Yoichi Chiba

Profile Information

Affiliation: Faculty of Medicine, Kagawa University

Degree: Ph.D.(Sep, 2005, Kyoto University)

J-GLOBAL ID: 200901008520160336
researchmap Member ID: 1000287885

Research Interests

Research Areas

Research History

Feb, 2021 - Present

Associate professor, Inflammatino Pathology, Faculty of Medicine, Kagawa University
Sep, 2013 - Jan, 2021

Lecturer, Inflammation Pathology, Faculty of Medicine, Kagawa University
Apr, 2003 - Aug, 2013

Research Scientist, Department of Pathology, Institute for Developmental Research, Aichi Human Service Center
Jun, 1996 - Mar, 1999

Clinical Fellow, Department of Neurology, Nagahama City Hospital
May, 1995 - May, 1996

Resident, Department of Neurology, Kyoto University Hospital

Education

Apr, 1999 - Mar, 2003

Graduate School of Medicine, Kyoto University
Apr, 1989 - Mar, 1995

Faculty of Medicine, Kyoto University
Clinical neurology, Graduate School, Division of Medicine, Kyoto University

Committee Memberships

Papers

Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model

Takayuki Fujii, Haruyuki Nakayama-Imaohji, Aya Tanaka, Hiroto Katami, Kazuya Tanaka, Yoichi Chiba, Machi Kawauchi, Masaki Ueno, Tomomi Kuwahara, Ryuichi Shimono

Pediatric Surgery International, Sep 12, 2022
Metabolites and Biomarker Compounds of Neurodegenerative Diseases in Cerebrospinal Fluid.

Keiji Wakamatsu, Yoichi Chiba, Ryuta Murakami, Yumi Miyai, Koichi Matsumoto, Masaki Kamada, Wakako Nonaka, Naoya Uemura, Ken Yanase, Masaki Ueno

Metabolites, 12(4), Apr 12, 2022 Peer-reviewedInvited
Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains.

Keiji Wakamatsu, Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Yumi Miyai, Machi Kawauchi, Ken Yanase, Naoya Uemura, Masaki Ueno

Neuropathology : official journal of the Japanese Society of Neuropathology, 42(2) 117-125, Apr, 2022
Constrictive pericarditis caused by pericardial metastasis from esophageal squamous cell carcinoma: a case report

Takayoshi Kishino, Kensuke Kumamoto, Hiroyuki Matsukawa, Akihiro Kondo, Yasuhisa Ando, Jun Uemura, Hironobu Suto, Eisuke Asano, Minoru Oshima, Yoichi Chiba, Masaki Ueno, Sayako Nakagawa, Shohei Kitamoto, Yoichi Yamashita, Taiko Horii, Keiichi Okano

International Cancer Conference Journal, Mar 15, 2022 Peer-reviewed
Perianal alveolar rhabdomyosarcoma with pulmonary lymphangitic sarcomatosis: Report of an autopsy case

Koichi Matsumoto, Ryou Ishikawa, Noriko Fuke, Takayuki Yokota, Takayuki Wakabayashi, Yoichi Chiba, Machi Kawauchi, Hitoshi Okada, Takako Yoshioka, Masaki Ueno

Human Pathology: Case Reports, 25 200544-200544, Sep, 2021 Peer-reviewed
Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta.

Maruf Mohammad Akbor, Nobuyuki Kurosawa, Hiroki Nakayama, Ayumi Nakatani, Koji Tomobe, Yoichi Chiba, Masaki Ueno, Masashi Tanaka, Yasuyuki Nomura, Masaharu Isobe

PloS one, 16(3) e0248027, Mar 4, 2021 Peer-reviewed
Immunoreactivity of receptor and transporters for lactate located in astrocytes and epithelial cells of choroid plexus of human brain.

Ryuta Murakami, Yoichi Chiba, Nozomu Nishi, Koichi Matsumoto, Keiji Wakamatsu, Ken Yanase, Naoya Uemura, Wakako Nonaka, Masaki Ueno

Neuroscience letters, 741 135479-135479, Jan 10, 2021 Peer-reviewed
Proteomic profile differentiating between mesial temporal lobe epilepsy with and without hippocampal sclerosis.

Ayako Furukawa, Akiyoshi Kakita, Yoichi Chiba, Hiroki Kitaura, Yukihiko Fujii, Masafumi Fukuda, Shigeki Kameyama, Atsuyoshi Shimada

Epilepsy research, 168 106502-106502, Dec, 2020 Peer-reviewed
Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium

Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Keiji Wakamatsu, Wakako Nonaka, Naoya Uemura, Ken Yanase, Masaki Kamada, Masaki Ueno

International Journal of Molecular Sciences, 21(19) 7230-7230, Sep 30, 2020 Peer-reviewedInvitedLead author
Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells in human and mouse brains

Yoichi Chiba, Yasunori Sugiyama, Nozomu Nishi, Wakako Nonaka, Ryuta Murakami, Masaki Ueno

Neuropathology, 40(5) 482-491, Jun, 2020 Peer-reviewedLead author
Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice.

