Osamu Hori

Profile Information

Affiliation: Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University

Degree: 博士(医学)(大阪大学)

J-GLOBAL ID: 200901057287094744
researchmap Member ID: 1000287595

External link: http://med03.w3.kanazawa-u.ac.jp/index.html

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Education

- 1989

Medical School, Faculty of Medicine, Osaka University
- 1989

Faculty of Medicine, Osaka University

Papers

125

Macrophage depletion attenuates degeneration of spiral ganglion neurons in kanamycin-induced unilateral hearing loss model.

Mari Dias Shimada, Masao Noda, Ryota Koshu, Yuji Takaso, Hisashi Sugimoto, Makoto Ito, Tomokazu Yoshizaki, Osamu Hori

Scientific reports, 13(1) 16741-16741, Oct 5, 2023
Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory.

Tsuyoshi Hattori, Stanislav M Cherepanov, Ryo Sakaga, Jureepon Roboon, Dinh Thi Nguyen, Hiroshi Ishii, Mika Takarada-Iemata, Takumi Nishiuchi, Takayuki Kannon, Kazuyoshi Hosomichi …

The EMBO journal, 42(15) e111247, Jun 26, 2023
Neuroprotective role of calreticulin after spinal cord injury in mice

Anastasiia Melnikova, Hiroshi Ishii, Takashi Tamatani, Tsuyoshi Hattori, Mika Takarada-Iemata, Osamu Hori

Neuroscience Research, Jun, 2023
Sympathetic Nervous Hyperactivity Impairs Microcirculation Leading to Early Brain Injury After Subarachnoid Hemorrhage

Munehiro Demura, Hiroshi Ishii, Mika Takarada-Iemata, Tomoya Kamide, Akifumi Yoshikawa, Mitsutoshi Nakada, Osamu Hori

Stroke, May 8, 2023
ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions

Takashi Tanaka, Dinh Thi Nguyen, Nichakarn Kwankaew, Megumi Sumizono, Reika Shinoda, Hiroshi Ishii, Mika Takarada-Iemata, Tsuyoshi Hattori, Seiichi Oyadomari, Nobuo Kato …

Neurochemical Research, Feb 28, 2023
Brain injury triggers cell‐type‐specific and time‐dependent endoplasmic reticulum stress responses

Qiyan Fan, Mika Takarada‐Iemata, Nahoko Okitani, Takashi Tamatani, Hiroshi Ishii, Tsuyoshi Hattori, Sumiko Kiryu‐Seo, Hiroshi Kiyama, Osamu Hori

Glia, Nov 22, 2022
Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes

Jureepon Roboon, Tsuyoshi Hattori, Dinh Thi Nguyen, Hiroshi Ishii, Mika Takarada-Iemata, Takayuki Kannon, Kazuyoshi Hosomichi, Takashi Maejima, Kengo Saito, Yohei Shinmyo …

Frontiers in Cellular Neuroscience, 16, Oct 6, 2022
Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Haruhiro Higashida, Kazumi Furuhara, Olga Lopatina, Maria Gerasimenko, Osamu Hori, Tsuyoshi Hattori, Yasuhiko Hayashi, Stanislav M. Cherepanov, Anna A. Shabalova, Alla B. Salmina …

Frontiers in Neuroscience, 16, Jul 7, 2022
Localized astrogenesis regulates gyrification of the cerebral cortex.

Yohei Shinmyo, Kengo Saito, Toshihide Hamabe-Horiike, Narufumi Kameya, Akitaka Ando, Kanji Kawasaki, Tung Anh Dinh Duong, Masataka Sakashita, Jureepon Roboon, Tsuyoshi Hattori …

Science Advances, 8(10) eabi5209, Mar 11, 2022 Peer-reviewed
A Fiber Dissection Study of the Anterior Commissure: Correlations with Diffusion Spectrum Imaging Tractography and Clinical Relevance in Gliomas.

