Takao Yamori - My portal

Profile Information

Affiliation: Member & Chief, Cancer Chemotherapy Center, of Molecular Pharmacology, Japanese Foundation for Cancer Research
: (Concurrent)客員研究員

Degree: (BLANK)
(BLANK)

J-GLOBAL ID: 200901001177717880
researchmap Member ID: 1000281776

External link: http://www.pmda.go.jp/

Research Interests

Research Areas

Committee Memberships

2008 - Present

評議員, 日本がん分子標的治療学会
2005 - Present

評議員, ＤＤＳ学会
2003 - Present

学術委員, 日本がん臨床試験推進機構
1996 - Present

評議員および機関誌Cancer Science のAssociate Editor, 日本癌学会
1992 - Present

評議員, がん転移学会
1992 - Present

代議員・関東支部幹事, 日本薬学会
2012 - Mar, 2015

研究開発専門委員会委員, （独）日本学術振興会

Awards

2008

財団法人癌研究会学術賞

矢守隆夫
1993

日本癌学会奨励賞

Misc.

269

Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model

Yusuke Matsumoto, Hironori Tsujimoto, Satoshi Ono, Nariyoshi Shinomiya, Hiromi Miyazaki, Shuichi Hiraki, Risa Takahata, Kazumichi Yoshida, Daizoh Saitoh, Takao Yamori …

ANNALS OF SURGICAL ONCOLOGY, 23 257-265, Feb, 2016
Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation

Tetsuo Mashima, Masaru Ushijima, Masaaki Matsuura, Satomi Tsukahara, Kazuhiro Kunimasa, Aki Furuno, Sakae Saito, Masami Kitamura, Taeko Soma-Nagae, Hiroyuki Seimiya …

CANCER SCIENCE, 106(7) 909-920, Jul, 2015
Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca2+ pumps with a unique mode of binding

Maho Morita, Haruo Ogawa, Osamu Ohno, Takao Yamori, Kiyotake Suenaga, Chikashi Toyoshima

FEBS LETTERS, 589(13) 1406-1411, Jun, 2015
Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics

Rie Horii, Masaaki Matsuura, Shingo Dan, Masaru Ushijima, Natsue Uehiro, Akiko Ogiya, Naoko Honma, Yoshinori Ito, Takuji Iwase, Takao Yamori …

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 20(3) 490-498, Jun, 2015
Synthesis of dansyl-labeled probe of thiophene analogue of annonaceous acetogenins for visualization of cell distribution and growth inhibitory activity toward human cancer cell lines

Naoto Kojima, Yuki Suga, Takuya Matsumoto, Tetsuaki Tanaka, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita

BIOORGANIC & MEDICINAL CHEMISTRY, 23(6) 1276-1283, Mar, 2015
Stromal Cells Positively and Negatively Modulate the Growth of Cancer Cells: Stimulation via the PGE2-TNF alpha-IL-6 Pathway and Inhibition via Secreted GAPDH-E-Cadherin Interaction

Manabu Kawada, Hiroyuki Inoue, Shun-ichi Ohba, Junjiro Yoshida, Tohru Masuda, Manabu Yamasaki, Ihomi Usami, Shuichi Sakamoto, Hikaru Abe, Takumi Watanabe …

PLOS ONE, 10(3), Mar, 2015
Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474

Sho Isoyama, Gensei Kajiwara, Naomi Tamaki, Mutsumi Okamura, Hisashi Yoshimi, Naoki Nakamura, Kento Kawamura, Yumiko Nishimura, Nachi Namatame, Takao Yamori …

CANCER SCIENCE, 106(2) 171-178, Feb, 2015
Securing the future of drug discovery for central nervous system disorders

Peter Hongaard Andersen, Richard Moscicki, Barbara Sahakian, Remi Quirion, Ranga Krishnan, Tim Race, Anthony Phillips

NATURE REVIEWS DRUG DISCOVERY, 13(12) 871-872, Dec, 2014
Thiophene-3-carboxamide analogue of annonaceous acetogenins as antitumor drug lead

Naoto Kojima, Tetsuya Fushimi, Takahiro Tatsukawa, Tetsuaki Tanaka, Mutsumi Okamura, Akinobu Akatsuka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 86 684-689, Oct, 2014
A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells

R. Yao, Y. Kondoh, Y. Natsume, H. Yamanaka, M. Inoue, H. Toki, R. Takagi, T. Shimizu, T. Yamori, H. Osada …

ONCOGENE, 33(33) 4242-4252, Aug, 2014
In Vitro Antitumor Activity of Stellettin B, a Triterpene from Marine Sponge Jaspis stellifera, on Human Glioblastoma Cancer SF295 Cells

Sheng-An Tang, Qianxiang Zhou, Wen-Zhi Guo, Yuling Qiu, Ran Wang, Meihua Jin, Wenjing Zhang, Ke Li, Takao Yamori, Shingo Dan …

MARINE DRUGS, 12(7) 4200-4213, Jul, 2014
Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity

Yurie Fukui, Koichi Narita, Singo Dan, Takao Yamori, Akihiro Ito, Minoru Yoshida, Tadashi Katoh

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 76 301-313, Apr, 2014
Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement

Yukitoshi Nagahara, Midori Takeyoshi, Seiya Sakemoto, Isamu Shiina, Kenya Nakata, Keiko Fujimori, Yanwen Wang, Eri Umeda, Chihiro Watanabe, Shoko Uetake …

Biochemical and Biophysical Research Communications, 435(4) 657-663, Jun 14, 2013
Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines

Wen-Zhi Guo, Yanwen Wang, Eri Umeda, Isamu Shiina, Shingo Dan, Takao Yamori

Biological and Pharmaceutical Bulletin, 36(6) 1008-1016, Jun, 2013
Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition.

