KIMURA Motoko

J-GLOBAL         Last updated: Aug 9, 2019 at 14:55
 
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Name
KIMURA Motoko
Affiliation
Chiba University
Job title
Chiba University
Research funding number
00345018

Research Areas

 
 

Academic & Professional Experience

 
Jan 2014
 - 
Dec 2015
Chiba University
 
Apr 2011
 - 
Dec 2013
National Cancer Institue/ NIH
 

Published Papers

 
Tumes D, Hirahara K, Papadopoulos M, Shinoda K, Onodera A, Kumagai J, Yip KH, Pant H, Kokubo K, Masahiro K, Aoki A, Obata-Ninomiya K, Tokoyoda K, Endo Y, Kimura MY, Nakayama T
The Journal of allergy and clinical immunology      Mar 2019   [Refereed]
Pobezinskaya, E.L., Wells, A.C., Angelou, C.C., Fagerberg, E., Aral, E., Iverson, E., Kimura, M.Y. and Pobezinsky, L.A.
Front. Immunol.   3(10) 955-955   May 2019   [Refereed]
Kimura MY, Igi A, Hayashizaki K, Mita Y, Shinzawa M, Kadakia T, Endo Y, Ogawa S, Yagi R, Motohashi S, Singer A, Nakayama T
Nature communications   9(1) 3749   Sep 2018   [Refereed]
Pobezinsky LA, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry TM, Kimura MY, Sharrow SO, Guinter TI, Feigenbaum L, Singer A
Nature immunology   16(5) 517-524   May 2015   [Refereed]
Kimura MY, Thomas J, Tai X, Guinter TI, Shinzawa M, Etzensperger R, Li Z, Love P, Nakayama T, Singer A
Nature immunology   17(12) 1415-1423   Dec 2016   [Refereed]
Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura MY, Tumes DJ, Motohashi S, Matsumoto M, Nakayama KI, Tanaka T, Nakayama T
The Journal of biological chemistry   290(21) 13095-13103   May 2015   [Refereed]
Hayashizaki K, Kimura MY, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, Nakayama T
Science immunology   1(3) eaaf9154   Sep 2016   [Refereed]
Mita Y, Kimura MY, Hayashizaki K, Koyama-Nasu R, Ito T, Motohashi S, Okamoto Y, Nakayama T
International immunology   30(12) 559-567   Aug 2018   [Refereed]
(*Corresponding author, Awarded the “Outstanding Merit Award 2018” by the Editor-in-Chief and Editorial Board of International Immunology. )
Luckey MA, Kimura MY, Waickman AT, Feigenbaum L, Singer A, Park JH
Nature immunology   15(7) 638-645   Jul 2014   [Refereed]
Namekawa M, Ishida K, Kimura M, Fujii C, Yamashita S
Journal of cardiothoracic and vascular anesthesia      Dec 2017   [Refereed]
Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A
Cell   154(6) 1326-1341   Sep 2013   [Refereed]
Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A
Immunity   38(6) 1116-1128   Jun 2013   [Refereed]
Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A
Nature immunology   14(2) 143-151   Feb 2013   [Refereed]
Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A
The EMBO journal   31(2) 366-377   Jan 2012   [Refereed]
Suzuki A, Iwamura C, Shinoda K, Tumes DJ, Kimura MY, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   184(8) 4510-4520   Apr 2010   [Refereed]
Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A
Nature immunology   11(3) 257-264   Mar 2010   [Refereed]
Nakayama T, Kimura MY
