SAKAGUCHI Kazuyasu

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Name
SAKAGUCHI Kazuyasu
URL
http://barato.sci.hokudai.ac.jp/~biochem/
Affiliation
Hokkaido University
Section
Faculty of Science, Department of Chemistry, Organic and Biological Chemistry
Job title
Professor
Research funding number
00315053

Research Areas

 
 

Awards & Honors

 
Oct 2010
PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression, 2010 年度(第18 回) JB 論文賞
Winner: Chuman, Y., Kurihashi, W., Mizukami, Y., Nashimoto, T., Yagi, H., and Sakaguchi, K
 

Published Papers

 
Interferon Stimulation Creates Chromatin Marks And Establishes Transcriptional Memory
Rui Kamada, Wenjing Yang, Yubo Zhang, Mira C. Patel, Yanqin Yang, Ryota Ouda, Anup Dey, Yoshiyuki Wakabayashi, Kazuyasu Sakaguchi, Takashi Fujita, Tomohiko Tamura, Jun Zhu, and Keiko Ozato
Proceedings of the National Academy of Sciences of the USA   115(39) E9162-E9171   Sep 2018   [Refereed]
Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells
Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita
Cell Peprots   23(13) 3721-3729   Jun 2018   [Refereed]
Janairo Jose Isagani B, Sakaguchi Tatsuya, Mine Kenta, Kamada Rui, Sakaguchi Kazuyasu
Protein and peptide letters   25(1) 4   2018   [Refereed][Invited]
Toguchi Yu, Kamada Rui, Kanno Madoka, Imagawa Toshiaki, Sakaguchi Kazuyasu
Chemistry Letters   47    2017   [Refereed]
Sakaguchi Tatsuya, Janairo Jose Isagani B, Lussier-Price Mathieu, Wada Junya, Omichinski James G, Sakaguchi Kazuyasu
Scientific Reports   7(1) 1400   2017   [Refereed]
Kamada Rui, Kudoh Fuki, Yoshimura Fumihiko, Tanino Keiji, Sakaguchi Kazuyasu
The Journal of Biochemistry   162(4) 303   2017   [Refereed]
Kamada Rui, Nakagawa Natsumi, Oyama Taiji, Sakaguchi Kazuyasu
Journal of Peptide Science   23(7-8) 644   2017   [Refereed]
Sakai Hiroki, Watanabe Ken, Kudoh Fuki, Kamada Rui, Chuman Yoshiro, Sakaguchi Kazuyasu
Scientific Reports   6 31993   2016   [Refereed]
Kozakai Yuuki, Kamada Rui, Furuta Junya, Kiyota Yuhei, Chuman Yoshiro, Sakaguchi Kazuyasu
Scientific Reports   6 33272   2016   [Refereed]
Kamada Rui, Tano Fumi, Kudoh Fuki, Kimura Nozomi, Chuman Yoshiro, Osawa Ayumi, Namba Kosuke, Tanino Keiji, Sakaguchi Kazuyasu
PloS one   11(8) e0160625   2016   [Refereed]
Namba Kosuke, Osawa Ayumi, Nakayama Akira, Mera Akane, Tano Fumi, Chuman Yoshiro, Sakuda Eri, Taketsugu Tetsuya, Sakaguchi Kazuyasu, Kitamura Noboru, others
Chemical Science   6(2) 1083   2015   [Refereed]
Cappadocia Laurent, Mascle Xavier H, Bourdeau V{é}ronique, Tremblay-Belzile Samuel, Chaker-Margot Malik, Lussier-Price Mathieu, Wada Junya, Sakaguchi Kazuyasu, Aubry Muriel, Ferbeyre Gerardo, others
Structure   23(1) 126   2015   [Refereed]
Wada Junya, Miyazaki Hiromitsu, Kamada Rui, Sakaguchi Kazuyasu
Chemistry Letters   45(2) 185   2015   [Refereed]
Ogasawara Sari, Kiyota Yuhei, Chuman Yoshiro, Kowata Ayano, Yoshimura Fumihiko, Tanino Keiji, Kamada Rui, Sakaguchi Kazuyasu
