Nov 2014
<p>Osteosarcoma is a malignant bone tumor in children and adolescents characterized by intrinsic therapeutic resistance. The IGF2 is expressed at elevated levels in osteosarcoma after treatment with chemotherapy, prompting an examination of its fu...
Maruoka Ryo, Takenouchi Toshiki, Torii Chiharu, Shimizu Atsushi, Misu Kumiko, Higasa Koichiro, Matsuda Fumihiko, Ota Arihito, Tanito Katsumi, Kuramochi Akira, Arima Yoshimi, Otsuka Fujio, Yoshida Yuichi, Moriyama Keiji, Niimura Michihito, Saya Hideyuki, Kosaki Kenjiro
Genetic Testing and Molecular Biomarkers   18(11) 722-735   Nov 2014
<p>AIMS: We assessed the validity of a next-generation sequencing protocol using in-solution hybridization-based enrichment to identify NF1 mutations for the diagnosis of 86 patients with a prototypic genetic syndrome, neurofibromatosis type 1. In...
Watanabe Yusaku, Yoshimura Kiyoshi, Yoshikawa Koichi, Tsunedomi Ryoichi, Shindo Yoshitaro, Matsukuma Sou, Maeda Noriko, Kanekiyo Shinsuke, Suzuki Nobuaki, Kuramasu Atsuo, Sonoda Kouhei, Tamada Koji, Kobayashi Sei, Saya Hideyuki, Hazama Shoichi, Oka Masaki
International Journal of Oncology   45(5) 1857-1866   Nov 2014
<p>Cancer stem cells (CSCs) have been studied for their self-renewal capacity and pluripotency, as well as their resistance to anticancer therapy and their ability to metastasize to distant organs. CSCs are difficult to study because their populat...
Techasen Anchalee, Loilome Watcharin, Namwat Nisana, Khuntikeo Narong, Puapairoj Anucha, Jearanaikoon Patcharee, Saya Hideyuki, Yongvanit Puangrat
Tumor Biology   35(9) 8645-8652   Oct 2014
<p>Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. E-cadherin, a cell adhesion molecule, is frequently downregulated and has been proposed as an important mediator in epithelial-mesenchymal tran...
Mori T., Sato Y., Miyamoto K., Kobayashi T., Shimizu T., Kanagawa H., Katsuyama E., Fujie A., Hao W., Tando T., Iwasaki R., Kawana H., Morioka H., Matsumoto M., Saya H., Toyama Y., Miyamoto T.
Oncogene   33(33) 4236-4241   Aug 2014
<p>Chronic inflammation is frequently associated with tumorigenesis in elderly people. By contrast, young people without chronic inflammation often develop tumors considered independent of chronic inflammation but driven instead by mutations. Thus...
Oshima H., Ishikawa T., Yoshida G. J., Naoi K., Maeda Y., Naka K., Ju X., Yamada Y., Minamoto T., Mukaida N., Saya H., Oshima M.
Oncogene   33(29) 3820-3829   Jul 2014
<p>Helicobacter pylori infection induces chronic inflammation that contributes to gastric tumorigenesis. Tumor necrosis factor (TNF-) is a proinflammatory cytokine, and polymorphism in the TNF- gene increases the risk of gastric cancer. We herein ...
Torii Koji, Yamada Suguru, Nakamura Kae, Tanaka Hiromasa, Kajiyama Hiroaki, Tanahashi Kuniaki, Iwata Naoki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Fujii Tsutomu, Nakayama Goro, Koike Masahiko, Sugimoto Hiroyuki, Nomoto Shuji, Natsume Atsushi, Fujiwara Michitaka, Mizuno Masaaki, Hori Masaru, Saya Hideyuki, Kodera Yasuhiro
Gastric Cancer   18(3) 635-643   Jul 2014
<p>Background: Treatment of peritoneal carcinomatosis arising from gastric cancer remains a considerable challenge. In recent years, the anticancer effect of nonequilibrium atmospheric pressure plasma (NEAPP) has been reported in several cancer ce...
Otsubo Chihiro, Otomo Ryo, Miyazaki Makoto, Matsushima-Hibiya Yuko, Kohno Takashi, Iwakawa Reika, Takeshita Fumitaka, Okayama Hirokazu, Ichikawa Hitoshi, Saya Hideyuki, Kiyono Tohru, Ochiya Takahiro, Tashiro Fumio, Nakagama Hitoshi, Yokota Jun, Enari Masato
Cell Reports   7(2) 527-538   Apr 2014
<p>In lung cancer progression, p53 mutations are more often observed in invasive tumors than in noninvasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor, i...
Takebe Naoko, Harris Pamela Jo, Kondo Yutaka, Nair Abhilasha, Percy Ivy S., Saya Hideyuki
295-317   Apr 2014
<p>Cancer stem cells (CSC) are important to understand in order to develop solutions to treat tumor metastasis and resistance to therapy. CSCs are characterized by their ability to self-renew and differentiate into tumors, ultimately leading to th...
Kobayashi Yusuke, Masuda Kenta, Banno Kouji, Kobayashi Nana, Umene Kiyoko, Nogami Yuya, Tsuji Kosuke, Ueki Arisa, Nomura Hiroyuki, Sato Kenji, Tominaga Eiichiro, Shimizu Takatsune, Saya Hideyuki, Aoki Daisuke
Oncology Reports   31(3) 1121-1126   Mar 2014
<p>Glycosylation is an important post-translational modification, in which attachment of glycans to proteins has effects on biological functions and carcinogenesis. Analysis of human chorionic gonadotropin, a glycoprotein hormone produced by place...
Okabe H., Ishimoto T., Mima K., Nakagawa S., Hayashi H., Kuroki H., Imai K., Nitta H., Saito S., Hashimoto D., Chikamoto A., Ishiko T., Watanabe M., Nagano O., Beppu T., Saya H., Baba H.
British Journal of Cancer   110(4) 958-966   Feb 2014
<p>Background:Circulating tumour cells (CTCs) have an important role in metastatic processes, but details of their basic characteristics remain elusive. We hypothesised that CD44-expressing CTCs show a mesenchymal phenotype and high potential for ...
Takenouchi Toshiki, Shimizu Atsushi, Torii Chiharu, Kosaki Rika, Takahashi Takao, Saya Hideyuki, Kosaki Kenjiro
American Journal of Medical Genetics, Part A   164(2) 392-396   Feb 2014
<p>Recent advances in genetic diagnostic technologies have made the classic disease nosology highly complicated. This situation is exemplified by rasopathies, among which neurofibromatosis type 1 and Noonan syndrome represent prototypic entities. ...
Kai K., Iwamoto T., Kobayashi T., Arima Y., Takamoto Y., Ohnishi N., Bartholomeusz C., Horii R., Akiyama F., Hortobagyi G. N., Pusztai L., Saya H., Ueno N. T.
Oncogene   33(4) 440-448   Jan 2014
<p>Intratumoral heterogeneity within individual breast tumors is a well-known phenomenon that may contribute to drug resistance. This heterogeneity is dependent on several factors, such as types of oncogenic drivers and tumor precursor cells. The ...
Yoshida Go J., Saya Hideyuki
Biochemical and Biophysical Research Communications   443(2) 622-627   Jan 2014
<p>Cancer stem-like cells express high amount of CD44 variant8-10 which protects cancer cells from redox stress. We have demonstrated by immunohistochemical analysis and Western blotting, and reverse-transcription polymerase chain reaction, that C...
Yoshida Go J., Saya Hideyuki
Biochemical and Biophysical Research Communications   443(1) 239-245   Jan 2014
<p>Introduction: Epithelial cell adhesion molecule (EpCAM) is expressed in tumors with an epithelial cell of origin, in a heterogeneous manner. Prostate cancer stem-like cells highly express EpCAM. However, little is known about how EpCAM is invol...
Hosonaga Mari, Arima Yoshimi, Sugihara Eiji, Kohno Norio, Saya Hideyuki
Cancer Science   105(7) 779-787   2014
<p>Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is treated with HER2-targeted agents, such as trastuzumab and lapatinib, that suppress signaling by phosphatidylinositol 3-kinase (PI3K)-Akt and MAPK pathways. However, resi...

Teaching Experience

 

Research Grants & Projects

 
Elucidation of underlyingmechanism of MKL1-mediated induction of cancer associated fibroblasts and its clinical applications
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): 佐谷 秀行