論文

査読有り
2003年2月

A time-dependent phase shift in the mammalian unfolded protein response

DEVELOPMENTAL CELL
  • H Yoshida
  • ,
  • T Matsui
  • ,
  • N Hosokawa
  • ,
  • RJ Kaufman
  • ,
  • K Nagata
  • ,
  • K Mori

4
2
開始ページ
265
終了ページ
271
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S1534-5807(03)00022-4
出版者・発行元
CELL PRESS

Unfolded or misfolded proteins in the endoplasmic reticulum (ER) must be refolded or degraded to maintain homeostasis of the ER. The ATF6 and IRE1-XBP1 pathways are important for the refolding process in mammalian cells; activation of these transcriptional programs culminates in induction of ER-localized molecular chaperones and folding enzymes. We show here that degradation of misfolded glycoprotein substrates requires transcriptional induction of EDEM (ER degradation-enhancing (x-mannosidase-like protein), and that this is mediated specifically by IRE1-XBP1 and not by ATF6. As XBP1 is produced after ATF6 activation, our results reveal a time-dependent transition in the mammalian unfolded protein response: an ATF6-mediated unidirectional phase (refolding only) is followed by an XBP1-mediated bidirectional phase (refolding plus degradation) as the response progresses.

リンク情報
DOI
https://doi.org/10.1016/S1534-5807(03)00022-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12586069
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000180984600016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S1534-5807(03)00022-4
  • ISSN : 1534-5807
  • PubMed ID : 12586069
  • Web of Science ID : WOS:000180984600016

エクスポート
BibTeX RIS