論文

査読有り
2017年2月

Regulation of visual Wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells

SCIENTIFIC REPORTS
  • Tomoharu Nakamori
  • ,
  • Tomomi Kato
  • ,
  • Hiroyuki Sakagami
  • ,
  • Kohichi Tanaka
  • ,
  • Hiroko Ohki-Hamazaki

7
開始ページ
42927
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep42927
出版者・発行元
NATURE PUBLISHING GROUP

Imprinting behaviour in chicks can be induced exclusively during a short period after hatching. During this period, visual information on the imprinting stimulus is conveyed to the visual Wulst (VW) in the telencephalon, which corresponds to the visual cortex of mammals, and then to the memory-storing region known as the intermediate medial mesopallium. These two regions are indispensable for imprinting. We previously showed that imprinting training altered the response pattern of the VW to the imprinting stimulus; however, the precise distribution of cells and the mechanism involved with this altered response remains unclear. Here we showed that a specific population of rostral VW cells responded to the imprinting stimulus by analysing the subcellular localization of Arc/arg3.1 transcripts in VW cells. GABAergic parvalbumin (PV) cells are abundant in the dorsal region of this area, and imprinting training doubled the number of activated PV-positive neurons. An injection of bicuculline, a GABA(A) receptor antagonist, in the dorsal VW disturbed the rostral distribution of responsive cells and thus resulted in a lack of imprinting. These results suggest that activated PV cells restrict VW cells response to dorsal area to form a specific imprinting pathway.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1038/srep42927
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28230107
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000394765400001&DestApp=WOS_CPL

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