TAKUWA Yoh

J-GLOBAL         Last updated: Jul 23, 2019 at 09:49
 
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Name
TAKUWA Yoh
Affiliation
Kanazawa University
Section
Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine
Research funding number
60171592

Research Interests

 
 

Research Areas

 
 

Education

 
 
 - 
1979
Faculty of Medicine, The University of Tokyo
 

Committee Memberships

 
2008
   
 
-: The Japanese Vascular and Medicine Organization 
 
2008
   
 
The Japanese Vascular and Medicine Organization  
 
1991
 - 
2004
: The Japan Endocrine Society 
 
1991
 - 
2004
The Japan Endocrine Society  
 
2004
   
 
-: The Society Cardiovascular Endocrinology and metabolism 
 
2004
   
 
-: Japanese Conference on the Biochemistry of Lipids 
 
2004
   
 
The Society Cardiovascular Endocrinology and metabolism  
 
2004
   
 
Japanese Conference on the Biochemistry of Lipids  
 
2000
   
 
-: Japan Society of Circulation Reseach 
 
2000
   
 
Japan Society of Circulation Reseach  
 
1996
   
 
-: Physiological Socitey of Japan 
 
1996
   
 
Physiological Socitey of Japan  
 

Published Papers

 
Kitano T, Takashima S, Inoue O, Goten C, Nomura A, Yoshioka K, Okajima M, Kaneko S, Takuwa Y, Takamura M.
Biochem. Biphys. res. Communi.   511(1) 179-184   Mar 2019   [Refereed]
LPA-induced YAP/TAZ activation promotes developmental angiogenesis by regulating Dll4 expression
Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T,Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S
J Clin Invest      2019   [Refereed]
Sarker MD. A. K, Aki S, Yoshioka K, Kuno K, Okamoto Y, Ishimaru K, Takuwa N, Takuwa Y.
Endocrinology   160(1) 235-248   Nov 2018   [Refereed]
Aung KT, Yoshioka K, Aki S, Ishimaru K, Takuwa N, Takuwa Y.
Journal of Physiological Sciences   69(2) 263-280   Oct 2018   [Refereed]
Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, Takuwa Y
Genes to cells : devoted to molecular & cellular mechanisms      Jul 2018   [Refereed]
Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK
Nature communications   9(1) 1479-1492   Apr 2018   [Refereed]
Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y
PloS one   13(5) e0197604   2018   [Refereed]
Okumura K, Yoshida K, Yoshioka K, Aki S, Yoneda N, Inoue D, Kitao A, Ogi T, Kozaka K, Minami T, Koda W, Kobayashi S, Takuwa Y, Gabata T
European radiology experimental   2(1) 5   2018   [Refereed]
Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S
Scientific reports   7(1) 16978   Dec 2017   [Refereed]
Mori M, Sakata K, Nakanishi C, Nakahashi T, Kawashiri MA, Yoshioka K, Takuwa Y, Okada H, Yokawa JI, Shimojima M, Yoshimuta T, Yoshida S, Yamagishi M, Hayashi K
Heart and vessels   32(10) 1244-1252   Oct 2017   [Refereed]
Serafimidis I, Rodriguez-Aznar E, Lesche M, Yoshioka K, Takuwa Y, Dahl A, Pan D, Gavalas A
PLoS biology   15(3) e2000949   Mar 2017   [Refereed]
Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y
PloS one   12(8) e0182329   2017   [Refereed]
Sphingosine-1-phosphate receptor type 2 (S1P2) inhibits bleomycin-induced cellular senescence in murine lung fibroblasts.
Zhao J., Okamoto Y., Takuwa Y.
J Zuzen Med Soc   125(1) 2-13   Mar 2016   [Refereed]
Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y
The Journal of biological chemistry   290(10) 6086-6105   Mar 2015   [Refereed]
Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, Takuwa Y, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I
Pharmacology research & perspectives   2(5) e00068   Oct 2014   [Refereed]
Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
Diabetologia   57(9) 1968-1976   Sep 2014   [Refereed]
Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T
Clinical and experimental nephrology   17(6) 793-804   Dec 2013   [Refereed]
Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, Zhang W, Asano M, Shibamoto T, Takuwa Y
The Journal of allergy and clinical immunology   132(5) 1205-1214.e9   Nov 2013   [Refereed]
Cui H., Okamoto Y., Yoshioka K., Du W., Takuwa N., Zhang W., Asano M., Shibamoto T., Takuwa Y.WA Yoh
J Allergy Clin Immunol 1   132(5) 1205-1214   Sep 2013   [Refereed]
[Physiological roles of class II PI3 kinase-C2alpha in endothelial cells].
Yoshioka K, Takuwa N, Okamoto Y, Takuwa Y
Seikagaku. The Journal of Japanese Biochemical Society   85(9) 775-780   Sep 2013   [Refereed]
Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, Takuwa Y
The Journal of biological chemistry   288(4) 2325-2339   Jan 2013   [Refereed]
Takuwa Y, Ikeda H, Okamoto Y, Takuwa N, Yoshioka K
Biochimica et biophysica acta   1831(1) 185-192   Jan 2013   [Refereed]
Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y, Meikle PJ, Pitson SM, Febbraio MA
Diabetes   61(12) 3148-3155   Dec 2012   [Refereed]
Yoshioka K, Yoshida K, Cui H, Wakayama T, Takuwa N, Okamoto Y, Du W, Qi X, Asanuma K, Sugihara K, Aki S, Miyazawa H, Biswas K, Nagakura C, Ueno M, Iseki S, Schwartz RJ, Okamoto H, Sasaki T, Matsui O, Asano M, Adams RH, Takakura N, Takuwa Y
Nature medicine   18(10) 1560-1569   Oct 2012   [Refereed]
Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, Satoh Y, Shimosawa T, Shinozaki K, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Yokota H, Koyama T, Ishimaru K, Okamoto Y, Takuwa Y, Koike K, Yatomi Y
Hepatology (Baltimore, Md.)   56(4) 1427-1438   Oct 2012   [Refereed]
Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N
BioFactors (Oxford, England)   38(5) 329-337   Sep 2012   [Refereed]
Takagi T, Okamoto Y, Tomita S, Sato A, Yamaguchi S, Takuwa Y, Watanabe G
The Journal of thoracic and cardiovascular surgery   142(2) e59-65   Aug 2011   [Refereed]
[Cardiovascular function of sphingosine 1-phosphate signaling].
Okamoto Y, Yoshioka K, Takuwa N, Takuwa Y
