Noriyuki Murai

Profile Information

Affiliation: Associate Professor, Department of Molecular Biology, The Jikei University School of Medicine

Degree: (BLANK)(Mar, 1997, Tokyo Institute of Technology)

Contact information: nmuraijikei.ac.jp
ORCID ID: https://orcid.org/0000-0002-1552-5104
researchmap Member ID: 1000296691

External link: http://www.jikei.ac.jp/mb/murai_e.html

Research Areas

Research History

Jun, 2022 - Present

Associate Professor, Molecular Biology, The Jikei University School of Medicine
Nov, 2009 - May, 2022

Assistant Professor (Assistant Professor), Molecular Biology, Jikei University
Apr, 2007 - Oct, 2009

Research associate, Department of Molecular Biology, The Jikei University School of Medicine
Apr, 1999 - Mar, 2007

Assistant Professor, Biochemistry 2, Jikei University
Apr, 1997 - Mar, 1999

Researcher, Bacteriology, National Institute of Infectious Diseases
Apr, 1996 - Mar, 1997

JSPS Research Fellowship for Young Scientists

Education

Apr, 1994 - Mar, 1997

Interdisciplinary Science and Engineering, Tokyo Institute of Technology

Committee Memberships

Jan, 2016 - Present

Planning and Steering Committee, The Japanese Society of Polyamines
Jan, 2015 - Present

councillor, The Japanese Society of Polyamine Resarch

Papers

Ubiquitin-Independent Proteasomal Degradation Mediated by Antizyme

Noriyuki Murai

Ubiquitin - Proteasome Pathway, Dec 9, 2020 Peer-reviewedInvitedLead authorCorresponding author
Novel biallelic splice-site BBS1 variants in Bardet-Biedle syndrome: a case report of the first Japanese patient.

Satoshi Katagiri, Katsuhiro Hosono, Takaaki Hayashi, Noriyuki Murai, Eiichi Wake, Ichiro Miyata, Kei Mizobuchi, Kentaro Kurata, Tomokazu Matsuura, Tadashi Nakano …

Documenta ophthalmologica. Advances in ophthalmology, 141(1) 77-88, Aug, 2020 Peer-reviewed
Investigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-4.

Takahiko J Fujimi, Yoshihiro Mezaki, Takahiro Masaki, Ayasa Tajima, Mariko Nakamura, Akira Yoshikawa, Noriyuki Murai, Mamoru Aizawa, Soichi Kojima, Yoshihiro Matsumoto …

Human cell, 33(3) 590-598, Jul, 2020 Peer-reviewed
Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2

Noriyuki Murai, Yasuko Murakami, Ayasa Tajima, Senya Matsufuji

Scientific Reports, 8(1) 3005-3005, Dec, 2018 Peer-reviewedLead authorCorresponding author
Compound heterozygous splice site variants in the SCLT1 gene highlight an additional candidate locus for Senior-Løken syndrome.

Satoshi Katagiri, Takaaki Hayashi, Kazutoshi Yoshitake, Noriyuki Murai, Zenichi Matsui, Hiroyuki Kubo, Hiroyuki Satoh, Senya Matsufuji, Tsuyoshi Takamura, Takashi Yokoo …

Scientific reports, 8(1) 16733-16733, Nov 13, 2018 Peer-reviewed
Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.

Keisuke Tamari, Masamitsu Konno, Ayumu Asai, Jun Koseki, Kazuhiko Hayashi, Koichi Kawamoto, Noriyuki Murai, Senya Matsufuji, Fumiaki Isohashi, Taroh Satoh …

Cell death discovery, 4 104-104, 2018 Peer-reviewed
Polyamine regulating protein antizyme binds to ATP citrate lyase to accelerate acetyl-CoA production in cancer cells.

Ayasa Tajima, Noriyuki Murai, Yasuko Murakami, Takeo Iwamoto, Toshiro Migita, Senya Matsufuji

Biochemical and biophysical research communications, 471(4) 646-51, Mar 18, 2016 Peer-reviewed
MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma.

Yukihiro Hirata, Noriyuki Murai, Nozomu Yanaihara, Misato Saito, Motoaki Saito, Mitsuyoshi Urashima, Yasuko Murakami, Senya Matsufuji, Aikou Okamoto

BMC cancer, 14 799-799, Nov 3, 2014 Peer-reviewed
Rho-kinase regulation of TNF-α-induced nuclear translocation of NF-κB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells

Keiichiro Matoba, Daiji Kawanami, Masami Tsukamoto, Jun Kinoshita, Tomoko Ito, Sho Ishizawa, Yasushi Kanazawa, Tamotsu Yokota, Noriyuki Murai, Senya Matsufuji …

American Journal of Physiology - Renal Physiology, 307(5) F571-F580, Sep 1, 2014 Peer-reviewed
Multiple forms of mouse antizyme inhibitor 1 mRNA differentially regulated by polyamines.

