SAKAGUCHI Kazuyasu

Last updated: Nov 7, 2018 at 15:48

Name	SAKAGUCHI Kazuyasu
URL	http://barato.sci.hokudai.ac.jp/~biochem/
Affiliation	Hokkaido University
Section	Faculty of Science, Department of Chemistry, Organic and Biological Chemistry
Job title	Professor
Research funding number	00315053

Research Interests

Inhibitor(14) , Enzyme(157) , Differentiation(100) , Cell Cycle(113) , Cancer(365) , Dephospharylation(1) , Biochemistry(510) , Peptide Science(10) , Protein Science(34) , Nanobiomaterial Science(1) , p53(58) , phosphatase(5) , oligomer(8) , posttranslational modification(42)

Research Areas

Biomolecular science / Biomolecular science /
Biological science / Functional biochemistry /
Biological science / Structural biochemistry /
Applied Chemistry / Bio-related chemistry /

Awards & Honors

Plain Text

Oct 2010

PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression, 2010 年度（第18 回） JB 論文賞

Winner: Chuman, Y., Kurihashi, W., Mizukami, Y., Nashimoto, T., Yagi, H., and Sakaguchi, K

Published Papers

Plain Text

Interferon Stimulation Creates Chromatin Marks And Establishes Transcriptional Memory

Rui Kamada, Wenjing Yang, Yubo Zhang, Mira C. Patel, Yanqin Yang, Ryota Ouda, Anup Dey, Yoshiyuki Wakabayashi, Kazuyasu Sakaguchi, Takashi Fujita, Tomohiko Tamura, Jun Zhu, and Keiko Ozato

Proceedings of the National Academy of Sciences of the USA 115(39) E9162-E9171 Sep 2018 [Refereed]

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells

Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita

Cell Peprots 23(13) 3721-3729 Jun 2018 [Refereed]

Synergic Strategies for the Enhanced Self-Assembly of Biomineralization Peptides for the Synthesis of Functional Nanomaterials

Janairo Jose Isagani B, Sakaguchi Tatsuya, Mine Kenta, Kamada Rui, Sakaguchi Kazuyasu

Protein and peptide letters 25(1) 4 2018 [Refereed][Invited]

Quantitative Single Cell Analysis for Transcriptional Activity of p53 Hetero-tetramers between Wild-type Protein and Oligomerization Domain

Toguchi Yu, Kamada Rui, Kanno Madoka, Imagawa Toshiaki, Sakaguchi Kazuyasu

Chemistry Letters 47 2017 [Refereed]

Oligomerization enhances the binding affinity of a silver biomineralization peptide and catalyzes nanostructure formation

Sakaguchi Tatsuya, Janairo Jose Isagani B, Lussier-Price Mathieu, Wada Junya, Omichinski James G, Sakaguchi Kazuyasu

Scientific Reports 7(1) 1400 2017 [Refereed]

Inhibition of Ser/Thr phosphatase PPM1D induces neutrophil differentiation in HL-60 cells

Kamada Rui, Kudoh Fuki, Yoshimura Fumihiko, Tanino Keiji, Sakaguchi Kazuyasu

The Journal of Biochemistry 162(4) 303 2017 [Refereed]

Heterochiral Jun and Fos bZIP peptides form a coiled-coil heterodimer that is competent for DNA binding

Kamada Rui, Nakagawa Natsumi, Oyama Taiji, Sakaguchi Kazuyasu

Journal of Peptide Science 23(7-8) 644 2017 [Refereed]

Patterning nanofibrils through the templated growth of multiple modified amyloid peptides

Sakai Hiroki, Watanabe Ken, Kudoh Fuki, Kamada Rui, Chuman Yoshiro, Sakaguchi Kazuyasu

Scientific Reports 6 31993 2016 [Refereed]

PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin

Kozakai Yuuki, Kamada Rui, Furuta Junya, Kiyota Yuhei, Chuman Yoshiro, Sakaguchi Kazuyasu

Scientific Reports 6 33272 2016 [Refereed]

