OHKUMA Takeshi

J-GLOBAL         Last updated: Dec 12, 2018 at 15:43
OHKUMA Takeshi
Hokkaido University
Faculty of Engineering, Division of Chemical Process Engineering
Job title
Master of Science (Keio University), January 1991 Doctor of Philosophy (Nagoya University)(Keio University)

Research Areas


Academic & Professional Experience

Apr 2016
Mar 2018
Deen, Graduate School of Chemical Sciences and Engineering, Hokkaido University
- Professor,Professor (Hokkaido University, Faculty of Chemical Process Engineering)
 Professor,Professor (Hokkaido University, Division of Chemical Process Engineering)
 Professor,Professor (Hokkaido University, Division of Molecular Chemistry)
 Associate Professor,Associate Professor (Nagoya University, Research Center for Materials Science)
 Associate Professor,Associate Professor (Nagoya University, Chemistry Department)
 Researcher,Molecular Catalysis Project Researcher (Japan Science and Technology Agency)
 Researcher,Post Doctoral Researcher (Stanford University, USA)
 Researcher,Researcher (Japan Society for Promotion of Science)


Graduate School, Division of Natural Science, Nagoya University
Graduate School, Division of Science and Engineering, Keio University
Faculty of Science and Engineering, Keio University

Awards & Honors

Mar 2018
Development of Asymmetric Reactions Catalyzed by Ruthenium Complexes with Two Kinds of Ligands, The 35th Excellent Scholar Award, Chemical Society of Japan
Dec 2014
Asian Core Program Lectureship Award, University of Malaya
International Scientist of the Year 2007
JSPS Prize

Published Papers

Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
N. Utsumi, N. Arai, K. Kawaguchi, T. Katayama, T. Yasuda, K. Murata, T. Ohkuma
ChmCatChem   10 3955-3959   Jul 2018   [Refereed]
Construction of Unique Heterocyclic Frameworks by Photochemical Reaction of 5- and 6-Membered Heteroaromatics
N. Arai, T. Ohkuma
Heterocycles   96(6) 997-1035   Mar 2018   [Refereed][Invited]
T. Ohkuma, N. Kurono, Y. Sakaguchi, K. Yamauchi, T. Yurino
Advanced Synthesis and Catalysis   360 1517-1522   Feb 2018   [Refereed]
OHKUMA Takeshi
Chemical Engineering Japan   81(12) 666-669   Dec 2017   [Refereed][Invited]
Synthetic Organic Chemistry (2)
N. Arai, T. Ohkuma
Chemistry Today   (12) 18-23   Dec 2017   [Refereed][Invited]
N. Arai, T. Namba, K. Kawaguchi, Y. Matsumoto, T. Ohkuma
Angewandte Chemie International Edition   57 1386-1389   Dec 2017   [Refereed]
Synthetic Organic Chemistry (1)
N. Arai, T. Ohkuma
Chemistry Today   (11) 17-21   Nov 2017   [Refereed][Invited]
Double Asymmetric Hydrogenation of Linear β,β-Disubstituted α,β-Unsaturated Ketones into γ-Substituted Secondary Alcohols Using a Dual Catalytic System
N. Arai, H. Satoh, R. Komatsu, T. Ohkuma
Chemistry A European Journal   23 8806-8809   May 2017   [Refereed]
OHKUMA Takeshi
The Chemical Record   16(6) 2428-2429   Dec 2016   [Refereed][Invited]
T. Ohkuma, N. Arai
The Chemical Record   16(6) 2801-2819   Aug 2016   [Refereed][Invited]
N. Arai, N. Onodera, T. Ohkuma
Tetrahedron Letters   57(37) 4183-4186   Aug 2016   [Refereed]
Development of Methods for Construction of Heterocyclic Frameworks by Photochemical Activation of Molecules
N. Arai, T.Ohkuma
Journal of Synthetic Organic Chemistry Japan   74(4) 360-371   Apr 2016   [Refereed][Invited]
N. Kurono, T. Ohkuma
ACS Catalysis   6(2) 989-1023   Dec 2015   [Refereed][Invited]
N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
Tetrahedron Letters   56 3913-3915   May 2015   [Refereed]
Asymmetric Hydrogenation of Ketones and Imines Catalyzed by Ru(II) Complexes
OHKUMA Takeshi
Pharmacia   51(4) 295-299   Apr 2015   [Refereed]
N. Arai, M. Mizota, T. Ohkuma
Heterocycles   90(1) 607-616   Apr 2015   [Refereed][Invited]
N. Arai, M. Mizota, T. Ohkuma
Organic Letters   17(1) 86-89   Dec 2014   [Refereed]
Y. Sakaguchi, N. Kurono, K. Yamauchi, T. Ohkuma
Organic Letters   16(3) 808-811   Jan 2014   [Refereed]
N. Arai, Y. Saruwatari, K. Isobe, T. Ohkuma
Advanced Synthesis and Catalysis   355 2769-2774   Oct 2013   [Refereed]