Seikagaku. The Journal of Japanese Biochemical Society   83(6) 536-544   Jun 2011   [Refereed]
Kamioka M, Ishibashi T, Ohkawara H, Nagai R, Sugimoto K, Uekita H, Matsui T, Yamagishi S, Ando K, Sakamoto T, Sakamoto N, Takuwa Y, Wada I, Shiomi M, Maruyama Y, Takeishi Y
Journal of cellular physiology   226(6) 1554-1563   Jun 2011   [Refereed]
Suzuki H, Hashimoto H, Kawasaki M, Watanabe M, Otsubo H, Ishikura T, Fujihara H, Ohnishi H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Nakamura T, Ueta Y
International journal of cancer   128(9) 2215-2223   May 2011   [Refereed]
Seok YM, Choi YW, Kim GD, Kim HY, Takuwa Y, Kim IK
Naunyn-Schmiedeberg's archives of pharmacology   383(1) 45-56   Jan 2011   [Refereed]
Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde.
Takuwa N, Du W, Kaneko E, Okamoto Y, Yoshioka K, Takuwa Y
American journal of cancer research   1(4) 460-481   2011   [Refereed]
Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y
Journal of atherosclerosis and thrombosis   18(9) 762-773   2011   [Refereed]
Ohkawara H, Ishibashi T, Saitoh S, Inoue N, Sugimoto K, Kamioka M, Uekita H, Kaneshiro T, Ando K, Takuwa Y, Maruyama Y, Takeishi Y
Cardiovascular research   88(3) 492-501   Dec 2010   [Refereed]
Seok YM, Azam MA, Okamoto Y, Sato A, Yoshioka K, Maeda M, Kim I, Takuwa Y
Hypertension (Dallas, Tex. : 1979)   56(5) 934-941   Nov 2010   [Refereed]
Takuwa Y, Du W, Qi X, Okamoto Y, Takuwa N, Yoshioka K
World journal of biological chemistry   1(10) 298-306   Oct 2010   [Refereed]
Qi X, Okamoto Y, Murakawa T, Wang F, Oyama O, Ohkawa R, Yoshioka K, Du W, Sugimoto N, Yatomi Y, Takuwa N, Takuwa Y
European journal of pharmacology   634(1-3) 121-131   May 2010   [Refereed]
Yoshida Y, Nakada M, Sugimoto N, Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Yachie A, Takuwa Y, Hamada J
International journal of cancer   126(10) 2341-2352   May 2010   [Refereed]
Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y
Cardiovascular research   85(3) 484-493   Feb 2010   [Refereed]
Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y
Cancer research   70(2) 772-781   Jan 2010   [Refereed]
SHIRATSUCHI Akiko, ICHIKI Manami, OKAMOTO Yasuo, OKAMOTO Yasuo, UEDA Natsuo, SUGIMOTO Naotoshi, TAKUWA Yoh, NAKANISHI Yoshinobu
J. Biochem   145(1) 43-50   2009   [Refereed]
Ohkawara H, Ishibashi T, Shiomi M, Sugimoto K, Uekita H, Kamioka M, Takuwa Y, Teramoto T, Maruyama Y, Takeishi Y
Journal of atherosclerosis and thrombosis   16(6) 846-856   2009   [Refereed]
The role of class II PI 3-kinase signaling pathway in physiology and diseases. Curr Biodata Targeted Proteins Database.
Takuwa Y, yoshioka K, Okamoto Y, Takuwa N.
Current Biodata. Targeted Proteins database   1-8   2009   [Refereed]
Yonesu K, Kawase Y, Inoue T, Takagi N, Tsuchida J, Takuwa Y, Kumakura S, Nara F.
BIOCHEMICAL PHARMACOLOGY   15(77) 1011-1020   2009   [Refereed]
Zhong H, Matsui O, Xu K, Ogi T, Sanada J, Okamoto Y, Tabata Y, Takuwa Y.
JOURNAL OF VASCULAR RESEARCH   50(6) 1433-1443   2009   [Refereed]
Sugimoto K, Ishibashi T, Sawamura T, Inoue N, Kamioka M, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T,
CARDIOVASCULAR RESEARCH   84(1) 127-136   2009   [Refereed]
TAKABATAKE Masayoshi, TAKUWA Yoh, TAKUWA Noriko, YASUNO Hironobu, MATSUMOTO Sayaka, SHIBUTANI Makoto, MITSUMORI Kunitoshi
The Journal of Veterinary Medical Science   70(5) 483-485   2008   [Refereed]
Takashima S, Sugimoto N, Takuwa N, Okamoto Y, Yoshioka K, Takamura M, Takata S, Kanekob S Takuwa Y.
CARDIOVASCULAR RESEARCH   79(4) 689-697   2008   [Refereed]
TAKABATAKE Masayoshi, TAKUWA Yoh, TAKUWA Noriko, YASUNO Hironobu, MATSUMOTO Sayaka, SHIBUTANI Makoto, MITSUMORI Kunitoshi
Journal of Veterinary Medical Science   70(5) 483-485   2008   [Refereed]
Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N
Biochimica et biophysica acta   1781(9) 483-488   2008   [Refereed]
Oyama O, Sugimoto N, Qi X, Takuwa N, Mizugishi K, Koizumi J, Takuwa Y.
CARDIOVASCULAR RESEARCH   73 301-307   2008   [Refereed]
Ueta Y, Hashimoto H, Onuma E, Takuwa Y, Ogata E
Endocrine journal   54(6) 831-838   Dec 2007   [Refereed]
Sakamoto T, Ishibashi T, Sugimoto K, Sakamoto N, Ohkawara H, Niinuma M, Nagata K, Kamioka M, Sugimoto N, Watanabe A, Kurabayashi M, Takuwa Y, Maruyama Y
Atherosclerosis   193(1) 44-54   Jul 2007   [Refereed]
Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada T, Brownlee M, Nishikawa T, Araki E
Circulation research   100(10) 1442-1451   May 2007   [Refereed]
Nakamura T, Yonesu K, Mizuno Y, Suzuki C, Sakata Y, Takuwa Y, Nara F, Satoh S
Bioorganic & medicinal chemistry   15(10) 3548-3564   May 2007   [Refereed]
Takuwa Y
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   129(4) 253-257   Apr 2007   [Refereed]
Hashimoto H, Azuma Y, Kawasaki M, Fujihara H, Onuma E, Yamada-Okabe H, Takuwa Y, Ogata E, Ueta Y
Clinical cancer research : an official journal of the American Association for Cancer Research   13(1) 292-298   Jan 2007   [Refereed]
Azam MA, Yoshioka K, Ohkura S, Takuwa N, Sugimoto N, Sato K and Takuwa Y
The Journal of pharmacology and experimental therapeutics   320(2) 907-916   2007   [Refereed]
Inoki I, Takuwa N, Sugimoto N, Yoshioka K, Takata S, Kaneko S, Takuwa Y
Biochemical and biophysical research communications   346(1) 293-300   Jul 2006   [Refereed]
Tanabe A, Kamisuki Y, Hidaka H, Suzuki M, Negishi M, Takuwa Y
Biochemical and biophysical research communications   345(1) 156-161   Jun 2006   [Refereed]
Sugimoto N, Takuwa N, Yoshioka K, Takuwa Y
Experimental cell research   312(10) 1899-1908   Jun 2006   [Refereed]
Zheng R, Iwase A, Shen R, Goodman Jr OB, Sugimoto N, Takuwa Y,
Oncogene.   25(44) 5942-5952   2006   [Refereed]
Wang Y, Yoshioka K, Azam MA, Takuwa N, Sakurada S, Kayaba Y, sugimoto N, Inoki, Kimura T, Kuwai T, Takuwa Y
