2003年2月
A time-dependent phase shift in the mammalian unfolded protein response
DEVELOPMENTAL CELL
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- 巻
- 4
- 号
- 2
- 開始ページ
- 265
- 終了ページ
- 271
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S1534-5807(03)00022-4
- 出版者・発行元
- CELL PRESS
Unfolded or misfolded proteins in the endoplasmic reticulum (ER) must be refolded or degraded to maintain homeostasis of the ER. The ATF6 and IRE1-XBP1 pathways are important for the refolding process in mammalian cells; activation of these transcriptional programs culminates in induction of ER-localized molecular chaperones and folding enzymes. We show here that degradation of misfolded glycoprotein substrates requires transcriptional induction of EDEM (ER degradation-enhancing (x-mannosidase-like protein), and that this is mediated specifically by IRE1-XBP1 and not by ATF6. As XBP1 is produced after ATF6 activation, our results reveal a time-dependent transition in the mammalian unfolded protein response: an ATF6-mediated unidirectional phase (refolding only) is followed by an XBP1-mediated bidirectional phase (refolding plus degradation) as the response progresses.
- リンク情報
- ID情報
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- DOI : 10.1016/S1534-5807(03)00022-4
- ISSN : 1534-5807
- PubMed ID : 12586069
- Web of Science ID : WOS:000180984600016