Osamu Hori

Profile Information

Affiliation: Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University

Degree: 博士(医学)(大阪大学)

J-GLOBAL ID: 200901057287094744
researchmap Member ID: 1000287595

External link: http://med03.w3.kanazawa-u.ac.jp/index.html

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Education

- 1989

Medical School, Faculty of Medicine, Osaka University
- 1989

Faculty of Medicine, Osaka University

Papers

110

Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD.

Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada-Iemata, Dinh Thi Nguyen, Collin D Heer, Denis O'Meally, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida, Osamu Hori

Journal of neurochemistry, 158(2) 311-327, Jul, 2021
The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.

Dinh Thi Nguyen, Thuong Manh Le, Tsuyoshi Hattori, Mika Takarada-Iemata, Hiroshi Ishii, Jureepon Roboon, Takashi Tamatani, Takayuki Kannon, Kazuyoshi Hosomichi, Atsushi Tajima, Shusuke Taniuchi, Masato Miyake, Seiichi Oyadomari, Takashi Tanaka, Nobuo Kato, Shunsuke Saito, Kazutoshi Mori, Osamu Hori

Scientific reports, 11(1) 13086-13086, Jun 22, 2021
RAGE signaling antagonist suppresses mouse macrophage foam cell formation.

Nontaphat Leerach, Seiichi Munesue, Ai Harashima, Kumi Kimura, Yu Oshima, Shuhei Kawano, Mariko Tanaka, Akane Niimura, Natthiya Sakulsak, Hiroshi Yamamoto, Osamu Hori, Yasuhiko Yamamoto

Biochemical and biophysical research communications, 555 74-80, May 28, 2021
Abnormal social behavior and altered gene expression in mice lacking NDRG2.

Mika Takarada-Iemata, Toru Yoshihara, Nahoko Okitani, Keiko Iwata, Tsuyoshi Hattori, Hiroshi Ishii, Jureepon Roboon, Dinh Thi Nguyen, Qiyan Fan, Takashi Tamatani, Takumi Nishiuchi, Masahide Asano, Osamu Hori

Neuroscience letters, 743 135563-135563, Jan 19, 2021
Astrocytes in the pathogenesis of multiple sclerosis

Mika Takarada-Iemata, Osamu Hori

Folia Pharmacologica Japonica, 156(4) 230-234, 2021
[Astrocytes in the pathogenesis of multiple sclerosis].

Mika Takarada-Iemata, Osamu Hori

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 156(4) 230-234, 2021
Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model.

Yuji Takaso, Masao Noda, Tsuyoshi Hattori, Jureepon Roboon, Miyako Hatano, Hisashi Sugimoto, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida, Makoto Ito, Tomokazu Yoshizaki, Osamu Hori

Scientific reports, 10(1) 17795-17795, Oct 20, 2020
Pyramid-Shape Crossings and Intercrossing Fibers Are Key Elements for Construction of the Neural Network in the Superficial White Matter of the Human Cerebrum

Harumichi Shinohara, Xiaoliang Liu, Riho Nakajima, Masashi Kinoshita, Noriyuki Ozaki, Osamu Hori, Mitsutoshi Nakada

Cerebral Cortex, 30(10) 5218-5228, Sep 3, 2020
Direct evidence of the relationship between brain metastatic adenocarcinoma and white matter fibers: A fiber dissection and diffusion tensor imaging tractography study

Xiaoliang Liu, Masashi Kinoshita, Harumichi Shinohara, Osamu Hori, Noriyuki Ozaki, Toshihisa Hatta, Satoru Honma, Mitsutoshi Nakada

Journal of Clinical Neuroscience, 77 55-61, Jul, 2020
Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia.

Yu Shimizu, Ai Harashima, Seiichi Munesue, Masahiro Oishi, Tsuyoshi Hattori, Osamu Hori, Yasuko Kitao, Hiroshi Yamamoto, Nontaphat Leerach, Mitsutoshi Nakada, Yasuhiko Yamamoto, Yasuhiko Hayashi

Aging and disease, 11(3) 547-558, May, 2020 Peer-reviewed
Does the superior fronto-occipital fascicle exist in the human brain? Fiber dissection and brain functional mapping in 90 patients with gliomas

Xiaoliang Liu, Masashi Kinoshita, Harumichi Shinohara, Osamu Hori, Noriyuki Ozaki, Mitsutoshi Nakada

NeuroImage: Clinical, 25 102192-102192, 2020
CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.

Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov SM, Shabalova AA, Gerasimenko M, Minami K, Yokoyama S, Munesue SI, Harashima A, Yamamoto Y, Salmina AB, Lopatina O

Cells, 9(1), Dec, 2019 Peer-reviewed
Soluble receptor for advanced glycation end products as a biomarker of symptomatic vasospasm in subarachnoid hemorrhage.

Aida Y, Kamide T, Ishii H, Kitao Y, Uchiyama N, Nakada M, Hori O

J Neurosurg, 1-9, Nov, 2019 Peer-reviewed
Microglial activation in the cochlear nucleus after early hearing loss in rats.

Noda M, Hatano M, Hattori T, Takarada-Iemata M, Shinozaki T, Sugimoto H, Ito M, Yoshizaki T, Hori O

Auris Nasus Larynx., 46(5) 716-723, Oct, 2019 Peer-reviewed
Pre-administration of low-dose methamphetamine enhances movement and neural activity after high-dose methamphetamine administration in the striatum.

Takeichi T, Hori O, Hattori T, Kiryu K, Zuka M, Kitamura O

Neurosci Lett., 703 119-124, Jun, 2019 Peer-reviewed
Caspase-1 initiates apoptosis in the absence of gasdermin D.

Tsuchiya K, Nakajima S, Hosojima S, Thi Nguyen D, Hattori T, Manh Le T, Hori O, Mahib MR, Yamaguchi Y, Miura M, Kinoshita T, Kushiyama H, Sakurai M, Shiroishi T, Suda T

Nat Commun., 10(1) 2091, May, 2019 Peer-reviewed
Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination.

Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada-Iemata, Thuong Manh Le, Yoshitake Shiraishi, Noriyuki Ozaki, Yasuhiko Yamamoto, Akira Sugawara, Hiroshi Okamoto, Haruhiro Higashida, Yasuko Kitao, Osamu Hori

Frontiers in cellular neuroscience, 13(258) 258-258, 2019 Peer-reviewed
Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.

Yasuhiko Yamamoto, Mingkun Liang, Seiichi Munesue, Kisaburo Deguchi, Ai Harashima, Kazumi Furuhara, Teruko Yuhi, Jing Zhong, Shirin Akther, Hisanori Goto, Yuya Eguchi, Yasuko Kitao, Osamu Hori, Yoshitake Shiraishi, Noriyuki Ozaki, Yu Shimizu, Tomoya Kamide, Akifumi Yoshikawa, Yasuhiko Hayashi, Mitsutoshi Nakada, Olga Lopatina, Maria Gerasimenko, Yulia Komleva, Natalia Malinovskaya, Alla B Salmina, Masahide Asano, Katsuhiko Nishimori, Steven E Shoelson, Hiroshi Yamamoto, Haruhiro Higashida

Communications biology, 2(76) 76-76, 2019 Peer-reviewed
A dibenzoylmethane derivative inhibits lipopolysaccharide-induced NO production in mouse microglial cell line BV-2.

Takano K, Ishida N, Kawabe K, Moriyama M, Hibino S, Choshi T, Hori O, Nakamura Y

Neurochemistry international, 119 126-131, Oct, 2018 Peer-reviewed
N-myc downstream-regulated gene 2 protects blood–brain barrier integrity following cerebral ischemia

Mika Takarada-Iemata, Akifumi Yoshikawa, Hieu Minh Ta, Nahoko Okitani, Takumi Nishiuchi, Yasuhiro Aida, Tomoya Kamide, Tsuyoshi Hattori, Hiroshi Ishii, Takashi Tamatani, Thuong Manh Le, Jureepon Roboon, Yasuko Kitao, Tomohiro Matsuyama, Mitsutoshi Nakada, Osamu Hori

GLIA, 66(7) 1432-1446, Jul 1, 2018 Peer-reviewed

Misc.

