2019年4月
A polyaromatic receptor with high androgen affinity
SCIENCE ADVANCES
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- 巻
- 5
- 号
- 4
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/sciadv.aav3179
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Biological receptors distinguish and bind steroid sex hormones, e.g., androgen-, progestogen-, and estrogen-type hormones, with high selectivity. To date, artificial molecular receptors have been unable to discriminate between these classes of biosubstrates. Here, we report that an artificial polyaromatic receptor preferentially binds a single molecule of androgenic hormones, known as "male" hormones (indicated with m), over progestogens and estrogens, known as "female" hormones (indicated with f), in water. Competitive experiments established the binding selectivity of the synthetic receptor for various sex hormones to be testosterone (m) > androsterone (m) >> progesterone (f) > beta-estradiol (f) > pregnenolone (f) > estriol (f). These bindings are driven by the hydrophobic effect, and the observed selectivity arises from multiple CH-pi contacts and hydrogen-bonding interactions in the semirigid polyaromatic cavity. Furthermore, micromolar fluorescence detection of androgen was demonstrated using the receptor containing a fluorescent dye in water.
- リンク情報
- ID情報
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- DOI : 10.1126/sciadv.aav3179
- ISSN : 2375-2548
- Web of Science ID : WOS:000466398400046