BIOCHEMICAL JOURNAL   394(Pt3) 581-592   2006   [Refereed]
Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle.
Takuwa Y., Yoshioka K., Takuwa N., Wang Y., Azam MA., Sugimoto N.
Biomed. Rev   16 13-21   2006   [Refereed]
Sakamoto T, Ishibashi T, Sakamoto N, Sugimoto K, Egashira K, Ohkawara H, Nagata K, Yokoyama K, Kamioka M, Ichiki T, Sugimoto N, Kurabayashi M, Suzuki K, Takuwa Y, Maruyama Y
Arteriosclerosis, thrombosis, and vascular biology   25(9) 2005-2011   Sep 2005   [Refereed]
Ohtsu H, Mifune M, Frank GD, Saito S, Inagami T, Kim-Mitsuyama S, Takuwa Y, Sasaki T, Rothstein JD, Suzuki H, Nakashima H, Woolfolk EA, Motley ED, Eguchi S
Arteriosclerosis, thrombosis, and vascular biology   25(9) 1831-1836   Sep 2005   [Refereed]
Maruko T, Nakahara T, Sakamoto K, Saito M, Sugimoto N, Takuwa Y, Ishii K
Naunyn-Schmiedeberg's archives of pharmacology   372(2) 153-159   Aug 2005   [Refereed]
Philippova M, Ivanov D, Allenspach R, Takuwa Y, Erne P, Resink T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   19(6) 588-590   Apr 2005   [Refereed]
Senokuchi T, Matsumura T, Sakai M, Yano M, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Imoto K, Nishikawa T, Kim-Mitsuyama S, Takuwa Y, Araki E
The Journal of biological chemistry   280(8) 6627-6633   Feb 2005   [Refereed]
OHKAWARA Hiroshi, ISHIBASHI Toshiyuki, SAKAMOTO Takayuki, SUGIMOTO Koichi, NAGATA Kenji, YOKOYAMA Keiko, FUKUHARA Shigetomo, SUGIMOTO Naotoshi, TAKUWA Yoh
JOURNAL OF BIOLOGICAL CHEMISTRY   280(11) 10182-10188   2005
Nagasawa S., Takuwa N., Sugimoto N., Mabuchi H., Takuwa Y.
BIOCHEMICAL JOURNAL   385(Pt3) 737-744   2005   [Refereed]
Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H
Experimental cell research   301(2) 168-178   Dec 2004   [Refereed]
Yamada M, Banno Y, Takuwa Y, Koda M, Hara A, Nozawa Y
The Biochemical journal   378(Pt 2) 649-656   Mar 2004   [Refereed]
[Rho-Rho kinase pathway].
Takuwa Y
Nihon rinsho. Japanese journal of clinical medicine   62(1) 43-48   Jan 2004   [Refereed]
Sakurai K, Matsuo Y, Sudo T, Takuwa Y, Kimura S, Kasuya Y
Journal of receptor and signal transduction research   24(4) 283-296   2004   [Refereed]
USUI S, SUGIMOTO N, TAKUWA N, SAKAGAMI S, TAKATA S, KANEKO S, TAKUWA Y
JOURNAL OF BIOLOGICAL CHEMISTRY   279(13) 12300-12311   2004
Sakurada S, Takuwa N, Sugimoto N, Wang Y, Seto M, Sasaki Y, Takuwa Y
Circulation research   93(6) 548-556   Sep 2003   [Refereed]
Arikawa K, Takuwa N, Yamaguchi H, Sugimoto N, Kitayama J, Nagawa H, Takehara K, Takuwa Y
The Journal of biological chemistry   278(35) 32841-32851   Aug 2003   [Refereed]
Ishibashi T, Sakamoto T, Ohkawara H, Nagata K, Sugimoto K, Sakurada S, Sugimoto N, Watanabe A, Yokoyama K, Sakamoto N, Kurabayashi M, Takuwa Y, Maruyama Y
Arteriosclerosis, thrombosis, and vascular biology   23(4) 681-687   Apr 2003   [Refereed]
Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.
Shida D, Kitayama J, Yamaguchi H, Okaji Y, Tsuno NH, Watanabe T, Takuwa Y, Nagawa H
Cancer research   63(7) 1706-1711   Apr 2003   [Refereed]
Ito K, Shimomura E, Iwanaga T, Shiraishi M, Shindo K, Nakamura J, Nagumo H, Seto M, Sasaki Y, Takuwa Y
The Journal of physiology   546(Pt 3) 823-836   Feb 2003   [Refereed]
Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, Arai M, Tejima K, Nagashima K, Maekawa H, Yahagi N, Yatomi Y, Sakurada S, Takuwa Y, Ogata I, Kimura S, Fujiwara K
Gastroenterology   124(2) 459-469   Feb 2003   [Refereed]
Banno Y, Takuwa Y, Yamada M, Takuwa N, Ohguchi K, Hara A, Nozawa Y
The Biochemical journal   369(Pt 2) 363-368   Jan 2003   [Refereed]
Regulation of the Rho signaling pathway by excitatory agonists in vascular smooth muscle.
Takuwa Y
Advances in experimental medicine and biology   538 67-75; discussion 75   2003   [Refereed]
Ca2+-dependent activation of Rho kinase in menbrane depolasiztion-induced and receptor stimulation-induced voscilae smooth muslce contraction.
Criculation Research   93 548-546   2003
Yamaguchi H., Kitayama J., Takuwa N., Arikawa K., Inoki I., Takehara K., Nagawa H., Takuwa Y.
Biochem. J.   374 715-722   2003   [Refereed]
Arikawa K., Takuwa N., Yamaguchi H., Sugimoto N., Kitayama J., Nagawa H., Takehara K., Takuwa Y.
JOURNAL OF BIOLOGICAL CHEMISTRY   278 32841-32851   2003   [Refereed]
XU J, WANG F, VAN KEYMEULEN A, STRAIGHT A, KELLY K, TAKUWA Y, SUGIMOTO N, MITCHISON T, BOURNE H R
CELL   114(2) 201-214   2003
SUGIMOTO N, TAKUWA N, OKAMOTO H, SAKURADA S, TAKUWA Y
MOLECULAR AND CELLULAR BIOLOGY   23(5) 1534-1545   2003
Nagata K, Ishibashi T, Sakamoto T, Ohkawara H, Shindo J, Yokoyama K, Sugimoto K, Sakurada S, Takuwa Y, Nakamura S, Teramoto T, Maruyama Y
Atherosclerosis   163(1) 39-47   Jul 2002   [Refereed]
Ishibashi T, Nagata K, Ohkawara H, Sakamoto T, Yokoyama K, Shindo J, Sugimoto K, Sakurada S, Takuwa Y, Teramoto T, Maruyama Y
Biochimica et biophysica acta   1590(1-3) 123-130   Jun 2002   [Refereed]
The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.
Takuwa Y, Takuwa N, Sugimoto N
Journal of biochemistry   131(6) 767-771   Jun 2002   [Refereed]
Takuwa Y
Biochimica et biophysica acta   1582(1-3) 112-120   May 2002   [Refereed]
[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors].
Takuwa Y
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   47(4 Suppl) 496-502   Mar 2002   [Refereed]
Ryu Y, Takuwa N, Sugimoto N, Sakurada S, Usui S, Okamoto H, Matsui O, Takuwa Y
Circulation research   90(3) 325-332   Feb 2002   [Refereed]
Takami K, Takuwa N, Okazaki H, Kobayashi M, Ohtoshi T, Kawasaki S, Dohi M, Yamamoto K, Nakamura T, Tanaka M, Nakahara K, Takuwa Y, Takizawa H
American journal of respiratory cell and molecular biology   26(2) 231-238   Feb 2002   [Refereed]

