SHIUCHI, Tetsuya

J-GLOBAL         Last updated: Nov 21, 2018 at 12:42
SHIUCHI, Tetsuya
The University of Tokushima Graduate School
Department of Integrative Physiology, Institute for Health Biosciences
Job title
Associate Professor (Lecturer)
Master (science)(The University of Tokushima), Doctor (medicine)(Ehime University)
Research funding number

Research Areas


Academic & Professional Experience

Oct 2015
Associate Professor, Department of Integrative Physiology, Institute of Biomedical Science, Tokushima University Graduate School
Apr 2015
Sep 2015
Lecturer, Institute of Biomedical Science, Tokushima University Graduate School
Nov 2010
Mar 2015
Lecturer, The University of Tokushima Graduate School, Institute of Health Bioscience
Apr 2007
Oct 2010
National Institute for Physiological Sciences
Apr 2004
Assistant Professor, National Institute for Physiological Sciences


Graduate School, Division of Medical Sciences, Ehime University
The University of Tokushima
Faculty of General Science, The University of Tokushima

Awards & Honors

Best teacher of the year 2017, Faculty of Medicine, Tokushima University
Winner: Tetsuya Shiuchi
大塚スポーツ医科学賞・奨励賞, The Japanese Society of Physical Fitness and Sports Medecine
Winner: 宮武 由美子, Tetsuya Shiuchi
Best teacher of the year 2013, 徳島大学医学部
Winner: Tetsuya Shiuchi
論文賞, ネスレ栄養科学会議
Winner: Tetsuya Shiuchi
若手研究者奨励賞, The Japanese Society of Physical Fitness and Sports Medecine
Winner: Tetsuya Shiuchi
大塚スポーツ医科学賞・奨励賞, The Japanese Society of Physical Fitness and Sports Medecine
Winner: Tetsuya Shiuchi

