2015年10月
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
CELL
- 巻
- 163
- 号
- 2
- 開始ページ
- 367
- 終了ページ
- 380
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.cell.2015.08.058
- 出版者・発行元
- CELL PRESS
Intestinal Th17 cells are induced and accumulate in response to colonization with a subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain extracellular pathogens. Here, we show that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction. Upon monocolonization of germ-free mice or rats with SFB indigenous to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specific adhesion to small intestinal ECs, accompanied by host-specific induction of Th17 cells. Citrobacter rodentium and Escherichia coli O157 triggered similar Th17 responses, whereas adhesion-defective mutants of these microbes failed to do so. Moreover, a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, also exhibited EC-adhesive characteristics.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.cell.2015.08.058
- ISSN : 0092-8674
- eISSN : 1097-4172
- PubMed ID : 26411289
- Web of Science ID : WOS:000362952700014