Misc

 
細胞内小胞輸送制御を介して血管新生を促進するクラスII 型PI3キナーゼ
吉岡 和晃 吉田 耕太郎 多久和 典子 岡本 安雄 多久和 陽 
BIO Clinica    28(5) 22-28   2013
血管新生の基礎と臨床 Bio Clinica 
多久和 陽 
Bio Clinica    28(5) 16-17   2013
Takuwa Y, Sugimoto N, Takuwa N, Igarasi Y.
Sphingolipid Biology.   415-425   2006
Rho-Rho kinase pathway.
多久和 陽
日本臨床.   62(43) 48   2004
Structure and Function of Homo sapiens VII Hematology, Immunology and Endocrinology
Japan Medical New Publishing      2002
Functional roles of locally produced vasoactive substances in vascular responses to mechanical stress and injury.
Takuwa Y., Hamada K., Abe J., Chang K., Deguchi J., Takuwa N.
CVD Grand Round Series Vol. 3 (Ed. T. Asano, T. Hayakawa, T. Kirino, T. Ohta, K. Sano, T. Sasaki, K. Takakura and A. Tamura, Tokyo) Neuron Publishing Co., Ltd. Tokyo   4 93-105   1997
Regulation of Ca2+-dependent phosphorylation of 20-kDa myosin light chain by the small molecular weight G protein rho p21 in vascular smooth muscle cells.
Takuwa Y., Noda M., Yasuda C., Kumada M., Kurokawa K.
In Nakano,T. and Hartshorne, D. J. (eds.), Regulation of the contractile cycle in smooth muscle. Springer.   103-110   1995
The pathogenetic mechanism underlying cerebral vasospasm.
Asano T., Mastui T., Watanabe T., Koide T., Takuwa Y.
Cellular membrane a key to disease processes. (T. Ohnishi ed. CRC Press, Inc.)   209-240   1993
Cardiovascular significance of endothelin.
Masaki T., Yanagisawa M., Goto K., Kimura S., Takuwa Y.
Cardiovascular significance of endothelium-derived vasoactive factors. (G. M. Rubanyi ed. Future Publishing Co.)   65-81   1991
Cellular mechanism of vasoconstriction induced by endothelin.
Masaki T., Yanagisawa M., Takuwa Y., Kasuya K., Kimura S., Goto K.
The Biology and Medicine of Signal Transduction. (Y. Nishizuka ed. Raven Press)   425-428   1990
Messenger Ca2+, protein kinase C and smooth muscle contraction.
Rasmussen H., Haller H., Takuwa Y., Kelley G., Park S.
Frontiers in Smooth Muscle Research   89-106   1990
The protein kinase C-dependent contractile system participates in the occurrence of chronic vasospasm.
Matsui T., Takuwa Y., Yamashita K., Asano T.
Pharmacology of Cerebral Ischemia (J. Krieglstein, H. Oberpichler eds. Wissenschaftliche Verlagsgesellschaft)   145-149   1990
The cellular basis for short-term memory in endocrine systems.
Rasmussen H., Isales C., Takuwa Y., Takuwa N., Barrett P., Zawalich W.
Cellular mechanisms of conditioning and behavioral plasticity (D. Woody, D. L. Alkon and J. L. McGaugh ed. Plenum Publishing Corporation)   3-10   1988
Multiplicity of Ca2+ signal transduction pathways.
Rasmussen H., Barrett P., Apfeldorf W., Takuwa Y., Takuwa N., Smallwood J., Isales C., Bollag W., Stein P.
Calcium-dependent processes in the liver. (C. Heilmann ed. MTP Press Limited)   9-29   1987
A temporo-spatial model of Ca2+ messenger action.
Rasmussen H., Park S., Takuwa Y., Takuwa N., Apfeldorf W., Barrett P.
Calcium regulation and bone metabolism: basic and clinical aspects (D. V. Chon, T. J. Martin, P. J. Meunier ed. Elsevier Science Publishers B. V. )   9 159-166   1987
Inositol lipids: integration of cellular signalling systems.
Rasmussen H., Apfeldorf W., Barret P., Takuwa N., Zawalich W., Kreutter D., Park S., Takuwa Y.
In: Phosphoinositides a.nd Receptor Mechanisms (Alan R. Liss, Inc.)   109-147   1986
Association of paravertebral ligamentous ossification with hypoparathyroidism.
Matsumoto T., Takuwa Y., Okazaki T., Hoshino Y., Iizuka M., Kurokawa T., Hata K., Ogata E.
Endocrine control of bone and calcium metabolism. (In D. V. Cohn, T. Fujita, J. T. Potts Jr, R. V. Talmage) Elsevier Scienc B.V.,   26-31   1984

