2011年
Genotypes of Candida albicans involved in development of candidiasis and their distribution in oral cavity of non-candidiasis individuals.(共著)
Medical Mycology Journal
- 巻
- 52
- 号
- 4
- 開始ページ
- 315
- 終了ページ
- 324
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3314/mmj.52.315
- 出版者・発行元
- The Japanese Society for Medical Mycology
Genotype characteristics and distribution of commensal Candida albicans should be studied to predict the development of candidiasis, however, extensive genotype analysis of commensal C. albicans has not been made. In this study, 508 C. albicans isolates were collected from patients with/without candidiasis and divided into 4 isolate groups (SG-1, oral cavity of non-candidiasis patients; SG-2, patients with cutaneous candidiasis; SG-3, patients with vaginal candidiasis; SG-4, patients with candidemia). These isolates were characterized to study the relationship between genotypes and pathogenicity using microsatellite analysis. Using CDC3 and CAI, 5 genotypes (I, 111: 115/33: 41; II, 115: 119/23: 23; III, 115: 123/18: 27; IV, 115: 123/33: 40; and V, 123: 127/32: 41) were found in 4.2%, 8.9%, 7.1%, 2.2% and 3.1% of the isolates, respectively. Genotypes II and III were commonly found in all isolate groups. These genotypes were further divided into 28 types by additional HIS3 and CAIII microsatellite markers. In this analysis, C. albicans with type 6 and type 23 was widely distributed as a commensal species in the oral cavity of non-candidiasis patients and found to be related with candidiasis development. Additionally, genotypes I and IV were found in SG-2 and/or SG-4, suggesting that the fungus with those genotypes is also involved in this development. In contrast, genotype V was not identified in any infective isolates.
- リンク情報
-
- DOI
- https://doi.org/10.3314/mmj.52.315
- CiNii Articles
- http://ci.nii.ac.jp/naid/10029775696
- CiNii Books
- http://ci.nii.ac.jp/ncid/AA12518136
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22123330
- URL
- http://id.ndl.go.jp/bib/023262663
- URL
- https://jlc.jst.go.jp/DN/JALC/00383170864?from=CiNii
- URL
- http://search.jamas.or.jp/link/ui/2012213607
- ID情報
-
- DOI : 10.3314/mmj.52.315
- ISSN : 2185-6486
- ISSN : 2186-165X
- CiNii Articles ID : 10029775696
- CiNii Books ID : AA12518136
- PubMed ID : 22123330