Effective cellular morphology analysis for differentiation processes by a fluorescent 1, 3a, 6a-triazapentalene derivative probe in live cells

Kamada Rui, Tano Fumi, Kudoh Fuki, Kimura Nozomi, Chuman Yoshiro, Osawa Ayumi, Namba Kosuke, Tanino Keiji, Sakaguchi Kazuyasu

PloS one 11(8) e0160625 2016 [Refereed]

Synthesis of yellow and red fluorescent 1, 3a, 6a-triazapentalenes and the theoretical investigation of their optical properties

Namba Kosuke, Osawa Ayumi, Nakayama Akira, Mera Akane, Tano Fumi, Chuman Yoshiro, Sakuda Eri, Taketsugu Tetsuya, Sakaguchi Kazuyasu, Kitamura Noboru, others

Chemical Science 6(2) 1083 2015 [Refereed]

Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1

Cappadocia Laurent, Mascle Xavier H, Bourdeau V{é}ronique, Tremblay-Belzile Samuel, Chaker-Margot Malik, Lussier-Price Mathieu, Wada Junya, Sakaguchi Kazuyasu, Aubry Muriel, Ferbeyre Gerardo, others

Structure 23(1) 126 2015 [Refereed]

Quantitative Correlation between the Protein Expression Level in Escherichia Coli and Thermodynamic Stability of Protein In Vitro

Wada Junya, Miyazaki Hiromitsu, Kamada Rui, Sakaguchi Kazuyasu

Chemistry Letters 45(2) 185 2015 [Refereed]

Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation

Ogasawara Sari, Kiyota Yuhei, Chuman Yoshiro, Kowata Ayano, Yoshimura Fumihiko, Tanino Keiji, Kamada Rui, Sakaguchi Kazuyasu

Bioorganic & medicinal Chemistry 23(19) 6246 2015 [Refereed]

Function of Proto-oncogene Product PPM1D and Development of PPM1D Inhibitors for Cancer Chemotherapy

Kamada R, Chuman Y, Kozakai Y, Sakaguchi K

Seikagaku. The Journal of Japanese Biochemical Society 87(5) 531 2015 [Refereed]

Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line

Kozakai Yuuki, Kamada Rui, Kiyota Yuhei, Yoshimura Fumihiko, Tanino Keiji, Sakaguchi Kazuyasu

Bioorganic & medicinal chemistry letters 24(24) 5593 2014 [Refereed]

Effects of buffer on the structure and catalytic activity of palladium nanomaterials formed by biomineralization

Janairo Jose Isagani B, Sakaguchi Kazuyasu

Chemistry Letters 43(8) 1315 2014 [Refereed]

Effects of biomineralization peptide topology on the structure and catalytic activity of Pd nanomaterials

Janairo Jose Isagani B, Sakaguchi Tatsuya, Hara Kenji, Fukuoka Atsushi, Sakaguchi Kazuyasu

Chemical Communications 50(66) 9259 2014 [Refereed]

Antiproliferative activity of silver nanoplates on human promyelocytic leukemia cell lines

Sakaguchi Tatsuya, Mine Kenta, Kudoh Fuki, Kamada Rui, Sakaguchi Kazuyasu

Chemistry Letters 44(3) 327 2014 [Refereed]

Formation of functionalized nanowires by control of self-assembly using multiple modified amyloid peptides

Sakai Hiroki, Watanabe Ken, Asanomi Yuya, Kobayashi Yumiko, Chuman Yoshiro, Shi Lihong, Masuda Takuya, Wyttenbach Thomas, Bowers Michael T, Uosaki Kohei, others

Advanced Functional Materials 23(39) 4881 2013 [Refereed]

Effects of E/Z Configuration of Fluoroalkene-containing HDAC Inhibitors on Selectivity for HDAC Isoforms

Chuman Yoshiro, Ueyama Mariko, Sano Satoshi, Wu Fei, Kiyota Yuhei, Higashi Takayoshi, Osada Satoshi, Sakaguchi Kazuyasu

Chemistry Letters 42(8) 833 2013 [Refereed]

Inhibition of tumor suppressor protein p53-dependent transcription by a tetramerization domain peptide via hetero-oligomerization

