2009年1月1日
Present and future of reverse genetics of rotavirus
Uirusu. Journal of virology
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- 巻
- 59
- 号
- 開始ページ
- 91
- 終了ページ
- 98
- DOI
- 10.2222/jsv.59.91
Rotavirus is the leading pathogen for acute gastroenteritis in mammals and birds. Although the reverse genetics system has been utilized in many viruses, the system using a helper virus was developed for rotavirus in 2006. As a step for antigenic analysis of VP4 antigen of rotavirus, we prepared an infectious rotavirus with a spike protein VP4 having an antigenic mosaic by substituting one of the cross-reactive neutralization epitopes of a simian strain SA-11 with the corresponding one of a human strain DS-1. The future improvement and application of the rotavirus reverse genetics were discussed in this review.
- リンク情報
- ID情報
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- DOI : 10.2222/jsv.59.91
- ISSN : 0042-6857
- PubMed ID : 19927993
- SCOPUS ID : 74249113467