MISC

2007年3月

Angiogenic factors in normal endometrium and endometrial adenocarcinoma

PATHOLOGY INTERNATIONAL
  • Mayumi Saito
  • ,
  • Yuichi Sato
  • ,
  • Jun Watanabe
  • ,
  • Hiroyuki Kuramoto
  • ,
  • Sadayuki Kaba
  • ,
  • Toshio Fukuda

57
3
開始ページ
140
終了ページ
147
記述言語
英語
掲載種別
DOI
10.1111/j.1440-1827.2006.02071.x
出版者・発行元
BLACKWELL PUBLISHING

In the endometrium, angiogenesis plays important roles not only in tumor growth but also in the menstrual cycle. The purpose of the present paper was to investigate immunohistochemically the correlation between angiogenic factor expression and angiogenic score in normal and neoplastic endometrium. Immunohistochemical staining for vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1, Ang2, Tie2, CD34 and CD105 was performed on formalin-fixed and paraffin-embedded tissues from 31 normal endometrium and 85 endometrial adenocarcinoma. VEGF, Ang1, Ang2 and Tie2 expression was localized in the cytoplasm of glandular and tumor cells. The levels of each angiogenic factor were different in the phases of the menstrual cycle and each layer of normal endometrium. In general, VEGF and Tie2 expression was higher in adenocarcinoma than in normal epithelial cells. Conversely, Ang1 and Ang2 expression was higher in normal epithelium than in adenocarcinoma. The angiogenic score (CD105/CD34) tended to be higher in the adenocarcinoma than in the normal epithelium. It is suggested that the angiogenic pathway and the role of these factors seem to differ between normal tissue and carcinoma of the endometrium.

Web of Science ® 被引用回数 : 22

リンク情報
DOI
https://doi.org/10.1111/j.1440-1827.2006.02071.x
CiNii Articles
http://ci.nii.ac.jp/naid/10020104826
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17295646
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000243977200004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1440-1827.2006.02071.x
  • ISSN : 1320-5463
  • CiNii Articles ID : 10020104826
  • PubMed ID : 17295646
  • Web of Science ID : WOS:000243977200004

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