Miki Nakajima

J-GLOBAL         Last updated: Apr 16, 2019 at 12:20
 
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Name
Miki Nakajima
Affiliation
Kanazawa University
Section
Institute of Medical,Pharmaceutical and Health Sciences, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy

Research Areas

 
 

Academic & Professional Experience

 
Apr 2018
 - 
Today
Professor, Nano Life Science Institute, Kanazawa University
 
Mar 2014
 - 
Mar 2018
Professor, Faculty of Pharmaceutical Sciences, Kanazawa University
 
Apr 2009
 - 
Feb 2014
Associate Professor, Faculty of Pharmaceutical Sciences, Kanazawa University
 
Apr 2007
 - 
Mar 2009
Associate Professor, Faculty of Pharmaceutical Sciences, Kanazawa University
 
Aug 2001
 - 
Mar 2007
Associate Professor, Faculty of Pharmaceutical Sciences, Kanazawa University
 

Education

 
 
 - 
1994
Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
 
 
 - 
1992
Faculty of Pharmaceutical Science, Hokkaido University
 

Committee Memberships

 
2002
   
 
The Japanese Society for the Study of Xenobiotics  
 
2002
   
 
-: The Japanese Society for the Study of Xenobiotics 
 

Awards & Honors

 
2007
Taro Yamshita Award
 
2008
Ebert Prize of the American Pharmacists Association
 
2005
Journal of Chromatography Top Cited Article Award
 
2009
DMPK Best Citation Award
 

Published Papers

 
RNA editing enzymes modulate the expression of hepatic CYP2B6, CYP2C8 and other P450 isoforms.
Kaori Nozaki, Masataka Nakano, Chika Iwakami, Tatsuki Fukami, and Miki Nakajima.
Drug Metab Dispos   in press    Apr 2019   [Refereed]
Quantitative Analysis of Ugt1a and Ugt2b mRNA Expression in Rat Liver and Small Intestine: Sex and Strain Differences
Kutsukake T, Furukawa Y, Ondo K, Gotoh S, Fukami T, Nakajima M
47 38-44   Jan 2019   [Refereed]
Substrate Selectivity of Human Aldehyde Oxidase 1 in Reduction of Nitroaromatic Drugs
Ogiso T, Fukami T, Mishiro K, Konishi K, Jones JP, and Nakajima M
Arch Biochem Biophys   659 85-92   Nov 2018   [Refereed]
Konishi K, Fukami T, Ogiso T, Nakajima M
Biochemical pharmacology   155 242-251   Sep 2018   [Refereed]
Tatsumi N, Tokumitsu S, Nakano M, Fukami T, Nakajima M
Drug metabolism and pharmacokinetics   33(4) 203-210   Aug 2018   [Refereed]
Mizuno K, Takeuchi K, Umehara K, Nakajima M
Biochemical pharmacology   156 312-321   Aug 2018   [Refereed]
Amano T, Fukami T, Ogiso T, Hirose D, Jones JP, Taniguchi T, Nakajima M
Biochemical pharmacology   151 69-78   May 2018   [Refereed]
Hata T, Kanazawa T, Hamada T, Nishihara M, Bush AI, Yoneda H, Nakajima M, Katsumata T
Journal of psychiatric research   97 94-100   Feb 2018   [Refereed]
Nakano M, Nakajima M
Expert opinion on drug metabolism & toxicology   14(5) 493-504   May 2018   [Refereed]
Yoshida T, Fukami T, Kurokawa T, Gotoh S, Oda A, Nakajima M
European journal of pharmaceutical sciences   111 167-176   Jan 2018   [Refereed]
Nakano M, Nakajima M
Pharmacology & therapeutics   181 13-21   Jan 2018   [Refereed]
Yamaura Y, Tatsumi N, Takagi S, Tokumitsu S, Fukami T, Tajiri K, Minemura M, Yokoi T, Nakajima M
Clinical biochemistry   50(18) 1034-1039   Dec 2017   [Refereed]
Cirillo F, Pellegrino M, Malivindi R, Rago V, Avino S, Muto L, Dolce V, Vivacqua A, Rigiracciolo DC, De Marco P, Sebastiani A, Abonante S, Nakajima M, Lappano R, Maggiolini M
Oncotarget   8(63) 106608-106624   Dec 2017   [Refereed]
Saito S, Nakanishi T, Shirasaki Y, Nakajima M, Tamai I
Journal of pharmaceutical sciences   106(9) 2873-2880   Sep 2017   [Refereed]
Back Hyun-moon, Pradhan Sudeep, Yoon Young-ran, Kang Wonku, Chae Jung-woo, Han Nayoung, Miki Nakajima, Kwon Kwang-il, Kim Sang-kyum, Yun Hwi-yeol
INTERNATIONAL JOURNAL OF PHARMACOLOGY   14(2) 276-284   Jan 2018   [Refereed]
Konishi K, Fukami T, Gotoh S, Nakajima M
Biochemical pharmacology   140 150-160   Sep 2017   [Refereed]
Oda S, Kato Y, Hatakeyama M, Iwamura A, Fukami T, Kume T, Yokoi T, Nakajima M
Drug metabolism and disposition: the biological fate of chemicals   45(9) 1027-1034   Sep 2017   [Refereed]
Nakano M, Fukami T, Gotoh S, Nakajima M
The Journal of biological chemistry   292(12) 4873-4884   Mar 2017   [Refereed]
Asakura M, Fukami T, Nakajima M, Fujii H, Atsuda K, Itoh T, Fujiwara R
Drug metabolism and disposition   45(2) 237-245   Feb 2017   [Refereed]
Iwamura A, Nakajima M, Oda S, Yokoi T
Drug metabolism and pharmacokinetics   32(1) 2-11   Feb 2017   [Refereed]
Nakajima M
Yakugaku zasshi   137(6) 697-705   Jun 2017   [Refereed]
Takai S, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T
Journal of applied toxicology : JAT   36(1) 35-47   Jan 2016   [Refereed]
Kurokawa T, Fukami T, Yoshida T, Nakajima M
Drug metabolism and disposition: the biological fate of chemicals   44(3) 409-416   Mar 2016   [Refereed]
Nakano Masataka, Fukami Tatsuki, Gotoh Saki, Takamiya Masataka, Aoki Yasuhiro, Nakajima Miki
DRUG METABOLISM AND PHARMACOKINETICS   32(1) S60   Jan 2017   [Refereed]
Sasaki E, Iida A, Oda S, Tsuneyama K, Fukami T, Nakajima M, Yokoi T
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie   68(1) 27-38   Jan 2016   [Refereed]
Nakano M, Fukami T, Gotoh S, Takamiya M, Aoki Y, Nakajima M
The Journal of biological chemistry   291(2) 894-903   Jan 2016   [Refereed]
Fukami T, Kariya M, Kurokawa T, Iida A, Nakajima M
European journal of pharmaceutical sciences   78 47-53   Oct 2015   [Refereed]
Iwamura A, Ito M, Mitsui H, Hasegawa J, Kosaka K, Kino I, Tsuda M, Nakajima M, Yokoi T, Kume T
Yakugaku zasshi   30 241-249   Dec 2015   [Refereed]
Muta K, Fukami T, Nakajima M
Biochemical pharmacology   98(4) 659-670   Dec 2015   [Refereed]
Fukami T, Iida A, Konishi K, Nakajima M
Biochemical pharmacology   116 153-161   Sep 2016   [Refereed]
Fujiwara R, Yokoi T, Nakajima M
Frontiers in pharmacology   7 388   Oct 2016   [Refereed]
Nakano M, Mohri T, Fukami T, Takamiya M, Aoki Y, McLeod HL, Nakajima M
Drug metabolism and disposition   43(10) 1450-1457   Oct 2015   [Refereed]
Kurokawa T, Fukami T, Nakajima M
Drug metabolism and disposition   43(8) 1218-1225   Aug 2015   [Refereed]
Tang SC, Kort A, Cheung KL, Rosing H, Fukami T, Durmus S, Wagenaar E, Hendrikx JJ, Nakajima M, van Vlijmen BJ, Beijnen JH, Schinkel AH
Molecular pharmaceutics   12(10) 3714-3723   Oct 2015   [Refereed]
Iida A, Sasaki E, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T
Drug metabolism and disposition   43(7) 958-968   Jul 2015   [Refereed]
Oda S, Fujiwara R, Kutsuno Y, Fukami T, Itoh T, Yokoi T, Nakajima M
Drug metabolism and disposition   43(6) 812-818   Jun 2015   [Refereed]
Nakano M, Fukushima Y, Yokota S, Fukami T, Takamiya M, Aoki Y, Yokoi T, Nakajima M
Drug metabolism and disposition   43(5) 703-712   May 2015   [Refereed]
Takai S, Higuchi S, Yano A, Tsuneyama K, Fukami T, Nakajima M, Yokoi T
Journal of applied toxicology : JAT   35(2) 142-151   Feb 2015   [Refereed]
Lim YP, Cheng CH, Chen WC, Chang SY, Hung DZ, Chen JJ, Wan L, Ma WC, Lin YH, Chen CY, Yokoi T, Nakajima M, Chen CJ
Archives of toxicology   89(1) 57-72   Jan 2015   [Refereed]
Oda S, Fukami T, Yokoi T, Nakajima M
Drug metabolism and pharmacokinetics   30(1) 30-51   Feb 2015   [Refereed]
Sasaki E, Iwamura A, Tsuneyama K, Fukami T, Nakajima M, Kume T, Yokoi T
Toxicology letters   232(1) 79-88   Jan 2015   [Refereed]
Fukami Tatsuki, Kariya Motoki, Kurokawa Takaya, Iida Azumi, Nakajima Miki
DRUG METABOLISM REVIEWS   47 211-212   Nov 2015   [Refereed]
Ito Y, Fukami T, Yokoi T, Nakajima M
Drug metabolism and disposition   42(12) 2109-2116   Dec 2014   [Refereed]
Yamaura Y, Nakajima M, Tatsumi N, Takagi S, Fukami T, Tsuneyama K, Yokoi T
Toxicology   322 89-98   Aug 2014   [Refereed]
Lim YP, Chen WC, Cheng CH, Ma WC, Lin YH, Chen CY, Hung DZ, Chen JJ, Yokoi T, Nakajima M, Chen CJ
Planta medica   80(13) 1097-1106   Aug 2014   [Refereed]
Yano A, Oda S, Fukami T, Nakajima M, Yokoi T
Toxicology letters   228(1) 13-24   Jul 2014   [Refereed]
Shimizu M, Fukami T, Nakajima M, Yokoi T
Drug metabolism and disposition   42(7) 1103-1109   Jul 2014   [Refereed]
Oda Y, Nakajima M, Tsuneyama K, Takamiya M, Aoki Y, Fukami T, Yokoi T
Biochemical pharmacology   90(2) 179-187   Jul 2014   [Refereed]
Endo S, Yano A, Fukami T, Nakajima M, Yokoi T
Toxicology   319 75-84   May 2014   [Refereed]
Shimizu M, Fukami T, Ito Y, Kurokawa T, Kariya M, Nakajima M, Yokoi T
Drug metabolism and disposition   42(4) 751-758   Apr 2014   [Refereed]

Misc

 
SIGNIFICANCE OF ORPHAN ESTERASES IN CONTROL OF PHARMACOKINETICS AND DRUG TOXICITIES
Fukami Tatsuki, Nakajima Miki
DRUG METABOLISM AND PHARMACOKINETICS   33(1) S13-S14   Jan 2018   [Refereed]
MicroRNA-RELATED POLYMORPHISMS TO PREDICT DRUG RESPONSE
Nakajima Miki
DRUG METABOLISM REVIEWS   47 28   Nov 2015   [Refereed]
HUMAN CYP2A6 IS REGULATED BY MIR-126*
Nakano Masataka, Nakajima Miki, Tatsuki Fukami, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   44 88   2012   [Refereed]
GLYCOSYLATION AND EPIGENETIC REGULATION OF HUMAN UGTS
Nakajima Miki
DRUG METABOLISM REVIEWS   44 15   2012   [Refereed]
PGRMC1 interacts with human drug-metabolizing P450s to modulate their activities
Oda Shingo, Nakajima Miki, Fukami Tatsuki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   43 43   May 2011   [Refereed]
Regulation of human cytochrome P450S and nuclear receptors by microRNAs
Yokoi Tsuyoshi, Nakajima Miki
DRUG METABOLISM REVIEWS   43 6-7   May 2011   [Refereed]
Human PPAR alpha is regulated by miR-21
Kida Katsuhiko, Nakajima Miki, Mohri Takuya, Oda Yuki, Takagi Shingo, Fukami Tatsuki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   42 284   Aug 2010   [Refereed]
Fukami Tatsuki, Watanabe Akinobu, Takahashi Shiori, Kobayashi Yuki, Nakagawa Nao, Nakajima Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   42 240   Aug 2010   [Refereed]
MicroRNA Regulation of Nuclear Receptors and Drug Metabolizing Cytochrome P450s
Nakajima Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   42 26-27   Aug 2010   [Refereed]
Mechanism of Hepatoprotective Effect of Tamoxifen Against Drug-induced Liver Injury
Yokoi Tsuyoshi, Yoshikawa Yukitaka, Toyoda Yasuyuki, Higuchi Satonori, Tsukui Tohru, Tsuneyama Koichi, Fukami Tatsuki, Nakajima Miki
DRUG METABOLISM REVIEWS   42 205   Aug 2010   [Refereed]
Ito K, Nakajima M
Drug metabolism and pharmacokinetics   25(1) 1-2   2010   [Refereed]
Ito Kiyomi, Nakajima Miki
DRUG METABOLISM AND PHARMACOKINETICS   25(1) 1-2   2010   [Refereed]
Human Hepatocyte Nuclear Factor 4 alpha Is Regulated by miR-24
Takagi Shingo, Nakajima Miki, Kida Katsuhiko, Fukami Tatsuki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   41 90   Aug 2009   [Refereed]
Metabolic Activation of Benzodiazepines by CYP3A4
Mizuno Katsuhiko, Katoh Miki, Okumura Hirotoshi, Nakagawa Nao, Nakajima Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   41 51   Aug 2009   [Refereed]
Differences in CYP2A13 Expression Level in Various Types of Human Lung Cancer
Fukami Tatsuki, Nakajima Miki, Zen Yoh, Matsumoto Isao, Oda Makoto, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   41 31   Aug 2009   [Refereed]
UGT Enzymes: Drug Interactions, Protein-Protein Interactions and Regulation
Yokoi Tsuyoshi, Fujiwara Ryoichi, Yamanaka Hiroyuki, Nakamura Akiko, Higashi Eriko, Matsui Tomohito, Katoh Miki, Nakajima Miki
DRUG METABOLISM REVIEWS   41 13-14   Aug 2009   [Refereed]
ALLOSTERIC EFFECTS OF HUMAN CARBOXYLESTERASE KINETICS LEAD TO INTERINDIVIDUAL VARIABILITY
Takahashi Shiori, Katoh Miki, Saitoh Takashi, Nakajima Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 263-264   2007   [Refereed]
MICRORNA POST-TRANSCRIPTIONALLY REGULATES HUMAN PXR AFFECTING THE EXPRESSION LEVEL OF CYP3A4
Takagi Shingo, Nakajima Miki, Mohri Takuya, Katoh Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 233   2007   [Refereed]
URIDINE DIPHOSPHATE (UDP) PRODUCED BY HIGH TURNOVER GLUCURONIDATION CONFUSES THE INHIBITORY EFFECTS ON UDP-GLUCURONOSYLTRANSFERASES
Fujiwara Ryoichi, Nakajima Miki, Yamanaka Hiroyuki, Katoh Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 185   2007   [Refereed]
CYP2A13 HAS HIGH CATALYTIC ACTIVITY TOWARD SUBSTRATES OF CYP1A2 AND CYP2E1
Fukami Tatsuki, Nakajima Miki, Sakai Haruko, Katoh Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 102-103   2007   [Refereed]
INHIBITORY EFFECT OF KAMPO MEDICINE ON HUMAN UGT1A1 ENZYME ACTIVITY
Katoh Miki, Yoshioka Yuko, Nakagawa Nao, Nakajima Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 189   2007   [Refereed]
THYROXINE GLUCURONIDATIONS IN HUMAN LIVER, JEJUNUM, AND KIDNEY MICROSOMES WERE CATALYZED BY UGT1A1, 1A7, 1A8, 1A9, AND 1A10: EFFECTS OF UGT-UGT INTERACTIONS
Yamanaka Hiroyuki, Nakajima Miki, Fujiwara Ryoichi, Katoh Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 184-185   2007   [Refereed]
Nrf2 REGULATES INDUCTION OF HUMAN UGT2B7 BY SULFORAPHANE
Nakamura Akiko, Nakajima Miki, Higashi Eriko, Yamanaka Hiroyuki, Katoh Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   39 128-129   2007   [Refereed]
INVESTIGATION OF DRUG INDUCED HEPATOTOXICITY BY KNOCKDOWN OF GLUTATHIONE SYNTHESIS
Yokoi Tsuyoshi, Akai Sho, Hosomi Hiroko, Minami Keiichi, Katoh Miki, Nakajima Miki
DRUG METABOLISM REVIEWS   39 19   2007   [Refereed]
Knockdown of γ-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity.
282, 23996-24003    2007
In vivo induction of CYP3A4 by rifabutin in chimeric mice with humanized liver
Katoh Miki, Watanabe Misaki, Nakajima Miki, Yokoi Tsuyoshi, Sato Yasushi, Iwasaki Kazuhide, Tateno Chise, Yoshizato Katsutoshi, Yoshizato Katsutoshi
DRUG METABOLISM REVIEWS   38 145-146   2006   [Refereed]
Ribosomal protein P0 dephosphorylation associated with troglitazone-induced cytotoxicity
Maniratanachote Rawiwan, Katoh Miki, Nakajima Miki, Yokoi Tsuyoshi
DRUG METABOLISM REVIEWS   38 51-52   2006   [Refereed]

Books etc

 
Pharmacogenomics and Stratified Medicines
Miki Nakajima and Tsuyoshi Yokoi (Part:Joint Work, Regulation of P450 and Pharmacogenetics)
Elsevir   2014   
Fifty Years of Cytochrome P450 Research
Miki Nakajima (Part:Joint Work, Control of xeno/endobiotics-metabolizing cytochrome P450s by microRNAs.)
Elsevir   2014   

Conference Activities & Talks

 
Significance of post-transcriptional regulation of drug-metabolizing enzymes: perspective insight into future pharmacotherapy [Invited]
Miki Nakajima
22nd Microsomal and Drug Oxidation/33rd JSSX, Plenary Lecture   5 Oct 2018   
microRNA-SNPs as biomarkers of drug response and toxicity. [Invited]
Miki Nakajima
18th Word Congress of Basic and Clinical Pharmacology   6 Jul 2018   
Roles of hydrolases and aldehyde oxidase in controlling of pharmacokinetics and drug toxicity
Tatsuki Fukami and Miki Nakajima
日本薬物動態学会第32回年会   29 Nov 2017   
Significance of orphan esterases in control of pharmacokinetics and drug toxicities [Invited]
Tatsuki Fukami and Miki Nakajima
21st North American ISSX Meeting   25 Sep 2017   
Post-transcriptional regulation of PK/PD-associated genes by A-to-I RNA editing [Invited]
Miki Nakajima and Masataka Nakano
19th International Conference on Cytochrome P450   26 Aug 2017   
Significance of arylacetamide deacetylase in drug metabolism and toxicity [Invited]
Tatsuki Fukami and Miki Nakajima
14th European ISSX Meeting   27 Jun 2017   
Diagnostic and therapeutic potential of miRNAs for liver injury [Invited]
Miki Nakajima
26 Mar 2017   
A-to-I RNA editing modulating drug response [Invited]
Miki Nakajima
13 Oct 2016   
Impact of RNA editing on microRNA function and drug-metabolizing enzymes [Invited]
Miki Nakajima
3 Oct 2016   
Impact of microRNA-dependent regulation on drug metabolism
Miki Nakajima
17 Dec 2015   
microRNAs regulating nuclear receptors in liver: therapeutic potential for liver fibrosis
Miki Nakajima
2015 International Joint Symposium of Kanazawa University – Pusan National University – Shenyang Pharmaceutical University   22 Oct 2015   
microRNAs regulating P450 expression and activities: perspective for future medicine [Invited]
Miki Nakajima
19th International Conference of Cytochrome P450   12 Jun 2015   
MicroRNA-related polymorphisms to predict drug response [Invited]
Miki Nakajima
19th North American Regional ISSX Meeting/29th JSSX Annual Meeting   18 Oct 2014   
Toxicological evaluation of the acyl glucuronide of nonsteroidal anti-inflammatory drugs [Invited]
Miki NakajimaTsuyoshi Yokoi, Taishi Miyashita, Toshihisa Koga, and Miki Nakajima
The Korean Federation of Analytical Science and Technology Societies Internal Symposium & The 52nd Convention of the Korean Society of Analytical Sciences   11 Jun 2014   
Modulation of drug metabolism and toxicity by microRNAs [Invited]
Miki Nakajima
20th International Symposium on Microsomes and Drug Oxidations   18 May 2014   
New knowledge of microRNAs controlling human P450 expression or activities [Invited]
Miki Nakajima
5th Asia Pacific ISSX Meeting   9 May 2014   
Establishment of animal model of drug-induced liver injury: Involvement of immune- and inflammatory-related factors and P450-mediated metabolism [Invited]
Tsuyoshi Yokoi, Miki Nakajima, and Eita Sasaki
5th Asia Pacific ISSX Meeting   9 May 2014   
New knowledge of the microRNA-mediated regulation of drug metabolism [Invited]
Miki Nakajima
9 Oct 2013   
Recent progress in characterization of esterases in human: implications in drug development. [Invited]
Tatsuki Fukami and Miki Nakajima
9 Oct 2013   
Control of xeno/endobiotics-metabolizing P450s by microRNAs. [Invited]
Miki Nakajima
チトクロムP450発見50周年記念シンポジウム   2 Dec 2012   

Research Grants & Projects

 
Regulation of drug metabolizing enzymes
Genetic polymorphism of Drug Metabolizing Enzymes
Drug Interaction