Xiaoliang Liu, Masashi Kinoshita, Harumichi Shinohara, Osamu Hori, Noriyuki Ozaki, Mitsutoshi Nakada

Brain topography, 35(2) 232-240, Mar, 2022
Astroglial CD38 regulates social memory and synapse formation through SPARCL1 in the medial prefrontal cortex

Hattori T, Cherepanov SM, Sakaga R, Roboon J, Nguyen DT, Ishii H, Takarada-Iemata M, Nishiuchi T, Kannon T, Hosomichi K …

Dec, 2021
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD.

Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada-Iemata, Dinh Thi Nguyen, Collin D Heer, Denis O'Meally, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto …

Journal of neurochemistry, 158(2) 311-327, Jul, 2021
The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.

Dinh Thi Nguyen, Thuong Manh Le, Tsuyoshi Hattori, Mika Takarada-Iemata, Hiroshi Ishii, Jureepon Roboon, Takashi Tamatani, Takayuki Kannon, Kazuyoshi Hosomichi, Atsushi Tajima …

Scientific reports, 11(1) 13086-13086, Jun 22, 2021
RAGE signaling antagonist suppresses mouse macrophage foam cell formation.

Nontaphat Leerach, Seiichi Munesue, Ai Harashima, Kumi Kimura, Yu Oshima, Shuhei Kawano, Mariko Tanaka, Akane Niimura, Natthiya Sakulsak, Hiroshi Yamamoto …

Biochemical and biophysical research communications, 555 74-80, May 28, 2021
Abnormal social behavior and altered gene expression in mice lacking NDRG2.

Mika Takarada-Iemata, Toru Yoshihara, Nahoko Okitani, Keiko Iwata, Tsuyoshi Hattori, Hiroshi Ishii, Jureepon Roboon, Dinh Thi Nguyen, Qiyan Fan, Takashi Tamatani …

Neuroscience letters, 743 135563-135563, Jan 19, 2021
Astrocytes in the pathogenesis of multiple sclerosis

Mika Takarada-Iemata, Osamu Hori

Folia Pharmacologica Japonica, 156(4) 230-234, 2021
[Astrocytes in the pathogenesis of multiple sclerosis].

Mika Takarada-Iemata, Osamu Hori

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 156(4) 230-234, 2021
Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model.

Yuji Takaso, Masao Noda, Tsuyoshi Hattori, Jureepon Roboon, Miyako Hatano, Hisashi Sugimoto, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida …

Scientific reports, 10(1) 17795-17795, Oct 20, 2020
Pyramid-Shape Crossings and Intercrossing Fibers Are Key Elements for Construction of the Neural Network in the Superficial White Matter of the Human Cerebrum

Harumichi Shinohara, Xiaoliang Liu, Riho Nakajima, Masashi Kinoshita, Noriyuki Ozaki, Osamu Hori, Mitsutoshi Nakada

Cerebral Cortex, 30(10) 5218-5228, Sep 3, 2020
Direct evidence of the relationship between brain metastatic adenocarcinoma and white matter fibers: A fiber dissection and diffusion tensor imaging tractography study

Xiaoliang Liu, Masashi Kinoshita, Harumichi Shinohara, Osamu Hori, Noriyuki Ozaki, Toshihisa Hatta, Satoru Honma, Mitsutoshi Nakada

Journal of Clinical Neuroscience, 77 55-61, Jul, 2020

Misc.

TK-7-5 Managing promising research themes

Hori Osamu

Proceedings of the IEICE General Conference, 2016(2) "SSS-64", Mar 1, 2016
ジベンゾイルメタン誘導体による培養アストロサイトの機能変化

高野桂, 杉田くみこ, 日比野俐, 町支臣成, 村上里香, 山田昌司, 鈴木啓仁, 堀修, 森山光章, 中村洋一

日本薬学会年会要旨集, 136年会(3) 159-159, Mar, 2016 Peer-reviewed
フェノール性カルバゾール類の抗酸化活性に関する研究

稗田雄三, 波多江典之, 安楽誠, 松浦信康, 上村和秀, 日比野俐, 町支臣成, 冨田久夫, 堀修, 藤岡晴人

日本薬学会年会要旨集, 136年会(2) 177-177, Mar, 2016
ジベンゾイルメタン誘導体による神経細胞死抑制

高野桂, 日比野俐, 町支臣成, 村上里香, 山田昌司, 鈴木啓仁, 堀修, 森山光章, 中村洋一

日本薬学会年会要旨集, 135年会(3) 59-59, Mar, 2015 Peer-reviewed
フェノール性カルバゾール類の抗酸化活性評価と構造相関について

