Naohiro Seo

Profile Information

Affiliation: Project Associate Professor, Graduate School of Engineering, Department of Bioengineering, Nanobio-Device Laboratory, The University of Tokyo

Degree: Doctor of Medical Sciences(Mar, 1995, The University of Tokyo)

Contact information: seo-naohirobionano.t.u-tokyo.ac.jp
Researcher number: 50283354
ORCID ID: https://orcid.org/0000-0002-8556-2437
J-GLOBAL ID: 200901080870395380
researchmap Member ID: 1000223333

External link: http://bionano.t.u-tokyo.ac.jp

He is currently working as a Research Associate Professor at the Nanobio Device Laboratory, Graduate School of Bioengineering, The University of Tokyo. The areas of his investigation are the biology and nanotechnology of extracellular vesicles including exosome and microvesicle from immune cells in tumor microenvironment.

Research Interests

Research Areas

Research History

Education

- 1995

腫瘍生化学, 医学系研究科, 東京大学大学院

Committee Memberships

Mar, 2017 - Present

編集委員, EnPress Trends in Immunotherapy
2011 - Present

編集委員, Hindawi Journal of Immunology Research
2001 - Present

評議員, 日本研究皮膚科学会

Papers

T cell receptor gene‐modified allogeneic T cells with siRNA for endogenous T cell receptor induce efficient tumor regression without graft‐versus‐host disease

Satomi Okada, Daisuke Muraoka, Kiyoshi Yasui, Isao Tawara, Ayumi Kawamura, Sachiko Okamoto, Junichi Mineno, Naohiro Seo, Hiroshi Shiku, Susumu Eguchi …

Cancer Science, Sep 7, 2023
CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy.

Yizheng Wang, Linan Wang, Naohiro Seo, Satoshi Okumura, Tae Hayashi, Yasushi Akahori, Hiroshi Fujiwara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno …

International journal of molecular sciences, 24(13), Jun 29, 2023
A phase 1 trial of NY-ESO-1-specific TCR-engineered T-cell therapy combined with a lymph node-targeting nanoparticulate peptide vaccine for the treatment of advanced soft tissue sarcoma.

Mikiya Ishihara, Yoshihiro Nishida, Shigehisa Kitano, Akira Kawai, Daisuke Muraoka, Fumiyasu Momose, Naozumi Harada, Yoshihiro Miyahara, Naohiro Seo, Hiroyoshi Hattori …

International journal of cancer, 152(12) 2554-2566, Feb 2, 2023
Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion‐exchange method

Naohiro Seo, Junko Nakamura, Tsuguhiro Kaneda, Hiroaki Tateno, Asako Shimoda, Takanori Ichiki, Koichi Furukawa, Jun Hirabayashi, Kazunari Akiyoshi, Hiroshi Shiku

Journal of Extracellular Vesicles, 11(3) e12205, Mar, 2022
Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications.

Asako Shimoda, Risako Miura, Hiroaki Tateno, Naohiro Seo, Hiroshi Shiku, Shin-Ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi

Small methods, 6(2) e2100785, Feb, 2022
Skin Inflammation and Testicular Function: Dermatitis Causes Male Infertility via Skin-Derived Cytokines.

Ai Umaoka, Hiroki Takeuchi, Kento Mizutani, Naohiro Seo, Yoshiaki Matsushima, Koji Habe, Kohei Hagimori, Yukie Yamaguchi, Tomoaki Ikeda, Keiichi Yamanaka

Biomedicines, 8(9), Aug 20, 2020
樹状細胞ワクチンによるWT-1を標的とするCAR-T細胞による抗腫瘍効果の増強

赤堀泰, 藤原弘, 王立楠, 米山元裕, 瀬尾尚宏, 奥村悟司, 宮原慶裕, 池田裕明, 天石泰典, 岡本幸子 …

血液内科, 78(5) 696-701, May, 2019 Peer-reviewed
Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance.

Muraoka D, Seo N, Hayashi T, Tahara Y, Fujii K, Tawara I, Miyahara Y, Okamori K, Yagita H, Imoto S …

The Journal of clinical investigation, 129(3) 1278-1294, Mar, 2019 Peer-reviewed
Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

Naohiro Seo, Yoshitaka Shirakura, Yoshiro Tahara, Fumiyasu Momose, Naozumi Harada, Hiroaki Ikeda, Kazunari Akiyoshi, Hiroshi Shiku

Nature Communications, 9(1), Dec 1, 2018
Anti-tumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination.

Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H …

Blood, 132(11) 1134-1145, Jul, 2018 Peer-reviewed
Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.

