UKAI Takashi

J-GLOBAL         Last updated: Sep 10, 2019 at 23:59
UKAI Takashi
Nagasaki University
Graduate School of Biomedical Sciences

Research Areas


Academic & Professional Experience

Apr 2018
Nagasaki University hospital


Graduate School, Division of Dental Research, Nagasaki University
Faculty of Dentistry, Nagasaki University

Published Papers

T cell and periosteum cooperation in osteoclastogenesis induced by lipopolysaccharide injection in transplanted mouse tibia.
Kobayashi H, Ukai T, Shiraishi C, Ozaki Y, Yoshimura A, Hara H.
J Dent Sci   13(3) 226-233   2018   [Refereed]
A histopathologic study of the controlling role of T cells on experimental periodontitis in rats.
Izumi S, Yoshinaga Y, Nakamura H, Takamori A, Takamori Y, Ukai T, Shiraishi C, Hara Y
J Dent Sci.   13(2) 87-96   2018   [Refereed]
Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells.
Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y
J. Periodont. Res.   53(3) 353-361   2018   [Refereed]
Topical application of glycyrrhetinic acid in the gingival sulcus inhibits attachment loss in lipopolysaccharide-induced experimental periodontitis in rats.
Takamori A, Yoshinaga Y, Ukai T, Nakamura H, Takamori Y, Izumi S, Shiraishi C, HaraY
J. Periodont. Res.   53(3) 422-429   2018   [Refereed]
The histopathological comparison on the destruction of the periodontal tissue between normal junctional epithelium and long junctional epithelium.
Noguchi S, Ukai T, Kuramoto A, Yoshinaga Y, Nakamura H, Takamori Y, Yamashita Y, Hara Y.
J. Periodont. Res.   52(1) 74-82   2017   [Refereed]
Dental Calculus Stimulates Interleukin-1β Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes.
Jorge Luis Montenegro Raudales, Atsutoshi Yoshimura , Ziauddin SM, Takashi Kaneko, Yukio Ozaki, Takashi Ukai, Toshihiro Miyazaki, Eicke Latz, Yoshitaka Hara
PLoS ONE   11(9) e0162865   2016   [Refereed]
RANKL pretreatment plays an important role in the differentiation of pit-forming osteoclasts induced by TNF-α on murine bone marrow macrophages
Yamashita Y, Ukai T, Nakamura H, Yoshinaga Y, Kobayashi H, Takamori Y, Noguchi S, Yoshimura A, Hara Y
Arch Oral Biol   60(9) 1273-1282   2015   [Refereed]
Green tea extract inhibits the onset of periodontal destruction in rat experimental periodontitis.
Y. Yoshinaga, T. Ukai, S. Nakatsu, A. Kuramoto, F. Nagano, M. Yoshinaga, J. L. Montenegro, C. Shiraishi, Y. Hara
J. Periodont. Res.   49(5) 652-659   2014   [Refereed]
Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction.
Nagano F, Kaneko T, Yoshinaga Y, Ukai T, Kuramoto N, Nakatsu S, Oshino K, Ichimura I, Hara Y
J. Periodont. Res.   48(4) 420-427   2013   [Refereed]
A Single Nucleotide Polymorphism in 3'-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation.
Sato K, Yoshimura A, Kaneko T, Ukai T, Ozaki Y, Nakamura H, Li X, Matumura H, Hara Y, Ogata Y
Journal of Biological Chemistry   282(30) 25163-25172   2012   [Refereed]
Topical application of lipopolysaccharide into gingival sulcus promotes periodontal destruction in rats immunized with lipopolysaccharide.
Yoshinaga Y, Ukai T, Kaneko T, Nakatsu S, Shiraishi C, Kuramoto A, Oshino K, Ichimura I, Hara Y.
J. Periodont. Res.   47(5) 674-680   2012   [Refereed]
The formation of immune complexes is involved in the acute phase of periodontal destruction in rats.
Kuramoto A, Yoshinaga Y, Kaneko T, Ukai T, Shiraishi C, Oshino K, Ichimura I, Hara Y
J Periodontal Res.   47(4) 455-462   2012   [Refereed]
Peptidoglycan and lipopolysaccharide synergistically enhance bone resorption and osteoclastogenesis.
Kishimoto T, Kaneko T, Ukai T, Yokoyama M, Ayon Haro R, Yoshinaga Y, Yoshimura A, Hara Y
J Periodontal Res   47(4) 446-454   2012   [Refereed]
Membrane-bound CD40 Ligand on T cells from mice injected with lipopolysaccharide (LPS) accelerates LPS-induced osteoclastogenesis
M Yokoyama, T Ukai, E.R. Ayon Haro, T Kishimoto, Y Yoshinaga, Y Hara
Journal of Periodontal Research   46 464-474   2011   [Refereed]
