2005年6月
Implication of cyclin-dependent kinase 5 in the development of psychological dependence on and behavioral sensitization to morphine
JOURNAL OF NEUROCHEMISTRY
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- 巻
- 93
- 号
- 6
- 開始ページ
- 1463
- 終了ページ
- 1468
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1111/j.1471-4159.2005.03136.x
- 出版者・発行元
- WILEY-BLACKWELL
In the present study, we investigated the role of cyclin-dependent kinase 5 (cdk5) in the brain dynamics changed by repeated in vivo treatment with morphine. The level of phosphorylated-cdk5 was significantly increased in the cingulate cortex of mice showing the morphine-induced rewarding effect. Under these conditions, roscovitine, a cdk5 inhibitor, given intracerebroventricularly (i.c.v.) caused a dose-dependent and significant inhibition of the morphine-induced rewarding effect. In addition, the dose-response effect of the morphine-induced rewarding effect was dramatically attenuated in cdk5 heterozygous (+/-) knockout mice. Furthermore, the development of behavioral sensitization by intermittent administration of morphine was virtually abolished in cdk5 (+/-) mice. These findings suggest that the induction and/or activation of cdk5 are implicated in the development of psychological dependence on morphine.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1471-4159.2005.03136.x
- ISSN : 0022-3042
- Web of Science ID : WOS:000229425800011