論文

査読有り
2016年11月

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

ELIFE
  • Mariko Yokouchi
  • ,
  • Toru Atsugi
  • ,
  • Mark van Logtestijn
  • ,
  • Reiko J. Tanaka
  • ,
  • Mayumi Kajimura
  • ,
  • Makoto Suematsu
  • ,
  • Mikio Furuse
  • ,
  • Masayuki Amagai
  • ,
  • Akiharu Kubo

5
開始ページ
e19593
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.7554/elife.19593
出版者・発行元
ELIFE SCIENCES PUBLICATIONS LTD

In multicellular organisms, cells adopt various shapes, from flattened sheets of endothelium to dendritic neurons, that allow the cells to function effectively. Here, we elucidated the unique shape of cells in the cornified stratified epithelia of the mammalian epidermis that allows them to achieve homeostasis of the tight junction (TJ) barrier. Using intimate in vivo 3D imaging, we found that the basic shape of TJ-bearing cells is a flattened Kelvin's tetrakaidecahedron (f-TKD), an optimal shape for filling space. In vivo live imaging further elucidated the dynamic replacement of TJs on the edges of f-TKD cells that enables the TJ-bearing cells to translocate across the TJ barrier. We propose a spatiotemporal orchestration model of f-TKD cell turnover, where in the classic context of 'form follows function', cell shape provides a fundamental basis for the barrier homeostasis and physical strength of cornified stratified epithelia.

Web of Science ® 被引用回数 : 46

リンク情報
DOI
https://doi.org/10.7554/elife.19593
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000389311000001&DestApp=WOS_CPL
ID情報
  • DOI : 10.7554/elife.19593
  • ISSN : 2050-084X
  • Web of Science ID : WOS:000389311000001

エクスポート
BibTeX RIS