Muraoka D, Seo N, Hayashi T, Hyuga-Amaike C, Okamori K, Tawara I, Harada N, Shiku H

Oncotarget, 8(19) 30766-30780, May, 2017 Peer-reviewed
Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types

Fumiyasu Momose, Naohiro Seo, Yasushi Akahori, Shin-ichi Sawada, Naozumi Harada, Toru Ogura, Kazunari Akiyoshi, Hiroshi Shiku

PLOS ONE, 11(4) e0154134-e0154134, Apr 21, 2016
Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome

Linan Wang, Ning Ma, Sachiko Okamoto, Yasunori Amaishi, Eiichi Sato, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, Takuma Kato, Hiroshi Shiku

ONCOIMMUNOLOGY, 5(9), 2016 Peer-reviewed
Development and Function of Exosomes as Bio–nanotransporters

Sawada Shinichi, Shimoda Asako, Sato Yuko, Seo Naohiro, Shiku Hiroshi, Akiyoshi Kazunari

MEMBRANE, 40(5) 254-259, 2015
Systemic CD8(+) T Cell-Mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-Induced Tumor Necrosis Factor Receptor

Mikiya Ishihara, Naohiro Seo, Jun Mitsui, Daisuke Muraoka, Maki Tanaka, Junichi Mineno, Hiroaki Ikeda, Hiroshi Shiku

PLOS ONE, 9(8) e104669, Aug, 2014 Peer-reviewed
Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation.

Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H …

PloS one, 9(9) e108494, 2014 Peer-reviewed
The possibility of antigenic peptide, protein and DNA delivery by percutaneous vaccination

Naohiro Seo, Hiroshi Shiku

Drug Delivery System, 27(3) 194-201, 2012 Peer-reviewed
Enhanced anti-tumor immunity by superantigen-pulsed dendritic cells

Masato Kato, Yutaro Nakamura, Takafumi Suda, Yuichi Ozawa, Naoki Inui, Naohiro Seo, Toshi Nagata, Yukio Koide, Pawel Kalinski, Hirotoshi Nakamura …

CANCER IMMUNOLOGY IMMUNOTHERAPY, 60(7) 1029-1038, Jul, 2011 Peer-reviewed
Stimulation of human butyrophilin 3 molecules results in negative regulation of cellular immunity

Hiromichi Yamashiro, Shinji Yoshizaki, Toshimasa Tadaki, Kohji Egawa, Naohiro Seo

Journal of Leukocyte Biology, 88(4) 757-767, Oct, 2010
Roxithromycin antagonizes catagen induction in murine and human hair follicles: implication of topical roxithromycin as hair restoration reagent

Taisuke Ito, Hidekazu Fukamizu, Natsuho Ito, Naohiro Seo, Hiroaki Yagi, Masahiro Takigawa, Hideo Hashizume

ARCHIVES OF DERMATOLOGICAL RESEARCH, 301(5) 347-355, Jun, 2009 Peer-reviewed

Misc.

遺伝子改変Vγ9Vδ2T細胞を用いたがん免疫療法の可能性

王藝錚, 奥村悟, 王立楠, 瀬尾尚宏, 天石泰典, 岡本幸子, 峰野純一, 田中義正, 加藤琢磨, 珠玖洋

日本癌学会総会記事, 80回 [P21-7], Sep, 2021
Murine CD8+T cell EV that prevents tumor metastasis is classified into exosome of late endosome origin

Naohiro Seo, Junko Nakamura, Tsuguhiro Kaneda, Asako Shimoda, Kazunari Akiyoshi, Hiroshi Shiku

CANCER SCIENCE, 112 693-693, Feb, 2021
Expression level of superoxide dismutase 3 and tumorigenicity

神生夏帆, 俵功, 坪井順哉, 加藤大祐, 桝屋正浩, 田辺秀之, 宮原慶裕, 瀬尾尚宏, 吉田利通, 宮野悟 …

日本癌学会学術総会抄録集(Web), 78th, 2019
Immune sensitivity of tumor is governed by the mechanism for differentiation of tumor-associated macrophages (TAMs)

Daisuke Muraoka, Naohiro Seo, Tae Hayashi, Keisuke Fujii, Hiroaki Ikeda, Kazunari Akiyoshi, Naozumi Harada, Hiroshi Shiku

CANCER SCIENCE, 109 1325-1325, Dec, 2018
Relationship between diversity of CD8+T cell exosomes and destruction of mesenchymal tumor stroma

Naohiro Seo, Tsuguhiro Kaneda, Junko Nakamura, Fumiyasu Momose, Kazunari Akiyoshi, Hiroshi Shiku