Wada Junya, Kamada Rui, Imagawa Toshiaki, Chuman Yoshiro, Sakaguchi Kazuyasu

Bioorganic & medicinal chemistry letters 22(8) 2780 2012 [Refereed]

Tetramerization of tumor suppressor protein p53

Kamada R, Sakaguchi K

Seikagaku. The Journal of Japanese Biochemical Society 82(6) 484 2010 [Refereed]

Enhancement of transcriptional activity of mutant p53 tumor suppressor protein through stabilization of tetramer formation by calix [6] arene derivatives

Kamada Rui, Yoshino Wataru, Nomura Takao, Chuman Yoshiro, Imagawa Toshiaki, Suzuki Takanori, Sakaguchi Kazuyasu

Bioorganic & medicinal chemistry letters 20(15) 4412 2010 [Refereed]

Drastic effects on fibril formation of amyloid-

peptides by the addition of amino acid residue units to the termini

Asanomi Yuya, Kobayashi Yumiko, Sakai Hiroki, Masuda Takuya, Chen Xinjiang, Chuman Yoshiro, Uosaki Kohei, Sakaguchi Kazuyasu

Protein and peptide letters 17(4) 458 2010 [Refereed]

PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression

Chuman Yoshiro, Kurihashi Wataru, Mizukami Yohei, Nashimoto Takehiro, Yagi Hiroaki, Sakaguchi Kazuyasu

Journal of biochemistry 145(1) 1 2008 [Refereed]

PILLARS OF IMMUNOLOGY

Stern Lawrence J, Hunt Donald F, Henderson Robert A, Shabanowitz Jeffrey, Sakaguchi Kazuyasu, Michel Hanspeter, Sevilir Noelle, Cox Andrea L, Appella Ettore, Engelhard Victor H, others

J Immunol 179 2665 2007 [Refereed]

BIOCHEMISTRY-Metabolism and Bioenergetics-Evidence for a Relationship between Activity and the Tetraprotomeric Assembly of Solubilized Pig Gastric H/K-ATPase

Abe K, Kaya S, Taniguchi K, Hayashi Y, Imagawa T, Kikumoto M, Oiwa K, Sakaguchi K

Journal of Biochemistry 138(3) 293 2005 [Refereed]

Site-directed affinity-labeling of delta opioid receptors by

Isozaki Kaname, Fukahori Hidehiko, Honda Takeshi, Shirasu Naoto, Okada Kazushi, Nose Takeru, Sakaguchi Kazuyasu, Shimohigashi Yasuyuki

Letters in Peptide Science 10(5-6) 511 2003 [Refereed]

TRANSCRIPTIONAL REGULATION-Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element

Kuwata Takeshi, Gongora Celine, Kanno Yuka, Sakaguchi Kazuyasu, Tamura Tomohiko, Kanno Tomohiko, Basrur Venkatesha, Martinez Robert, Appella Ettore, Golub Todd, others

Molecular and Cellular Biology 22(21) 7439 2002 [Refereed]

PROTEIN SYNTHESIS, POST-TRANSLATION MODIFICATION, AND DEGRADATION-Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2

Sakaguchi Kazuyasu, Saito Shin'ichi, Higashimoto Yuichiro, Roy Siddhartha, Anderson Carl W, Appella Ettore

Journal of Biological Chemistry 275(13) 9278 2000 [Refereed]

Identification of gel-separated tumor marker proteins by mass spectrometry

Bergman Ann-Charlotte, Benjamin Timothy, Alaiya Ayodele, Waltham Mark, Sakaguchi Kazuyazu, Franz{é}n Bo, Linder Stig, Bergman Tomas, Auer Gert, Appella Ettore, others

ELECTROPHORESIS: An International Journal 21(3) 679 2000 [Refereed]

Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts

Bergman A-C, Alaiya AA, Wendler W, Binetruy B, Shoshan M, Sakaguchi K, Bergman T, Kronenwett U, Auer G, Appella E, others

Cellular and Molecular Life Sciences CMLS 55(3) 467 1999 [Refereed]

