2018年7月1日
Irradiation-induced fusion between giant vesicles and photoresponsive large unilamellar vesicles containing malachite green derivative
Colloids and Surfaces B: Biointerfaces
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- 巻
- 167
- 号
- 開始ページ
- 544
- 終了ページ
- 549
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.colsurfb.2018.04.061
- 出版者・発行元
- Elsevier B.V.
Light-initiated fusion between vesicles has attracted much attention in the research community. In particular, fusion between photoresponsive and non-photoresponsive vesicles has been of much interest in the development of systems for the delivery of therapeutic agents to cells. We have performed fusion between giant vesicles (GVs) and photoresponsive smaller vesicles containing malachite green (MG) derivative, which undergoes ionization to afford a positive charge on the molecule by irradiation. The fusion proceeds as the concentration of GV lipid increases toward equimolarity with the lipid of the smaller vesicle. It is also dependent on the molar percentage of photoionized MG in the lipid of the smaller vesicle. On the other hand, the fusion is hardly affected by the anionic component of the GV. The photoinduced fusion was characterized by two methods, involving the mixing of lipid membranes and of aqueous contents. Fluorescence microscopy revealed that irradiation triggered the fusion of a single GV with the smaller vesicles containing MG.
- ID情報
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- DOI : 10.1016/j.colsurfb.2018.04.061
- ISSN : 1873-4367
- ISSN : 0927-7765
- SCOPUS ID : 85046728509