Locally administered interferon-g accelerates lipopolysaccharide-induced osteoclastogenesis independent of immunohistological RANKL upregulation
E.R. Ayon Haro, T Ukai, M Yokoyama, T Kishimoto, Y Yoshinaga, Y Hara
Journal of Periodontal Research   46 361-373   2011   [Refereed]
Pathogen Mediated Inflammatory Atherosclerosis is Mediated in Part via TLR2 Induced Inflammatory Responses
Chie Hayashi, Andres G. Madrigal, Xinyan Liu, Takashi Ukai, Sulip Goswami, Cynthia V. Gudino, Frank C. Gibson III and Caroline A. Genco.
J Innate Immun   2(4) 334-343   Mar 2010   [Refereed]
Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo.
H Nakamura, T Ukai, A Yoshimura, Y Kozuka, H Yoshioka, Y Yoshinaga, Y Abe, Y Hara
Journal of Periodontal Research   45(1) 23-30   2010   [Refereed]
Locally administered T cells from mice immunized with lipoplysaccharide (LPS) accelerate LPS-induced bone resorption.
Y Ozaki, T Ukai, M Yamaguchi, M Yokoyama, ER Ayon Haro, M Yoshimoto, K Kaneko, M Yoshinaga, H Nakamura, C Shiraishi, Y Hara
44 1169-1176   2009   [Refereed]
T cells are able to promote LPS-induced bone resorption under the condition of absence of B cells in mice.
M. Yamaguchi, T. Ukai, T. Kaneko, M. Yoshinaga, M. Yokoyama, Y. Ozaki, Y. Hara
Journal of Periodontal Research   43(5) 549-555   2008   [Refereed]
Bacterial Fimbriae Stimulate Pro Inflammatory Activation in the Endothelium Through Distinct TLRs
Michael Davey, Xinyan Liu, Takashi Ukai, Frank C. Gibson III, Cynthia Gudino, Vishal Jain, Douglas Golenbock, Alberto Visintin, and Caroline A. Genco
Journal of Immunology   180(4) 2187-2195   2008   [Refereed]
Macrophage-Elicited Osteoclastogenesis in Response to Bacterial Stimulation Requires Toll-like Receptor 2 Dependent Tumor Necrosis Factor-{alpha} Production.
Ukai T, Yumoto H, Gibson FC 3rd, Genco CA.
Infect Immun   76(2) 812-819   2008   [Refereed]
Engagement of specific innate immune signaling pathways during Porphyromonas gingivalis induced chronic inflammation and atherosclerosis.
Gibson FC 3rd, Ukai T, Genco CA.
Front Biosci.   1(13) 2041-2059   2008   [Refereed]
Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids.
Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson FC 3rd, Genco CA.
Atherosclerosis.   196(1) 146-154   2008   [Refereed]
Expression of receptor activator of NFkB ligand relates to inflammatory bone resorption with or without occlusal trauma in rat.
Yoshinaga Y, Ukai T, Abe Y, Hara Y.
Journal of Periodontal Research   42(5) 402-409   2007   [Refereed]
B cells play an important role in lipopolysaccharide-induced bone resorption.
UKAI Takashi
Calcif Tissue Int   78(3) 125-132   2006   [Refereed]
Immunohistochemical localization of Toll-like receptors 2 and 4 in gingival tissue from patients with periodontitis.
Mori Y, Yoshimura A, Ukai T, Lien E, Espevik T, Hara Y
Oral Microbiol Immunol   18 54-58   2003   [Refereed]
Shiraishi C., Hara Y., Abe Y., Ukai T., Kato I.
Archives of Oral Biology   46, 99-107    2001
Bone resorption and local interleukin-1 α and interleukin-1 β synthesis by Actinobacillus actionomycetemcomitans and Porphromonas gingivalis lipopolysaccharide
Eiji Nishida, Yoshitaka Hara, Takashi Kaneko, Yasuo Ikeda, Takashi Ukai, Ihachi Kato
J Periodont Res   36, 1-8    2001
Hara Y., Ukai T., Yoshimura A., Shiku H., Kato I.
Calcif. Tissue Int.   63, 63-66    1998
Histochemical study on alkaline phosphatase of rat cementoblasts
Hara Y., Abe Y., Ukai T., Kaneko T., Kato I.
Dentistry in Japan   34, 105-107    1998
Effects of T cell adoptive transfer into nude mice on alveolar bone resorption induced by endotoxin
Ukai T., Hara Y., Kato I.
J. Periodont. Res.   31(6) 414-422   1996

Conference Activities & Talks

Involvement of receptor activator of NF-kB ligand and vascular endothelial growth factor on bone destruction in response to traumatic occlusal force
UKAI Takashi
Nagasaki University-Seoul national University Joint Symposium   2009   

Research Grants & Projects

study on occlusal trauma
Study on osteoclast formation
Nuclear and Atomic Science Research