Advances in experimental medicine and biology   684 1-10   2010   [Refereed]
Iwamura C, Kimura MY, Shinoda K, Endo Y, Hasegawa A, Yamashita M, Nakayama T
International immunology   19(6) 755-762   Jun 2007   [Refereed]
Kimura MY, Iwamura C, Suzuki A, Miki T, Hasegawa A, Sugaya K, Yamashita M, Ishii S, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   178(8) 4926-4936   Apr 2007   [Refereed]
Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura MY, Kitajiama M, Kimura F, Miyazaki M, Nakayama T
Molecular immunology   44(9) 2249-2256   Mar 2007   [Refereed]
Hosokawa H, Kimura MY, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   177(11) 7656-7664   Dec 2006   [Refereed]
Tenda Y, Yamashita M, Kimura MY, Hasegawa A, Shimizu C, Kitajima M, Onodera A, Suzuki A, Seki N, Nakayama T
The Journal of allergy and clinical immunology   118(3) 725-733   Sep 2006   [Refereed]
Yamashita M, Hirahara K, Shinnakasu R, Hosokawa H, Norikane S, Kimura MY, Hasegawa A, Nakayama T
Immunity   24(5) 611-622   May 2006   [Refereed]
Hasegawa A, Miki T, Hosokawa H, Hossain MB, Shimizu C, Hashimoto K, Kimura MY, Yamashita M, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   176(4) 2546-2554   Feb 2006   [Refereed]
Nigo YI, Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M, Hasegawa A, Kohno Y, Nakayama T
Proceedings of the National Academy of Sciences of the United States of America   103(7) 2286-2291   Feb 2006   [Refereed]
Yamashita M, Shinnakasu R, Asou H, Kimura M, Hasegawa A, Hashimoto K, Hatano N, Ogata M, Nakayama T
The Journal of biological chemistry   280(33) 29409-29419   Aug 2005   [Refereed]
Miyamoto T, Kaneko T, Yamashita M, Tenda Y, Inami M, Suzuki A, Ishii S, Kimura M, Hashimoto K, Shimada H, Yahata H, Ochiai T, Saito I, DeGregori J, Nakayama T
International immunology   17(6) 759-768   Jun 2005   [Refereed]
Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S, Nakayama T
The Journal of experimental medicine   201(3) 397-408   Feb 2005   [Refereed]
Chromatin remodeling of the Th2 cytokine gene loci.
Nakayama, T., Yamashita, M., Kimura, M., Hasegawa, A., Omori, M., Inami, M., Motohashi, S., Kitajima, M., Hashimoto, K., Hosokawa, H. and Shinnakasu, R.
International Congress Series.   1285(-) 137-144   2005   [Refereed]
Th1/Th2バランスの制御とTh2細胞の分化機構
木村元子、中山俊憲
63(-) 40-45   2005   [Refereed]
Fukuda K, Yoshida H, Sato T, Furumoto TA, Mizutani-Koseki Y, Suzuki Y, Saito Y, Takemori T, Kimura M, Sato H, Taniguchi M, Nishikawa S, Nakayama T, Koseki H
Developmental biology   255(2) 278-289   Mar 2003   [Refereed]
Sakamoto, M., Hasegawa, A., Sugaya, K., Hashimoto, K., Kimura, M., Yamashita, M., Suzuki, K. and Nakayama, T
Bioimages.   11(-) 1-8   2003   [Refereed]
アレルギー発症に関わるTh2細胞の分化維持機構
木村 元子
Pharma Medica   21(-) 17-24   2003   [Refereed]
Shimizu, C., Kawamoto, H., Yamashita, M., Kimura, M., Kondo, E., Kaneko, Y., Okada, S., Tokuhisa T., Yokoyama, M., Taniguchi, M., Katsura, Y. and Nakayama, T.
Int. Immunol.   13(-) 105-117   2001   [Refereed]