Ryohei Katayama, Aki Aoyama, Takao Yamori, Jie Qi, Tomoko Oh-hara, Youngchul Song, Jeffrey A Engelman, Naoya Fujita

Cancer research, 73(10) 3087-96, May 15, 2013
Structure-activity relationships of hybrid annonaceous acetogenins: Powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell lines

Naoto Kojima, Tetsuya Fushimi, Takahiro Tatsukawa, Takehiko Yoshimitsu, Tetsuaki Tanaka, Takao Yamori, Shingo Dan, Hiroki Iwasaki, Masayuki Yamashita

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 63 833-839, May, 2013
Development of a gene expression database and related analysis programs for evaluation of anticancer compounds

Masaru Ushijima, Tetsuo Mashima, Akihiro Tomida, Shingo Dan, Sakae Saito, Aki Furuno, Satomi Tsukahara, Hiroyuki Seimiya, Takao Yamori, Masaaki Matsuura

CANCER SCIENCE, 104(3) 360-368, Mar, 2013
Identification of Transporters Associated with Etoposide Sensitivity of Stomach Cancer Cell Lines and Methotrexate Sensitivity of Breast Cancer Cell Lines by Quantitative Targeted Absolute Proteomics

Wataru Obuchi, Sumio Ohtsuki, Yasuo Uchida, Ken Ohmine, Takao Yamori, Tetsuya Terasaki

MOLECULAR PHARMACOLOGY, 83(2) 490-500, Feb, 2013
Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities

Koichi Narita, Yurie Fukui, Yui Sano, Takao Yamori, Akihiro Ito, Minoru Yoshida, Tadashi Katoh

European Journal of Medicinal Chemistry, 60 295-304, Feb, 2013
Total Synthesis of AMF-26, an Antitumor Agent for Inhibition of the Golgi System, Targeting ADP-Ribosylation Factor 1

Isamu Shiina, Yuma Umezaki, Yoshimi Ohashi, Yuta Yamazaki, Shingo Dan, Takao Yamori

JOURNAL OF MEDICINAL CHEMISTRY, 56(1) 150-159, Jan, 2013

Books and Other Publications

がん細胞パネルによる創薬

細胞工学, 2013
特集・制がん剤の分子標的スクリーニング成績化学療法基盤情報支援班報告-制がん候補物質のスクリーニング成績・第14報-

癌と化学療法, 2013
特集・制がん剤の分子標的スクリーニング成績化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報-

癌と化学療法, 2013
産学連携による日本発の医薬品創出へ向けて

臨床医薬, 2013
膜小胞輸送にかかわるADPリボシル化因子1の新規阻害剤AMF-26によるゴルジ装置の破壊と抗がん作用

生体の科学, 2012
PI3K-Akt-mTOR経路とその阻害剤

がん分子標的治療, 2012
アカデミアの立場からの新薬開発支援がん支援・化学療法基盤支援活動の取り組み

腫瘍内科, 2012
JFCR39がん細胞パネルの活用による新たな抗がん剤創薬

実験医学, 2012
PI3K/mTOR経路阻害薬（西尾和人編「がん分子標的薬治療の現状と展望」2541-2547/2750ページ）

東京: ライフ・サイエンス, 2011
プロテインチップを利用した抗がん剤の作用因子解析（小田吉哉・長野光司編「創薬・タンパク質研究のためのプロテオミクス解析-バイオマーカー・標的探索、作用機序解析の研究戦略と実践マニュアル」175-181/227ページ）

東京: 羊土社, 2010
PI3キナーゼを標的とした癌治療－PI3K阻害剤開発の現状（佐々木雄彦・横溝岳彦・竹縄忠臣編「分子から個体へと深化する脂質生物学」164-172/235ページ）

東京: 羊土社, 2010
キナーゼ阻害薬

日本臨牀, 2010
特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第13報-

癌と化学療法, 2010
ヒトがん細胞パネルによる分子標的薬スクリーニング（日本がん分子標的治療学会編「がん分子標的治療研究実践マニュアル」53-58/329ページ）

京都: 金芳堂, 2009
癌領域におけるPI3キナーゼ阻害剤の開発

Medical Science Digest, 2009
分子標的薬の基礎および研究動向（山本重夫編「バイオ医薬の開発技術とシーズ」3-11/384ページ）

東京: シーエムシー出版, 2009
アカデミアの立場からの新薬開発支援（西條長宏・西尾和人編「がん化学療法・分子標的治療 update」138-142/733ページ）

東京: 中外医学社, 2009
PI3K-Akt-mTOR経路

カレントテラピー, 2009
分子標的薬創薬に有用なCancer Cell Informaticsの構築と応用

展望 Promising Vistas in Cancer Research, 2009
総論分子標的薬の動向

細胞 The CELL, 2009

Professional Memberships

Research Projects

がん研究分野の特性等を踏まえた支援活動

科学研究費補助金, 2010 - 2015
薬理活性の評価

科学研究費補助金, 2010 - 2012
Cancer Cell Informaticsによる革新的分子標的薬の創薬研究

科学研究費補助金, 2010 - 2012
生物情報科学的手法による抗がん剤の分子薬理学研究
がん転移の分子機構
新規抗がん剤の探索と評価
Study of Molecular Pharmacology of Anticancer Drugs by a Bioinformatic Approach
Molecular Mechanism of Cancer Metastasis
Discovery and evaluation of New Anticancer drugs