1999年4月
Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation
BRITISH JOURNAL OF HAEMATOLOGY
- 巻
- 105
- 号
- 1
- 開始ページ
- 295
- 終了ページ
- 302
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1111/j.1365-2141.1999.01290.x
- 出版者・発行元
- BLACKWELL SCIENCE LTD
Herpesviruses frequently cause serious complications after allogeneic bone marrow transplantation (allo-BMT). Recent studies have shown more rapid immune reconstitution after allogeneic peripheral blood stem cell transplantation (allo-PBSCT) compared with allo-BMT. However, it has not been clarified whether the improved immune reconstitution after allo-PBSCT is associated with a lower incidence of herpesvirus infections. We monitored the emergence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and HHV-7 DNA by a nested-double polymerase chain reaction in peripheral blood leucocytes from 22 allo-BMT and 16 allo-PBSCT patients, Each virus had an unique temporal profile of detection. HHV-6 DNA was detected most frequently at 3 weeks after transplantation, whereas CMV and EBV DNA were detected later (2-3 months). Detection rates of HHV-6 DNA at 3 and 4 weeks after allo-BMT were significantly higher than those after allo-PBSCT (9/16 v 2/13 at 3 weeks, P< 0.01; 10/21 v 1/15 at 4 weeks, P<0.01). Detection rates of the other three herpesviruses after the two types of allogeneic transplantation were not significantly different throughout observation period. Furthermore, detection of HHV-6 DNA within the first 4 weeks was associated with delayed platelet engraftment after both allo-BMT and allo-PBSCT (P<0.01). These results suggest an advantage for allo-PBSCT over allo-BMT in terms of suppression of HHV-6 reactivation and prevention of subsequent complications.
- リンク情報
- ID情報
-
- DOI : 10.1111/j.1365-2141.1999.01290.x
- ISSN : 0007-1048
- Web of Science ID : WOS:000080060900042