稗田雄三, 安楽誠, 町支臣成, 波多江典之, 冨田久夫, 藤岡晴人, 堀修, 日比野俐

日本薬学会年会要旨集, 135年会(2) 241-241, Mar, 2015
多置換カルバゾールアルカロイド類の全合成と抗酸化活性に関する研究

稗田雄三, 安楽誠, 町支臣成, 波多江典之, 冨田久夫, 藤岡晴人, 堀修, 広瀬順造, 日比野俐

メディシナルケミストリーシンポジウム講演要旨集, 32nd, 2014
Regulation of astroglial activation by N-myc downstream-regulated gene 2 (Ndrg2) after cortical stab injury

Mika Takarada-Iemata, Dai Kezuka, Toshiaki Takeichi, Yasuko Kitao, Osamu Hori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 74P-74P, 2014
Efficacy of dibenzoylmethane derivatives in protecting against endoplasmic reticulum stress and inhibiting nuclear factor kappa B on dextran sulfate sodium induced colitis in mice.

Choshi Tominari

(29) 31-32, Dec 25, 2011
The effects of dibenzoylmethane derivatives on the function of cultured astrocytes

Katsura Takano, Kumiko Sugita, Mitsuaki Moriyama, Koji Hashida, Satoshi Hibino, Tominari Choshi, Rika Murakami, Masashi Yamada, Hiroto Suzuki, Osamu Hori …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 187P-187P, 2011
ジベンゾイルメタン誘導体による培養アストロサイトの機能変化(A dibenzoylmethane derivative protects H2O2-induced cell death and inhibits lipopolysaccharide-induced NO production in cultured rat astrocytes)

高野桂, 杉田くみこ, 森山光章, 橋田耕治, 日比野俐, 町支臣成, 村上里香, 山田昌司, 鈴木啓仁, 堀修 …

神経化学, 49(2-3) 701-701, Aug, 2010 Peer-reviewed
NDRG2 suppresses proliferation and facilitates process extension of astrocytes

Mika Takarada-Iemata, Koji Hashida, Hirofumi Sudo, Junya Hamanaka, Hideaki Hara, Yasuko Kitao, Osamu Hori

NEUROSCIENCE RESEARCH, 68 E236-E236, 2010
Roles of ERAD molecule Herp in the Parkinson's disease (PD) models

Hirofumi Sudo, Mika Takarada-Iemata, Koji Hashida, Kokame Koichi, Yasuko Kitao, Osamu Hori

NEUROSCIENCE RESEARCH, 68 E307-E307, 2010
Ultra structural changes in rat livers induced by endotoxic shock and underlying molecular mechanisms

Sylvia Nuernberger, Sanjeev Gupta, J. Catharina Duvigneau, Osamu Hori, Heinz Redl, Andrey V. Kozlov

INFLAMMATION RESEARCH, 59 S73-S73, 2010
A carbazole derivative protects cells against endoplasmic reticulum (ER) stress and glutathione depletion.

(27) 29-30, Dec 25, 2009
A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress.

(26) 48-49, Dec 25, 2008
A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress

Katsura Takano, Yasuko Kitao, Yoshiyuki Tabata, Hikari Miura, Satoshi Hibino, Tominari Choshi, Munekazu Iinuma, Hiroto Suziki, Rika Murakami, Masashi Yamada …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 192P-192P, 2008
Decreased expression of ERAD molecule Herp facilitates degradation of alpha-synuclein and synphilin-1

Hikari Miura, Yasuko Kitao, Satoshi Ogawa, Osamu Hori

NEUROSCIENCE RESEARCH, 61 S123-S123, 2008
A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress

Katsura Takano, Yasuko Kitao, Yoshiyuki Tabata, Hikari Miura, Kosuke Sato, Kazuhiro Takuma, Kiyofumi Yamada, Satoshi Hibino, Tominari Choshi, Munekazu Iinuma …

