論文

査読有り
2015年1月

Positive feedback of NR2B-containing NMDA receptor activity is the initial step toward visual imprinting: a model for juvenile learning

JOURNAL OF NEUROCHEMISTRY
  • Tomoharu Nakamori
  • ,
  • Katsushige Sato
  • ,
  • Masae Kinoshita
  • ,
  • Tomoyuki Kanamatsu
  • ,
  • Hiroyuki Sakagami
  • ,
  • Kohichi Tanaka
  • ,
  • Hiroko Ohki-Hamazaki

132
1
開始ページ
110
終了ページ
123
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/jnc.12954
出版者・発行元
WILEY-BLACKWELL

Imprinting in chicks is a good model for elucidating the processes underlying neural plasticity changes during juvenile learning. We recently reported that neural activation of a telencephalic region, the core region of the hyperpallium densocellulare (HDCo), was critical for success of visual imprinting, and that N-Methyl-D-aspartic (NMDA) receptors containing the NR2B subunit (NR2B/NR1) in this region were essential for imprinting. Using electrophysiological and multiple-site optical imaging techniques with acute brain slices, we found that long-term potentiation (LTP) and enhancement of NR2B/NR1 currents in HDCo neurons were induced in imprinted chicks. Enhancement of NR2B/NR1 currents as well as an increase in surface NR2B expression occurred even following a brief training that was too weak to induce LTP or imprinting behavior. This means that NR2B/NR1 activation is the initial step of learning, well before the activation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors which induces LTP. We also showed that knockdown of NR2B/NR1 inhibited imprinting, and inversely, increasing the surface NR2B expression by treatment with a casein kinase 2 inhibitor successfully reduced training time required for imprinting. These results suggest that imprinting stimuli activate post-synaptic NR2B/NR1 in HDCo cells, increase NR2B/NR1 signaling through up-regulation of its expression, and induce LTP and memory acquisition.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1111/jnc.12954
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25270582
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000346492300011&DestApp=WOS_CPL

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