藤田禎三 (Teizo Fujita) - マイポータル

基本情報

学位: 医学博士(北海道大学)

J-GLOBAL ID: 200901077468396166
researchmap会員ID: 1000227091

研究分野

経歴

福島県立医科大学医学部医学科医学部医学科免疫学講座, 教授

学歴

- 1970年

北海道大学, 医学部, 医学科
- 1970年

北海道大学

委員歴

受賞

MISC

Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin

Wei-Chuan Chang, Kevan L. Hartshorn, Mitchell R. White, Patience Moyo, Ian C. Michelow, Henry Koziel, Bernard T. Kinane, Emmett V. Schmidt, Teizo Fujita, Kazue Takahashi

BIOCHEMICAL PHARMACOLOGY 81(3) 388-395 2011年2月
Essential Role of Complement Mannose-Binding Lectin-Associated Serine Proteases-1/3 in the Murine Collagen Antibody-Induced Model of Inflammatory Arthritis

Nirmal K. Banda, Minoru Takahashi, Brandt Levitt, Magdalena Glogowska, Jessica Nicholas, Kazue Takahashi, Gregory L. Stahl, Teizo Fujita, William P. Arend, V. Michael Holers

JOURNAL OF IMMUNOLOGY 185(9) 5598-5606 2010年11月
Complement drives Th17 cell differentiation and triggers autoimmune arthritis

Motomu Hashimoto, Keiji Hirota, Hiroyuki Yoshitomi, Shinji Maeda, Shin Teradaira, Shuji Akizuki, Paz Prieto-Martin, Takashi Nomura, Noriko Sakaguchi, Joerg Koehl …

JOURNAL OF EXPERIMENTAL MEDICINE 207(6) 1135-1143 2010年6月
IgG subclasses and complement pathway in segmental and global membranous nephropathy

Yoshie Segawa, Satoshi Hisano, Misao Matsushita, Teizo Fujita, Shinichi Hirose, Morishige Takeshita, Hiroshi Iwasaki

PEDIATRIC NEPHROLOGY 25(6) 1091-1099 2010年6月
Mannose-binding lectin and its associated proteases (MASPs) Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravasc・・・

Takahashi K, Chang WC, Takahashi M, Pavlov V, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL, Van Cott EM

Immunobiology. 2010年
Mannose-binding lectin and its associated proteases (MASPs) Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravasc・・・

Takahashi K, Chang WC, Takahashi M, Pavlov V, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL, Van Cott EM

Immunobiology. 2010年
Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

Minoru Takahashi, Yumi Ishida, Daisuke Iwaki, Kazuko Kanno, Toshiyuki Suzuki, Yuichi Endo, Yoshimi Homma, Teizo Fujita

JOURNAL OF EXPERIMENTAL MEDICINE 207(1) 29-37 2010年1月
Interactions of Ficolin and Mannose-Binding Lectin with Fibrinogen/Fibrin Augment the Lectin Complement Pathway

Yuichi Endo, Naomi Nakazawa, Daisuke Iwaki, Minoru Takahashi, Misao Matsushita, Teizo Fujita

JOURNAL OF INNATE IMMUNITY 2(1) 33-42 2010年
Enhanced humoral immune responses against T-independent antigens in Fc alpha/mu R-deficient mice

Shin-ichiro Honda, Naoki Kurita, Akitomo Miyamoto, Yukiko Cho, Kenta Usui, Kie Takeshita, Satoru Takahashi, Teruhito Yasui, Hitoshi Kikutani, Taroh Kinoshita …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106(27) 11230-11235 2009年7月
Unique Phenotypes of C1s Deficiency and Abnormality Caused by Two Compound Heterozygosities in a Japanese Family

Katsuaki Abe, Yuichi Endo, Naomi Nakazawa, Kazuko Kanno, Mitsuo Okubo, Tadashi Hoshino, Teizo Fujita

JOURNAL OF IMMUNOLOGY 182(3) 1681-1688 2009年2月
Factor C Acts as a Lipopolysaccharide-Responsive C3 Convertase in Horseshoe Crab Complement Activation

Shigeru Ariki, Shusaku Takahara, Toshio Shibata, Takaaki Fukuoka, Aya Ozaki, Yuichi Endo, Teizo Fujita, Takumi Koshiba, Shun-ichiro Kawabata

JOURNAL OF IMMUNOLOGY 181(11) 7994-8001 2008年12月
Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway

Minoru Takahashi, Daisuke Iwaki, Kazuko Kanno, Yumi Ishida, Jie Xiong, Misao Matsushita, Yuichi Endo, Shigeto Miura, Naoto Ishii, Kazuo Sugamura …

JOURNAL OF IMMUNOLOGY 180(9) 6132-6138 2008年5月
マンノース結合レクチン（MBL)とフィコリン（ficolin)の構造と機能

遠藤雄一, 松下操, 藤田禎三

臨床検査 52(8) 841-850 2008年
パターン認識分子としてのフィコリン

遠藤雄一, 藤田禎三

日本細菌学雑誌 63(2) 399-405 2008年
Plasma UGRP1 levels associate with promoter G-112A polymorphism and the severity of asthma