CANCER SCIENCE, 109 948-948, Dec, 2018
Exosome-mediated regulation of tumor immunology

Naohiro Seo, Kazunari Akiyoshi, Hiroshi Shiku

CANCER SCIENCE, 109(10) 2998-3004, Oct, 2018
Activated CD8+T cells interrupt tumor invasion and metastasis in exosome-dependent manners

Naohiro Seo, Junko Nakamura, Kazunari Akiyoshi, Hiroshi Shiku

CANCER SCIENCE, 109 872-872, Jan, 2018
Skin inflammation leads immunoglobulin G aggregation and deposition in multiple organs

Keiichi Yamanaka, Karin Okada, Takehisa Nakanishi, Kento Mizutani, Yoshiaki Matsushima, Makoto Kondo, Koji Habe, Hitoshi Mizutani, Naohiro Seo

JOURNAL OF DERMATOLOGICAL SCIENCE, 88(1) 146-148, Oct, 2017
Antigen delivery targeting tumor-infiltrating macrophages leads to eradication of tumor highly resistant to immune checkpoint inhibitors

Muraoka Daisuke, Harada Naozumi, Seo Naohiro, Hayashi Tae, Fujii Keisuke, Yamaguchi Rui, Imoto Seiya, Miyano Satoru, Yagita Hideo, Akiyoshi Kazunari …

CANCER IMMUNOLOGY RESEARCH, 5(3), Mar, 2017 Peer-reviewed
免疫担当細胞とエクソソーム

瀬尾尚宏

癌と化学療法社, 44 373-377, 2017
変異抗原の免疫原性は腫瘍局所における炎症反応を誘導し免疫チェックポイント療法に対する応答性を規定する

村岡大輔, 瀬尾尚宏, 林妙, 藤井啓介, 原田直純, 井本清哉, 山口類, 上村光弘, 宮野悟, 八木田秀雄 …

日本がん免疫学会総会プログラム・抄録集, 20回 158-158, Jun, 2016
Future possibility of tumor immunotherapy by exosomes

48(1) 21-24, Jan, 2016
免疫細胞が放出するものはサイトカインだけではない（CD8+ T細胞放出エキソソームの腫瘍に対する驚くべき役割）

瀬尾尚宏

実験医学, 34 1368-1373, 2016
A NOVEL STRATEGY OF CANCER GENE THERAPY BY TRANSCRIPTIONAL TARGETING OF AN ALLOGENEIC HISTOCOMPATIBILITY TRANSGENE

Eri Kuwada, Katsuo Noguchi, Naohiro Seo, Hiromichi Yamashiro, Kohji Egawa

JOURNAL OF GENE MEDICINE, 12(12) 1044-1044, Dec, 2010
Emergence of circulating monomyeloid precursors predicts reactivation of human herpesvirus-6 in drug-induced hypersensitivity syndrome

H. Hashizume, M. Aoshima, T. Ito, N. Seo, M. Takigawa, H. Yagi

BRITISH JOURNAL OF DERMATOLOGY, 161(2) 486-488, Aug, 2009
Anti-infective and anti-tumor agents based on the depletion of immune suppressive effects

Naohiro Seo, Hiromichi Yamashiro, Toshimasa Tadaki

CURRENT MEDICINAL CHEMISTRY, 15(10) 991-996, Apr, 2008
CD4+CD25+Foxp3+ regulatory T cells induced by plasmacytoid dendritic cells show unique cytokine profile in atopic dermalitis

H. Hashizume, N. Seo, Y. Yoshinari, N. Ito, H. Yagi, M. Takigawa

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128 S177-S177, Apr, 2008
The current status and future direction of percutaneous peptide immunization against melanoma

Naohiro Seo, Masahiro Takigawa

JOURNAL OF DERMATOLOGICAL SCIENCE, 48(2) 77-85, Nov, 2007
Male New Zealand Black/KN mice: a novel model for autoimmune-induced permanent alopecia?

