論文

2016年3月

Fabrication of Porous alpha-TCP/Gellan Gum Scaffold for Bone Tissue Engineering

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
  • Jian Wen
  • ,
  • Ill Yong Kim
  • ,
  • Koichi Kikuta
  • ,
  • Chikara Ohtsuki

16
3
開始ページ
3077
終了ページ
3083
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1166/jnn.2016.12463
出版者・発行元
AMER SCIENTIFIC PUBLISHERS

alpha-tricalcium phosphate (alpha-TCP, alpha-Ca-3(PO4)(2)) receives great attention for bone repairing due to its biodegradability and capability of transformation to human bone's main inorganic components, hydroxyapatite (HAp). alpha-TCP porous scaffold is easily procurable by sintering of the low-temperature polymorph of TCP, alpha-TCP. Still, porous body of alpha-TCP is too brittle to being handled and shaped, limiting its clinical application as implant materials. To improve mechanical properties of alpha-TCP porous scaffold, the present study focused on coating of a type of polysaccharides on alpha-TCP scaffolds. Gellan gum was chosen as the polysaccharide for coating because of its biodegradability as well as the potential acting as substrate for HAp deposition during hydration of alpha-TCP after exposure to body fluid. After coating of gellan gum on alpha-TCP scaffolds with porosity of 75 vol%, the compressive strength increased from 0.45 MPa to around 2.00 MPa. Among the coated scaffold, the maximum compressive strength, 3.97 MPa, was obtained on the scaffold with porosity of 63 vol%. Improvement of mechanical properties of alpha-TCP/gellan gum composites was achieved to show easy handling performance for a bone substitute for tissue repairing. The dissolving rate of the coated scaffolds was also controlled by adjusting the concentration of GG solutions.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1166/jnn.2016.12463
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000374153800157&DestApp=WOS_CPL

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