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

Bulavin Dmitry V, Saito Shi{ń}ichi, Hollander M Christine, Sakaguchi Kazuyasu, Anderson Carl W, Appella Ettore, Fornace Albert J

The EMBO journal 18(23) 6845 1999 [Refereed]

Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas

Chuman Yoshiko, Bergman Ann-Charlotte, Ueno Takayuki, Saito Shin'ichi, Sakaguchi Kazuyasu, Alaiya Ayodele A, Franz{é}n Bo, Bergman Tomas, Arnott David, Auer Gert, others

FEBS letters 462(1-2) 129 1999 [Refereed]

Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth

Pike Sandra E, Yao Lei, Setsuda Joyce, Jones Karen D, Cherney Barry, Appella Ettore, Sakaguchi Kazuyasu, Nakhasi Hira, Atreya Chintamani D, Teruya-Feldstein Julie, others

Blood 94(7) 2461 1999 [Refereed]

Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth

Pike Sandra E, Yao Lei, Jones Karen D, Cherney Barry, Appella Ettore, Sakaguchi Kazuyasu, Nakhasi Hira, Teruya-Feldstein Julie, Wirth Peter, Gupta Ghanshyam, others

Journal of Experimental Medicine 188(12) 2349 1998 [Refereed]

Posttranslational modifications involved in the DNA damage response.

Anderson CW, Appella E, Sakaguchi K

Journal of protein chemistry 17(6) 527 1998 [Refereed]

Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells

Pise-Masison Cynthia A, Radonovich Michael, Sakaguchi Kazuyasu, Appella Ettore, Brady John N

Journal of virology 72(8) 6348 1998 [Refereed]

Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1,-A2, and-A3 alleles

Kawakami Yutaka, Robbins Paul F, Wang Xiang, Tupesis Janis P, Parkhurst Maria R, Kang Xiaoqiang, Sakaguchi Kazuyasu, Appella Ettore, Rosenberg Steven A

The Journal of Immunology 161(12) 6985 1998 [Refereed]

Dilation of the human immunodeficiency virus--1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41

Mu{ñ}oz-Barroso Isabel, Durell Stewart, Sakaguchi Kazuyasu, Appella Ettore, Blumenthal Robert

The Journal of cell biology 140(2) 315 1998 [Refereed]

An efficient and cost-effective isotope labeling protocol for proteins expressed in shape Escherichia coli

Cai Mengli, Huang Ying, Sakaguchi Kazuyasu, Clore G Marius, Gronenborn Angela M, Craigie Robert

Journal of biomolecular NMR 11(1) 97 1998 [Refereed]

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

Fiscella Michele, Zhang HongLiang, Fan Saijun, Sakaguchi Kazuyasu, Shen Songfa, Mercer W Edward, Woude George F Vande, O?Connor Patrick M, Appella Ettore

Proceedings of the National Academy of Sciences 94(12) 6048 1997 [Refereed]

Potent immunogenic short linear peptide constructs composed of B cell epitopes and Pan DR T helper epitopes (PADRE) for antibody responses in vivo

Del Guercio Marie-France, Alexander Jeff, Kubo Ralph T, Arrhenius Thomas, Maewal Ajesh, Appella Ettore, Hoffman Stephen L, Jones Trevor, Valmori Danila, Sakaguchi Kazuyasu, others

Vaccine 15(4) 441 1997 [Refereed]

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

Sakaguchi Kazuyasu, Sakamoto Hiroshi, Lewis Marc S, Anderson Carl W, Erickson John W, Appella Ettore, Xie Dong

Biochemistry 36(33) 10117 1997 [Refereed]

Increased expression of

-enolase in c-jun transformed rat fibroblasts without increased activation of plasminogen

Bergman Ann-Charlotte, Linder Christina, Sakaguchi Kazuyasu, Sten-Linder Margareta, Alaiya Ayodele A, Franz{é}n Bo, Shoshan Maria C, Bergman Tomas, Wiman Bj{ö}rn, Auer Gert, others

FEBS letters 417(1) 17 1997 [Refereed]

Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells.