Bioorganic & medicinal Chemistry   23(19) 6246   2015   [Refereed]
Kamada R, Chuman Y, Kozakai Y, Sakaguchi K
Seikagaku. The Journal of Japanese Biochemical Society   87(5) 531   2015   [Refereed]
Kozakai Yuuki, Kamada Rui, Kiyota Yuhei, Yoshimura Fumihiko, Tanino Keiji, Sakaguchi Kazuyasu
Bioorganic & medicinal chemistry letters   24(24) 5593   2014   [Refereed]
Janairo Jose Isagani B, Sakaguchi Kazuyasu
Chemistry Letters   43(8) 1315   2014   [Refereed]
Janairo Jose Isagani B, Sakaguchi Tatsuya, Hara Kenji, Fukuoka Atsushi, Sakaguchi Kazuyasu
Chemical Communications   50(66) 9259   2014   [Refereed]
Sakaguchi Tatsuya, Mine Kenta, Kudoh Fuki, Kamada Rui, Sakaguchi Kazuyasu
Chemistry Letters   44(3) 327   2014   [Refereed]
Sakai Hiroki, Watanabe Ken, Asanomi Yuya, Kobayashi Yumiko, Chuman Yoshiro, Shi Lihong, Masuda Takuya, Wyttenbach Thomas, Bowers Michael T, Uosaki Kohei, others
Advanced Functional Materials   23(39) 4881   2013   [Refereed]
Chuman Yoshiro, Ueyama Mariko, Sano Satoshi, Wu Fei, Kiyota Yuhei, Higashi Takayoshi, Osada Satoshi, Sakaguchi Kazuyasu
Chemistry Letters   42(8) 833   2013   [Refereed]
Wada Junya, Kamada Rui, Imagawa Toshiaki, Chuman Yoshiro, Sakaguchi Kazuyasu
Bioorganic & medicinal chemistry letters   22(8) 2780   2012   [Refereed]
Kamada R, Sakaguchi K
Seikagaku. The Journal of Japanese Biochemical Society   82(6) 484   2010   [Refereed]
Kamada Rui, Yoshino Wataru, Nomura Takao, Chuman Yoshiro, Imagawa Toshiaki, Suzuki Takanori, Sakaguchi Kazuyasu
Bioorganic & medicinal chemistry letters   20(15) 4412   2010   [Refereed]
Asanomi Yuya, Kobayashi Yumiko, Sakai Hiroki, Masuda Takuya, Chen Xinjiang, Chuman Yoshiro, Uosaki Kohei, Sakaguchi Kazuyasu
Protein and peptide letters   17(4) 458   2010   [Refereed]
Chuman Yoshiro, Kurihashi Wataru, Mizukami Yohei, Nashimoto Takehiro, Yagi Hiroaki, Sakaguchi Kazuyasu
Journal of biochemistry   145(1) 1   2008   [Refereed]
Stern Lawrence J, Hunt Donald F, Henderson Robert A, Shabanowitz Jeffrey, Sakaguchi Kazuyasu, Michel Hanspeter, Sevilir Noelle, Cox Andrea L, Appella Ettore, Engelhard Victor H, others
J Immunol   179 2665   2007   [Refereed]
Abe K, Kaya S, Taniguchi K, Hayashi Y, Imagawa T, Kikumoto M, Oiwa K, Sakaguchi K
Journal of Biochemistry   138(3) 293   2005   [Refereed]
Isozaki Kaname, Fukahori Hidehiko, Honda Takeshi, Shirasu Naoto, Okada Kazushi, Nose Takeru, Sakaguchi Kazuyasu, Shimohigashi Yasuyuki
Letters in Peptide Science   10(5-6) 511   2003   [Refereed]
Kuwata Takeshi, Gongora Celine, Kanno Yuka, Sakaguchi Kazuyasu, Tamura Tomohiko, Kanno Tomohiko, Basrur Venkatesha, Martinez Robert, Appella Ettore, Golub Todd, others
Molecular and Cellular Biology   22(21) 7439   2002   [Refereed]
Sakaguchi Kazuyasu, Saito Shin'ichi, Higashimoto Yuichiro, Roy Siddhartha, Anderson Carl W, Appella Ettore
Journal of Biological Chemistry   275(13) 9278   2000   [Refereed]