ジベンゾイルメタン誘導体による培養アストロサイトの機能変化

高野桂, 杉田くみこ, 日比野俐, 町支臣成, 村上里香, 山田昌司, 鈴木啓仁, 堀修, 森山光章, 中村洋一

日本薬学会年会要旨集, 136年会(3) 159-159, Mar, 2016 Peer-reviewed
フェノール性カルバゾール類の抗酸化活性に関する研究

稗田雄三, 波多江典之, 安楽誠, 松浦信康, 上村和秀, 日比野俐, 町支臣成, 冨田久夫, 堀修, 藤岡晴人

日本薬学会年会要旨集, 136年会(2) 177-177, Mar, 2016
ジベンゾイルメタン誘導体による神経細胞死抑制

高野桂, 日比野俐, 町支臣成, 村上里香, 山田昌司, 鈴木啓仁, 堀修, 森山光章, 中村洋一

日本薬学会年会要旨集, 135年会(3) 59-59, Mar, 2015 Peer-reviewed
フェノール性カルバゾール類の抗酸化活性評価と構造相関について

稗田雄三, 安楽誠, 町支臣成, 波多江典之, 冨田久夫, 藤岡晴人, 堀修, 日比野俐

日本薬学会年会要旨集, 135年会(2) 241-241, Mar, 2015
多置換カルバゾールアルカロイド類の全合成と抗酸化活性に関する研究

稗田雄三, 安楽誠, 町支臣成, 波多江典之, 冨田久夫, 藤岡晴人, 堀修, 広瀬順造, 日比野俐

メディシナルケミストリーシンポジウム講演要旨集, 32nd, 2014
Regulation of astroglial activation by N-myc downstream-regulated gene 2 (Ndrg2) after cortical stab injury

Mika Takarada-Iemata, Dai Kezuka, Toshiaki Takeichi, Yasuko Kitao, Osamu Hori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 74P-74P, 2014
Efficacy of dibenzoylmethane derivatives in protecting against endoplasmic reticulum stress and inhibiting nuclear factor kappa B on dextran sulfate sodium induced colitis in mice.

Choshi Tominari

(29) 31-32, Dec 25, 2011
The effects of dibenzoylmethane derivatives on the function of cultured astrocytes

Katsura Takano, Kumiko Sugita, Mitsuaki Moriyama, Koji Hashida, Satoshi Hibino, Tominari Choshi, Rika Murakami, Masashi Yamada, Hiroto Suzuki, Osamu Hori, Yoichi Nakamura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 187P-187P, 2011
ジベンゾイルメタン誘導体による培養アストロサイトの機能変化(A dibenzoylmethane derivative protects H2O2-induced cell death and inhibits lipopolysaccharide-induced NO production in cultured rat astrocytes)

高野桂, 杉田くみこ, 森山光章, 橋田耕治, 日比野俐, 町支臣成, 村上里香, 山田昌司, 鈴木啓仁, 堀修, 中村洋一

神経化学, 49(2-3) 701-701, Aug, 2010 Peer-reviewed
NDRG2 suppresses proliferation and facilitates process extension of astrocytes

Mika Takarada-Iemata, Koji Hashida, Hirofumi Sudo, Junya Hamanaka, Hideaki Hara, Yasuko Kitao, Osamu Hori

NEUROSCIENCE RESEARCH, 68 E236-E236, 2010
Roles of ERAD molecule Herp in the Parkinson's disease (PD) models

Hirofumi Sudo, Mika Takarada-Iemata, Koji Hashida, Kokame Koichi, Yasuko Kitao, Osamu Hori

NEUROSCIENCE RESEARCH, 68 E307-E307, 2010
Ultra structural changes in rat livers induced by endotoxic shock and underlying molecular mechanisms

Sylvia Nuernberger, Sanjeev Gupta, J. Catharina Duvigneau, Osamu Hori, Heinz Redl, Andrey V. Kozlov

INFLAMMATION RESEARCH, 59 S73-S73, 2010
A carbazole derivative protects cells against endoplasmic reticulum (ER) stress and glutathione depletion.