Tsai Van, Southwood Scott, Sidney John, Sakaguchi Kazuyasu, Kawakami Yutaka, Appella Ettore, Sette Alessandro, Celis Esteban

The Journal of Immunology 158(4) 1796 1997 [Refereed]

DNA damage induces phosphorylation of the amino terminus of p53

Siliciano Janet D, Canman Christine E, Taya Yoichi, Sakaguchi Kazuyasu, Appella Ettore, Kastan Michael B

Genes & development 11(24) 3471 1997 [Refereed]

The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain.

Fineschi Beatrice, Sakaguchi Kazuyasu, Appella Ettore, Miller Jim

The Journal of Immunology 157(8) 3211 1996 [Refereed]

Chemical synthesis of phosphorylated peptides of the carboxy-terminal domain of human p53 by a segment condensation method

Sakamoto Hiroshi, Kodama Hiroaki, Higashimoto Yuichiro, Kondo Michio, Lewis Marc S, Anderson Carl W, Appella Ettore, Sakaguchi Kazuyasu

Chemical Biology & Drug Design 48(5) 429 1996 [Refereed]

Chemical synthesis and applications of phosphopeptides

Sakaguchi Kazuyasu, Roller Peter P, Appella Ettore

Genetic engineering 249 1996 [Refereed]

Refined solution structure of the oligomerization domain of the tumour suppressor p53

Clore G Marius, Ernst James, Clubb Robert, Omichinski James G, Kennedy WM Poindexter, Sakaguchi Kazuyasu, Appella Ettore, Gronenborn Angela M

Nature Structural and Molecular Biology 2(4) 321 1995 [Refereed]

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

Kawakami Yutaka, Eliyahu Siona, Jennings Christopher, Sakaguchi Kazuyasu, Kang Xiaoqiang, Southwood Scott, Robbins Paul F, Sette Alessandro, Appella Ettore, Rosenberg Steven A

The Journal of Immunology 154(8) 3961 1995 [Refereed]

Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1.

Rivoltini Licia, Kawakami Yutaka, Sakaguchi Kazuyasu, Southwood Scott, Sette Alessandro, Robbins Paul F, Marincola Francesco M, Salgaller Michael L, Yannelli John R, Appella Ettore

The Journal of Immunology 154(5) 2257 1995 [Refereed]

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

Kang Xiaoqiang, Kawakami Yutaka, El-Gamil Mona, Wang Rongfu, Sakaguchi Kazuyasu, Yannelli John R, Appella Ettore, Rosenberg Steven A, Robbins Paul F

The Journal of Immunology 155(3) 1343 1995 [Refereed]

Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.

Robbins Paul F, El-Gamil Mona, Li Yong F, Topalian Suzanne L, Rivoltini Licia, Sakaguchi Kazuyasu, Appella Ettore, Kawakami Yutaka, Rosenberg Steven A

The Journal of Immunology 154(11) 5944 1995 [Refereed]

Backbone dynamics of the oligomerization domain of p53 determined from 15N NMR relaxation measurements

Clubb Robert T, Omichinski James G, Gronenborn Angela M, Marius Clore G, Sakaguchi Kazuyazu, Appella Ettore

Protein Science 4(5) 855 1995 [Refereed]

The peripheral subunit-binding domain of the dihydrolipoyl acetyltransferase component of the pyruvate dehydrogenase complex of Bacillus stearothermophilus: preparation and characterization of its binding to the dihydrolipoyl dehydrogenase component

Hipps DS, Packman LC, Allen MD, Fuller C, Sakaguchi K, Appella E, Perham RN

Biochemical Journal 297(1) 137 1994 [Refereed]

THE HUMAN DNA-ACTIVATED PROTEIN-KINASE, DNA-PK, IS ACTIVATED BY DNA BREAKS AND PHOSPHORYLATES NUCLEAR DNA-BINDING PROTEIN SUBSTRATES ON SERINES AND THREONINES FOLLOWING BY GLUTAMINE

Anderson CW, Connelly MA, Zhang H, Sipley JD, Leesmiller SP, Sakaguchi K, Ullrich SJ, Jackson SP, Appella E

