2001年12月
Complementary signaling pathways regulate the unfolded protein response and are required for C-elegans development
CELL
- 巻
- 107
- 号
- 7
- 開始ページ
- 893
- 終了ページ
- 903
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0092-8674(01)00612-2
- 出版者・発行元
- CELL PRESS
The unfolded protein response (UPR) is a transcriptional and translational intracellular signaling pathway activated by the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). We have used C. elegans as a genetic model system to dissect UPR signaling in a multicellular organism. C. elegans requires ire-l-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress. In addition, ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival. We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0092-8674(01)00612-2
- ISSN : 0092-8674
- J-Global ID : 200902188305724310
- Web of Science ID : WOS:000173024200010