2008年8月
Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy
NANOMEDICINE
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- 巻
- 3
- 号
- 4
- 開始ページ
- 453
- 終了ページ
- 463
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2217/17435889.3.4.453
- 出版者・発行元
- FUTURE MEDICINE LTD
Aim: Functional analyses of water-dispersed carbon nanohorns with antitumor activity were performed to explore their potential as a drug carrier for local cancer chemotherapy. Materials & methods: Water-dispersed carbon nanohorns were prepared through adsorption of polyethylene glycol-doxorubicin conjugate (PEG-DXR) onto oxidized single-wall carbon nanohorns (oxSWNHs). PEG-DXR-bound oxSWNHs were administered intratumorally to human nonsmall cell lung cancer-cell NCI-H460-bearing mice. Results & discussion: When injected intratumorally, PEG-DXR-bound oxSWNHs caused significant retardation of tumor growth associated with prolonged DXR retention in the tumor. In accordance with this DXR retention, a large number of oxSWNH agglomerates was found in the periphery of the tumor. Histological analyses showed migration of oxSWNHs to the axillary lymph node, which is a major site of breast cancer metastasis near the tumor, possibly by means of interstitial lymphatic-fluid transport. Conclusions: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy.
- リンク情報
- ID情報
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- DOI : 10.2217/17435889.3.4.453
- ISSN : 1743-5889
- Web of Science ID : WOS:000258612700008