Books etc

 
多久和 典子, 多久和 陽
多久和典子   1999   

Conference Activities & Talks

 
Sequential phosphoinositide conversion is required for transforming growth factor β-induced receptor endocytosis and Smad2/3 activation in endothelial cells
Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa
60th International Conference on the Bioscience of Lipids   17 Jun 2019   
Differential roles of class II PI3K in endocytosis and endosomal signaling
Kazuaki Yoshioka, Khin Thuzar Aun1, Md Azadul Kabir Sarker, Sho Aki1, Kuntal Biswas, Noriko Takuwa, Yoh Takuwa
60th International Conference on the Bioscience of Lipids   17 Jun 2019   
S1P2 aggravates lung fibrosis through altering alveolar macrophage. polarization in mice
Yasuo Okamoto, Juanjuan Zhao, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Noriko Takuwa, Yoh Takuwa
the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)   28 Mar 2019   
Sequential phosphoinositide conversion is required for TGFβ– induced receptor endocytosis in ECs.
Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa
the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)    28 Mar 2019   
Essential role of class II PI3K in endocytosis and endosomal signaling.
Kazuaki Yoshioka, Khin Thuzar Aung, Md Azadul Kabir Sarker, Sho Aki, Kuntal Biswas, Noriko Takuwa, Yoh Takuwa
the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)  Dynamics of membrane trafficking and intracellular signaling Symposium   28 Mar 2019   
Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor
Azadul Kabir Sarker, Sho Aki, Kazuaki Yoshioka, Koji Kuno, Kazuhiro Ishimaru Noriko Takuwa, Yoh Takuwa
3 Jun 2018   
Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells 
Pham Quynh Hoa, Yoshioka Kazuaki, Azadul Sarker Kabir, Aung Thuzar Khin, Islam Shahidul, Aki Sho, Ishimaru Kazuhiro, Takuwa Noriko, Takuwa Yoh
第 95 回日本生理学会大会    28 Mar 2018   
Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor 
Yoh Takuwa Juanjuan Zhao, Yasuo, Okamoto, Kazuaki Yoshioka and Noriko Takuwa.
第 95 回日本生理学会大会    28 Mar 2018   
Class II phosphoinositide 3-kinase isoforms PI3K-C2αand PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells 
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa 
第 95 回日本生理学会大会    28 Mar 2018   
抗がん剤による臓器障害におけるスフィンゴシン-1-リン酸(S1P)情報伝達系の関与 
Yoh Takuwa
第27回日本病態生理学会大会    7 Dec 2017   
Myotubularin?related protein 4 (MTMR4), a phosphoinositide 3'? speci?c phosphatase, regulates endolysosome integrity and autophagy ?ux in A549 human lung carcinoma cells 
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Sho Aki, JuanJuan Zhao, Hoa Quynh Pham, Md. Azadul Kabir Sarker, Saori Koizumi, Yoh Takuwa
第40回日本分子生物学会年会    7 Dec 2017   
Phosphoinositide-specific 3'-phosphatase, myotubularin-related protein 4 (MTMR4), regulates lysosomal activity and autophagy 
Pham Quynh Hoa, Kazuaki Yoshioka, Sato Nakamura, MD Azadul Kabir Sarker, Khin Thuzar Aung, Shahidul Islam, Sho Aki, Noriko Takuwa and Yoh Takuwa 
第94回日本生理学会大会    28 Mar 2017   
Phosphotidylinositol 3-kinase Class II isoforms, PI3K-C2a and PI3K-C2b are necessary for Pinocytosis in Endothelial Cells 
Khin Thuzar Aung, Sho Aki, Kazuaki Yoshioka, Pham Hoa Quynh , MD Azadul Kabir Sarker, Islam Shahidul, Noriko Takuwa, Yoh Takuwa. 
第94回日本生理学会大会    28 Mar 2017   
Endothelial Class II PI3K-C2α is Necessary for Vasucular Formation and Integrity through Regulating Endocytic Membrane Trafficking Topic 3 「Endothelium, Health and Diseases」
Yoh Takuwa, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa
第81回日本循環器学会学術集会    17 Mar 2017   
Phosphatidylinositol 3-kinase class II α?isoform PI3K-C2α is required for transforming growth factor β-induced receptor endocytosis and endosomal signaling in endothelial cells 
Yasuo Okamoto, Cui Hong, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
第39回日本分子生物学会年会    30 Nov 2016   
S1P2, A Receptor for the Lysophospholipid Mediator Sphingosine 1-phosphate, Protects Against Vascular Barrier Disruption
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
International Shock Congress Symposium "Microcirculation and endothelial damage in sepsis and shock"     3 Oct 2016   
S1P2 による血管新生と血管障壁機能の制御 
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Juanjuan Zhao, Yoh Takuwa
第58回 日本脂質生化学会 シンポジウム:リゾリン脂質による血管新生制御   9 Jun 2016   
Phosphatidylinositol 3-kinase class IIαisoform PI3K-C2α is required for transforming growth factor β-induced receptor endocytosis and endosomal signaling in endothelial cells  [Invited]
Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa and Yoh Takuwa 
第2回春期特別日本血管生物医学会シンポジウム    3 Jun 2016   
Sphingosine 1-phospahte (S1P) receptor-2 (S1P2) aggravates lung fibrosis through altering alveolar macrophage polarization and cellular senescence in mice  
JuanJuan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa, Takashi Wada, Yutaka Inagaki, Chiaki Takahashi,Yoh Takuwa
日本生化学会北陸支部第34回大会    28 May 2016   
PI3K-C2α is required for TGFβ-induced receptor endocytosis and endosomal signaling inendothelial cells  [Invited]
Aki Sho, Yoshioka Kazuaki, Okamoto Yasuo, Takuwa Noriko, Takuwa Yoh 
第93回日本生理学会 シンポジウム:血管形成と分化を制御するシグナル機構   22 Mar 2016   
The announcement title: Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P2) inhibitslung fibrosis throughaltering alveolar macrophage polarization and senescence in mice 
Juanjuan Zhao, Yasuo Okamoto, Yoh Takuwa. 
Gorden research conference “Glycolipid and Sphingolipid Biology”   6 Mar 2016   
