2018年6月1日
Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries
BioEssays
- ,
- 巻
- 40
- 号
- 6
- 開始ページ
- e1800008
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/bies.201800008
- 出版者・発行元
- John Wiley and Sons Inc.
Microautophagy is originally defined as lysosomal (vacuolar) membrane dynamics to directly enwrap and transport cytosolic components into the lumen of the lytic organelle. Molecular details of microautophagy had remained unknown until genetic studies in yeast identified a set of proteins required for the process. Subsequent studies with other experimental model organisms resulted in a series of discoveries that accompanied an expansion of the definition of microautophagy to also encompass endosomal membrane dynamics. These findings, however, still impose puzzling, non-integrated images as to the molecular mechanism of microautophagy. By reviewing recent studies on microautophagy in various experimental systems, we propose the classification of microautophagy into three types, as the basis for developing a comprehensive view of the process.
- ID情報
-
- DOI : 10.1002/bies.201800008
- ISSN : 1521-1878
- ISSN : 0265-9247
- PubMed ID : 29708272
- SCOPUS ID : 85048711745