JOURNAL OF PROTEIN CHEMISTRY 13(5) 500 1994 [Refereed]

Structural essentials of Ser-1 in tethered peptide ligand of human thrombin receptor for phosphoinositide hydrolysis

Sakaguchi Kazuyasu, Kodama Hiroaki, Ogino Yoshio, Costa Tommaso, Nose Takeru, Shimohigashi Yasuyuki

Bulletin of the Chemical Society of Japan 67(6) 1659 1994 [Refereed]

STRUCTURE AND POSTTRANSLATIONAL MODIFICATION OF THE HUMAN P53 PROTEIN

APPELLA E, FISCELLA M, ZAMBRANO N, ULLRICH SJ, SAKAGUCHI K, SAKAMOTO H, LEWIS MS, LIN D, MERCER WE, ANDERSON CW

JOURNAL OF PROTEIN CHEMISTRY 13(5) 499 1994 [Refereed]

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2. 1 with high affinity and in different conformations.

Chen YE, Sidney John, Southwood Scott, Cox Andrea L, Sakaguchi Kazuyasu, Henderson Robert A, Appella Ettore, Hunt Donald F, Sette Alessandro, Engelhard Victor H

The journal of immunology 152(6) 2874 1994 [Refereed]

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family

Bovolenta Chiara, Driggers Paul H, Marks Michael S, Medin Jeffrey A, Politis Alexander D, Vogel Stefanie N, Levy David E, Sakaguchi Kazuyasu, Appella Ettore, Coligan John E

Proceedings of the National Academy of Sciences 91(11) 5046 1994 [Refereed]

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

Kawakami Yutaka, Eliyahu Siona, Sakaguchi Kazuyasu, Robbins Paul F, Rivoltini Licia, Yannelli John R, Appella Ettore, Rosenberg Steven A

Journal of Experimental Medicine 180(1) 347 1994 [Refereed]

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection

Kawakami Yutaka, Eliyahu Siona, Delgado Cynthia H, Robbins Paul F, Sakaguchi Kazuyasu, Appella Ettore, Yannelli John R, Adema Gosse J, Miki Toru, Rosenberg Steven A

Proceedings of the National Academy of Sciences 91(14) 6458 1994 [Refereed]

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

Clore G Marius, Omichinski James G, Sakaguchi Kazuyasu, Zambrano Nicola, Sakamoto Hiroshi, Appella Ettore, Gronenborn Angela M

Science 265(5170) 386 1994 [Refereed]

Definition of specific peptide motifs for four major HLA-A alleles.

Kubo Ralph T, Sette Alessandro, Grey Howard M, Appella Ettore, Sakaguchi Kazuyasu, Zhu Nian-Zhou, Arnott David, Sherman Nicholas, Shabanowitz Jeffrey, Michel Hanspeter

The Journal of Immunology 152(8) 3913 1994 [Refereed]

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

Burns Christopher M, Sakaguchi Kazuyasu, Appella Ettore, Ashwell Jonathan D

Journal of Biological Chemistry 269(18) 13594 1994 [Refereed]

Two-dimensional nuclear magnetic resonance analysis of a labeled peptide bound to a class II major histocompatibility complex molecule

Driscoll Paul C, Altman John D, Boniface J Jay, Sakaguchi Kazuyasu, Reay Philip A, Omichinski James G, Appella Ettore, Davis Mark M

1993 [Refereed]

The high-resolution structure of the peripheral subunit-binding domain of dihydrolipoamide acetyltransferase from the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus

Kalia Yogeshvar N, Brocklehurst Simon M, Hipps Deborah S, Appella Ettore, Sakaguchi Kazuyasu, Perham Richard N

Journal of molecular biology 230(1) 323 1993 [Refereed]

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

Fazioli F, Wong WT, Ullrich SJ, Sakaguchi K, Appella E, Di PP Fiore

Oncogene 8(5) 1335 1993 [Refereed]

Sequence of a cDNA encoding bovine apolipoprotein H

Gao Bin, Virmani M, Romm E, Lazar-Wesley E, Sakaguchi K, Appella E, Kunos G, Takacs L