Asymmetric Hydrogenation of Ketones catalyzed by Ru Complexes.
Catalysts & Catalysis   51(8) 577-582   2009

Books etc

Handbook of Organic Synthesis Experiment
N. Arai, T. Ohkuma (Part:Contributor, Reduction with Gaseous Hydrogen)
Maruzen   2015   
Comprehensive Chirality, Vol. 5
Ohkuma T, Arai N (Part:Contributor, Reduction–Hydrogenation: C=O; Chemoselective.)
Elsevier   2012   
Privileged Chiral Ligands and Catalysts
Ohkuma T, Kurono N (Part:Contributor, BINAP)
Wiley-VCH   2011   
Science of Synthesis: Stereoselective Synthesis 2
Arai N, Ohkuma T (Part:Contributor, Reduction of Carbonyl Compound: Hydrogenation.)
Thieme   2010   
Modern Reduction Methods
Arai N, Ohkuma T (Part:Contributor, Carbonyl Hydroboration.)
Wiley-VCH   2008   
The Handbook of Homogeneous Hydrogenation
Ohkuma T, Noyori R (Part:Contributor, Enantioselective Ketone and β-Keto Ester Hydrogenation (Including Mechanisms).)
Wiley-VCH Verlag GmbH & Co. KGaA   2007   
New Frontiers in Asymmetric Catalysis
Ohkuma T, Kitamura M, Noyori R (Part:Contributor, Ligand Design for Catalytic Asymmetric Reduction.)
John Wiley & Sons, Inc.   2007   
Chirality on Organic Chemistry
Maruzen   2005   
The Fifth Series of Chemistry Handbook
Marzen   2004   
The Fifth Series of Experimental Chemistry
Marzen   2004   
Catalytic Organic Reactions
Tokyo Kagaku Dozin   2004   
Catalytic Organic Reactions
Tokyo Kagaku Dozin   2004   
Catalytic Organic Reactions
Tokyo Kagaku Dozin   2004   

Conference Activities & Talks

Asymmetric Hydrogenation and Isomerization Catalyzed byChiral Ruthenium Complexes [Invited]
OHKUMA Takeshi
The 5th International Symposium on AMBITIOOUS LEASR'S PROGRAM   21 Nov 2017   
Asymmetric Hydrogenation and Isomerization with Chiral Ru(II) Catalysts [Invited]
OHKUMA Takeshi
5th UK-Japanese Symposium on Asymmetric Catalysis   15 Mar 2016   
Enantioselective Cyanation Catalyzed by Ru Complex/Li Compound Combined Systems [Invited]
OHKUMA Takeshi
The 6th Japanese-Sino Symposium on Organic Chemistry for Young Scientists   7 Jul 2015   
Asymmetric Hydrogenation and Isomerization Catalyzed by Ruthenium(II) Complexes [Invited]
OHKUMA Takeshi
8th Singapore International Chemistry Conference 2014   16 Dec 2014   
Enantioselective Hydrogenation and Isomerization with Chiral Ruthenium(II) Catalysts [Invited]
OHKUMA Takeshi
The 9th International Conference on Cutting-Edge Organic Chemistry in Asia   2 Dec 2014   