Published Papers

Sachiko Chikahisa, Daiki Chida, Tetsuya Shiuchi, Saki Harada, Noriyuki Shimizu, Airi Otsuka, Daisuke Tanioka, Hiroyoshi Sei
Behavioural Brain Research      Sep 2018   [Refereed]
Peroxisome proliferator-activated receptor alpha (PPAR) is a member of the nuclear receptor superfamily and regulates fatty acid oxidation. Although PPAR is expressed not only in the peripheral tissues but also in the brain, its role in higher bra...
Shiuchi T, Toda C, Okamoto S, Coutinho EA, Saito K, Miura S, Ezaki O, Minokoshi Y
Scientific reports   7(1) 15141   Nov 2017   [Refereed]
Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y
Cell reports   22(3) 706-721   Jan 2018   [Refereed]
Chikahisa S, Harada S, Shimizu N, Shiuchi T, Otsuka A, Nishino S, Séi H
Scientific reports   7(1) 13640   Oct 2017   [Refereed]
We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week ...
Miyatake Y, Shiuchi T, Mawatari K, Toda S, Taniguchi Y, Futami A, Sato F, Kuroda M, Sebe M, Tsutsumi R, Harada N, Minokoshi Y, Kitamura T, Gotoh K, Ueno M, Nakaya Y, Sakaue H
Peptides   87 12-19   Jan 2017   [Refereed]
There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our labo...
Oura K, Otsuka A, Shiuchi T, Chikahisa S, Shimizu N, Séi H
Life sciences   160 18-26   Sep 2016   [Refereed]
Sleep and feeding behaviors closely interact to maintain energy homeostasis. While it is known that sleep disorders can lead to various metabolic issues such as insulin resistance, the mechanism for this effect is poorly understood. We thus invest...
Otsuka A, Shiuchi T, Chikahisa S, Shimizu N, Séi H
Physiology & behavior   151 264-271   Nov 2015   [Refereed]
It is well-established that exercise can influence psychological conditions, cognitive function, and energy metabolism in peripheral tissues including the skeletal muscle. However, it is not clear whether exercise can influence social interaction ...
Tang L, Okamoto S, Shiuchi T, Toda C, Takagi K, Sato T, Saito K, Yokota S, Minokoshi Y
Endocrinology   156(10) 3680-3694   Oct 2015   [Refereed]
Adipose tissue macrophages (ATMs) play an important role in the inflammatory response in obese animals. How ATMs are regulated in lean animals has remained elusive, however. We now show that the sympathetic nervous system (SNS) is necessary to mai...
Miyatake Y, Shiuchi T, Ueta T, Taniguchi Y, Futami A, Sato F, Kitamura T, Tsutsumi R, Harada N, Nakaya Y, Sakaue H
The journal of medical investigation : JMI   62(3-4) 199-203   2015   [Refereed]
Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavi...
Chikahisa S, Shimizu N, Shiuchi T, Séi H
Neuropharmacology   79 399-404   Apr 2014   [Refereed]
A link has been established between energy metabolism and sleep homeostasis. The ketone bodies acetoacetate and -hydroxybutyrate, generated from the breakdown of fatty acids, are major metabolic fuels for the brain under conditions of low glucose ...
Chitoku Toda, Tetsuya Shiuchi, Hiroaki Kageyama, Shiki Okamoto, Eulalia A. Coutinho, Tatsuya Sato, Yuko Okamatsu-Ogura, Shigefumi Yokota, Kazuyo Takagi, Lijun Tang, Kumiko Saito, Seiji Shioda, Yasuhiko Minokoshi
Diabetes   Vol.62(No.7) 2295-2307   Jul 2013   [Refereed]
Leptin is a key regulator of glucose metabolism in mammals, but the mechanisms of its action have remained elusive. We now show that signaling by extracellular signal-regulated kinase (ERK) and its upstream kinase MEK in the ventromedial hypothala...
Shimizu N, Chikahisa S, Nishi Y, Harada S, Iwaki Y, Fujihara H, Kitaoka K, Shiuchi T, Séi H
PloS one   8(5) e64263-e64263   May 2013   [Refereed]
Nutritional state in the gestation period influences fetal growth and development. We hypothesized that undernutrition during gestation would affect offspring sleep architecture and/or homeostasis. Pregnant female mice were assigned to either cont...
Rodriguez-Araujo G, Nakagami H, Hayashi H, Mori M, Shiuchi T, Minokoshi Y, Nakaoka Y, Takami Y, Komuro I, Morishita R, Kaneda Y
Cellular and molecular life sciences : CMLS   70(6) 1123-1133   Mar 2013   [Refereed]
Eiko Matsuo, Ayako Mochizuki, Kiyomi Nakayama, Shiro Nakamura, Takashi Yamamoto, Seiji Shioda, Takeshi Sakurai, Masashi Yanagisawa, Tetsuya Shiuchi, Yasuhiko Minokoshi, Tomio Inoue
Journal of Molecular Neuroscience : MN   Vol.43(No.2) 217-224   Feb 2011   [Refereed]
Orexins are synthesized by lateral hypothalamic neurons and are suggested to be implicated in feeding behavior. Recent studies have shown that intracerebroventricular administration of orexin-A increases intake of sweet-tasting solution. Effects o...
Nobuya Ogawa, Makoto Ito, Hideki Yamaguchi, Tetsuya Shiuchi, Shiki Okamoto, Korekiyo Wakitani, Yasuhiko Minokoshi, Masamitsu Nakazato
Metabolism: Clinical and Experimental   61(9) 1312-1320   Mar 2012   [Refereed]
The intestine plays important roles in the regulation of feeding behavior by sensing macronutrients. Intestinal fatty acids strongly suppress food intake, but little is known about whether intestinal fatty acids affect food preference. We investig...
Kumiko Saito, Suni Lee, Tetsuya Shiuchi, Chitoku Toda, Masahiro Kamijo, Kyoko Inagaki-Ohara, Shiki Okamoto, Yasuhiko Minokoshi
Analytical Biochemistry: Methods in the Biological Sciences   Vol.412(No.1) 9-17   Jan 2011   [Refereed]
An enzymatic assay adapted to photometric analysis with 96-well microplates was evaluated for the measurement of 2-deoxyglucose (2DG) uptake in insulin-responsive tissues and differentiated 3T3-L1 adipocytes. For in vivo measurements, a small amou...
Kunitoshi Uchida, Katsuya Dezaki, Boldbaatar Damdindorj, Hitoshi Inada, Tetsuya Shiuchi, Yasuo Mori, Toshihiko Yada, Yasuhiko Minokoshi, Makoto Tominaga
Diabetes   Vol.60(No.1) 119-126   Jan 2011   [Refereed]
OBJECTIVE TRPM2 is a Ca(2+)-permeable nonselective cation channel activated by adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by coapplication of heat and intracellular cyclic adenosine 5'-diphosphoribose, which h...
Tsutomu Sasaki, Hye-Jin Kim, Masaki Kobayashi, Yukari-Ido Kitamura, Hiromi Yokota-Hashimoto, Tetsuya Shiuchi, Yasuhiko Minokoshi, Tadahiro Kitamura
Endocrinology   Vol.151(No.6) 2556-2566   Apr 2010   [Refereed]
Silent information regulator (SIR)2 is an nicotinamide adenine dinucleotide dependent deacetylase implicated in the regulation of life span in species as diverse as yeast, worms, and flies. Mammalian Sirt1 is the most closely related homolog of th...
Kunitoshi Uchida, Tetsuya Shiuchi, Hitoshi Inada, Yasuhiko Minokoshi, Makoto Tominaga
Pfl?gers Archiv : European Journal of Physiology   Vol.459(No.5) 765-774   Feb 2010   [Refereed]
Homeothermic animals, including humans, live by adapting to changes in ambient temperature. Numerous studies have demonstrated cold exposure (at approximately 5 degrees C) improves glucose tolerance despite reducing insulin secretion and increasin...
Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.
Cell Metab   10(6) 466-480   Dec 2009   [Refereed]
Hypothalamic neurons containing orexin (hypocretin) are activated during motivated behaviors and active waking. We show that injection of orexin-A into the ventromedial hypothalamus (VMH) of mice or rats increased glucose uptake and promoted insul...


