1995年6月
Effects of Low-Dose γ-irradiation to the Chest Regions on the Blood Pressure of Spontaneous Hypertensive Rat
Physiological Chemistry & Physics and Medical NMR
- ,
- 巻
- 27
- 号
- 3
- 開始ページ
- 161
- 終了ページ
- 165
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
We examined changes in the blood pressure and the superoxide dismutase (SOD) activities in aortic tissue after gamma-irradiation to the chest regions of spontaneous hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and obtained the following results. After 5 Gy irradiation, there was no change with time in the blood pressure in WKY rats, while a transient decrease (3 days later) was observed in SHR rats. The Cu/Zn-SOD activity in the aorta of SHR was less than that of WKY. 5 Gy irradiation induced an increase in the Cu/Zn-SOD activity in SHR nearly to the level observed in WKY, which remained unchanged upon irradiation. Therefore, unlike high-dose irradiation, irradiation at a relatively low-dose of 5 Gy to SHR appears to increase the aortic Cu/Zn-SOD activity, which is lacking in SHR, leading to a decrease in the blood pressure.
- リンク情報
- ID情報
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- ISSN : 0748-6642
- PubMed ID : 8868576
- SCOPUS ID : 0029433974