Bergman Ann-Charlotte, Benjamin Timothy, Alaiya Ayodele, Waltham Mark, Sakaguchi Kazuyazu, Franz{é}n Bo, Linder Stig, Bergman Tomas, Auer Gert, Appella Ettore, others
ELECTROPHORESIS: An International Journal   21(3) 679   2000   [Refereed]
Bergman A-C, Alaiya AA, Wendler W, Binetruy B, Shoshan M, Sakaguchi K, Bergman T, Kronenwett U, Auer G, Appella E, others
Cellular and Molecular Life Sciences CMLS   55(3) 467   1999   [Refereed]
Bulavin Dmitry V, Saito Shi{ń}ichi, Hollander M Christine, Sakaguchi Kazuyasu, Anderson Carl W, Appella Ettore, Fornace Albert J
The EMBO journal   18(23) 6845   1999   [Refereed]
Chuman Yoshiko, Bergman Ann-Charlotte, Ueno Takayuki, Saito Shin'ichi, Sakaguchi Kazuyasu, Alaiya Ayodele A, Franz{é}n Bo, Bergman Tomas, Arnott David, Auer Gert, others
FEBS letters   462(1-2) 129   1999   [Refereed]
Pike Sandra E, Yao Lei, Setsuda Joyce, Jones Karen D, Cherney Barry, Appella Ettore, Sakaguchi Kazuyasu, Nakhasi Hira, Atreya Chintamani D, Teruya-Feldstein Julie, others
Blood   94(7) 2461   1999   [Refereed]
Pike Sandra E, Yao Lei, Jones Karen D, Cherney Barry, Appella Ettore, Sakaguchi Kazuyasu, Nakhasi Hira, Teruya-Feldstein Julie, Wirth Peter, Gupta Ghanshyam, others
Journal of Experimental Medicine   188(12) 2349   1998   [Refereed]
Anderson CW, Appella E, Sakaguchi K
Journal of protein chemistry   17(6) 527   1998   [Refereed]
Pise-Masison Cynthia A, Radonovich Michael, Sakaguchi Kazuyasu, Appella Ettore, Brady John N
Journal of virology   72(8) 6348   1998   [Refereed]
Kawakami Yutaka, Robbins Paul F, Wang Xiang, Tupesis Janis P, Parkhurst Maria R, Kang Xiaoqiang, Sakaguchi Kazuyasu, Appella Ettore, Rosenberg Steven A
The Journal of Immunology   161(12) 6985   1998   [Refereed]
Mu{ñ}oz-Barroso Isabel, Durell Stewart, Sakaguchi Kazuyasu, Appella Ettore, Blumenthal Robert
The Journal of cell biology   140(2) 315   1998   [Refereed]
Cai Mengli, Huang Ying, Sakaguchi Kazuyasu, Clore G Marius, Gronenborn Angela M, Craigie Robert
Journal of biomolecular NMR   11(1) 97   1998   [Refereed]
Fiscella Michele, Zhang HongLiang, Fan Saijun, Sakaguchi Kazuyasu, Shen Songfa, Mercer W Edward, Woude George F Vande, O?Connor Patrick M, Appella Ettore
Proceedings of the National Academy of Sciences   94(12) 6048   1997   [Refereed]
Del Guercio Marie-France, Alexander Jeff, Kubo Ralph T, Arrhenius Thomas, Maewal Ajesh, Appella Ettore, Hoffman Stephen L, Jones Trevor, Valmori Danila, Sakaguchi Kazuyasu, others
Vaccine   15(4) 441   1997   [Refereed]
Sakaguchi Kazuyasu, Sakamoto Hiroshi, Lewis Marc S, Anderson Carl W, Erickson John W, Appella Ettore, Xie Dong
Biochemistry   36(33) 10117   1997   [Refereed]
Bergman Ann-Charlotte, Linder Christina, Sakaguchi Kazuyasu, Sten-Linder Margareta, Alaiya Ayodele A, Franz{é}n Bo, Shoshan Maria C, Bergman Tomas, Wiman Bj{ö}rn, Auer Gert, others
FEBS letters   417(1) 17   1997   [Refereed]
Tsai Van, Southwood Scott, Sidney John, Sakaguchi Kazuyasu, Kawakami Yutaka, Appella Ettore, Sette Alessandro, Celis Esteban
