2007年11月
Inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw
Journal of Radiation Research
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- 巻
- 48
- 号
- 6
- 開始ページ
- 505
- 終了ページ
- 513
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1269/jrr.07060
- 出版者・発行元
- OXFORD UNIV PRESS
We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At I hr after reperfusion from ischemia for I hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or I hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
- リンク情報
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- DOI
- https://doi.org/10.1269/jrr.07060
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17928744
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000252511000008&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36749092757&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=36749092757&origin=inward
- ID情報
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- DOI : 10.1269/jrr.07060
- ISSN : 0449-3060
- eISSN : 1349-9157
- PubMed ID : 17928744
- SCOPUS ID : 36749092757
- Web of Science ID : WOS:000252511000008