(27) 29-30, Dec 25, 2009
A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress.

(26) 48-49, Dec 25, 2008
A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress

Katsura Takano, Yasuko Kitao, Yoshiyuki Tabata, Hikari Miura, Satoshi Hibino, Tominari Choshi, Munekazu Iinuma, Hiroto Suziki, Rika Murakami, Masashi Yamada, Satoshi Ogawa, Osamu Hori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 192P-192P, 2008
Decreased expression of ERAD molecule Herp facilitates degradation of alpha-synuclein and synphilin-1

Hikari Miura, Yasuko Kitao, Satoshi Ogawa, Osamu Hori

NEUROSCIENCE RESEARCH, 61 S123-S123, 2008
A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress

Katsura Takano, Yasuko Kitao, Yoshiyuki Tabata, Hikari Miura, Kosuke Sato, Kazuhiro Takuma, Kiyofumi Yamada, Satoshi Hibino, Tominari Choshi, Munekazu Iinuma, Hiroto Suzuki, Rika Murakami, Masashi Yamada, Satoshi Ogawa, Osamu Hori

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 293(6) C1884-C1894, Dec, 2007
Methoxyflavones protect cells against endoplasmic reticulum (ER) stress and neurotoxin

Katsura Takano, Yoshiyuki Tabata, Yasuko Kitao, Rika Murakami, Hiroto Suzuki, Masashi Yamada, Munekazu Iinuma, Yukio Yoneda, Satoshi Ogawa, Osamu Hori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 78P-78P, 2007
糖尿病と小胞体ストレス (あゆみ小胞体ストレスと疾患)

小川智, 堀修

医学のあゆみ, 216(12) 877-880, Mar 25, 2006
Screening of neuroprotective agents against ER stress and oxidative stress

Osamu Hori, Katsura Takano, Yoshiyuki Tabata, Masashi Yamada, Hiroto Suzuki, Rika Murakami, Satoshi Hibino, Munekazu Iinuma, Yasuko Kitao, Satoshi Ogawa

NEUROSCIENCE RESEARCH, 55 S202-S202, 2006

Teaching Experience

Professional Memberships

Works

Research Projects

RAGEシグナルを標的とした脳血管障害創薬の為の国際共同研究

国際共同研究加速基金（国際共同研究強化(B)）, Apr, 2018 - Mar, 2022

堀修
多発性硬化症モデルマウスにおける小胞体ストレス応答因子ATF6betaの重要性

科学研究費補助金（基盤研究 (C)）, Apr, 2018 - Mar, 2021

堀修
高橋良輔

Apr, 2014 - Mar, 2017
ATF6ノックアウトマウスを用いたALSの病態解明

科学研究費補助金（基盤研究 (C)）, Apr, 2014 - Mar, 2017

堀修
ＡＴＦ６による黒質神経細胞の救済と蛋白質凝集抑制

科学研究費補助金（基盤研究 (C)）, Apr, 2011 - Mar, 2014

堀修
小胞体ストレス応答を利用した革新的脳血管障害治療薬候補の開発

研究成果最適展開支援プログラム（A-STEP）探索タイプ, Apr, 2012 - Mar, 2013

堀修
パーキンソン病遺伝子ネットワーク解明と新規治療戦略

戦略的創造研究推進事業（CREST）, Apr, 2007 - Mar, 2012

高橋良輔
小胞体関連分解(ERAD)制御によるタンパク分解ストレスの軽減と細胞保護

科学研究費補助金（特定領域研究）, Apr, 2008 - Mar, 2010

堀修
小胞体内レドックス異常により誘導される神経細胞死とその制御

科学研究費補助金（基盤研究 (C)）, Apr, 2005 - Mar, 2008

堀修
小胞体ストレス下で起こるミトコンドリア蛋白の変化とその応答について

科学研究費補助金（特定領域研究）, Apr, 2003 - Mar, 2005

堀修
小胞体からミトコンドリアへのストレス伝達と神経細胞死についての研究

科学研究費補助金（基盤研究（C））, Apr, 2002 - Mar, 2005

堀修
Stress Response of Cells in Central Nervous System

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