Gene 126(2) 287 1993 [Refereed]

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53

Ullrich Stephen J, Sakaguchi Kazuyasu, Lees-Miller Susan P, Fiscella Michele, Mercer W Edward, Anderson Carl W, Appella Ettore

Proceedings of the National Academy of Sciences 90(13) 5954 1993 [Refereed]

Optimum cross-linking spacer length of dimeric neurokinin B analogs for interaction with NK-1 tachykinin receptors

Matsumoto Hiroshi, Shimohigashi Yasuyuki, Takano Yukio, Sakaguchi Kazuyasu, Kamiya Hiro-o, Ohno Motonori

Bulletin of the Chemical Society of Japan 66(1) 196 1993 [Refereed]

Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein

Sakaguchi Kazuyasu, Zambrano Nicola, Baldwin Eric T, Shapiro Bruce A, Erickson John W, Omichinski James G, Clore G Marius, Gronenborn Angela M, Appella Ettore

Proceedings of the National Academy of Sciences 90(11) 5219 1993 [Refereed]

Direct identification of an endogenous peptide recognized by multiple HLA-A2. 1-specific cytotoxic T cells

Henderson Robert A, Cox Andrea L, Sakaguchi Kazuyasu, Appella Ettore, Shabanowitz Jeffrey, Hunt Donald F, Engelhard Victor H

Proceedings of the National Academy of Sciences 90(21) 10275 1993 [Refereed]

Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling.

Huczko EL, Bodnar WM, Benjamin D, Sakaguchi K, Zhu N Zhou, Shabanowitz J, Henderson RA, Appella E, Hunt DF, and Engelhard VH

The Journal of Immunology 151(5) 2572 1993 [Refereed]

Thymocyte costimulating antigen is CD26 (dipeptidyl-peptidase IV). Costimulation of granulocyte, macrophage, and T lineage cell proliferation via CD26.

Bristol LA, Sakaguchi K, Appella E, Doyle D, Takacs L

The Journal of Immunology 149(2) 367 1992 [Refereed]

Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli

Robien Mark A, Clore G Marius, Omichinski James G, Perham Richard N, Appella Ettore, Sakaguchi Kazuyasu, Gronenborn Angela M

Biochemistry 31(13) 3463 1992 [Refereed]

Receptor interactions of synthetic morphiceptin analogs containing phenylalanine homologs in position 4

Sakaguchi Kazuyasu, Costa Tommaso, Sakamoto Hiroshi, Shimohigashi Yasuyuki

Bulletin of the Chemical Society of Japan 65(4) 1052 1992 [Refereed]

Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

Hunt Donald F, Michel Hanspeter, Dickinson Tracey A, Shabanowitz Jeffrey, Cox Andrea L, Sakaguchi Kazuyasu, Appella Ettore, Grey Howard M, Sette Alessandro

Science 256(5065) 1817 1992 [Refereed]

Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant

Sette Alessandro, Ceman Stephanie, Kubo Ralph T, Sakaguchi Kazuyasu, Appella Ettore, Hunt Donald F, Davis Theresa A, Michel Hanspeter, Shabanowitz Jeffrey, Rudersdorf Richard, others

Science 258(5089) 1801 1992 [Refereed]

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

Olson D, P{ö}ll{ä}nen J, H{\o}yer-Hansen G, R{\o}nne E, Sakaguchi K, Wun T Ch, Appella E, Dan{\o} K, Blasi F

Journal of Biological Chemistry 267(13) 9129 1992 [Refereed]

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW

Molecular and cellular biology 12(11) 5041 1992 [Refereed]

High-resolution structure of a double zinc finger from the human enhancer binding protein MPB-1 in solution

Omichinski James G, Sakaguchi Kazuyasu, Clore G Marius, Gronenborn Angela M, Appella Ettore

Journal of Protein Chemistry 11(4) 408 1992 [Refereed]

HLA-A2. 1-associated peptides from a mutant cell line: a second pathway of antigen presentation

