論文

査読有り 本文へのリンクあり
2019年8月10日

Contrasting toxin selectivity between the marine pufferfish takifugu pardalis and the freshwater pufferfish pao suvattii

Toxins
  • Wei Gao
  • ,
  • Yoko Kanahara
  • ,
  • Misako Yamada
  • ,
  • Ryohei Tatsuno
  • ,
  • Hiroyuki Yoshikawa
  • ,
  • Hiroyuki Doi
  • ,
  • Tomohiro Takatani
  • ,
  • Osamu Arakawa

11
8
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/toxins11080470

© 2019 by the authors. To clarify the differences in toxin selectivity between marine and freshwater pufferfish, we conducted experiments in artificially reared nontoxic specimens of Takifugu pardalis (marine) and Pao suvattii (freshwater) using tetrodotoxin (TTX) and paralytic shellfish poison (PSP; decarbamoylsaxitoxin (dcSTX) or saxitoxin (STX)). T. pardalis specimens were administered feed homogenate containing TTX or dcSTX (dose of toxin, 55.2 nmol/fish) and P. suvattii specimens were administered feed homogenate containing TTX + STX (dose of each toxin, 19.2 nmol/fish) by oral gavage. The toxin content in the intestine, muscle, skin, liver, and gonads was quantified after 24 and 48 or 72 h. In T. pardalis, TTX administered into the intestine was absorbed into the body and transferred and retained mainly in the skin and liver, while dcSTX was hardly retained in the body, although it partly remained in the intestine. In strong contrast, in P. suvattii, little TTX remained in the body, whereas STX was absorbed into the body and was transferred and retained in the ovary and skin. The findings revealed that TTX/PSP selectivity differs between the marine species T. pardalis and the freshwater species P. suvattii. T. pardalis, which naturally harbors TTX, selectively accumulates TTX, and P. suvattii, which naturally harbors PSP, selectively accumulates PSP.

リンク情報
DOI
https://doi.org/10.3390/toxins11080470
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31405182
Scopus
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