The Journal of Immunology   158(4) 1796   1997   [Refereed]
Siliciano Janet D, Canman Christine E, Taya Yoichi, Sakaguchi Kazuyasu, Appella Ettore, Kastan Michael B
Genes & development   11(24) 3471   1997   [Refereed]
Fineschi Beatrice, Sakaguchi Kazuyasu, Appella Ettore, Miller Jim
The Journal of Immunology   157(8) 3211   1996   [Refereed]
Sakamoto Hiroshi, Kodama Hiroaki, Higashimoto Yuichiro, Kondo Michio, Lewis Marc S, Anderson Carl W, Appella Ettore, Sakaguchi Kazuyasu
Chemical Biology & Drug Design   48(5) 429   1996   [Refereed]
Sakaguchi Kazuyasu, Roller Peter P, Appella Ettore
Genetic engineering   249   1996   [Refereed]
Clore G Marius, Ernst James, Clubb Robert, Omichinski James G, Kennedy WM Poindexter, Sakaguchi Kazuyasu, Appella Ettore, Gronenborn Angela M
Nature Structural and Molecular Biology   2(4) 321   1995   [Refereed]
Kawakami Yutaka, Eliyahu Siona, Jennings Christopher, Sakaguchi Kazuyasu, Kang Xiaoqiang, Southwood Scott, Robbins Paul F, Sette Alessandro, Appella Ettore, Rosenberg Steven A
The Journal of Immunology   154(8) 3961   1995   [Refereed]
Rivoltini Licia, Kawakami Yutaka, Sakaguchi Kazuyasu, Southwood Scott, Sette Alessandro, Robbins Paul F, Marincola Francesco M, Salgaller Michael L, Yannelli John R, Appella Ettore
The Journal of Immunology   154(5) 2257   1995   [Refereed]
Kang Xiaoqiang, Kawakami Yutaka, El-Gamil Mona, Wang Rongfu, Sakaguchi Kazuyasu, Yannelli John R, Appella Ettore, Rosenberg Steven A, Robbins Paul F
The Journal of Immunology   155(3) 1343   1995   [Refereed]
Robbins Paul F, El-Gamil Mona, Li Yong F, Topalian Suzanne L, Rivoltini Licia, Sakaguchi Kazuyasu, Appella Ettore, Kawakami Yutaka, Rosenberg Steven A
The Journal of Immunology   154(11) 5944   1995   [Refereed]
Clubb Robert T, Omichinski James G, Gronenborn Angela M, Marius Clore G, Sakaguchi Kazuyazu, Appella Ettore
Protein Science   4(5) 855   1995   [Refereed]
Anderson CW, Connelly MA, Zhang H, Sipley JD, Leesmiller SP, Sakaguchi K, Ullrich SJ, Jackson SP, Appella E
JOURNAL OF PROTEIN CHEMISTRY   13(5) 500   1994   [Refereed]
Sakaguchi Kazuyasu, Kodama Hiroaki, Ogino Yoshio, Costa Tommaso, Nose Takeru, Shimohigashi Yasuyuki
Bulletin of the Chemical Society of Japan   67(6) 1659   1994   [Refereed]
APPELLA E, FISCELLA M, ZAMBRANO N, ULLRICH SJ, SAKAGUCHI K, SAKAMOTO H, LEWIS MS, LIN D, MERCER WE, ANDERSON CW
JOURNAL OF PROTEIN CHEMISTRY   13(5) 499   1994   [Refereed]
Chen YE, Sidney John, Southwood Scott, Cox Andrea L, Sakaguchi Kazuyasu, Henderson Robert A, Appella Ettore, Hunt Donald F, Sette Alessandro, Engelhard Victor H
The journal of immunology   152(6) 2874   1994   [Refereed]
Bovolenta Chiara, Driggers Paul H, Marks Michael S, Medin Jeffrey A, Politis Alexander D, Vogel Stefanie N, Levy David E, Sakaguchi Kazuyasu, Appella Ettore, Coligan John E
Proceedings of the National Academy of Sciences   91(11) 5046   1994   [Refereed]
