論文

国際誌
2021年1月19日

Abnormal social behavior and altered gene expression in mice lacking NDRG2.

Neuroscience letters
  • Mika Takarada-Iemata
  • ,
  • Toru Yoshihara
  • ,
  • Nahoko Okitani
  • ,
  • Keiko Iwata
  • ,
  • Tsuyoshi Hattori
  • ,
  • Hiroshi Ishii
  • ,
  • Jureepon Roboon
  • ,
  • Dinh Thi Nguyen
  • ,
  • Qiyan Fan
  • ,
  • Takashi Tamatani
  • ,
  • Takumi Nishiuchi
  • ,
  • Masahide Asano
  • ,
  • Osamu Hori

743
開始ページ
135563
終了ページ
135563
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.neulet.2020.135563

N-myc downstream-regulated gene 2 (NDRG2), a member of the NDRG family, has multiple functions in cell proliferation, differentiation, and stress responses, and is predominantly expressed by astrocytes in the central nervous system. Previous studies including ours demonstrated that NDRG2 is involved in various central nervous system pathologies. However, the significance of NDRG2 in neurodevelopment is not fully understood. Here, we investigated the expression profile of NDRG2 during postnatal brain development, the role of NDRG2 in social behavior, and transcriptome changes in the brain of NDRG2-deficient mice. NDRG2 expression in the brain increased over time from postnatal day 1 to adulthood. Deletion of NDRG2 resulted in abnormal social behavior, as indicated by reduced exploratory activity toward a novel mouse in a three-chamber social interaction test. Microarray analysis identified genes differentially expressed in the NDRG2-deficient brain, and upregulated gene expression of Bmp4 and Per2 was confirmed by quantitative PCR analysis. Expression of both these genes and the encoded proteins increased over time during postnatal brain development, similar to NDRG2. Gene expression of Bmp4 and Per2 was upregulated in cultured astrocytes isolated from NDRG2-deficient mice. These results suggest that NDRG2 contributes to brain development required for proper social behavior by modulating gene expression in astrocytes.

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2020.135563
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33359046
ID情報
  • DOI : 10.1016/j.neulet.2020.135563
  • PubMed ID : 33359046

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