Yasuko Murakami, Makiko Ohkido, Hiroko Takizawa, Noriyuki Murai, Senya Matsufuji

Amino acids, 46(3) 575-83, Mar, 2014 Peer-reviewed
Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α.

Keiichiro Matoba, Daiji Kawanami, Rina Okada, Masami Tsukamoto, Jun Kinoshita, Tomoko Ito, Sho Ishizawa, Yasushi Kanazawa, Tamotsu Yokota, Noriyuki Murai …

Kidney international, 84(3) 545-54, Sep, 2013 Peer-reviewed
Protocols for studying antizyme expression and function.

Noriyuki Murai, Yasuko Murakami, Senya Matsufuji

Methods in molecular biology (Clifton, N.J.), 720 237-67, 2011 Peer-reviewed
Subcellular localization and phosphorylation of antizyme 2.

Noriyuki Murai, Akihiro Shimizu, Yasuko Murakami, Senya Matsufuji

Journal of cellular biochemistry, 108(4) 1012-21, Nov 1, 2009 Peer-reviewed
The change of antizyme inhibitor expression and its possible role during mammalian cell cycle.

Yasuko Murakami, Jun-ichiro Suzuki, Keijiro Samejima, Kenjiro Kikuchi, Tomasz Hascilowicz, Noriyuki Murai, Senya Matsufuji, Takami Oka

Experimental cell research, 315(13) 2301-11, Aug 1, 2009 Peer-reviewed
Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity

T Shimamura, A Koike-Takeshita, K Yokoyama, R Masui, N Murai, M Yoshida, H Taguchi, S Iwata

STRUCTURE, 12(8) 1471-1480, Aug, 2004
Identification of nuclear export signals in antizyme-1

N Murai, Y Murakami, S Matsufuji

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(45) 44791-44798, Nov, 2003
Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio).

Tomasz Hascilowicz, Noriyuki Murai, Senya Matsufuji, Yasuko Murakami

Biochimica et biophysica acta, 1578(1-3) 21-8, Oct 11, 2002 Peer-reviewed
Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio)

T Hascilowicz, N Murai, S Matsufuji, Y Murakami

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1578(1-3) 21-28, Oct, 2002
Synchronized domain-opening motion of GroEL is essential for communication between the two rings

K Shiseki, N Murai, F Motojima, T Hisabori, M Yoshida, H Taguchi

JOURNAL OF BIOLOGICAL CHEMISTRY, 276(14) 11335-11338, Apr, 2001
Genetic and immunological analyses of Vls (VMP-like sequences) of Borrelia burgdorferi

H Kawabata, F Myouga, Y Inagaki, N Murai, H Watanabe

MICROBIAL PATHOGENESIS, 24(3) 155-166, Mar, 1998

Misc.

Moleculer Mechanism of H+(Na+)/Alanine Symporter of Thermophilic Bacterium PS3.

平田肇, 鎌田英明, 村井法之, 永島祐司

生体エネルギー研究会討論会講演要旨集, 19th 100-101, 1993
Expression of Thermophilic Bacterium PS3 Alanine Carrier Protein Gene.

村井法之, 鎌田英明, 永島祐司, 平田肇

日本生物物理学会年会講演予稿集, 31st S181, Sep, 1993
Moleculer Mechanism of H+(Na+)/Alanine Symporter of Thermophilic Bacterium PS3.

平田肇, 鎌田英明, 村井法之, 金森睦

生体エネルギー研究会討論会講演要旨集, 20th 88-89, 1994
好熱菌PS3アラニンキャリアタンパク質(ACP)遺伝子の発現と大腸菌アラニン輸送体(E.DagA)

金森睦, 村井法之, 永島祐司, 鎌田英明, 平田肇

日本生物物理学会年会講演予稿集, 32nd S98, Sep, 1994
Action mechanism of schapelonin.

吉田賢右, 山越美津子, 村井法之, 牧野祥嗣, 安藤亮太, 石井則行, 田口英樹

日本細胞生物学会大会講演要旨集, 48th 11, 1995
Chaperonin and protein folding

Noriyuki Murai, Masasuke Yoshida

実験医学, 13(12) 1405-1412, Jul 20, 1995 Peer-reviewedInvitedLead author
Mechanism of Chaperonin. Is the Football-Type Chaperonin Essential for the Functional Cycle?

吉田賢右, 山越美津子, 村井法之, 牧野祥嗣, 安藤亮太, 石井則行, 田口英樹

日本分子生物学会年会プログラム・講演要旨集, 18th 164, Nov, 1995
A functional role of structural change of the chaperonin GroEL.