Yuki Nakano, Kazuyuki Hirooka, Yoichi Chiba, Masaki Ueno, Daiki Ojima, Md Razib Hossain, Hiroo Takahashi, Tohru Yamamoto, Yoshiaki Kiuchi

Cell death & disease, 11(3) 166-166, Mar 3, 2020 Peer-reviewed
Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains.

Ken Yanase, Naoya Uemura, Yoichi Chiba, Ryuta Murakami, Ryuji Fujihara, Koichi Matsumoto, Gotaro Shirakami, Nobukazu Araki, Masaki Ueno

Neuropathology : official journal of the Japanese Society of Neuropathology, 40(1) 75-83, Feb, 2020 Peer-reviewed
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.

Takayuki Fujii, Yoichi Chiba, Haruyuki Nakayama-Imaohji, Shun Onishi, Aya Tanaka, Hiroto Katami, Tatsuru Kaji, Satoshi Ieiri, Takanori Miki, Masaki Ueno, Tomomi Kuwahara, Ryuichi Shimono

Journal of pediatric surgery, 54(12) 2514-2519, Dec, 2019 Peer-reviewed
Neuroprotective activation of astrocytes by methymercury exposure in the inferior colliculus.

Ishihara Y, Itoh K, Oguro A, Chiba Y, Ueno M, Tsuji M, Vogel CFA, Yamazaki T

Sci Rep, 9(1) 13899, Sep, 2019 Peer-reviewed
Disturbance of intracerebral fluid clearance and blood-brain barrier in vascular cognitive impairment.

Ueno M, Chiba Y, Murakami R, Matsumoto K, Fujihara R, Uemura N, Yanase K, Kamada M

Int J Mol Sci, 20(10) 2600, May, 2019 Peer-reviewedInvited
Histomorphometry of ectopic mineralization using undecalcified frozen bone sections.

Fujihara R, Chiba Y, Nakagawa T, Murakami R, Matsumoto K, Kawauchi M, Fujii T, Shimono R, Yamamoto T, Ueno M

Microsc Res Tech, 81(11) 1318-1324, Oct, 2018 Peer-reviewed
Characterization of neutralizing antibodies reacting with the 213-224 amino-acid segment of human galectin-9.

Lhuillier C, Barjon C, Baloche V, Niki T, Gelin A, Mustapha R, Claër L, Hoos S, Chiba Y, Ueno M, Hirashima M, Wei M, Morales O, Raynal B, Delhem N, Dellis O, Busson P

PLoS ONE, 13(9) e202512, Sep, 2018 Peer-reviewed
Correlation of 4’-[methyl-11C]-thiothymidine uptake with human equilibrative nucleoside transporter-1 and thymidine kinase-1 expressions in patients with newly diagnosed gliomas.

Takami Y, Yamamoto Y, Ueno M, Chiba Y, Norikane T, Hattakeyama T, Miyake K, Toyohara J, Nishiyama Y

Ann Nucl Med, 32(9) 634-641, Jul, 2018 Peer-reviewed
Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains

Naoya Uemura, Ryuta Murakami, Yoichi Chiba, Ken Yanase, Ryuji Fujihara, Masato Mashima, Koichi Matsumoto, Machi Kawauchi, Gotaro Shirakami, Masaki Ueno

NEUROSCIENCE LETTERS, 659 99-103, Oct, 2017 Peer-reviewed
SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.

Ichiro Akiguchi, Mercè Pallàs, Herbert Budka, Haruhiko Akiyama, Masaki Ueno, Jingxian Han, Hideo Yagi, Tomohumi Nishikawa, Yoichi Chiba, Hiroshi Sugiyama, Ryoya Takahashi, Keiko Unno, Keiichi Higuchi, Masanori Hosokawa

Neuropathology : official journal of the Japanese Society of Neuropathology, 37(4) 293-305, Aug, 2017 Peer-reviewed

Misc.

血液脳脊髄液関門におけるアミロイドベータおよび糖等の輸送体の局在について

上野正樹, 千葉陽一, 村上龍太, 松本晃一

香川県医師会誌, 69, 2016
錐体路変性に左右差がみられた筋萎縮性側索硬化症(ALS)例の臨床病理学的検討

千葉陽一, 池本明人, 杉山博, 重松一生, 鵜沼恒夫, 島田厚良, 細川昌則, 秋口一郎

Neuropathology : official journal the Japanese Society of Neuropathology, 23 99-99, May 1, 2003
老化促進モデルマウスの大脳辺縁系に好発するユビキチン化封入体

島田厚良, 河村則子, 柏井明子, 続木雅子, 千葉陽一, 細川昌則

Neuropathology : official journal the Japanese Society of Neuropathology, 23 231-231, May 1, 2003
Ultrastructure of the Aging Tissues in SAM Mice Morphological Basis of the Senescence Acceleration and Age-dependent Degenerative Disorders

HOSOKAWA M., UENO M., NISHIKAWA T., CHIBA Y., AKIGUCHI I.

