J-GLOBAL         Last updated: Mar 28, 2019 at 17:35
Chiba University
Job title
Chiba University
Research funding number

Research Areas


Academic & Professional Experience

Jan 2014
Dec 2015
Chiba University
Apr 2011
Dec 2013
National Cancer Institue/ NIH

Published Papers

Tumes D, Hirahara K, Papadopoulos M, Shinoda K, Onodera A, Kumagai J, Yip KH, Pant H, Kokubo K, Masahiro K, Aoki A, Obata-Ninomiya K, Tokoyoda K, Endo Y, Kimura MY, Nakayama T
The Journal of allergy and clinical immunology      Mar 2019   [Refereed]
Kimura MY, Igi A, Hayashizaki K, Mita Y, Shinzawa M, Kadakia T, Endo Y, Ogawa S, Yagi R, Motohashi S, Singer A, Nakayama T
Nature communications   9(1) 3749   Sep 2018   [Refereed]
Kimura MY, Hayashizaki K, Tokoyoda K, Takamura S, Motohashi S, Nakayama T
Immunological reviews   278(1) 87-100   Jul 2017   [Refereed]
Pobezinsky LA, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry TM, Kimura MY, Sharrow SO, Guinter TI, Feigenbaum L, Singer A
Nature immunology   16(5) 517-524   May 2015   [Refereed]
Kimura MY, Thomas J, Tai X, Guinter TI, Shinzawa M, Etzensperger R, Li Z, Love P, Nakayama T, Singer A
Nature immunology   17(12) 1415-1423   Dec 2016   [Refereed]
Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura MY, Tumes DJ, Motohashi S, Matsumoto M, Nakayama KI, Tanaka T, Nakayama T
The Journal of biological chemistry   290(21) 13095-13103   May 2015   [Refereed]
Hayashizaki K, Kimura MY, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, Nakayama T
Science immunology   1(3) eaaf9154   Sep 2016   [Refereed]
Mita Y, Kimura MY, Hayashizaki K, Koyama-Nasu R, Ito T, Motohashi S, Okamoto Y, Nakayama T
International immunology   30(12) 559-567   Aug 2018   [Refereed]
Luckey MA, Kimura MY, Waickman AT, Feigenbaum L, Singer A, Park JH
Nature immunology   15(7) 638-645   Jul 2014   [Refereed]
Namekawa M, Ishida K, Kimura M, Fujii C, Yamashita S
Journal of cardiothoracic and vascular anesthesia      Dec 2017   [Refereed]
Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A
Cell   154(6) 1326-1341   Sep 2013   [Refereed]
Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A
Immunity   38(6) 1116-1128   Jun 2013   [Refereed]
Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A
Nature immunology   14(2) 143-151   Feb 2013   [Refereed]
Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A
The EMBO journal   31(2) 366-377   Jan 2012   [Refereed]
Suzuki A, Iwamura C, Shinoda K, Tumes DJ, Kimura MY, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   184(8) 4510-4520   Apr 2010   [Refereed]
Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A
Nature immunology   11(3) 257-264   Mar 2010   [Refereed]
Nakayama T, Kimura MY
Advances in experimental medicine and biology   684 1-10   2010   [Refereed]
Iwamura C, Kimura MY, Shinoda K, Endo Y, Hasegawa A, Yamashita M, Nakayama T
International immunology   19(6) 755-762   Jun 2007   [Refereed]
Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo.
Kimura MY, Iwamura C, Suzuki A, Miki T, Hasegawa A, Sugaya K, Yamashita M, Ishii S, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   178(8) 4926-4936   Apr 2007   [Refereed]
Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura MY, Kitajiama M, Kimura F, Miyazaki M, Nakayama T
Molecular immunology   44(9) 2249-2256   Mar 2007   [Refereed]
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.
Hosokawa H, Kimura MY, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   177(11) 7656-7664   Dec 2006   [Refereed]
Tenda Y, Yamashita M, Kimura MY, Hasegawa A, Shimizu C, Kitajima M, Onodera A, Suzuki A, Seki N, Nakayama T
The Journal of allergy and clinical immunology   118(3) 725-733   Sep 2006   [Refereed]
Yamashita M, Hirahara K, Shinnakasu R, Hosokawa H, Norikane S, Kimura MY, Hasegawa A, Nakayama T
Immunity   24(5) 611-622   May 2006   [Refereed]
Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.
Hasegawa A, Miki T, Hosokawa H, Hossain MB, Shimizu C, Hashimoto K, Kimura MY, Yamashita M, Nakayama T
Journal of immunology (Baltimore, Md. : 1950)   176(4) 2546-2554   Feb 2006   [Refereed]
Nigo YI, Yamashita M, Hirahara K, Shinnakasu R, Inami M, Kimura M, Hasegawa A, Kohno Y, Nakayama T
Proceedings of the National Academy of Sciences of the United States of America   103(7) 2286-2291   Feb 2006   [Refereed]
Yamashita M, Shinnakasu R, Asou H, Kimura M, Hasegawa A, Hashimoto K, Hatano N, Ogata M, Nakayama T
The Journal of biological chemistry   280(33) 29409-29419   Aug 2005   [Refereed]
Miyamoto T, Kaneko T, Yamashita M, Tenda Y, Inami M, Suzuki A, Ishii S, Kimura M, Hashimoto K, Shimada H, Yahata H, Ochiai T, Saito I, DeGregori J, Nakayama T
International immunology   17(6) 759-768   Jun 2005   [Refereed]
[Mechanism of Th2 cell differentiation and regulation of Th1/Th2 balance].
Kimura M
Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 4 40-45   Apr 2005   [Refereed]
Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S, Nakayama T
The Journal of experimental medicine   201(3) 397-408   Feb 2005   [Refereed]
Kimura MY, Nakayama T
Critical reviews in immunology   25(5) 361-374   2005   [Refereed]
Fukuda K, Yoshida H, Sato T, Furumoto TA, Mizutani-Koseki Y, Suzuki Y, Saito Y, Takemori T, Kimura M, Sato H, Taniguchi M, Nishikawa S, Nakayama T, Koseki H
Developmental biology   255(2) 278-289   Mar 2003   [Refereed]
Kamata T, Yamashita M, Kimura M, Murata K, Inami M, Shimizu C, Sugaya K, Wang CR, Taniguchi M, Nakayama T
The Journal of clinical investigation   111(1) 109-119   Jan 2003   [Refereed]
[Th1/Th2 cell differentiation processes that regulated by polycomb group gene products].
Kimura M, Nakayama T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   47(16 Suppl) 2286-2292   Dec 2002   [Refereed]


T cell signal transduction -The differentiation and intracellular signal transduction of Th1・Th2 cells.
T cell antigen receptor mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.
Requirement for p56lck tyrosine kinase activation in T helper subset differentiation.
Impaired Ca/calcineurin pathway in in vivo anergized CD4 T cells
The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression.
T cell hyporesponsiveness induced by oral administration of ovalbumin is associated with impaired NFAT nuclear translocation and p27kip1 degradation.
Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus.
Ras activation in T cells determines the development of antigen-induced airway hyperresponsiveness and eosinophilic inflammation.
T(h)1/T(h)2 cell differentiation of developing CD4 single-positive thymocytes.
CD69-null mice protected from arthritis induced with anti-type II collagen antibodies.
CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA.
TH1-biased immunity induced by exposure to Antarctic winter.
CD28 costimulation controls histone hyperacetylation of the IL-5 gene locus in developing Th2 cells.
Essential role of GATA3 for the maintenance of Type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.
Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.
STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells.