KANEGANE Hirokazu

J-GLOBAL         Last updated: Nov 20, 2019 at 03:05
 
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Name
KANEGANE Hirokazu
E-mail
hkanegane.pedtmd.ac.jp
Affiliation
Tokyo Medical and Dental University
Section
Graduate School of Medical and Dental Sciences Endowed Departments Department of Child Health and Development
Job title
Professor
Research funding number
00293324

Research Areas

 
 

Academic & Professional Experience

 
Jul 2018
 - 
Today
Professor, Graduate School of Medical and Dental Sciences Endowed Departments Department of Child Health and Development, Tokyo Medical and Dental University
 
Apr 2018
 - 
Jun 2018
Associate Professor, Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Environmental Response Pediatrics and Developmental Biology, Tokyo Medical and Dental University
 
Oct 2014
 - 
Mar 2018
Associate Professor, Graduate School of Medical and Dental Sciences Medical and Dental Sciences Bio-Environmental Response Pediatrics and Developmental Biology, Tokyo Medical and Dental University
 

Education

 
Apr 1987
 - 
Mar 1991
Graduate School, Division of Medicine, Kanazawa University
 
Apr 1980
 - 
Mar 1986
Faculty of Medicine, Kanazawa University
 

Published Papers

 
Nobuyoshi Kusano, Naoki Sakata, Keisuke Sugimoto, Tomoki Miyazawa, Satoshi Ueda, Munehiro Okano, Ken-Ichi Imadome, Akihiro Hoshino, Hirokazu Kanegane, Masatomo Kimura, Takao Sato, Mitsuru Okada, Tsukasa Takemura
J. Pediatr. Hematol. Oncol.   41(8) e538-e541   Nov 2019   [Refereed]
X-linked lymphoproliferative syndrome type 1 (XLP1) is a rare congenital immunodeficiency disease. We report the case of an 18-year-old male who developed hemophagocytic lymphohistiocytosis (HLH) with neurological complications after primary Epste...
Makiko Egawa, Hirokazu Kanegane, Kohsuke Imai, Tomohiro Morio, Naoyuki Miyasaka
J. Matern. Fetal. Neonatal. Med.   32(18) 3092-3096   Sep 2019   [Refereed]
Immunoglobulin replacement therapy, including intravenous immunoglobulin (IVIG), is essential for pregnant women with common variable immunodeficiency (CVID) since it prevents infection and improves the health of the newborn. There are no establis...
Ibusuki A, Nishikawa T, Hiraki T, Okano T, Imai K, Kanegane H, Ohnishi H, Kato Z, Fujii K, Tanimoto A, Kawano Y, Kanekura T.
J. Dermatol.      Aug 2019   [Refereed]
immunophenotype and genetic analysis, a novel mutation in the IL2RG gene (c.337_339delTCT, p.Ser113del). The final diagnosis was that of OS. He responded well to an allograft umbilical cord blood transplantation that was performed when the patient...
Takeru Yamauchi, Kei Takasawa, Takahiro Kamiya, Shizuka Kirino, Maki Gau, Kento Inoue, Akihiro Hoshino, Kenichi Kashimada, Hirokazu Kanegane, Tomohiro Morio
Pediatr Diabetes      Jul 2019   [Refereed]
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome is an autoimmune disorder caused by the dysfunction of FOXP3, which leads to regulatory T (Treg) cell dysfunction and subsequently autoimmunity including type 1 di...
Hoshino A, Kanegane H, Nishi M, Tsuge I, Tokuda K, Kobayashi I, Imai K, Morio T, Takagi M
Clin. Immunol.   203 9-13   Jun 2019   [Refereed]
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is one of the inborn errors of immunity, characterized by impaired function of the regulatory T cells. Clinical manifestations of IPEX syndrome are characterized by va...

Misc

 
Ryu Yanagisawa, Kazuyuki Matsuda, Shouichi Ohga, Hirokazu Kanegane, Akira Morimoto, Yasuhiro Okamoto, Akira Ohara, Keitaro Fukushima, Manabu Sotomatsu, Keiko Nomura, Akiko M Saito, Keizo Horibe, Eiichi Ishii, Yozo Nakazawa
Int. J. Hematol.   109(5) 629   May 2019
The correct name of the first author should be ''Ryu Yanagisawa'', and not ''Ryu Yanagaisawa'' as given in the original publication of the article.
Kanegane H, Hoshino A, Takagi M
Rinsho Ketsueki (The Japanese journal of clinical hematology)   59(11) 2459-2467   Dec 2018
Primary immunodeficiency disease (PID) is characterized by an impaired immune system along with recurrent and severe and/or opportunistic infections; these infections are frequently associated with malignancies and autoimmune disorders. Dysregulat...
Hirokazu Kanegane, Kohsuke Imai, Tomohiro Morio
Nihon Rinsho Meneki Gakkai Kaishi   40(3) 145-154   Mar 2017
  Severe combined immunodeficiency (SCID) is impaired in lymphocyte development and function. Affected children have extreme susceptibility to infections, which are fatal in the first year of life without treatment. The estimate of incidence is on...
Hirokazu Kanegane
Rinsho Ketsueki   57(10) 2275-2284   Oct 2016   [Refereed]
Primary immunodeficiency disease (PID) is an inborn error of the immune system, and is characterized by not only susceptibility to infection but also frequent combination with autoimmune diseases and malignancies. PID is principally caused by a ge...

Books etc

 
Primary Immunodeficiency Diseases
Aghamohammadi A, Plebani A, Lougaris V, DurandynA, Condino-Neto A, Kanegane H, Hammarstrom L (Part:Joint Work, Predominantly Antibody Deficiencies)
Springer   Jan 2017   ISBN:978-3-662-52907-2

Conference Activities & Talks

 
Genetic test for the suspected patients of inborn errors of immunity
7 Nov 2019   
Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder with Multiple Autoantibodies in a XIAP Deficient Patient
Hoshino A, Okano T, Matsumoto K, Nishimura A, Shintaku H, Tokoro S, Okamoto H, Wada T, Mitsuiki N, Kajiwara M, Takagi M, Imai K, Kanegane H, Morio T
19th Biennial Meeting of the European Society of Immunodeficiencies (ESID2019)   20 Sep 2019   
Genomics Analysis of Leukemia Predisposition in X-Linked Agammaglobulinemia
Nishimura A, Naruto T, Hoshino A, Amano K, Iwamoto S, Hirayama M, Grigg A, Bosco J J, Migita M, Takagi M, Ohara O, Morio T, van Zelm MC, Kanegane H
19th Biennial Meeting of the European Society of Immunodeficiencies (ESID2019)   20 Sep 2019   
A CTLA-4 Haploinsufficiency Case with Multiple Brain and Pulmonary Lesions - Dilemmas in Management.
Honda Y, Yasumi T, Miyamoto T, Nishitani M, Nihira H, Shiba T, Shibata H, Tanaka T, Kanda K, Izawa K, Kanegane H, Heike T, Takita J, Nishikomori R.
19th Biennial Meeting of the European Society of Immunodeficiencies (ESID2019).   20 Sep 2019   
Diagnostic Approach by Whole Exome Sequencing for 141 Patients of Inborn Errors of Immunity
Okano T, Imai K, Naruto T, Okada S, Okamoto K, Yamashita M, Yeh T. W, Takagi M, Kanegane H, Morio T
19th Biennial Meeting of the European Society of Immunodeficiencies (ESID2019)   19 Sep 2019