Electron-microscopy, 34 55-58, Nov 1, 1999
前頭側頭葉優位の脳萎縮と広範なLewy小体の出現をみたNiemann-Pick病C型の一剖検例

千葉陽一, 小森拓, 吉田太, 足立香織, 難波栄二, 武井史郎, 石井さなえ, 上野正樹, 細川昌則, 島田厚良

日本病理学会会誌, 104(1) 435-435, Mar, 2015

Books and Other Publications

The senescence-accelerated mouse (SAM): Achievements and Future Directions.

Chiba Y, Fujisawa-Tsukaguchi H, Nishikawa T, Hosokawa M (Role: Contributor, Higher oxidative stress status and micochondrial alterations as a possible mechanism for senescence acceleration.)

Elsevier, 2013
Aging and Age-related DIsorders, Oxidative Stress in Applied Basic Research and Clinical Practice 3

Chiba Y, Shimada A, Hosokawa M (Role: Contributor, The SAM strain of mice, a higher oxidative stress, age-dependent degenerative diseasse, and senescence acceleration model.)

Springer Science+Business Media LLC, 2010
新老年学

細川昌則, 千葉陽一, 塚口(藤澤)裕美 (Role: Contributor, 老化モデル：マウス)

東京大学出版会, 2010
老化・老年病研究のための動物実験ガイドブック

細川昌則, 千葉陽一 (Role: Contributor, SAMマウス)

アドスリー, 2008
Neural Proteoglycans

Saitoh Y, Chiba Y, Shimada A (Role: Contributor, Aging and Proteoglycan.)

Research Signpost, 2007

Presentations

Expression of transporters of glucose and fructose in epithelial cells of the choroid plexus and ependymal cells of human and mouse brains.

Chiba Y, Matsumoto K, Murakami R, Uemura N, Mashima M, Yanase K, Fujihara R, Kawauchi M, Ueno M

19th International Congress of Neuropathology, Sep 25, 2018
Mitochondrial alterations and a higher oxidative status in cultured fibroblast-like cells from senescence-accelerated mice.

Chiba Y, Yamashita Y, Hirayoshi K, Ueno M, Fujisawa H, Matsushita T, Kogishi K, Akiguchi I, Satoh M, Shimada A, Hosokawa M

The 2nd International Conference of Senescence: The SAM Model, Jul 21, 2003

Professional Memberships

Research Projects

細胞老化によるアストロサイト機能不全が神経変性をもたらす分子メカニズムの解明

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2019 - Mar, 2022

千葉陽一
疾患モデルマウスを用いたSLC19A3欠損症の治療法の確立

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2017 - Mar, 2020

若松延昭
ニューロンの細胞老化は加齢性神経変性疾患発症の要因となりうるか？

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2015 - Mar, 2018

千葉陽一
脳内炎症と低酸素が惹起する脳室周囲白質軟化症におけるエピゲノム変化の分子病態解析

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2013 - Mar, 2016

細川昌則
果糖過剰摂取による認知症に対する影響について

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2012 - Mar, 2015

上野正樹
知的障害者用認知症スクリーニング尺度の標準化

科学研究費補助金基盤研究（Ｃ）, 日本学術振興会, Apr, 2009 - Mar, 2015

長谷川桜子
オリゴデンドロサイトの髄鞘化と軸索保護におけるプロスタグランジンの役割の解明

科学研究費補助金基盤研究(C), 日本学術振興会, Apr, 2011 - Mar, 2014

千葉陽一
細胞内コレステロール代謝異常がα-synuclein凝集を促進する分子機構の解明

第１回医学研究助成, 中京長寿医療研究推進財団, Apr, 2012 - Mar, 2013

千葉陽一
創薬のための新たな皮膚光老化自然発症モデルマウスの開発

第25回研究助成金, 中富健康科学振興財団, Apr, 2012 - Mar, 2013

千葉陽一
パーキンソン病における酸化ストレス誘導神経細胞死の新規解明と予防法の確立

科学研究費補助金基盤研究（B）, 日本学術振興会, Apr, 2008 - Mar, 2011

及川伸二
プロテアソーム・オートファジー不全による神経細胞変性のリアルタイムイメージング

科学研究費補助金若手研究(B), 日本学術振興会, Apr, 2008 - Mar, 2010

千葉陽一
知的障害者の認知症と転棟リスクをスクリーニングする評価法の作成

第22回研究奨励助成金, 総合研究推進財団, Jan, 2006 - Dec, 2006

千葉陽一
培養系を用いたミトコンドリア機能障害と酸化的ストレスによる神経細胞変性機構の解明

科学研究費補助金若手研究（B）, 日本学術振興会, Apr, 2004 - Mar, 2006

千葉陽一

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Research Interests

Research Areas

Research History

Education

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Papers

Misc.

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