Yamashita, M., Katsumata, M., Iwashima, M., Kimura, M., Shimizu, C., Kamata, T., Shin, T., Seki, N., Suzuki, S., Taniguchi, M. and Nakayama, T.
J. Exp. Med.   191(-) 1869-1879   2000   [Refereed]
Cui, J., Watanabe, N., Kawano, T., Yamashita, Y., Kamata, T., Shimizu, C., Kimura, M., Shimizu, E., Koike, J., Koseki, H., Tanaka, Y., Taniguchi, M. and Nakayama, T.
J. Exp. Med.   190(-) 783-792   1999   [Refereed]
Yamashita, M., Kimura, M., Kubo, M., Shimizu, C., Tada, T., Perlmutter, R. M. and Nakayama, T.
Proc. Natl. Acad. Sci.   96(-) 1024-1029   1999   [Refereed]
TCR -mediated signal transduction pathways that control helper T cell differentiation: Requirement for activation of Lck tyrosine kinase and Ras/MAPK pathway in Th2 cell differentiation.
Nakayama, T., Yamashita, M., Kubo, M., Kimura, M., Shimizu, C. and Tada, T.
10th International congress of Immunology International Proceedings Division Co., Bologna, Italy.   589-593   1998   [Refereed]
Shimizu, C., Li, X.-K., Kimura, M., Hashimoto, K., Sugaya, K., Kubo, M., Suzuki, S. and Nakayama, T.
Immunology.   94(-) 503-512   1998   [Refereed]
Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.
Int. Immunol.   10(-) 577-591   1998   [Refereed]
TCR-mediated signaling events required for T helper subset differentiation in kinases and phosphatases.
Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.
Lymphocyte and Neuronal Signaling.   -(-) 350-351   1997   [Refereed]
Kimura, M., Yamashita, M., Kubo, M., Iwashima, M., Shimizu, C., Chiba, J., Taniguchi, M., Katsumata, M. and Nakayama, T
Int. Immunol.   12(-) 817-824   2000   [Refereed]
Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Taniguchi M., Koseki, H. and Nakayama, T.
Immunity.   15(-) 275-287   2001   [Refereed]
Nakayama, T., Kasprowicz, D., Yamashita, M., Schubert, L. A., Gillard, G., Kimura, M., Didierlaurent, A., Koseki, H. and Ziegler, S.F.
J. Immunol.   168(-) 87-94   2002   [Refereed]
Kikkawa, E., Yamashita, M., Kimura, M., Omori, M., Sugaya, K., Shimizu, C., Katsumoto, T., Ikekita, M., Taniguchi, M. and Nakayama, T.
Int. Immunol.   14(-) 943-951   2002   [Refereed]
Shibata, Y., Kamata, T., Kimura, M., Yamashita, M., Wang, CR., Murata, K., Miyazaki, M., Yaniguchi, M., Watanabe, N. and Nakayama, T.:
J. Immunol.   169(-) 2134-2140   2002   [Refereed]
Asai, K., Hachimura, S., Kimura, M., Toraya, T, Yamashita, M., Nakayama, T. and Kaminogawa, S.
J. Immunol.   169(-) 4723-4731   2002   [Refereed]
Yamashita, M., Ukai-Tadenuma, M., Kimura, M., Omori, M., Inami, M., Taniguchi, M. and Nakayama, T.
J. Biol. Chem.   277(-) 42399-42408   2002   [Refereed]
Shirai, T., Magara, K. K., Motohashi, S., Yamashita, M., Kimura, M., Suwazomo, Y., Nogawa, K., Kuriyama, T., Taniguchi, M. and Nakayama, T.
J. Allergy Clinical Immunol.   111(-) 1353-1360   2003   [Refereed]
Omori, M., Yamashita, M., Inami, M., Ukai-Tadenuma, M., Kimura, M., Nigo, Y., Hasegawa, A., Taniguchi, M. and Nakayama, T.
Immunity   19(-) 281-294   2003   [Refereed]