Symposium Organizer "Frontier Chemistry Center The 3rd International Symposium" "Challenges at the Frontier of Chemical Sciences"
OHKUMA Takeshi   The Others   Jun 2014
Symposium Organizer "Frontier Chemistry Center The 2nd International Symposium" "Advanced Materials Science"
OHKUMA Takeshi   The Others   Dec 2013
Symposium Organizer "Frontier Chemistry Center The 1st International Symposium" "Next Generation of Molecular Chemistry"
OHKUMA Takeshi   The Others   Feb 2013
Symposium Organizer "2012 Hokkaido University & Peking University Joint Symposium on Organic and Organometallic Chemistry"
OHKUMA Takeshi   The Others   Jul 2012
Division reports of Japan Chemical Society
Inovation Japan 2007

Research Grants & Projects

Strategic Molecular and Materials Chemistry through Innovative Coupling Reactions
Ministry of Education, Culture, Sports, Science, and Technology, Japan: 
Project Year: Apr 2012 - Mar 2016    Investigator(s): OHKUMA Takeshi
Overseas Visit Program for Young Prospective Researchers Involved in Innovative Chemistry for Efficient Molecular Conversion and the Creation of New Functional Materials
Japan Society for the Promotion of Science: Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation
Project Year: Oct 2012 - Mar 2015    Investigator(s): OHKUMA Takeshi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2006 - 2007    Investigator(s): Takeshi OHKUMA
A series of ruthenium complexes with both chiral diphosphine and diamine ligands was designed and applied to asymmetric hydrogenation of ketones. The obtained results are described below1) Chiral 1,4-diamine IPHAN was prepared from mannitol. The T...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(学術創成研究費)
Project Year: 2002 - 2006    Investigator(s): Ryoji NOYORI
(1) Asymmetric Hydrogenation of Ketones: Chiral RuC1_2(binap)(1, 2-diamine) complexes allow rapid, enantioselective hydrogenation of various simple, unfunctionalized ketones with a high substrate/catalyst molar ratio up to 2, 400, 000. As high pra...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2004    Investigator(s): Takeshi OHKUMA
Chiral diphosphine/1,2-diamine Ru(II) complexes catalyze the rapid, productive, and enantioselective hydrogenation of simple ketones. The reaction proceeds smoothly even at an atmospheric pressure of H_2 at room temperature and is further accelera...
Development of Stereoselective Hydrogenation Catalyzed by Metal Nanoparticles
Basic Science Research Program
Project Year: 2004   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2001 - 2002    Investigator(s): Takeshi OHKUMA
Homogeneous asymmetric catalysis provides a fundamental tool for the preparation of chiral building blocks for biologically important substances and advanced materials. Polymer-bound catalysts have inherent operational and economical advantages : ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1999 - 2000    Investigator(s): Takeshi OHKUMA
The development of practical methods effecting stereoselective hydrogenation of simple ketones is highly desirable, since the existing homogeneous catalysts lack reactivity and/or stereoselectivity. A new Ru (II) complex, trans-RuCl_2 [(S)-xylbina...
Development of Asymmetric Reactions with Molecular Catalysts
Basic Science Research Program
Project Year: 1994   


Preparation of Alkens
Preparation of Optically Active Alcohols
WO2005/092825 A1
Preparation of Cyanohydrin Silyl Ethers
Hydrogenation Catalysts and Preparation of Alkens
WO2005/094993 A1
Preparation of Optically Active Qunuclidinol
WO2006/103756 A1
Sulfonate catalysts and Procedure to Produce Alcohols
Hydrogenation Catalysts and Preparation of Alcoholic Compounds
Ru Complexes and Preparation of tert-Alkyl Alcohols
US7,378,560 B2
Sulfonate catalysts and Procedure to Produce Alcohols
US7,601,667 B2
Procedure for Synthesis of Chiral β,β-Bishetero Substituted Alcohols
特願 2006-209433