ClassII PI3-kinase, PI3K-C2alpha, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation
Yoh Takuwa
Gordon Reseach Conference Vascular Cell Biology   27 Jan 2016   
Endothelial PI3K-C2a, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.
Yoshioka K, Yoshida K, Biswas K, Takuwa Y, et al.
Gordon Reseach Conference Vascular Cell Biology   27 Jan 2016   
Endothelial PI3K-C2a, a class II PI3K in angiogenesis and vascular barrier function [Invited]
Yoh Takuwa
Gordon Reseach Conference Vascular Cell Biology   27 Jan 2016   
Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P-2-) inhibits lung fibrosis through altering alveolar macrophage polarization and senescence in mice.
Yoh Takuwa
BMB2015(第38回日本分子生物学会・第88回日本生化学会)   1 Dec 2015   
クラス II PI3-キナーゼ PI3K-C2αはエンドソーム上でのTGFβ/Smad2/3シグナリングに必須である 
Yoh Takuwa 
第62回 中部日本生理学会    13 Nov 2015   
Role of S1P2 in inflammation and fibrosis  [Invited]
Yoh Takuwa Juanjuan Zhao, Yasuo, Okamoto, Kazuaki Yoshioka and Noriko Takuwa.
14 th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases Plenary Lecture    12 Jul 2015   
Sphingosine 1-phosphate receptor-2 plays a protective role against anaphylaxis and acute lung injury
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa 
第10回スフィンゴテラピィ(STC)研究会    16 Jun 2015   
Sphingosine 1-phosphate receptor-2 plays a protective role against lipopolysaccharide (LPS)-induced acute lung injury 
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Sho Aki, JuanJuan Zhao, Hoa Quynh Pham, Md. Azadul Kabir Sarker, Saori Koizumi, Yoh Takuwa
第92回日本生理学会大会   21 Mar 2015   
Essential role of PI3K class II α for endosomal signaling of S1P1 and other receptors [Invited]
Yoh Takuwa
6th international conference on Phospholipase A2 and Lipid Mediators   10 Feb 2015   
クラスII 型PI3 キナーゼ-C2α によるTGFβ 血管内皮作用の調節機構 
Yoshioka K, Yoshida K, Biswas K, Takuwa Y, et al.
第61回中部日本生理学会    6 Nov 2014   
クラスIIα型PI3K-C2αはALK5 内在化及び足場タンパクSARA のエンドソームへの動員を制御しTGF?1-Smad2/3 を介した血管新生を調節する 
Kuntal Biswas, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa and Yoh Takuwa
第56回 日本脂質生化学会    6 Jun 2014   
Sphingosine-1-phosphate receptor-2 (S1P2) negatively regulates eNOS and protects against acute vascular barrier disruption
Yasuo Okamoto, Cui Hong, Kazuaki Yoshioka, Noriko Takuwa, Toshishige Shibamoto, Yoh Takuwa
The 18th International Vascular Biology Meeting 2014 (IVBM 2014)   14 Apr 2014   
Distinct role of S1P2 in the functional regulation of vascular endothelium and smooth muscle [Invited]
Kuntal Biswas, 吉岡 和晃, 岡本 安雄, 多久和 典子, 多久和 陽 
The 18th International Vascular Biology Meeting 2014 (IVBM 2014)   14 Apr 2014   
Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through inhibiting eNOS 
Yasuo Okamoto, Hong Cui, Kazuaki Yoshioka, Noriko Takuwa, Juanjuan Zhao, Yoh Takuwa
第91回日本生理学会大会 Symposium “Mechanisms on distributive shock and other blood pressure control failures”   15 Mar 2014   
クラスII 型PI3K-C2αはメンブレン・トラフィック調節を介して血管バリア機能を制御する  [Invited]
Kazuaki Yoshioka, Kotaro Yoshida, Noriko Takuwa, Yasuo Okamoto,Yoh Takuwa
第91回日本生理学会大会 シンポジウム「心血管系の形態・機能研究の最前線」   15 Mar 2014   
クラスII 型PI3K-C2αはSARA のエンドソームへの動員を制御しTGF?1-Smad2/3シグナル伝達系を介した血管新生を調節する 
Kazuaki Yoshioka, Noriko Takuwa, Yasuo Okamoto, Yoh Takuwa
第36回日本分子生物学会    3 Dec 2013   
S1P受容体はeNOS-NO経路を抑制することによりアナフラキシーショックに対して抑制的に働く 
Yoh Takuwa
第21回日本血管生物医学会    26 Sep 2013   
Sphingosine-1-phosphate receptor-2 negatively regulates eNOS and protects against acute vascular barrier disruption. [Invited]
Kuntal Biswas、吉岡和晃、多久和典子、岡本安雄、多久和陽 
2013FASEB Summer Research Conference “Lysophospholipid and Other Related Mediators - From Bench to Clinic”    4 Aug 2013   
Phosphatidylinositol 3-kinase class? α-isoform contols vesicular trafficking in endothelial cells to serve the essential role in angiogenesis and vascular barrier integrity  [Invited]
Yoh Takuwa 
第45回動脈硬化学会    18 Jul 2013   
S1P2は内皮型一酸化窒素合成酵素を抑制することによりアナフラキシーショックに対して防御的に働く 
Yasuo Okamoto, Xun Qi, Wa Du, Noriko Takuwa, kazuaki Yoshioka, Yoh Takuwa
第55回日本脂質生化学会    6 Jun 2013   
スフィンゴシン1-リン酸特異的2 型受容体は内皮型一酸化窒素合成酵素を抑制することによりアナフィラキシーショックに対して保護的に働く 
Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Xun Qi, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Kazushi Sugihara, Sho Aki, Kuntal Biswas, Masahide Asano, Yoh Takuwa.
第90回日本生理学会    27 Mar 2013   
クラスII 型PI3 キナーゼC2α はエンドソーム上でのS1P によるRac1 活性化を制御して内皮細胞遊走を調節する 
Yoh Takuwa, Noriko Takuwa, Seiichiro Ohkura, Shin-ichiro Takashima, Soichiro Usui, Shuichi Kaneko, Yasuo Okamoto, Kazuaki Yoshioka
第90回日本生理学会    27 Mar 2013   
クラスII型PI3キナーゼC2αはメンブレン・トラフィッキング調節を介する血管形成及び恒常性維持に必須である 第90回日本生理学会 シンポジウム「細胞膜と細胞内膜における脂質制御とその生理機能」 [Invited]
吉岡和晃、多久和典子、岡本安雄、多久和陽 
The 90th Annual Meeting of the Physiological Society of Japan Symposium “Physiological function of lipid dynamics in plasma and endo membrane”   27 Mar 2013   
Class II PI3 kinase C2α has a crucial role in vascular formation and barrier integrity 
Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, and Yoh Takuwa 
第20回日本血管生物医学会    5 Dec 2012   
Class II PI3K-C2α is essential for vascular barrier integrity
Kazuaki Yoshioka, Noriko Takuwa, Yasuo Okamoto, Yoh Takuwa
International Endotoxin and Innate Immunity Society Meeting 2012 JST-CREST International Symposium"Frontiers in Immunology & Inflammation: From Molecules to Disease"    16 Nov 2012   
Essential role of class IIα-isoform PI3 kinase (PI3K-C2α) in sphingosine-1-phosphate(S1P-induced endothelial cell migration
多久和 陽 