Keiichi Inoue, Xintao Wang, Junpei Saito, Yoshinori Tanino, Takashi Ishida, Daisuke Iwaki, Teizo Fujita, Shioko Kimura, Mitsuru Munakata

Allergology International 57(1) 57-64 2008年
L-Ficolin/Mannose-Binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway

Youko Aoyagi, Elisabeth E. Adderson, Craig E. Rubens, John F. Bohnsack, Jin G. Min, Misao Matsushita, Teizo Fujita, Yoshiyuki Okuwaki, Shinji Takahashi

INFECTION AND IMMUNITY 76(1) 179-188 2008年1月
Stat3 is involved in control of MASP2 gene expression

Claudia Unterberger, Steven Hanson, Andreas Klingenhoff, Daniela Oesterle, Marion Frankenberger, Yuichi Endo, Misao Matsushita, Teizo Fujita, Wilhelm Schwaeble, Elisabeth H. Weiss …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 364(4) 1022-1025 2007年12月
Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch

Virginie Garlatti, Lydie Martin, Evelyne Gout, Jean-Baptiste Reiser, Teizo Fujita, Gerard J. Arlaud, Nicole M. Thielens, Christine Gaboriaud

JOURNAL OF BIOLOGICAL CHEMISTRY 282(49) 35814-35820 2007年12月
Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis

Satoshi Hisano, Misao Matsushita, Teizo Fujita, Morishige Takeshita, Hiroshi Iwasaki

PATHOLOGY INTERNATIONAL 57(6) 351-357 2007年6月
Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway.

TAKAHASHI,Minoru, MORI,Shuichi, SHIGETA,Shiro, FUJITA,Teizo

Advances in Experimental Medicine and Biology. 598 93-104 2007年

もっとみる

書籍等出版物

JAPAN MEDICAL EDUCATION FOUNDATION

財団法人医学教育振興財団 2010年
生体防御医学事典

朝倉書店 2007年

講演・口頭発表等

Abnormalities of fat metabolism in MBL-associated serine protease-1/3-deficient mouse

第14回国際免疫学会 2010年
Establishment of three lineages of ficolin-deficient mice and their phenotypes

第14回国際免疫学会 2010年
IRF4-deficient lupus-prone MRL/lpr mice lack serum immunoglobulin and glomerular immune complex/C3 deposits but develop diffuse proliferative glomerulonephritis and dermatitis/ear necrosis

第14回国際免疫学会 2010年
MBL/MASP-1 complexes efficiently cleave a zymogen of complement factor D

XXIII International Complement Workshop 2010年
Abnormalities of fat metabolism in MBL-associated serine protease-1/3-deficient mouse

14th International Congress of Immunology 2010年
Establishment of three lineages of ficolin-deficient mice and their phenotypes

14th International Congress of Immunology 2010年
IRF4-deficient lupus-prone MRL/lpr mice lack serum immunoglobulin and glomerular immune complex/C3 deposits but develop diffuse proliferative glomerulonephritis and dermatitis/ear necrosis

14th Internatinal Congress of Immunology 2010年
MBL/MASP-1 complexes efficiently cleave a zymogen of complement factor D

XXIII International Complement Workshop 2010年
補体系におけるレクチン経路の役割とその活性化機構

第82回日本生化学会大会 2009年
レクチンを介した病原体認識と補体活性化

動物と植物の免疫系：その共通性と多様性 2009年
Contributions of MASP-1 and MASP-3 to fat metabolism by activation of complement factor D.

12th European Meeting on Complement in Human Disease 2009年
Collaboration of the lectin complement pathway with the coagulation system.

11th Congress of the International Society of Developmental and Comparative Immunology 2009年
Role of the lectin pathway in activation of the complement system.

2009年
Contributions of MASP-1 and MASP-3 to fat metabolism by activation of complement factor D.

12th European Meeting on Complement in Human Disease 2009年
Collaboration of the lectin complement pathway with the coagulation system.

11th Congress of the International Society of Developmental and Comparative Immunology 2009年
Mannose-binding lectin-associated serine protease 3 (MASP-3)の機能解析

第31回日本分子生物学会 2008年
A novel role of MASP-1to activate the alternative complement pathway.

第38回日本免疫学会 2008年
Lectin pathway is coming.

Frontiers in the Molecular Mechanisms of the Complement System, Parasite Immunology & Vaccine Development 2008年
Activation of mannose binding lectin-associated serine protease3.

XXⅡth International Complement Workshop 2008年
MASP1/3 knockout mouse lacks the alternative pathway activation due to deficiency of factor D activation.

XXⅡth International Complement Workshop 2008年

もっとみる

所属学協会

Works(作品等)

生体防御におけるたんぱく質間相互作用と機能発現機構の解析

2003年10月 - 2009年3月

共同研究・競争的資金等の研究課題

補体レクチン経路の研究

ＪＳＴ戦略的創造研究推進制度（研究チーム型）（戦略的基礎研究推進事業：ＣＲＥＳＴ）
補体レクチン経路の起源
The lectin complement pathway

JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST)
The origin of the lectin complement pathway