MISC

2005年6月

Implication of cyclin-dependent kinase 5 in the development of psychological dependence on and behavioral sensitization to morphine

JOURNAL OF NEUROCHEMISTRY
  • M Narita
  • ,
  • M Shibasaki
  • ,
  • Y Nagumo
  • ,
  • M Narita
  • ,
  • Y Yajima
  • ,
  • T Suzuki

93
6
開始ページ
1463
終了ページ
1468
記述言語
英語
掲載種別
DOI
10.1111/j.1471-4159.2005.03136.x
出版者・発行元
WILEY-BLACKWELL

In the present study, we investigated the role of cyclin-dependent kinase 5 (cdk5) in the brain dynamics changed by repeated in vivo treatment with morphine. The level of phosphorylated-cdk5 was significantly increased in the cingulate cortex of mice showing the morphine-induced rewarding effect. Under these conditions, roscovitine, a cdk5 inhibitor, given intracerebroventricularly (i.c.v.) caused a dose-dependent and significant inhibition of the morphine-induced rewarding effect. In addition, the dose-response effect of the morphine-induced rewarding effect was dramatically attenuated in cdk5 heterozygous (+/-) knockout mice. Furthermore, the development of behavioral sensitization by intermittent administration of morphine was virtually abolished in cdk5 (+/-) mice. These findings suggest that the induction and/or activation of cdk5 are implicated in the development of psychological dependence on morphine.

リンク情報
DOI
https://doi.org/10.1111/j.1471-4159.2005.03136.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000229425800011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1471-4159.2005.03136.x
  • ISSN : 0022-3042
  • Web of Science ID : WOS:000229425800011

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