MISC

1997年3月

Suppression of tumour necrosis factor-alpha expression in leprosy skin lesions during treatment for leprosy

BRITISH JOURNAL OF DERMATOLOGY
  • Y Sugita
  • ,
  • M Miyamoto
  • ,
  • M Koseki
  • ,
  • N Ishii
  • ,
  • H Nakajima

136
3
開始ページ
393
終了ページ
397
記述言語
英語
掲載種別
出版者・発行元
BLACKWELL SCIENCE LTD

The expression of tumour necrosis factor (TNF)-alpha in leprosy skin lesions was examined before and during successful treatment in a patient with borderline lepromatous leprosy. Before treatment, immunohistochemical staining of a skin biopsy specimen showed diffuse TNF-alpha deposits in granulomas and significant TNF-alpha deposits on infiltrated mononuclear cells. After 1 year's treatment, the skin lesions exhibited a reduction in granulomas, and a concomitant reduction in deposits of TNF-alpha. Furthermore, the level of expression of TNF-alpha messenger RNA, as examined using a reverse transcriptase-polymerase chain reaction method, was reduced markedly after treatment. These findings provide evidence for a correlation between the expression of TNF-alpha and disease activity suggesting that TNF-alpha is a useful prognostic indicator for inflammation in leprosy.

Web of Science ® 被引用回数 : 8

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1997WM10500019&DestApp=WOS_CPL

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