村井法之, 牧野祥詞, 吉田賢右

日本分子生物学会年会プログラム・講演要旨集, 19th 178, Jul, 1996
シャペロニンに依存したタンパク質折れ畳みの分子機構

田口英樹, 天田啓, 村井法之, 牧野祥嗣, 山越美津子, 元島史尋, 青木勝彦, 始関紀彰, 吉田賢右

日本生物物理学会年会講演予稿集, 34th S152, Oct, 1996
Molecular medicine of infectious diseases. Fundamentals and clinical practice. Pathogenicity of fulminant A group streptococcus.

村井法之, 渡辺治雄

現代医療, 30(5) 1211-1219, May, 1998
オルニチン脱炭酸酵素の分解機構

村井法之, 松藤千弥, 棚橋伸行, 田中啓二, 村上安子

生化学, 72(8) 772, Aug 25, 2000
アンチザイム1,2の核内外移行

村井法之, 村上安子, 松藤千弥

生化学, 73(8) 754, Aug 25, 2001
アンチザイム1,2のリン酸化

村井法之, 松藤千弥

生化学, 74(8) 1013, Aug 25, 2002
アンチザイム1, 2の細胞内局在 (第119回成医会総会一般演題)

村井法之, 村上安子, 松藤千弥

東京慈恵会医科大学雑誌, 117(6) 368-368, Nov 15, 2002
アンチザイム2のリン酸化

村井法之, 松藤千弥

日本分子生物学会年会プログラム・講演要旨集, 26th 729, Nov 25, 2003
アンチザイム2の相互作用分子の探索

村井法之, 松藤千弥

日本分子生物学会年会プログラム・講演要旨集, 27th 742, Nov 25, 2004
Two-Dimensional Protein Analysis of Functional Liver Cells For Bioartificial Liver

HASCILOWICZ Tomasz, KOSUGE Makoto, MATSUURA Tomokazu, MATSUFUJI Senya, MURAI Noriyuki

Jikeikai medical journal, 52(4) 109-114, Dec 10, 2005
細胞内在性RNAアプタマーの標的分子としてのアンチザイム・シュードノットRNA結合タンパク質の探索

堀谷学, HOWARD Michael T, ATKINS John F, 村井法之, 松藤千弥

日本RNA学会年会要旨集, 8th 77, Jul 18, 2006
傍腫瘍性小脳変性疾患関連タンパク質CDR2とアンチザイム2の相互作用

村井法之, 松藤千弥

生化学, 4P-1001, 2007
部分融解したアンチザイム・シュードノットを認識するRNA結合タンパク質

堀谷学, HOWARD Michael. T, ATKINS John F, 村井法之, 松藤千弥

日本RNA学会年会要旨集, 9th 165, Jul 28, 2007

Books and Other Publications

Lippincott Illus

(Role: Joint translator) (Original Author(s): Richard A. Harvey)

Jan 30, 2018
Polyamines

Noriyuki Murai

Springer Tokyo, 2015
Polyamines Methods and Protocols

Noriyuki Murai, Yasuko Murakami, Senya Matsufuji (Role: Joint author, Chapter 15 Protocol for Studying Antizyme Expression and Function)

Feb 21, 2011
The Analysis of Protein-protein Interaction

Noriyuki Murai, Masasuke Yoshida (Role: Joint author, [Molecular Chaperon] Real Time Analysis of Biomoleculer Interaction)

Springer-Verlag Tokyo, 2000
タンパク質-タンパク質相互作用の解析「分子シャペロン」生体物質間相互作用のリアルタイム解析実験法

(Role: Joint author)

シュプリンガー・フェアラーク東京, 1998
Chaperonin and proteinfolding

Noriyuki Murai, Yoshida Masasuke (Role: Joint author)

1995

Professional Memberships

Research Projects

The analyses of substrate recognition and protein unfolding function of 26S proteasome

Apr, 2000 - Mar, 2001

Noriyuki Murai
アンチザイムの細胞内局在と相互作用分子の一細胞イメージング

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2002 - 2003

村井法之
Significance of the interaction between antizyme 2 and CDR2 under hypoxia in cancer cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MURAI Noriyuki
Fluorescent visualization of cancer cellsby monitoring cellular polyamines

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MATSUFUJI Senya, MURAI Noriyuki
Functional Significance of Interaction between MYCN and AZ2 in Neuroblastoma Cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

MURAI NORIYUKI
Elucidation of ubiquitin-independent MYCN degradation mechanism mediated by AZ2 in neuroblastoma tumors

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Noriyuki Murai

Social Activities

日本女子大理学部物質生物化学科非常勤講師

Lecturer

Apr 1, 2018 - Present
工学院大学先進工学部非常勤講師

Lecturer

Oct 1, 2013 - Present
共立女子大看護学部非常勤講師

Lecturer

Apr 1, 2013 - Present
日本ポリアミン学会評議員

Other

Jan, 2013 - Present

Profile Information

Research Areas

Research History

Education

Committee Memberships

Papers

Misc.

Books and Other Publications

Professional Memberships

Research Projects

Social Activities

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Coauthors