論文

国際誌
2017年10月

Optical Dynamic Analysis of Thrombus Inside a Centrifugal Blood Pump During Extracorporeal Mechanical Circulatory Support in a Porcine Model.

Artificial organs
  • Tatsuki Fujiwara
  • ,
  • Daisuke Sakota
  • ,
  • Katsuhiro Ohuchi
  • ,
  • Shu Endo
  • ,
  • Tomoki Tahara
  • ,
  • Tomotaka Murashige
  • ,
  • Ryo Kosaka
  • ,
  • Keiji Oi
  • ,
  • Tomohiro Mizuno
  • ,
  • Osamu Maruyama
  • ,
  • Hirokuni Arai

41
10
開始ページ
893
終了ページ
903
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/aor.12862

Complications due to pump thrombus remain the weak point of mechanical circulatory support (MCS), such as the use of a left ventricular assist device (LVAD) or extracorporeal membrane oxygenation, leading to poor outcomes. Hyperspectral imaging (HSI) is an effective imaging method using a hyperspectral (HS) camera, which comprises a spectrophotometer and a charge-coupled device camera to discriminate thrombus from whole blood. Animal experiments were conducted to analyze dynamic imaging of thrombus inside a prototype of a hydrodynamically levitated centrifugal blood pump using an HSI system. Six pigs were divided into a venous circulation group (n = 3) and an arterial circulation group (n = 3). Inflow and outflow cannulae were inserted into the jugular veins in the venous circulation group. The latter simulated an LVAD application. To create thrombogenic conditions, pump flow was maintained at 1 L/min without anticoagulation. An image of the bottom surface of the pump was captured by the HS camera every 4 nm over the wavelength range of 608-752 nm. Real-time dynamic images of the inside of the pump were displayed on the monitor. Appearance of an area displaying thrombus was detected within 24 h after the start of the circulation in every experiment. This imaging system also succeeded in determining the origins of pump thrombus: from inside the pump in two cases, and from outside in four cases. Two main possible sources of pump thrombus originating outside the pump were identified on autopsy: wedge thrombus around the inflow cannula; and string-like thrombus at the junction between the pump inlet and circuit tube. The results of this study from close observation of the changing appearance of pump thrombus may contribute to improvements in the safety of extracorporeal MCS.

リンク情報
DOI
https://doi.org/10.1111/aor.12862
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28321882
ID情報
  • DOI : 10.1111/aor.12862
  • ISSN : 1525-1594
  • PubMed ID : 28321882

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