OHTSUKA Toshiyuki

J-GLOBAL         Last updated: Jun 21, 2018 at 17:24
 
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Name
OHTSUKA Toshiyuki
Affiliation
Kyoto University
Section
Institute for Virus Research, Laboratory of Growth Regulation
Job title
Associate Professor
Degree
Doctor of Medicine(Kyoto University)

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
2000
   
 
Institute for Virus Research, Kyoto University,
 
 
   
 
Assistant Professor
 
2004
   
 
Institute for Virus Research, Kyoto University,
 
 
   
 
Associate Professor
 

Education

 
 
 - 
1997
Graduate School, Division of Medicine, Kyoto University
 
 
 - 
1990
Faculty of Medicine, Kyoto University
 

Published Papers

 
Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development.
Bansod S, Kageyama R, Ohtsuka T.
Development   144(17) 3156-3167   Sep 2017   [Refereed]
Shimojo H, Isomura A, Ohtsuka T, Kori H, Miyachi H, Kageyama R.
Genes and Development   30(1) 102-116   Jan 2016   [Refereed]
Goto M, Hojo M, Ando M, Kita A, Kitagawa M, Ohtsuka T, Kageyama R, Miyamoto S.
Brain Research   1625 206-217   Nov 2015   [Refereed]
Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R.
PLoS Genetics   11(9) e1005503   Sep 2015   [Refereed]
Watanabe N, Kageyama R, Ohtsuka T.
Development   142(13) 2278-2290   Jul 2015   [Refereed]
M. Kitagawa; M. Hojo; I. Imayoshi; M. Goto; M. Ando; T. Ohtsuka; R. Kageyama; S. Miyamoto
Mechanisms of Development   130(9-10) 458-466   2013   [Refereed]
I. Imayoshi; H. Shimojo; M. Sakamoto; T. Ohtsuka; R. Kageyama
Cellular and Molecular Life Sciences   70(12) 2045-2057   2013   [Refereed]
Y. Harima; Y. Takashima; Y. Ueda; T. Ohtsuka; R. Kageyama
Cell Reports   3(1) 1-7   2013   [Refereed]
S.-L. Tan; T. Ohtsuka; A. González; R. Kageyama
Genes to Cells   17(12) 952-961   2012   [Refereed]
S.-L. Tan; M. Nishi; T. Ohtsuka; T. Matsui; K. Takemoto; A. Kamio-Miura; H. Aburatani; Y. Shinkai; R. Kageyama
Development (Cambridge)   139(20) 3806-3816   2012   [Refereed]
T. Ueno; J. Ito; S. Hoshikawa; Y. Ohori; S. Fujiwara; S. Yamamoto; T. Ohtsuka; R. Kageyama; M. Akai; K. Nakamura; T. Ogata
GLIA   60(10) 1495-1505   2012   [Refereed]
T. Ueo; I. Imayoshi; T. Kobayashi; T. Ohtsuka; H. Seno; H. Nakase; T. Chiba; R. Kageyama
Development   139(6) 1071-1082   2012   [Refereed]
M. Sakamoto; I. Imayoshi; T. Ohtsuka; M. Yamaguchi; K. Mori; R. Kageyama
Proceedings of the National Academy of Sciences of the United States of America   108(20) 8479-8484   May 2011   [Refereed]
Y. Takashima; T. Ohtsuka; A. González; H. Miyachi; R. Kageyama
Proceedings of the National Academy of Sciences of the United States of America   108(8) 3300-3305   Feb 2011   [Refereed]
H. Shimojo; T. Ohtsuka; R. Kageyama
Frontiers in Neuroscience   (JUN)    2011   [Refereed]
T. Ohtsuka; H. Shimojo; M. Matsunaga; N. Watanabe; K. Kometani; N. Minato; R. Kageyama
Stem Cells   29(11) 1817-1828   2011   [Refereed]
R. Kageyama; Y. Niwa; H. Shimojo; T. Kobayashi; T. Ohtsuka
Current Topics in Developmental Biology   92 311-331   2010   [Refereed]
T. Ohtsuka; R. Kageyama
Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems   15-34   2010   [Refereed]
M.A. Arai; A. Masada; T. Ohtsuka; R. Kageyama; M. Ishibashi
Bioorganic and Medicinal Chemistry Letters   19(19) 5778-5781   Oct 2009   [Refereed]
Kageyama R, Ohtsuka T, Ohsawa R, Hatakeyama J
In Encyclopedia of Neuroscience (Ed. L.R. Squire). Academic Press, Oxford. vol. 4, pp. 1057-1065.      2009   [Refereed]
Cell differentiation
Kageyama R, Ohsawa R, Ohtsuka T
In Encyclopedia of Neuroscience (Eds. M.D. Binder, N. Hirokawa, and U. Windhorst) Academic Press, Oxford, pp. 591-596      2009   [Refereed]
J. Murata; T. Ohtsuka; A. Tokunaga; S. Nishiike; H. Inohara; H. Okano; R. Kageyama
Journal of Neuroscience Research   87(16) 3521-3534   2009   [Refereed]
R. Kageyama; T. Ohtsuka; H. Shimojo; I. Imayoshi