第7回 スフィンゴテラピィ研究会    13 Jul 2012   
Role of sphingosine-1-phosphate in cardiac remodeling and protection [Invited]
Yoh Takuwa
The 1st International Symposium on Lipid Mediators   6 Jun 2012   
クラスII型PI3キナーゼC2αノックアウトマウスにおける血管障壁機能の異常  [Invited]
Yoshioka, Kazuaki Yoshida, Kotaro Cui, Hong Aki, Sho;Biswas, Kuntal Zhao, JuanJuan Takuwa, Noriko Okamoto, Yasuo Takuwa, Yoh
第89回日本生理学会大会    29 Mar 2012   
スフィンゴシン−1−リン酸による血管内皮細胞遊走におけるクラスII 型PI3 キナーゼC2α の役割 
Biswas, Kuntal Yoshioka, Kazuaki Takuwa, Noriko Okamoto, Yasuo Takuwa, Yoh
第89回日本生理学会大会    29 Mar 2012   
Function role of sphingosine-1-phosphate signaling in angiogenesis. [Invited]
Yasuo Okamoto, Xun Qi, Wa Du, Noriko Takuwa, kazuaki Yoshioka, Yoh Takuwa
The 1st Asia-Pacific Vascular Biology Meeting/   8 Dec 2011   
Role of Lysophospholipid Mediator Sphingosine-1-phosphate in Cardiac Fibrosis  [Invited]
Yoh Takuwa, Noriko Takuwa, Seiichiro Ohkura, Shin-ichiro Takashima, Soichiro Usui, Shuichi Kaneko, Yasuo Okamoto, Kazuaki Yoshioka
1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration /   2 Jun 2011   
Endothelial class II PI3K-Ca2a has an essential role for physiological and pathological angiogenesis.
Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Xun Qi, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Kazushi Sugihara, Sho Aki, Kuntal Biswas, Masahide Asano, Yoh Takuwa.
日本分子生物学会第11回春季シンポジウム    25 May 2011   
Proatherogenic activity of sphingosine-1- phosphate receptor-2.  [Invited]
多久和 陽 
第75回日本循環器学会    18 Mar 2011   
A novel Ca2+ - and phosphoinositide 3-kinase- depend mechanism for myosin phosphatase inhibition and Ca2+ -sensitization in vascular smooth muscle. [Invited]
Yoh Takuwa
Winter work shop   25 Jan 2011   
Sphingosine-1-phosphate receptor-2 inhibits tumor angiogenesis and tumor growth in vivo in mice 
Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, and Yoh Takuwa 
Keystone Symposia Bioactive Lipids: Biochemistry and Diseases   6 Jun 2010   
Signaling of vascular smooth muscle contraction. [Invited]
多久和 陽、岡本 安雄、吉岡 和晃、多久和 典子
第1回国際バイオレオロジーシンポジウム    1 Jun 2010   
サイクリックAMPによる血管平滑筋Ca2+-PI3KC2α- Rho経路の調節 
多久和 陽、モハメド アリ アザム、吉岡 和晃、多久和 典子、杉 本 直俊 佐藤 晃一 
筋生理の集い    Dec 2006   
カルシウムイオンによるRac,Racキナーゼ依存的なミオシン軽鎖ホスファターゼの抑制-PI3キナーゼ・クラスIIaの関与 
吉岡 和晃、Mohammed Ali Azam,多久和 典子、杉本 直俊、Wang Yu,多久和 陽 
第16回日本循環薬理学会    Nov 2006   
Negative regulation of myosin phosphatase by Ca2+ in vascular smooth muscle: involvement of the novel Rho regulator phosphoinositide 3-kinase class IIa isoform. [Invited]
Y. Takuwa, K. Yoshioka, M.A. Azam, N. Takuwa and N. Sugimoto:
Federation of Asian and Oceanian Physiolgical Scientists 2006. Symposium “ Regulation of vascular tone”.   15 Oct 2006   
Receptor and Calcium Coupling to Myosin Light Chain Phosphatase [Invited]
Yoh Takuwa,
2006 FASEB Summer Research Conferences Smooth Muscle    Jul 2006   
Age-dependent progression of cardiac fibrosis but not spontaneous malignancy in sphingosine kinase 1 transgenic mice
Noriko Takuwa, Sei-Ichiro Ohkura, Shin-Ichiro Takashima, Wa Du1, Osamu Oyama, Naotoshi Sugimoto, Motoko Sasaki, Yoshiko Banno, Kunitoshi Mitsumori, Tamotsu Tanaka, Kaoru Hirano, Kiyoshi Satouchi, Yasuni Nakanuma, Yoh Takuwa
第79回日本生化学会大会   6 Jun 2006   
スフィンゴシン-1-リン酸受容体1(S1P1)トランスジェニックマウスにおける病的肥大心の発症と病態生理 
大倉 誓一郎、多久和 典子、高島 伸一郎、杉本 直俊、多久和 陽 
第48回日本脂質生化学会    Jun 2006   
S1P受容体S1P2による細胞遊走抑制はがん抑制遺伝子産物PTENに依存しない
杉本 直俊、多久和 典子、多久和 陽 
第48回日本脂質生化学会    Jun 2006   
PI3キナーゼ・クラスIIαはRho活性化を介してカルシウム依存性血管平滑筋収縮を制御する  
吉岡 和晃、Wang Yu、Azam Mohammed Ali、宮澤 秀和、多久和 典子、杉本 直俊、多久和 陽 
第48回日本脂質生化学会    Jun 2006   
Identification of class II phosphoinositide 3-kinase α-isoform as a regulator of myosin phosphatase and contraction in vascular smooth muscle cells 
Kazuaki Yoshioka, Noriko Takuwa, Naotoshi Sugimoto, Mohammed Ali Azam, Takaharu Kimura, Yoh Takuwa 
第79回日本生化学会大会   Jun 2006   
Topical administration of sphingosine-1-phosphate (S1P) stimulates ischemia-induced angiogenesis in the mouse limb. 
Xun Qi, Naotoshi Sugimoto, Noriko Takuwa, Osamu Oyama, Fei Wang, Yoh Takuwa 
第84回日本生理学会大会    Jun 2006   
Phosphoinositide 3-kinase regulates Rho, myosin phosphatase and contraction in vascular smooth muscle
Yoh Takuwa, Yu Wang, Kazuaki Yoshioka, Mohammed Ali Azam, Noriko Takuwa, Sotaro Sakurada, Naotoshi Sugimoto, Isao Inoki, Yuji Kayaba, Tomoyuki Kuwaki
79回日本生化学会大会、   Jun 2006   
Forskolin inhibits membrane depolarization-induced Rho activation and contraction through inhibition of PI3K-C2α in Vascular Smooth Muscle.
Mohammed Ali Azam, Kazuaki Yoshioka, Noriko Takuwa, Naotoshi Sugimoto, Yoh Takuwa
第79回日本生化学会大会   Jun 2006   
Development of decompensated cardiac hypertrophy with fibrosis in transgenic mice that overexpress S1P1 under the control of a smooth muscle actin promoter
Sei-Ichiro Ohkura, Shin-Ichiro Takashima, Naotoshi Sugimoto, Noriko Takuwa, Motoko Sasaki, Kunitoshi Mitsumori, Masayuki Takamura, Shigeo Shigeo Takata, Shuh-ichi Kaneko, Yasuni Nakanuma, Yoh Takuwa
第79回日本生化学会大会   Jun 2006   
Regulation of Akt activation and cell migration by Lysophosphatidic acid (LPA)
Naotoshi Sugimoto, Noriko Takuwa, Yoh Takuwa
第79回日本生化学会大会   Jun 2006   
Sphingosine-1-phosphate negatively regulates endothelial morphogenesis and angiogenesis via its receptor S1P2
Isao Inoki, Noriko Takuwa, Naotoshi Sugimoto, Kazuaki Yoshioka, Yoh Takuwa
第79回日本生化学会大会   Jun 2006   
血管平滑筋におけるカルシウム依存的Rho活性化を制御するシグナル分子PIK-C2αの同定 
多久和 陽、吉岡 和晃、王 ?、Mohammed Ali Azam、多久和 典子、杉本 直俊 
第83回 日本生理学会    Mar 2006   
