2004年1月
Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus
NEUROTOXICOLOGY
- 巻
- 25
- 号
- 1-2
- 開始ページ
- 205
- 終了ページ
- 213
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0161-813X(03)00100-1
- 出版者・発行元
- ELSEVIER SCIENCE BV
We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin or selegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for 1 week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum. (C) 2003 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0161-813X(03)00100-1
- ISSN : 0161-813X
- Web of Science ID : WOS:000187910600023