2018年1月1日
Development of a real-time and quantitative thrombus sensor for an extracorporeal centrifugal blood pump by near-infrared light
Biomedical Optics Express
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- 巻
- 9
- 号
- 1
- 開始ページ
- 190
- 終了ページ
- 201
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1364/BOE.9.000190
- 出版者・発行元
- OSA - The Optical Society
We developed an optical thrombus sensor for a monopivot extracorporeal centrifugal blood pump. In this study, we investigated its quantitative performance for thrombus detection in acute animal experiments of left ventricular assist using the pump on pathogen-free pigs. Optical fibers were set in the driver unit of the pump. The incident light at the near-infrared wavelength of 810 nm was aimed at the pivot bearing, and the resulting scattered light was guided to the optical fibers. The detected signal was analyzed to obtain the thrombus formation level. As a result, real-time and quantitative monitoring of the thrombus surface area on the pivot bearing was achieved with an accuracy of 3.6 ± 2.3 mm2. In addition, the sensing method using the near-infrared light was not influenced by changes in the oxygen saturation and the hematocrit. It is expected that the developed sensor will be useful for optimal anticoagulation management for long-term extracorporeal circulation therapies.
- ID情報
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- DOI : 10.1364/BOE.9.000190
- ISSN : 2156-7085
- PubMed ID : 29359096
- SCOPUS ID : 85039755657