Misc

 
The basis of T cell development and lineage choice in the thymus.
Kimura, M.Y.
Chiba Medical Journal   94(3) 19-23   2018
Kimura MY, Hayashizaki K, Tokoyoda K, Takamura S, Motohashi S, Nakayama T
Immunological reviews   278(1) 87-100   Jul 2017
[Mechanism of Th2 cell differentiation and regulation of Th1/Th2 balance].
Kimura M
Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 4 40-45   Apr 2005   [Refereed]
Kimura MY, Nakayama T
Critical reviews in immunology   25(5) 361-374   2005
T cell signal transduction -The differentiation and intracellular signal transduction of Th1・Th2 cells.

Books etc

 
Memory Th1/Th2 cell generation controlled Schnurri-2. Memory T-cells
Nakayama, T., and Kimura, M.Y.:
2009   
TCR-mediated signaling events required for T helper subset differentiation. in kinases and phosphatases in lymphocyte and neuronal signaling
Yamashita, M., Hashimoto, K., Kimura, M., Kubo, M., Tada, T., and Nakayama, T.
1997   

Conference Activities & Talks

 
Inhibition of acetyl-CoA carboxylase enhances memory Th2 cell generation and Th2 mediated anti-tumor immunity
Koyama-Nasu R., Endo Y., Ito T., Kanno T., Nakajima T., Kimura M.Y. and Nakayama T.
23 Aug 2019   
How does CD69 regulate T cell development and immune responses? [Invited]
Kimura M.Y.
DRFZ   27 May 2019   
CD69 regulates residency time of developing thymocytes that is important for NKT2 cell differentiation in the thymus
Kimura M.Y.
21 May 2019   
Role of CD69 on iNKT cell development in the thymus.
Kimura M.Y., Hayashizaki, K., Yagi, R., Endo, Y., Motohashi, S. and Nakayama, T
The 47th Annual Meeting of The Japanese Society for Immunology   10 Dec 2018   
CD69 regulates T cell exhaustion at the tumor microenvironment. [Invited]
Kimura M.Y.
3rd Annual CU-UCSD cMAV , UC San Diego   8 Nov 2018   
The role of CD69 on iNKT cell development in the thymus [Invited]
KIMURA Motoko
KAI International Meeting 2018   8 Nov 2018   
CD69 regulates T-cell exhaustionin the tumor microenvironment [Invited]
Kimura M.Y., Mita Y. and Nakayama, T.
Pusan National University   7 Nov 2018   
The role of CD69 on iNKT cell development in the thymus [Invited]
Kimura M.Y., Hayashizaki K. and Nakayama T.
2018 NIH Thymus symposium   26 Sep 2018   
CD69-Myl9 system regulates pathogenesis of inflammatory disorders. [Invited]
Kimura M.Y., Hayashizaki K. and Nakayama T.
The 2nd Chiba University-UC San Diego Symposium "Mucosal Immunology, Allergy and Vaccine"   28 May 2018   
Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. [Invited]
Kimura M.Y., Hayashizaki K. and Nakayama T.
The 5th Annual Meeting of the International Cytokine and Interferon Society 2017   31 Oct 2017   
Roles of CD69 on NKT cell development. [Invited]
Kimura M.Y.
Experimental Immunology Branch, NCI/NIH   5 May 2017   
Timing and duration of MHC-I positive selection and CD8 lineage choice in the thymus. [Invited]
Kimura M.Y.
5th Anniversary of the Japan Center for Health Professions Education and Research in Japan Week, Thomas Jefferson University   3 May 2017   
Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation.
Hayashizaki K., Kimura M.Y., Igi A. and Nakayama T.
7th International Workshop of Kyoto T Cell Conference   13 Mar 2017   
Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation.
Hayashizaki K., Kimura M.Y. and Nakayama T.
The 19th Takeda Science Foundation Symposium on Bioscience “Chronic Inflammation –Initiation, Progression and Resolution”   20 Jan 2017   
Timing and duration of MHC-I positive selection and CD8 lineage choice in the thymus. [Invited]
Kimura M.Y.
NIH Thymus Symposium, Bethesda USA   9 Dec 2016   
Timing and duration of MHC-I positive selection signals in the thymus reveal a novel compensatory signaling mechanism that prevents lineage fate errors.
Kimura M.Y., Nakayama T. and Singer A.
The 45th Annual Meeting of The Japanese Society for Immunology   5 Dec 2016   
(Best presentation award)
A compensatory signaling mechanisms that prevents lineage errors during MHC class I positive selection in the thymus.
Kimura M.Y., Nakayama T. and Singer A.
ThymUS international conference 2016   5 Jun 2016   
A compensatory signaling mechanisms that prevents lineage errors during MHC class I positive selection in the thymus.
Kimura M.Y., Hayashizaki K., Singer A., Nakayama T.
Kyoto T Cell Conference   20 May 2016   
Roles of IkBNS in T follicular helper cell differentiation and function.
Sarkar, H. M., Yagi, R., Nakajima, T., Kimura, M.Y., Nakayama, T., and Zhu, J.
The 44th Annual Meeting of The Japanese Society for Immunology   18 Nov 2015   
Strong TCR signaling prolongs lineage uncertainty during MHC-I specific positive selection.
Kimura M.Y., Nakayama T. and Singer A
Immunology 2015   8 May 2015   

Social Contribution

 
”Lineage choice in the thymus”
[Lecturer]  NIH, NCI  (NIH, NCI Experimental Immunology Branch)  2013 - 2013
”Thymocyte development & lineage Choice”
[Lecturer]  NIH, NCI  (NIH, NCI Experimental Immunology Branch)  2011 - 2012
”T cell homeostasis”
[Lecturer]  NIH,NCI  (NIH,NCI Experimental Immunology Branch)  2008 - 2010