Otsuka A, Shiuchi T
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan   138(10) 1297-1304   2018   [Refereed]
Tetsuya Shiuchi
PharmaMedica   Vol.34(No.5) 27-31   May 2016   [Invited]
宮武 由美子, Tetsuya Shiuchi, 東 千尋, 阪上 浩
内分泌・糖尿病・代謝内科   Vol.41(No.1) 31-35   Jul 2015
Tetsuya Shiuchi
内分泌・糖尿病・代謝内科   Vol.41(No.1) 43-49   Jul 2015   [Invited]
Tetsuya Shiuchi
Journal of Health, Physical Education and Recreation   Vol.64(No.5) 331-338   May 2014
Tetsuya Shiuchi
Vascular Biology & Medicine   Vol.14(No.1) 45-52   Mar 2013
Shiuchi T
Nihon rinsho. Japanese journal of clinical medicine   70 Suppl 3 69-73   May 2012   [Refereed]
Tetsuya Shiuchi, 箕越 靖彦
Annual Review 糖尿病・代謝・内分泌 2011   Vol.2011 4-11   2011
Tetsuya Shiuchi, 箕越 靖彦
糖尿病学2010   22-30   2010
Tetsuya Shiuchi, 箕越 靖彦
Journal of Health, Physical Education and Recreation   Vol.59(No.7) 457-464   Jul 2009
Tetsuya Shiuchi, 堀内 正嗣
腎臓ナビゲーター   66-67   2004
Tetsuya Shiuchi, 堀内 正嗣
Q&Aでわかる肥満と糖尿病   Vol.3(No.1) 130-131   2004
Tetsuya Shiuchi, 堀内 正嗣
New Horizon for Medicine   Vol.35(No.9) 2147-2152   Sep 2003
Tetsuya Shiuchi, 中神 啓徳, 堀内 正嗣
血管内科   115-124   2001
Tetsuya Shiuchi, 堀内 正嗣
糖尿病性腎症のすべて   80-86   2001