Current Opinion in Cell Biology   21(6) 733-740   2009   [Refereed]
I. Imayoshi; M. Sakamoto; T. Ohtsuka; R. Kageyama
Development Growth and Differentiation   51(3) 379-386   2009   [Refereed]
R. Kageyama; T. Ohtsuka; H. Shimojo; I. Imayoshi
Nature Neuroscience   11(11) 1247-1251   Nov 2008   [Refereed]
I. Imayoshi; M. Sakamoto; T. Ohtsuka; K. Takao; T. Miyakawa; M. Yamaguchi; K. Mori; T. Ikeda; S. Itohara; R. Kageyama
Nature Neuroscience   11(10) 1153-1161   Oct 2008   [Refereed]
I. Imayoshi; T. Shimogori; T. Ohtsuka; R. Kageyama
Development   135(15) 2531-2541   Aug 2008   [Refereed]
H. Shimojo; T. Ohtsuka; R. Kageyama
Neuron   58(1) 52-64   Apr 2008   [Refereed]
H. Kokubu; T. Ohtsuka; R. Kageyama
Genes to Cells   13(1) 41-51   Jan 2008   [Refereed]
T. Nakamura; T. Ohtsuka; E. Sekiyama; L.J. Cooper; H. Kokubu; N.J. Fullwood; Y. Barrandon; R. Kageyama; S. Kinoshita
Stem Cells   26(5) 1265-1274   2008   [Refereed]
R. Kageyama; T. Ohtsuka; T. Kobayashi
Development Growth and Differentiation   50(SUPPL. 1) S97-S103   2008   [Refereed]
S. Yoshiura; T. Ohtsuka; Y. Takenaka; H. Nagahara; K. Yoshikawa; R. Kageyama
Proceedings of the National Academy of Sciences of the United States of America   104(27) 11292-11297   Jul 2007   [Refereed]
R. Kageyama; T. Ohtsuka; T. Kobayashi
Development   134(7) 1243-1251   Apr 2007   [Refereed]
T. Muraguchi; Y. Takegami; T. Ohtsuka; S. Kitajima; E.P.S. Chandana; A. Omura; T. Miki; R. Takahashi; N. Matsumoto; A. Ludwig; M. Noda; C. Takahashi
Nature Neuroscience   10(7) 838-845   2007   [Refereed]
A. Kita; I. Imayoshi; M. Hojo; M. Kitagawa; H. Kokubu; R. Ohsawa; T. Ohtsuka; R. Kageyama; N. Hashimoto
Molecular Endocrinology   21(6) 1458-1466   2007   [Refereed]
J.H. Baek; J. Hatakeyama; S. Sakamoto; T. Ohtsuka; R. Kageyama
Development   133(13) 2467-2476   Jul 2006   [Refereed]
Y. Masamizu; T. Ohtsuka; Y. Takashima; H. Nagahara; Y. Takenaka; K. Yoshikawa; H. Okamura; R. Kageyama
Proceedings of the National Academy of Sciences of the United States of America   103(5) 1313-1318   Jan 2006   [Refereed]
T. Ohtsuka; I. Imayoshi; H. Shimojo; E. Nishi; R. Kageyama; S.K. McConnell
Molecular and Cellular Neuroscience   31(1) 109-122   Jan 2006   [Refereed]
Kageyama R., Ohtsuka T., Hatakeyama J.
(Ed. G. Thiel) . Wiley-VCH Verlag, Weinheim. Pp3-22.      2006   [Refereed]
R. Kageyama; J. Hatakeyama; T. Ohtsuka
Transcription Factors in the Nervous System: Development, Brain Function, and Diseases   1-22   2006   [Refereed]
M. Moriyama; M. Osawa; S.-S. Mak; T. Ohtsuka; N. Yamamoto; H. Han; V. Delmas; R. Kageyama; F. Beermann; L. Larue; S.-I. Nishikawa
Journal of Cell Biology   173(3) 333-339   2006   [Refereed]
C.-T. Ong; H.-T. Cheng; L.-W. Chang; T. Ohtsuka; R. Kageyama; G.D. Stormo; R. Kopan
Journal of Biological Chemistry   281(8) 5106-5119   2006   [Refereed]
I. Imayoshi; T. Ohtsuka; D. Metzger; P. Chambon; R. Kageyama
Genesis   44(5) 233-238   2006   [Refereed]
R. Ohsawa; T. Ohtsuka; R. Kageyama
Journal of Neuroscience   25(25) 5857-5865   2005   [Refereed]
R. Kageyama; T. Ohtsuka; J. Hatakeyama; R. Ohsawa
Experimental Cell Research   306(2) 343-348   2005   [Refereed]
M. Sakamoto; H. Hirata; T. Ohtsuka; Y. Bessho; R. Kageyama
Journal of Biological Chemistry   278(45) 44808-44815   2003   [Refereed]
H. Hirata; S. Yoshiura; T. Ohtsuka; Y. Bessho; T. Harada; K. Yoshikawa; R. Kageyama
Science   298(5594) 840-843   Oct 2002   [Refereed]
T. Ohtsuka; M. Sakamoto; F. Guillemot; R. Kageyama
Journal of Biological Chemistry   276(32) 30467-30474   Aug 2001   [Refereed]
H. Hirata; T. Ohtsuka; Y. Bessho; R. Kageyama
Journal of Biological Chemistry   275(25) 19083-19089   Jun 2000   [Refereed]
Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina
M. Hojo; T. Ohtsuka; N. Hashimoto; G. Gradwohl; F. Guillemot; R. Kageyama
Development   127(12) 2515-2522   Jun 2000   [Refereed]

