立花 誠

CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. 

Proceedings of the National Academy of Sciences of the United States of America 120(20) e2221499120 2023年5月16日  査読有り

HP1 maintains protein stability of H3K9 methyltransferases and demethylases. 

EMBO reports 23(4) e53581 2022年4月5日  査読有り

Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY. 

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 1-9 2021年9月28日  査読有り招待有り

The mouse Sry locus harbors a cryptic exon that is essential for male sex determination. 

Science (New York, N.Y.) 370(6512) 121-124 2020年10月2日  査読有り

H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline. 

Stem cell reports 15(2) 424-438 2020年8月11日  査読有り

TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression. 

Scientific reports 9(1) 13462-13462 2019年9月17日  査読有り

Role of epigenetic regulation in mammalian sex determination. 

Current topics in developmental biology 134 195-221 2019年  査読有り招待有り

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis. 

Stem cell reports 10(4) 1340-1354 2018年4月10日  査読有り

Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance 

PLoS Genetics 13(9) e1007034 2017年9月1日  査読有り

Epigenetics of sex determination in mammals. 

Reproductive medicine and biology 15(2) 59-67 2016年4月  査読有り

Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination. 

Genesis (New York, N.Y. : 2000) 53(6) 387-93 2015年6月  査読有り

JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice. 

Biology of reproduction 89(4) 93-93 2013年10月  査読有り

Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. 

Science (New York, N.Y.) 341(6150) 1106-9 2013年9月6日  査読有り

Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells. 

Biology of reproduction 88(2) 36-36 2013年2月  査読有り

H3K9 methyltransferase G9a and the related molecule GLP. 

Genes & development 25(8) 781-8 2011年4月15日  査読有り

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. 

Nature 464(7290) 927-31 2010年4月8日  査読有り

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. 

Genes to cells : devoted to molecular & cellular mechanisms 14(8) 991-1001 2009年8月  査読有り

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. 

The EMBO journal 27(20) 2681-90 2008年10月22日  査読有り

Functional dynamics of H3K9 methylation during meiotic prophase progression. 

The EMBO journal 26(14) 3346-59 2007年7月25日  査読有り

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. 

The Journal of biological chemistry 281(29) 20120-8 2006年7月21日  査読有り

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. 

Genes & development 19(7) 815-26 2005年4月1日  査読有り

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. 

Genes & development 16(14) 1779-91 2002年7月15日  査読有り

SET domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3 

JOURNAL OF BIOLOGICAL CHEMISTRY 276(27) 25309-25317 2001年7月  査読有り

Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human immunodeficiency virus 

JOURNAL OF BIOLOGICAL CHEMISTRY 275(27) 20288-20294 2000年7月  査読有り