スフィンゴシン-1-リン酸 産生酵素 スフィンゴシン キナーゼ1 トランスジェニックマウスにおける心筋線維化発症とその分子機構 
多久和典子、大倉 誓一郎、尾山 治、高島 伸一郎、杉本 直俊、多久和 陽 
第83回 日本生理学会    Mar 2006   
PI3K-C2αは血管平滑筋細胞のイオノマイシンによるCa2+依存的Rho活性化と収縮に必須である。 
吉岡 和晃、アザム モハメド アリ、宮澤 秀和、多久和 典子、杉本 直俊、多久和 陽 
第83回 日本生理学会    Mar 2006   
リゾホスファチジン酸受容体LPA1による細胞遊走の抑制は、ROCKを介したPI3キナーゼ産物レベルの抑制には依存しない 
杉本 直俊、多久和 典子、多久和 陽 
第83回 日本生理学会    Mar 2006   
スフィンゴシン-1-リン酸はマウス下肢における虚血応答性血管新生を促進する 
尾山 治、多久和 典子、杉本 直俊、小泉 順二、多久和 陽
第83回日本生理学会     Mar 2006   
生理活性脂質スフィンゴシン-1-リン酸(S1P)による受容体サブタイプ特異的な細胞遊走・浸潤制御の分子機構 
多久和 陽、杉本 直俊、多久和 典子 
第28回日本分子生物学会年会    Dec 2005   
Noriko Takuwa, Seiichiroh Ohkura, Osamu Oyama, Shin-Ichiro Takashima, Naotoshi Sugimoto, Yoh Takuwa 
Development of cardiac fibrosis in sphingosine kinase 1 (SPHK1) transgenic mice:
第78回日本生化学会    Oct 2005   
Osamu Oyama, Noriko Takuwa, Naotoshi Sugimoto, Junji Koizumi, Yoh Takuwa 
S1P accelerates ischemia-induced angiogenesis in the mouse limb:
第78回日本生化学会    Oct 2005   
Naotoshi Sugimoto, Noriko Takuwa, Yoh Takuwa 
Lysophosphatidic acid (LPA)-induced cell migration inhibition is not dependent on ROCK-mediated reduction in PI3-kinase (PI3K) products:
第78回日本生化学会    Oct 2005   
Kazuaki Yoshioka, Yu Wang, Mohammed Ali Azam, Noriko Takuwa, Soutaro Sakurada, Yuji Kayaba, Naotoshi Sugimoto, Isao Inoki, Takaharu Kimura, Tomoyuki Kuwaki, Yoh Takuwa 
Phosphoinositide 3-kinase class IIα regulates vascular smooth muscle contraction through Rho/Rho kinase and myosin phosphatase:
第78回日本生化学会    Oct 2005   
Mohammed Ali Azam, Kazuaki Yoshioka, Yu Wang, Noriko Takuwa, Naotoshi Sugimoto, Yoh Takuwa 
Forskolin inhibition of membrane depolarization-induced vascular smooth muscle contraction involves suppression of Ca2+-dependent Rho activation and myosin phosphatase inhibition:
第78回日本生化学会    Oct 2005   
Positive and negative regulation of cell motility by the blood lysophospholipid mediator sphingosine-1-phosphate and its pathophysiological implications
Yoh Takuwa, Nagatoshi Sugimoto, Noriko Takuwa, Hironori Yamaguchi, Kayo Arikawa, So-ichiro Usui and Osamu Oyama.
中国医科大―金沢大学合同シンポジウム    Oct 2005   
S1P・Edgシステムの心血管病態生理における意義 
多久和 陽
第9回分子心血管会議    Aug 2005   
PI3キナーゼC2αアイソフォームは血管平滑筋収縮を制御する新規収縮シグナル伝達分子である 
吉岡 和晃、王 煌、モハメドアリ アザム、多久和 典子、杉本 直俊、桜田 惣太郎、多久和 陽 
第47回日本脂質生化学会    Jun 2005   
リゾフォスファチジン酸受容体LPA1による低分子量Rac 及び細胞遊走の制御 
杉本 直俊、多久和 典子、多久和 陽
第47回日本脂質生化学会    Jun 2005   
スフィンゴシン キナーゼ (SphK)1トランスジェニックマウスにおける心筋線維化発症とその病態生理の検討 
多久和 典子、杉本 直俊、高島 伸一郎、尾山 治、大倉 誠一郎、多久和 陽
第47回日本脂質生化学会    Jun 2005   
スフィンゴシンー1?リン酸情報伝達系の虚血後血管新生における役割の検討 
尾山 治、多久和 典子、杉本 直俊、多久和 陽
第47回日本脂質生化学会    Jun 2005   
cAMPは血管平滑筋における膜脱分極誘発カルシウム依存性Rho活性化及びミオシン脱リン酸化酵素抑制を阻害する 
Azam, Mohammed Ali ,吉岡 和晃,Wang, Y.,多久和 典子,杉本 直俊,多久和 陽 
第82回日本生理学会大会    May 2005   
リゾフォスファチジン酸受容体LPA1によるRac及び細胞遊走の促進及び抑制性の二重制御 
杉本 直俊,多久和 典子,多久和 陽 
第82回日本生理学会大会    May 2005   
スフィンゴシンー1−リン酸はEdg5受容体を介して血管内皮細胞の形態形成および血管新生を抑制する 
居軒 功,多久和 典子,杉本 直俊,吉岡 和晃,阪上 学,高田 重男,多久和 陽 
第82回日本生理学会大会    May 2005   
S1P2受容体を介したB16メラノーマ細胞の制御 
多久和 典子,杉本 直俊,尾山 治,多久和 陽 
第82回日本生理学会大会    May 2005   
Lysophosphatidic acid (LPA) receptor LPA1/Edg2 generates both the stimulatory and inhibitory signals for Rac and cell migration.
Sugimoto. N, Takuwa. N, Takuwa. Y.
International Union of Physiological Sciences 2005.   Apr 2005   
Ca2+ regulation of smooth muscle myosin phosphatase and Ca2+ sensitization. International
Y. Takuwa, K. Yoshioka, Y. Wang, M.A. Azam, N. Takuwa and N. Sugimoto:
Union of Physiological Sciences 2005. Symposium “Emerging modes of Ca2+ signaling in the regulation of smooth muscle contractile proteins.   31 Mar 2005   
Sphingosine-1-phosphate G protein-coupled receptor subtype-specific, ligand-dependent bidirectional regulation of B16 melanoma cell migration, invasion, metastasis and tumor formation.
Takuwa. N, Arikawa. K, Yamaguchi. H Sugimoto. N Takuwa. Y.
31 Mar 2005   International Union of Physiological Sciences
平滑筋収縮制御におけるRhoの役割 
多久和 陽 
Symposium on “Mysteries about the sliding filament mechanism: fifty years after its proposal”    7 Mar 2005   
Koichi Sugimoto,Toshiyuki Ishibashi,Takayuki Sakamoto,Hiroshi Ohkawara,Nobuo Sakamoto,Masashi Kamioka,keiko Yokoyama,Tamio Teramoto,Yo Takuwa,Yukio Maruyama 
Inhibition of Matrix Metalloproteases (MMPs) Suppresses Rac/NADPH Oxidase-derived Reactive Oxygen Species (ROS) Generation in Oxidized Low Density Lipoprotein-stimuleted Endothelial Cells 
第69回日本循環器学会    Mar 2005   
Koichi Sugimoto,Toshiyuki Ishibashi, Takayuki Sakamoto, Hiroshi Ohkawara ,Nobuo Sakamoto ,Keiko Yokoyama ,Masashi Kamioka ,Tamio Teramoto ,Yo Takuwa, Yukio Maruyama
Membrane type 1 Metalloproteinase (MT1-MMP) is Involved in the RhoA-dependent eNOS Downergulation Induced by Oxidized LDL in Endothelial Cells 
第69回日本循環器学会    Mar 2005   
Masashi Kamioka, Toshiyuki Ishibashi, Hiroshi Ohkawara, Koichi Sugimoto, Nobuo Sakamoto, Tamio Teramoto, Yo Takuwa, Yukio Maruyama,
Blockade of Renin-angiotensin System (RAS) Inhibits Oxidized LDL-induced Superoxide Generation by Suppressing NADPH Oxidase Component Nox-4 , p47phox and Rac
第69回日本循環器学会    Mar 2005   

Works

 
a
2006

Research Grants & Projects

 
Studies of the physiological and pathological roles of the lipid mediator sphingosine-1-phosphate
Project Year:  - 1998
Studies of the physiological and pathological roles of the lipid kinase PI3-kinase
Project Year: 2005   
Mechanism of vascular smooth muscle contraction
Basic Research Promotion Service for Health and Medical Field
Project Year: 1985   

Patents

 
4117379号