Misc

 
Overexpression of Hes1 leads to prolonged neocortical neurogenesis and expansion of neural stem cell reservoir in postnatal brain
Toshiyuki Ohtsuka, Ryoichiro Kageyama
ISDN 2018      May 2018   [Refereed]
Overexpression of Hes1 leads to prolonged neocortical neurogenesis and expansion of neural stem cell reservoir in postnatal brain
Toshiyuki Ohtsuka, Ryoichiro Kageyama
The CDB Symposium 2018      Mar 2018   [Refereed]
Hes genes regulate the transition timing of neurogenesis and gliogenesis in neocortical development
OHTSUKA Toshiyuki
   Jul 2017
Hes5 regulates the transition timing of neurogenesis and gliogenesis in neocortical development via downregulation of Hmga genes
Toshiyuki Ohtsuka, Bansod Shama, 影山 龍一郎
   Jul 2017
Notch signaling dynamics during murine morphogenesis
Shimojo, H., Kori, H., Isomura, A., Ohtsuka, T., Miyachi, H., and Kageyama, R.
   Nov 2016   [Refereed]
Ultradian oscillations in Notch signaling during tissue morphogenesis
Shimojo, H., Kori, H., Isomura, A., Ohtsuka, T., Miyachi, H., and Kageyama, R.
Sapporo Symposium on Biological Rhythm      Nov 2016
Oscillatory Control of Delta-Like1 in Cell Interactions Regulates Dynamic Gene Expression and Tissue Morphogenesis
Shimojo, H., Kori, H., Isomura, A., Ohtsuka, T., Miyachi, H., and Kageyama, R.
The 10th Notch Meeting      Oct 2016   [Refereed]
Oscillatory Control of Delta-Like1 in Cell Interactions Regulates Dynamic Gene Expression and Tissue Morphogenesis
Shimojo, H., Kori, H., Isomura, A., Ohtsuka, T., Miyachi, H., and Kageyama, R.
   Sep 2016   [Refereed]
Oscillatory Control of Delta-Like1 in Cell Interactions Regulates Dynamic Gene Expression and Tissue Morphogenesis
Shimojo, H., Kori, H., Isomura, A., Ohtsuka, T., Miyachi, H., and Kageyama, R.
Gordon Research Seminar      Jul 2016   [Refereed]
Dynamic expression of Notch ligand Dll1 during development
Shimojo, H., Kori, H., Isomura, A., Ohtsuka, T., Miyachi, H., and Kageyama, R.
CDB Symposium      Mar 2016   [Refereed]

Books etc

 
Cortical Development
Hiromi Shimojo, Yuki Maeda, Toshiyuki Ohtsuka, Ryoichiro Kageyama (Part:Contributor, Dynamic Notch signaling in neuralprogenitor cells)
Springer Science+Business Media   2013   
Stem Cells and Cancer Stem Cells: Therapeutic Applications in Disease and Injury
Ryoichiro Kageyama, Hiromi Shimojo, Toshiyuki Ohtsuka, Itaru Imayoshi (Part:Contributor, Maintenance of neural stem cells in the brain: role of Notch signaling)
Springer Science+Business Media   2012   
Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems
Toshiyuki Ohtsuka, Ryoichiro Kageyama (Part:Contributor, The Basic Helix-Loop-Helix Transcription Factors in Neural Differentiation)
Springer Science+Business Media   2010   
Encyclopedia of Neuroscience
Ryoichiro Kageyama, Ryosuke Ohsawa, Toshiyuki Ohtsuka (Part:Contributor, Cell differentiation)
Academic Press   2009   
Transcription Factors in the Nervous System
Ryoichiro Kageyama, Jun Hatakeyama, Toshiyuki Ohtsuka (Part:Contributor, Roles of Hes bHLH factors in neural development)
Wiley-VCH Verlag   2005   

Conference Activities & Talks

 
Accelerated tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.
Harima, Y., Takashima, Y., Ueda, Y., Ohtsuka, T.,Kageyama, R.
The 20th East Asia Joint Symposium   2013   

Research Grants & Projects

 
Study on Maintenance and Differentiation of Neural Stem Cells