Kawakami Yutaka, Eliyahu Siona, Sakaguchi Kazuyasu, Robbins Paul F, Rivoltini Licia, Yannelli John R, Appella Ettore, Rosenberg Steven A
Journal of Experimental Medicine   180(1) 347   1994   [Refereed]
Kawakami Yutaka, Eliyahu Siona, Delgado Cynthia H, Robbins Paul F, Sakaguchi Kazuyasu, Appella Ettore, Yannelli John R, Adema Gosse J, Miki Toru, Rosenberg Steven A
Proceedings of the National Academy of Sciences   91(14) 6458   1994   [Refereed]
Clore G Marius, Omichinski James G, Sakaguchi Kazuyasu, Zambrano Nicola, Sakamoto Hiroshi, Appella Ettore, Gronenborn Angela M
Science   265(5170) 386   1994   [Refereed]
Kubo Ralph T, Sette Alessandro, Grey Howard M, Appella Ettore, Sakaguchi Kazuyasu, Zhu Nian-Zhou, Arnott David, Sherman Nicholas, Shabanowitz Jeffrey, Michel Hanspeter
The Journal of Immunology   152(8) 3913   1994   [Refereed]
Burns Christopher M, Sakaguchi Kazuyasu, Appella Ettore, Ashwell Jonathan D
Journal of Biological Chemistry   269(18) 13594   1994   [Refereed]
Driscoll Paul C, Altman John D, Boniface J Jay, Sakaguchi Kazuyasu, Reay Philip A, Omichinski James G, Appella Ettore, Davis Mark M
   1993   [Refereed]
Kalia Yogeshvar N, Brocklehurst Simon M, Hipps Deborah S, Appella Ettore, Sakaguchi Kazuyasu, Perham Richard N
Journal of molecular biology   230(1) 323   1993   [Refereed]
Fazioli F, Wong WT, Ullrich SJ, Sakaguchi K, Appella E, Di PP Fiore
Oncogene   8(5) 1335   1993   [Refereed]
Gao Bin, Virmani M, Romm E, Lazar-Wesley E, Sakaguchi K, Appella E, Kunos G, Takacs L
Gene   126(2) 287   1993   [Refereed]
Ullrich Stephen J, Sakaguchi Kazuyasu, Lees-Miller Susan P, Fiscella Michele, Mercer W Edward, Anderson Carl W, Appella Ettore
Proceedings of the National Academy of Sciences   90(13) 5954   1993   [Refereed]
Matsumoto Hiroshi, Shimohigashi Yasuyuki, Takano Yukio, Sakaguchi Kazuyasu, Kamiya Hiro-o, Ohno Motonori
Bulletin of the Chemical Society of Japan   66(1) 196   1993   [Refereed]
Sakaguchi Kazuyasu, Zambrano Nicola, Baldwin Eric T, Shapiro Bruce A, Erickson John W, Omichinski James G, Clore G Marius, Gronenborn Angela M, Appella Ettore
Proceedings of the National Academy of Sciences   90(11) 5219   1993   [Refereed]
Henderson Robert A, Cox Andrea L, Sakaguchi Kazuyasu, Appella Ettore, Shabanowitz Jeffrey, Hunt Donald F, Engelhard Victor H
Proceedings of the National Academy of Sciences   90(21) 10275   1993   [Refereed]
Huczko EL, Bodnar WM, Benjamin D, Sakaguchi K, Zhu N Zhou, Shabanowitz J, Henderson RA, Appella E, Hunt DF, and Engelhard VH
The Journal of Immunology   151(5) 2572   1993   [Refereed]
Bristol LA, Sakaguchi K, Appella E, Doyle D, Takacs L
The Journal of Immunology   149(2) 367   1992   [Refereed]
Robien Mark A, Clore G Marius, Omichinski James G, Perham Richard N, Appella Ettore, Sakaguchi Kazuyasu, Gronenborn Angela M
Biochemistry   31(13) 3463   1992   [Refereed]
Sakaguchi Kazuyasu, Costa Tommaso, Sakamoto Hiroshi, Shimohigashi Yasuyuki