Henderson Robert A, Michel Hanspeter, Sakaguchi Kazuyasu, Shabanowitz Jeffrey, Appella Ettore, Hunt Donald F, Engelhard Victor H

Science 255(5049) 1264 1992 [Refereed]

Characterization of peptides bound to the class I MHC molecule HLA-A2. 1 by mass spectrometry

Hunt Donald F, Henderson Robert A, Shabanowitz Jeffrey, Sakaguchi Kazuyasu, Michel Hanspeter, Sevilir Noelle, Cox Andrea L, Appella Ettore, Engelhard Victor H

Science 255(5049) 1261 1992 [Refereed]

Specific DNA binding to a major histocompatibility complex enhancer sequence by a synthetic 57-residue double zinc finger peptide from a human enhancer binding protein.

Sakaguchi K, Appella E, Omichinski JG, Clore GM, Gronenborn AM

Journal of Biological Chemistry 266(11) 7306 1991 [Refereed]

Opioid activities of morphiceptin-like peptides latent in various natural proteins.

Shimohigashi Y, Sakaguchi K, Sakamoto H, Waki M, Costa T

Peptide research 3(5) 216 1990 [Refereed]

Opioid Activities of Morphiceptin Analogs Derived from Human

-Casein

Sakaguchi Kazuyasu, Sakamoto Hiroshi, Tsubaki Yoshiko, Waki Michinori, Costa Tommaso, Shimohigashi Yasuyuki

Bulletin of the Chemical Society of Japan 63(6) 1753 1990 [Refereed]

High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution

Omichinski James G, Clore G Marius, Appella Ettore, Sakaguchi Kazuyasu, Gronenborn Angela M

Biochemistry 29(40) 9324 1990 [Refereed]

Characterization of tachykinin receptors in endothelial cells of porcine artery

Saito Ryo, Konishi Hiroki, Takano Yukio, Nonaka Shigeyuki, Sakaguchi Kazuyasu, Shimohigashi Yasuyuki, Kamiya Hiro-o

Neuroscience letters 110(3) 337 1990 [Refereed]

Design and synthesis of dimeric analogs of neurokinin A and B: effect of dimerization of COOH-terminal heptapeptides on receptor selection.

Sakaguchi K, Kodama H, Matsumoto H, Yoshida M, Takano Y, Kamiya H, Waki M, Shimohigashi Y

Peptide research 2(5) 345 1989 [Refereed]

STUDIES OF PEPTIDE ANTIBIOTICS. 48. CONFORMATIONALLY STABILIZED GRAMICIDIN S-ANALOG CONTAINING DEHYDROPHENYLALANINE IN PLACE OF D-PHENYLALANINE4, 4'-SYNTHESIS AND ANTIMICROBIAL ACTIVITY

IMAZU S, SHIMOHIGASHI Y, KODAMA H, SAKAGUCHI K, WAKI M, KATO T, IZUMIYA N

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 32(4) 298 1988 [Refereed]

Dimerization of neurokin A and B COOH-terminal heptapeptide fragments enhanced the selectivity for tachykinin receptor subtypes

Kodama Hiroaki, Shimohigashi Yasuyuki, Sakaguchi Kazuyasu, Waki Michinori, Takano Yukio, Yamada Akiko, Hatae Yasuyuki, Kamiya Hiro-o

European journal of pharmacology 151(2) 317 1988 [Refereed]

Biological evaluation of dimeric analogues of tachykinin peptides

Shimohigashi Y, Kodama H, Sakaguchi K, Kato T, Waki M, Kamiya H, Yamada A, Higuchi Y, Takano Y

Regulatory Peptides 22(1-2) 172 1988 [Refereed]

Association Memberships

JAPANESE SOCIETY FOR CHEMICAL BIOLOGY(174) , The Chemical Society of Japan(2753) , The Japanese Peptide Society(103) , Japan Proteome Society(2)

Research Grants & Projects

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Structure and Post-translational Modification of Tumor suppressor Protein p53 and its related proteins

Project Year: 2003

Cell cycle control by protein phosphatase

Project Year: 1999

Patents

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US 6,309,863, B1