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 293(6) C1884-C1894, Dec, 2007
Methoxyflavones protect cells against endoplasmic reticulum (ER) stress and neurotoxin

Katsura Takano, Yoshiyuki Tabata, Yasuko Kitao, Rika Murakami, Hiroto Suzuki, Masashi Yamada, Munekazu Iinuma, Yukio Yoneda, Satoshi Ogawa, Osamu Hori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 78P-78P, 2007
Human image processing technologies and their applications

HORI Osamu

IEICE technical report, 106(72) 107-112, May 25, 2006

Teaching Experience

Professional Memberships

Works

Research Projects

Analysis of neural networks in brain shallow layer responsible for functional shift aiming at innovation of neurosurgery and neuroscience

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Jun, 2022 - Mar, 2026
超音波診断装置を用いて脂肪由来幹細胞を経時的に複数回投与した自家神経移植の研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

多田薫, 堀修
RAGEシグナルを標的とした脳血管障害創薬の為の国際共同研究

国際共同研究加速基金（国際共同研究強化(B)）, Apr, 2018 - Mar, 2022

堀修
多発性硬化症モデルマウスにおける小胞体ストレス応答因子ATF6betaの重要性

科学研究費補助金（基盤研究 (C)）, Apr, 2018 - Mar, 2021

堀修
Analysis of development of oligodendtocytes in autism-related mouse model

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Hattori Tsuyoshi, HORI Osamu, TAKARADA Mika, ISHII Hiroshi, Higashida Haruhiro
高橋良輔

Apr, 2014 - Mar, 2017
ATF6ノックアウトマウスを用いたALSの病態解明

科学研究費補助金（基盤研究 (C)）, Apr, 2014 - Mar, 2017

堀修
Protective roles of ATF6 and ATF4 in the mouse model of stroke

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

KITAO Yasuko, HORI Osamu, TAKARADA Mika
ＡＴＦ６による黒質神経細胞の救済と蛋白質凝集抑制

科学研究費補助金（基盤研究 (C)）, Apr, 2011 - Mar, 2014

堀修
小胞体ストレス応答を利用した革新的脳血管障害治療薬候補の開発

研究成果最適展開支援プログラム（A-STEP）探索タイプ, Apr, 2012 - Mar, 2013

堀修
パーキンソン病遺伝子ネットワーク解明と新規治療戦略

戦略的創造研究推進事業（CREST）, Apr, 2007 - Mar, 2012

高橋良輔
小胞体関連分解(ERAD)制御によるタンパク分解ストレスの軽減と細胞保護

科学研究費補助金（特定領域研究）, Apr, 2008 - Mar, 2010

堀修
小胞体内レドックス異常により誘導される神経細胞死とその制御

科学研究費補助金（基盤研究 (C)）, Apr, 2005 - Mar, 2008

堀修
Endoplasmicreticulum(ER)stress and Parkinsonism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2007

KITAO Yasuko, OGAWA Satoshi, HORI Osamu
小胞体ストレス下で起こるミトコンドリア蛋白の変化とその応答について

科学研究費補助金（特定領域研究）, Apr, 2003 - Mar, 2005

堀修
小胞体からミトコンドリアへのストレス伝達と神経細胞死についての研究

科学研究費補助金（基盤研究（C））, Apr, 2002 - Mar, 2005

堀修
Rescue of Neuronal Cell Death by ER-stress protein overexpression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2003 - 2005

OGAWA Satoshi, HORI Osamu, KITAO Yasuko
Rescue of Neuronal Cell Death by ER-stress protein over expression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2004

KITAO Yasuko, OGAWA Satoshi, HORI Osamu
Visualization and regulation of ischemia-induced stress response in brain.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

OGAWA Satoshi, HORI Osamu, TAMATANI Michio, TOHYAMA Masaya
Role of Anti-ORP150 autoantibody in transplanted heart

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1997 - 1998

TOHYAMA Masaya, YONEDA Takunari, HORI Osamu, TAMATANI Michio, OGAWA Satoshi

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