Bulletin of the Chemical Society of Japan   65(4) 1052   1992   [Refereed]
Hunt Donald F, Michel Hanspeter, Dickinson Tracey A, Shabanowitz Jeffrey, Cox Andrea L, Sakaguchi Kazuyasu, Appella Ettore, Grey Howard M, Sette Alessandro
Science   256(5065) 1817   1992   [Refereed]
Sette Alessandro, Ceman Stephanie, Kubo Ralph T, Sakaguchi Kazuyasu, Appella Ettore, Hunt Donald F, Davis Theresa A, Michel Hanspeter, Shabanowitz Jeffrey, Rudersdorf Richard, others
Science   258(5089) 1801   1992   [Refereed]
Olson D, P{ö}ll{ä}nen J, H{\o}yer-Hansen G, R{\o}nne E, Sakaguchi K, Wun T Ch, Appella E, Dan{\o} K, Blasi F
Journal of Biological Chemistry   267(13) 9129   1992   [Refereed]
Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW
Molecular and cellular biology   12(11) 5041   1992   [Refereed]
Omichinski James G, Sakaguchi Kazuyasu, Clore G Marius, Gronenborn Angela M, Appella Ettore
Journal of Protein Chemistry   11(4) 408   1992   [Refereed]
Henderson Robert A, Michel Hanspeter, Sakaguchi Kazuyasu, Shabanowitz Jeffrey, Appella Ettore, Hunt Donald F, Engelhard Victor H
Science   255(5049) 1264   1992   [Refereed]
Hunt Donald F, Henderson Robert A, Shabanowitz Jeffrey, Sakaguchi Kazuyasu, Michel Hanspeter, Sevilir Noelle, Cox Andrea L, Appella Ettore, Engelhard Victor H
Science   255(5049) 1261   1992   [Refereed]
Sakaguchi K, Appella E, Omichinski JG, Clore GM, Gronenborn AM
Journal of Biological Chemistry   266(11) 7306   1991   [Refereed]
Shimohigashi Y, Sakaguchi K, Sakamoto H, Waki M, Costa T
Peptide research   3(5) 216   1990   [Refereed]
Sakaguchi Kazuyasu, Sakamoto Hiroshi, Tsubaki Yoshiko, Waki Michinori, Costa Tommaso, Shimohigashi Yasuyuki
Bulletin of the Chemical Society of Japan   63(6) 1753   1990   [Refereed]
Omichinski James G, Clore G Marius, Appella Ettore, Sakaguchi Kazuyasu, Gronenborn Angela M
Biochemistry   29(40) 9324   1990   [Refereed]
Saito Ryo, Konishi Hiroki, Takano Yukio, Nonaka Shigeyuki, Sakaguchi Kazuyasu, Shimohigashi Yasuyuki, Kamiya Hiro-o
Neuroscience letters   110(3) 337   1990   [Refereed]
Sakaguchi K, Kodama H, Matsumoto H, Yoshida M, Takano Y, Kamiya H, Waki M, Shimohigashi Y
Peptide research   2(5) 345   1989   [Refereed]
IMAZU S, SHIMOHIGASHI Y, KODAMA H, SAKAGUCHI K, WAKI M, KATO T, IZUMIYA N
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH   32(4) 298   1988   [Refereed]
Kodama Hiroaki, Shimohigashi Yasuyuki, Sakaguchi Kazuyasu, Waki Michinori, Takano Yukio, Yamada Akiko, Hatae Yasuyuki, Kamiya Hiro-o
European journal of pharmacology   151(2) 317   1988   [Refereed]
Shimohigashi Y, Kodama H, Sakaguchi K, Kato T, Waki M, Kamiya H, Yamada A, Higuchi Y, Takano Y
Regulatory Peptides   22(1-2) 172   1988   [Refereed]

Research Grants & Projects

 
Structure and Post-translational Modification of Tumor suppressor Protein p53 and its related proteins
Project Year: 2003   
Cell cycle control by protein phosphatase
Project Year: 1999   

Patents

 
US 6,309,863, B1