Conference Activities & Talks

中枢性代謝調節機構におけるβアドレナリン受容体の役割 [Invited]
Tetsuya Shiuchi
第2回NIPS-ARIHHP共同ワークショップ   Aug 2018   
Paternal psychological stress just before mating influences a formation of emotional behavior in next generation offspring mice
Noriyuki Shimizu, Sachiko Chikahisa, Tetsuya Shiuchi, Airi Otsuka, Daisuke Tanioka, Hiroyoshi Sei
The 41st Annual Meeting of the Japan Neuroscience Society   27 Jul 2018   
Airi Otuska, Tetsuya Shiuchi, Hiroyoshi Sei
第41回日本神経科学学会大会   26 Jul 2018   
Takuya Masuda, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei
第41回日本神経科学学会大会   26 Jul 2018   
Social behavior is affected by mast cells activity in mice
Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Hiroyoshi Sei
The 41st Annual Meeting of the Japan Neuroscience Society   26 Jul 2018   
視床下部Agouti-related protein (AgRP)産生神経が絶食や再摂餌による睡眠調節に果たす役割
Noriyuki Shimizu, Tetsuya Shiuchi, Sachiko Chikahisa, Airi Otsuka, Hiroyoshi Sei
日本睡眠学会第43回定期学術集会   12 Jul 2018   
Daisuke Tanioka, Michio Ohue, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Hiroyoshi Sei
The 43rd Annual Meeting of Japanese Society of Sleep Research   12 Jul 2018   
大塚 愛理, Tetsuya Shiuchi
第72回日本栄養食糧学会大会   May 2018   
Paternal psychological stress causes an impairment of emotional behavior in offspring mice
Noriyuki Shimizu, Sachiko Chikahisa, Tetsuya Shiuchi, Daisuke Tanioka, Airi Otsuka, Hiroyoshi Sei
The 95th Annual Meeting of the Physiological Society of Japan   29 Mar 2018   
The role of brain mast cells in mood and behavior
Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Hiroyoshi Sei
The 95th Annual Meeting of the Physiological Society of Japan   28 Mar 2018   
Noriyuki Shimizu, Sachiko Chikahisa, Tetsuya Shiuchi, Daisuke Tanioka, Airi Otsuka, Hiroyoshi Sei
第13回環境生理学プレコングレス   27 Mar 2018   
大塚 愛理, Tetsuya Shiuchi, Sachiko Chikahisa, Hiroyoshi Sei
第95回日本生理学会大会   Mar 2018   
Tetsuya Shiuchi, 大塚 愛理, Sachiko Chikahisa, Hiroyoshi Sei
第32回日本糖尿病・肥満動物学会   Feb 2018   
Tetsuya Shiuchi, 大塚 愛理, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei
2017年度生命科学系学会合同年次大会(ConBio2017)   Dec 2017   
Daisuke Tanioka, Sachiko Chikahisa, Saki Harada, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Hiroyoshi Sei
The 69th Annual Meeting of the PSJ Chugoku-Shikoku Division   28 Oct 2017   
Tetsuya Shiuchi
第38回日本肥満学会   Oct 2017   
視床下部を介したエネルギー調節機構と摂食リズムの連関 [Invited]
Tetsuya Shiuchi
Scientific Exchange Meeting in KOBE   Oct 2017   
末梢シグナル分子を介した運動モチベーション活性化への挑戦 [Invited]
Tetsuya Shiuchi
生理研研究会   Sep 2017   
末梢―中枢連関を利用した運動モチベーションの制御 [Invited]
Tetsuya Shiuchi
第72回日本体力医学会大会   Sep 2017   
宮武 由美子, Tetsuya Shiuchi
第1回スポーツニューロサイエンス研究会   Sep 2017   

Research Grants & Projects

Grants-in-Aid for Scientific Research
Project Year: Apr 2018 - Mar 2022    Investigator(s): 志内 哲也
Grants-in-Aid for Scientific Research
Project Year: Jun 2018 - Mar 2021    Investigator(s): 志内 哲也
Grants-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2018    Investigator(s): 志内 哲也
Japan Science and Technology Agency: PRESTO(Precursory Research for Embryonic Science and Technology)
Project Year: Oct 2013 - Mar 2017    Investigator(s): SHIUCHI, Tetsuya
Grants-in-Aid for Scientific Research
Project Year: Apr 2014 - Mar 2016    Investigator(s): SHIUCHI Tetsuya