ICHIKAWA Tomohiko

J-GLOBAL         Last updated: Jan 4, 2020 at 05:33
 
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Name
ICHIKAWA Tomohiko
Affiliation
Chiba University
Section
Graduate School of Medicine
Job title
Chiba University
Degree
(BLANK)(Chiba University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2004
 - 
Today
Professor, Department of Urology, Graduate School of Medicine, Chiba University
 

Education

 
Apr 1985
 - 
Mar 1989
Graduate School of Medicine, Chiba University
 
Apr 1978
 - 
Mar 1984
School of Medicine, Chiba University
 

Published Papers

 
Kuroiwa K, Inokuchi J, Nishiyama H, Kojima T, Kakehi Y, Sugimoto M, Tanigawa T, Fujimoto H, Gotoh M, Masumori N, Ogawa O, Eto M, Ohyama C, Yokomizo A, Matsuyama H, Ichikawa T, Mizusawa J, Eba J, Naito S, JCOG UOSG.
The Journal of urology   202(6) 1127-1135   Dec 2019   [Refereed]
Sazuka T, Sakamoto S, Nakamura K, Imamura Y, Yamamoto S, Komiya A, Ichikawa T
International journal of urology : official journal of the Japanese Urological Association   26(12) 1106-1112   Dec 2019   [Refereed]
Ando K, Sakamoto S, Takeshita N, Fujimoto A, Maimaiti M, Saito S, Sanjyon P, Imamura Y, Sato N, Komiya A, Akakura K, Ichikawa T
The Prostate      Dec 2019   [Refereed]
Higuchi K, Sakamoto S, Ando K, Maimaiti M, Takeshita N, Okunushi K, Reien Y, Imamura Y, Sazuka T, Nakamura K, Matsushima J, Furihata T, Ikehara Y, Ichikawa T, Anzai N
Scientific reports   9(1) 16776   Nov 2019   [Refereed]
Sugiyama M, Fujimura M, Nakamori H, Nishikawa R, Sakamoto S, Sekita N, Suzuki H, Mikami K, Ichikawa T
Urology case reports   24 100854   May 2019   [Refereed]
Nagano H, Kono T, Saiga A, Kubota Y, Fujimoto M, Felizola SJA, Ishiwata K, Tamura A, Higuchi S, Sakuma I, Hashimoto N, Suzuki S, Koide H, Takeshita N, Sakamoto S, Ban T, Yokote K, Nakamura Y, Ichikawa T, Uno T, Tanaka T
The Journal of clinical endocrinology and metabolism      Oct 2019   [Refereed]
Ishige T, Itoga S, Kawasaki K, Utsuno E, Beppu M, Sawai S, Nishimura M, Ichikawa T, Nomura F, Matsushita K
Clinica chimica acta; international journal of clinical chemistry   495 562-569   Aug 2019   [Refereed]
Namekawa T, Ikeda K, Horie-Inoue K, Suzuki T, Okamoto K, Ichikawa T, Yano A, Kawakami S, Inoue S
International journal of cancer      Jun 2019   [Refereed]
Yamada Y, Kato M, Arai T, Sanada H, Uchida A, Misono S, Sakamoto S, Komiya A, Ichikawa T, Seki N
Molecular oncology      Jun 2019   [Refereed]
Yamamoto S, Sakamoto S, Imamura Y, Sazuka T, Nakamura K, Inoue T, Chiba K, Miyazaki K, Inoue A, Nagata M, Ichikawa T
International journal of urology : official journal of the Japanese Urological Association      May 2019   [Refereed]
Arai T, Kojima S, Yamada Y, Sugawara S, Kato M, Yamazaki K, Naya Y, Ichikawa T, Seki N
International journal of urology : official journal of the Japanese Urological Association   26(4) 506-520   Apr 2019   [Refereed]
Sakamoto S, Maimaiti M, Xu M, Kamada S, Yamada Y, Kitoh H, Matsumoto H, Takeuchi N, Higuchi K, Uchida HA, Komiya A, Nagata M, Nakatsu H, Matsuyama H, Akakura K, Ichikawa T
Journal of clinical medicine   8(4)    Apr 2019   [Refereed]
Arai T, Kojima S, Yamada Y, Sugawara S, Kato M, Yamazaki K, Naya Y, Ichikawa T, Seki N
Molecular oncology   13(2) 322-337   Feb 2019   [Refereed]
Wakabayashi S, Takaoka H, Miyauchi H, Sazuka T, Saito Y, Sugimoto K, Funabashi N, Ichikawa T, Matsubara H, Kobayashi Y
Internal medicine (Tokyo, Japan)      Feb 2019   [Refereed]
Sakamoto S, Miyazawa K, Yasui T, Iguchi T, Fujita M, Nishimatsu H, Masaki T, Hasegawa T, Hibi H, Arakawa T, Ando R, Kato Y, Ishito N, Yamaguchi S, Takazawa R, Tsujihata M, Taguchi M, Akakura K, Hata A, Ichikawa T
International journal of urology : official journal of the Japanese Urological Association   26(1) 96-101   Jan 2019   [Refereed]
Harada T, Kuji N, Ishihara O, Ichikawa T, Irahara M, Katagiri Y, Saito H, Harada T, Wada-Hiraike O, Taniguchi F, Ethics Committee in Japan Society of Reproductive Medicine.
Reproductive medicine and biology   18(1) 3-6   Jan 2019   [Refereed]
Kasuya G, Tsuji H, Nomiya T, Makishima H, Haruyama Y, Kobashi G, Hayashi K, Ebner DK, Omatsu T, Kishimoto R, Yasuda S, Igarashi T, Oya M, Akakura K, Suzuki H, Ichikawa T, Shimazaki J, Kamada T, Working Group for Genitourinary Tumors.
Oncotarget   10(1) 76-81   Jan 2019   [Refereed]
Role of pre-miR-532 (miR-532-5p and miR-532-3p) in regulation of gene expression and molecular pathogenesis in renal cell carcinoma.
Yamada Y, Arai T, Kato M, Kojima S, Sakamoto S, Komiya A, Naya Y, Ichikawa T, Seki N
American journal of clinical and experimental urology   7(1) 11-30   2019   [Refereed]
Asazawa K, Jitsuzaki M, Mori A, Ichikawa T, Shinozaki K, Porter SE
Japan journal of nursing science : JJNS      Dec 2018   [Refereed]
Namekawa T, Imamoto T, Kato M, Komiya A, Ichikawa T
Reproductive medicine and biology   17(4) 343-355   Oct 2018   [Refereed]

