1998年5月
Loss of merlin-p85 protein complex in NF2-related tumors
INTERNATIONAL JOURNAL OF ONCOLOGY
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- 巻
- 12
- 号
- 5
- 開始ページ
- 1073
- 終了ページ
- 1078
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- PROFESSOR D A SPANDIDOS
The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.
- リンク情報
- ID情報
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- ISSN : 1019-6439
- Web of Science ID : WOS:000073176200015