A. Hiroi, T. Ito, N. Seo, K. Uede, T. Yoshimasu, M. Ito, K. Nakamura, N. Ito, R. Paus, F. Furukawa

BRITISH JOURNAL OF DERMATOLOGY, 155(2) 437-445, Aug, 2006
Cytokine profiles of skin lesions in murine lupus models

NISHIDE Takeshi, YOSHIMASU Takashi, IKEDA Takaharu, SEO Naohiro, OHTANI Toshio, FURUKAWA Fukumi

J Dermatol Sci Suppl, 1(2) S37-S43, Dec 1, 2005

Books and Other Publications

エクソソーム−生命現象の鍵を握る膜小胞

瀬尾尚宏 (Role: Joint author, エクソソームがわかる生理機能：免疫システムとエクソソーム)

化学同人 in press, 2018
最新DDS技術の先端バイオ医薬品への応用開発

瀬尾尚宏 (Role: Joint author, がんをターゲットとしたDDS技術の開発と製剤応用：エクソソームを用いた癌進行阻害技術の開発)

（株）技術情報協会, 2017
遺伝子医学MOOK31号「がん免疫療法—What’s now and what’s next?−」

瀬尾尚宏 (Role: Joint author, 次世代がん免疫療法へのチャレンジ：Ｔ細胞放出エクソソームによるがんの浸潤・転移抑制)

(株)メディカルドゥ, 2017
パラダイムシフトをもたらすエクソソーム機能研究最前線～シグナル伝達からがん、免疫、神経疾患との関わり、創薬利用まで～

瀬尾尚宏 (Role: Joint author, 機能研究：免疫系における機能)

エヌ・ティー・エス, 2017
樹状細胞-基礎から臨床へ

瀬尾尚宏 (Role: Joint author, メラノーマ)

南江堂, 2000

Professional Memberships

Works

Research Projects

Aim to eliminate a bottleneck in the practical realization of anticancer immunotherapy with gene-modified allogeneic gammadelta T cells.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
馬場嘉信研究総括『細胞外微粒子に起因する生命現象の解明とその制御に向けた基盤技術の創出』秋吉一成研究代表者『糖鎖を基軸とするエクソソームの多様性解析と整体応答・制御のための基盤研究』

戦略的創造研究推進事業(CREST), 日本研究開発法人科学技術振興機構(JST), Oct, 2017 - Mar, 2022

秋吉一成
Optimization of tumor-infiltrating of cytotoxic T cells using capacity of the anti-mesenchymal tumor stromal cells of CD8+ T cell exosomes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2021

Seo Naohiro
Kinetics of suppressor T cells in spontaneous tumor-bearing mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2012 - Mar, 2014

SEO Naohiro
制御性T細胞が表皮ランゲルハンス細胞の動態に及ぼす影響に関する研究

2009 - 2011

瀬尾尚宏
Immunotherapy with percutaneous peptide immunization in human melanoma

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2006 - 2009

TAKIGAWA Masahiro, HASHIZUME Hideo, YAGI Hiroaki, ITO Taisuke, SEO Naohiro, TOKURA Yoshiki, SHIMAUCHI Takatoshi, SHIMADA Shinji, SHIBAGAKI Naotaka, SHIBAKI Akihiko
Regulation of cell migration and chemokine expressions on cytotoxic T cells induced by percutaneous immunization in melanoma patients

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

YAGI Hiroaki, SEO Naohiro, SEO Naohiro
Gタンパク質共役型受容体制御による新しいメラノーマ免疫治療法の開発

2007 - 2008

瀬尾尚宏
Inflammatory response and regulatory mechanism in drug allergy.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

HASHIZUME Hideo, SEO Naohiro, TAKIGAWA Masahiro, YAGI Hiroaki
メラノーマを用いた腫瘍内抑制性T細胞と神経系細胞網とのシナプスに関する研究

2005 - 2006

瀬尾尚宏
Regulation of chemokine receptor expression on tumor specific cytotoxic T cells induced by percutaneous peptide immunization.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

YAGI Hiroaki, SEO Naohiro
抑制系免疫反応除去に注目した近未来的メラノーマ免疫治療法の基礎構築に関する研究

2002 - 2004

瀬尾尚宏
Percutaneous Peptide immunization for Human Tumor therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

TAKIGAWA Masahiro, SEO Naohiro
キラーT細胞活性化と抑制性細胞除去によるメラノーマ免疫治療法の確立に関する研究

2000 - 2001

瀬尾尚宏
Petcutaneats Peptide immuni Eation Via Lorneum tarrier-disrupted murine skin for fumorimmunoprophylaxis.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

TAKIGAWA Masahiro, SEO Haohiro
B16メラノーマ担癌マウスで生ずるNK活性の抑制機構に関する研究

1998 - 1999

瀬尾尚宏
Studies on autoimmune alopecia in New Zealand Black/KN mouse

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

FURUKAWA Fukumi, SEO Naohiro, TOKURA Yoshiki
免疫抑制性細胞除去によるがん免疫治療法に関する研究
担癌マウスで生じる免疫抑制反応機構
経表皮的癌ワクチン法の開発に関する研究

Industrial Property Rights

キラーT細胞賦活剤(特許出願平9-130031)