Misc

 
[原著]Suzuki H, Komiya A, Kamiya N, Imamoto T, Kawamura K, Miura J, Suzuki N,Nakatsu H, Hata A, Ichikawa T.:Development of a nomogram to predict probability of positive initial prostate biopsy among Japanese patients.
[原著]Ueda T, Komiya A, Suzuki H, Shimbo M, Sakamoto S, Imamoto T, Akakura K, Shiraishi T, Ichikawa T.:Loss of heterozygosity on chromosome 2 in Japanese patients with prostate cancer.
Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11.
Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8.
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11、2.
Expression of the KAI1 protein in benign prostatic hyperplasia and prostate cancer.
Mapping of metastasis suppressor gene(S) for rat prostate cancer on the short arm of human chromosome 8 by irradicated microcell-mediated chromosome transfer.
Localization for KAIl on the short arm of human chromosome 11 and frequency of allelic loss in advanced human prostate cancer.
Identification of a novel metastasis-suppressor region on human chromosome 12.
Metastasis suppressor gene(s) for rat prostate cancer on the long arm of human chromosome 7.
Identification of a LcM region of common deletion on 13q14 associated with metastasis of human prostate cancer.
Microsurgical subinguinal varicocelectomy
Laparoscopic adrenalectomy for functioning adrenal tumors : clinical experiences with 38 cases and comparison with open adrenalectomy
Mapping of metastasis suppressor genes for prostate cancer by micro cell-mediated chromosome transfer.
Role of chromosomal loss in the progression of prostate cancer.
Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.
Functional evidence for a metastasis suppressor gene for rat prostate cancer within a 60-kilobase region on human chromosome 8p21-p12.
Suppression of metastasis of rat prostate cancer by introduction of human chromosome 13.
[総説] Ichikawa T, Hosoki S, Suzuki H, Akakura K, Igarashi T, Furuya Y, Oshimura M, Rinker-Schaeffer CW, Nihei N, Barrett JC, Isaacs JT, Ito H.: Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer.

