内海健 (Takeshi Uchiumi) - マイポータル - researchmap

基本情報

所属: 旧所属産業医科大学医学部助手

学位: 医学博士

J-GLOBAL ID: 200901034215718271
researchmap会員ID: 1000223898

研究キーワード

2

研究分野

1

ライフサイエンス / 医化学 /

経歴

6

1996年 - 2000年

九州大学医学部生化学第1講座助手
1996年 - 2000年

Department of Biochemistry, Kyushu University School of Medicine
2000年

- 九州大学大学院医学研究院医化学分野
2000年

- Department of Medical Biochemisty, Graduate School of Medical Sciences, Kyushu University
1993年 - 1996年

大分医科大学医学部生化学助手
1993年 - 1996年

Department of Biochemistry, Oita Medical University

学歴

4

MISC

20

Y box-binding protein-1 binds preferentially to single-stranded nucleic acids and exhibits 3 '-> 5 ' exonuclease activity

H Izumi, T Imamura, G Nagatani, T Ise, T Murakami, H Uramoto, T Torigoe, H Ishiguchi, Y Yoshida, M Nomoto …

NUCLEIC ACIDS RESEARCH 29(5) 1200-1207 2001年3月
Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma

S Haga, E Hinoshita, K Ikezaki, M Fukui, GL Scheffer, T Uchiumi, M Kuwano

JAPANESE JOURNAL OF CANCER RESEARCH 92(2) 211-219 2001年2月
YB-1 binds preferentially to single-stranded nucleic acid and exhibit 3'-5' exonuclease activity.

Nucl. Acids Res. 29 1200-1207 2001年
Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression

T Okamoto, H Izumi, T Imamura, H Takano, T Ise, T Uchiumi, M Kuwano, K Kohno

ONCOGENE 19(54) 6194-6202 2000年12月
Human placental transport of vinblastine, vincristine, digoxin and progesterone : contribution of P-glycoprotein.

Eur. J. Pharmacol. 408(1) 1-10 2000年
The human multidrug resistance protein 2 gene: Functional characterization of the 5 '-flanking region and expression in hepatic cells

T Tanaka, T Uchiumi, E Hinoshita, A Inokuchi, S Toh, M Wada, H Takano, K Kohno, M Kuwano

HEPATOLOGY 30(6) 1507-1512 1999年12月
Enhanced transport of anticancer agents and leukotriene C-4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)

T Kawabe, ZS Chen, M Wada, T Uchiumi, M Ono, S Akiyama, M Kuwano

FEBS LETTERS 456(2) 327-331 1999年8月
Cellular balance of glutathione levels through the expression of gamma-glutamylcysteine synthetase and glutathione thiol transferase genes in human hepatic cells resistant to a glutathione poison

T Tanaka, T Uchiumi, M Nomoto, K Kohno, T Kondo, K Nishio, N Saijo, M Kuwano

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1427(3) 367-377 1999年5月
Functional Characterization of 5'-Flanking Region of the Human Canalicular Multispecific Organic Anion Transporter/Multidrug Resistance Protein2(cMOAT/MRP2)Gene and its Specific Expression in Hepatic Cells.

Hepatology 1999年
Effect of Multidrug Resistance Reversing Agents on the Transporting Activity of Human Canalicular Multispecific Organic Anion Transporter(cMOAT)^*.

Molec. Pharmacology 1999年
Multidrug resistance-associated protein subfamily transporters and drug resistance(review).

Anti-Cancer Drug Design 14 129-131 1999年
Genomic structure of the canalicular multispecitic organic anion transporter(cMOAT) gene and mutations in the ATP binding cassette region in Dubin-Johnson syndrome.

Am. J. Human Genet. 64 739-746 1999年
The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase II gene in response to heat shock.

J. Biol. Chem. 273(17) 10550-10555 1998年
Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene.

J. Biol. Chem. 273(11) 5997-6000 1998年
Glutathione homeostasis in human hepatic cells : overexpression of-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor fo glutathione synthesis

Biochem. Biophys. Res. Commun. 246(2) 398-403 1998年
Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin resistant cancer cells with decreased ATP-dependent drug transport.

Biochem. Biophys. Res. Commun. 1998年
Cell Cycle Regulation of PLK promoter

Journal of Biological Chemistry 272(14) 9166-9174 1997年
Activation of the human multidrug resistance(MDR1)gene promoter in reponse to environmental stress. I Anticancer agents and ultravioler light irradiation.

The Mechanism and New Appruch on Drug-Resistance of Cancer Cells. 71-75 1993年
Enhanced expression of the human multidrug resistance 1 gene in response to ultraviolet light irradiation.

Cell Grouth & Differenciation 4 147-157 1993年
Involvement of protein kinase in environmental stress-induced activation of human multidrug resistance I(MDRI)gene promoter.

FEBS letter 326(1/3) 11-16 1993年

所属学協会

3

共同研究・競争的資金等の研究課題

6