Feb, 1998
Inhibitory effects of prior low dose X-ray irradiation on Fe3+-NTA-induced hepatopathy in rats
Physiological Chemistry & Physics and Medical NMR
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- ,
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- Volume
- 30
- Number
- 1
- First page
- 15
- Last page
- 23
- Language
- English
- Publishing type
- Research paper (scientific journal)
- Publisher
- PHYSIOL CHEM PHYSICS MED NMR
Blood activities of hepatocellular enzymes such as lactate dehydrogenase (LDH), glutamic pyruvic transaminase (GPT) and glutamic oxalacetic transaminase (GOT) peaked at 12 hours after a single intraabdominal injection of ferric nitrilotriacetate (Fe3+-NTA) in rats. Enzymes such as alkaline phosphatase (ALP) and leucin amino peptidase (LAP) originating in the capillary bile ducts or bile secretory liver cells were also released into the blood between 6-24 hours after intraabdominal injection of Fe3+-NTA in rats. Furthermore, hyperoxidation of lipids occurred in rat hepatic cell membranes, reaching a peak 6 hours after intraabdominal injection of Fe3+-NTA. It was found that a single prior 0.5 Gy whole body X-ray irradiation significantly increased superoxide dismutase (SOD) activities and suppressed above-mentioned symptoms of transient hepatopathy in rats.
- Link information
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- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/9807233
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000076765800002&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031610221&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0031610221&origin=inward
- ID information
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- ISSN : 0748-6642
- Pubmed ID : 9807233
- SCOPUS ID : 0031610221
- Web of Science ID : WOS:000076765800002