Research Grants & Projects

 
Japan Agency for Medical Research and Development: 日本医療研究開発機構研究費
Project Year: 2018 - 2020    Investigator(s): Tomohiko Ichikawa
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (B)
Project Year: 2016 - 2018    Investigator(s): Tomohiko Ichikawa
We constructed the microRNA (miRNA) expression signature of castration-resistant prostate cancer (CRPC) using clinical specimens, and investigated the functional significance of tumor-suppressive miRNAs. We further investigated oncogenes regulated...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (B)
Project Year: 2013 - 2015    Investigator(s): Tomohiko Ichikawa
We constructed the microRNA (miRNA) expression signature of castration-resistant prostate cancer (CRPC) using clinical specimens, and investigated the functional significance of tumor-suppressive miRNAs. We further investigated oncogenes regulated...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (B)
Project Year: 2008 - 2011    Investigator(s): Tomohiko Ichikawa
Using SELDI-TOF MS, we performed protein mass profiling of the sera from the patients with castration-resistant prostate cancer and identified apolipoprotein C-I (ApoC-I), which level increased with disease progression. MicroRNAs (miRNAs) are smal...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (A)
Project Year: 2002 - 2005    Investigator(s): Tomohiko Ichikawa
Identification of molecular and cellular markers for the progression of prostate cancer would be useful in developing diagnostic methods for substaging prostate cancers. To isolate such genes, I have established a rat prostate cancer system. Clini...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research (A)
Project Year: 1999 - 2001    Investigator(s): Tomohiko Ichikawa
Identification of molecular and cellular markers for the metastatic ability of prostate cancer would be useful in developing diagnostic methods for substaging histologically localized prostate cancers. To isolate metastasis suppressor genes, I hav...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 1997 - 1998    Investigator(s): Tomohiko Ichikawa
Identification of molecular and cellular markers for the metastatic ability of prostate cancer would be useful in developing diagnostic methods for substaging histologically localized prostate cancers. To isolate metastasis suppressor genes, we ha...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 1996 - 1996    Investigator(s): Tomohiko Ichikawa
我々は前立腺癌の実験モデルとして全世界で用いられているDunning R3327ラット前立腺癌の高率に肺転移を示すサブラインを用いて,転移抑制遺伝子のヒト染色体上における位置の同定を研究してきた。このサブラインに微小細胞融合法を用いてヒト正常染色体を1本移入させることにより,移入されたヒト染色体が転移を抑制するか否かをみることが可能である。我々のグループはこのラット前立腺癌モデルを用いた実験系により、ヒト11番染色体の11p11.2よりKAI1前立腺癌転移抑制遺伝子をクローニングした。KA...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 1995 - 1995    Investigator(s): Tomohiko Ichikawa
Dunning R3327ラット前立腺癌の高率に肺転移を示すサブラインにヒト正常染色体を移入し、宿主細胞の性状の変化をみることにより前立腺癌に対する転移抑制遺伝子を検索しようと試みている。これはヒト臨床材料において異型接合性を示す対立遺伝子の欠失(LOH)を検索することにより癌遺伝子などを同定する、従来から行われている手法とは異なった方面からの検索である。平成6年度までにヒト11p13-p11.2,8p23-q12,10cen-q22にはこのラット前立腺癌に対する転移抑制遺伝子が存在するこ...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 1994 - 1994    Investigator(s): Tomohiko Ichikawa
DunningR3327ラット前立腺癌の高率に肺転移を示すサブラインにヒト正常染色体を移入し、宿主細胞の性状の変化をみることにより前立腺癌に対する転移抑制遺伝子を検索しようと試みている。これはヒト臨床材料において異型接合性を示す対立遺伝子の欠失(LOH)を検索することにより癌遺伝子などを同定する、従来から行われている手法とは異なった方面からの検索である。平成5年度までにヒト11番染色体の11p13-p11.2にはこのラット前立腺癌に対する転移抑制遺伝子が存在することを示した。平成6年度の成...
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 1993 - 1993    Investigator(s): Tomohiko Ichikawa
ネオマイシン耐性マーカーを含むヒト正常第8番染色体を一本含むマウスA9細胞株から微小細胞を作成し、これを高率に肺転移するラット前立腺癌細胞株(Dunning R3327 AT6 サブライン)と細胞融合させ、G418存在下でヒト第8番染色体を含んだAT6細胞(AT6-8細胞)を6クローン得た。コントロールとして転移抑制遺伝子の含まれていないことがわかっている、ヒト染色体の小断片(11p11.2->11cen)を同様の方法でAT6細胞に移入し(AT6-s11細胞)4クローンを得た。これらのクロ...