- ELSEVIER SCIENCE BV
Iron-based compounds, especially magnetite (Fe3O4), can be a candidate of thermoseeds for hyperthermia therapy. When iron-based compounds are applied for bone tumor treatment, they should have a heat generating property and a bone-bonding property. However, the bone-bonding property of iron-based compounds is still unclear. The bone-bonding property of materials is estimated by their bone-like apatite formation property in simulated body fluid (SBF). The method to estimate apatite forming ability of materials by utilizing SBF was introduced by Kokubo et al. We thus report fundamental research into the behavior of iron oxides and an iron oxyhydroxide namely: FeO, Fe3O4, alpha-Fe2O3, gamma-Fe2O3, and alpha-FeOOH, in SBF. Calcium phosphate precipitation was found in Fe3O4 and alpha-Fe2O3 within 7 and 28 days after soaking in SBF, respectively, while FeO, gamma-Fe2O3, and alpha-FeOOH did not. Our results indicate that Fe3O4 and alpha-Fe2O3 have a better potential bone-bonding property than FeO gamma-Fe2O3, and alpha-FeOOH. The induction of apatite precipitation in SBF can be attributed to the specific structure of Fe-OH groups on the surface of Fe3O4 and alpha-Fe3O4. (C) 2014 The Ceramic Society of Japan and the Korean Ceramic Society. Production and hosting by Elsevier B.V. All rights reserved.
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