論文

査読有り
2015年1月

Sympathetic regulation of vascular tone via noradrenaline and serotonin in the rat carotid body as revealed by intracellular calcium imaging

BRAIN RESEARCH
  • Takuya Yokoyama
  • ,
  • Nobuaki Nakamuta
  • ,
  • Tatsumi Kusakabe
  • ,
  • Yoshio Yamamoto

1596
開始ページ
126
終了ページ
135
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.brainres.2014.11.037
出版者・発行元
ELSEVIER SCIENCE BV

Hypoxia-induced chemosensory activity in the carotid body (CB) may be enhanced by the sympathetic regulation of vascular tone in the CB. In the present study, we recorded cervical sympathetic nerve activity in rats exposed to hypoxia, and examined noradrenaline (NA)-and serotonin (5-HT)-induced intracellular Ca2+ ([Ca2+](i)) responses in smooth muscle cells and pericytes in isolated blood vessels from the CB. Multifiber electrical activity recorded from the cervical sympathetic trunk was increased during the inhalation of hypoxic gas. NA induced [Ca2+](i) increases in smooth muscle cells in arteriole specimens, whereas 5-HT did not cause any [Ca2+](i) responses. However, NA did not induce [Ca2+](i) increases in pericytes in capillaries, whereas 5-HT did and this response was inhibited by the 5-HT2 receptor antagonist, ketanserin. In conclusion, cervical sympathetic nerves enhanced by hypoxia may reduce blood flow in the CB in order to increase chemosensitivity. Thus, hypoxic chemosensitivity in the CB may involve a positive feedback mechanism via sympathetic nerves. (C) 2014 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1016/j.brainres.2014.11.037
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000348951000013&DestApp=WOS_CPL

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